DE102006026578B4 - Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung - Google Patents
Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung Download PDFInfo
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- DE102006026578B4 DE102006026578B4 DE102006026578A DE102006026578A DE102006026578B4 DE 102006026578 B4 DE102006026578 B4 DE 102006026578B4 DE 102006026578 A DE102006026578 A DE 102006026578A DE 102006026578 A DE102006026578 A DE 102006026578A DE 102006026578 B4 DE102006026578 B4 DE 102006026578B4
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- water
- transdermal therapeutic
- therapeutic system
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- active ingredient
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006026578A DE102006026578B4 (de) | 2006-06-08 | 2006-06-08 | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| JP2009513577A JP5757682B2 (ja) | 2006-06-08 | 2007-05-30 | 活性成分粒子を含み増大した活性成分流量を有する経皮治療システム |
| PT07725656T PT2029121E (pt) | 2006-06-08 | 2007-05-30 | Sistema terapêutico transdérmico compreendendo partículas de princípio activo e possuindo um fluxo acrescido de princípio activo |
| PL07725656T PL2029121T3 (pl) | 2006-06-08 | 2007-05-30 | Transdermalny system terapeutyczny zawierający cząstki substancji czynnej, o zwiększonym przepływie substancji czynnej |
| PCT/EP2007/004765 WO2007140909A1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
| DK07725656.8T DK2029121T3 (da) | 2006-06-08 | 2007-05-30 | Transdermalt terapeutisk system indeholdende partikler af virksom bestanddel og med forøget strøm af virksom bestanddel |
| DE502007003020T DE502007003020D1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
| CN200780021134XA CN101466361B (zh) | 2006-06-08 | 2007-05-30 | 具有增加活性成分通量的含活性成分颗粒的透皮治疗系统 |
| ES07725656T ES2340732T3 (es) | 2006-06-08 | 2007-05-30 | Sistema terapeutico transdermico que contiene particulas de una sustancia activa, con un flujo aumentado de la sustancia activa. |
| BRPI0712420-1A BRPI0712420A2 (pt) | 2006-06-08 | 2007-05-30 | sistema terapêutico transdérmico, que contém partìculas de substáncia ativa, com fluxo mais alto de substáncia ativa |
| CA2652216A CA2652216C (en) | 2006-06-08 | 2007-05-30 | Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux |
| US12/302,065 US10292942B2 (en) | 2006-06-08 | 2007-05-30 | Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux |
| AT07725656T ATE459345T1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
| EP07725656A EP2029121B1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
| US16/380,069 US10596126B2 (en) | 2006-06-08 | 2019-04-10 | Transdermal therapeutic system comprising active ingredient particles and having increased active ingredient flux |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006026578A DE102006026578B4 (de) | 2006-06-08 | 2006-06-08 | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE102006026578A1 DE102006026578A1 (de) | 2007-12-13 |
| DE102006026578B4 true DE102006026578B4 (de) | 2009-01-08 |
Family
ID=38520773
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102006026578A Expired - Fee Related DE102006026578B4 (de) | 2006-06-08 | 2006-06-08 | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| DE502007003020T Active DE502007003020D1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE502007003020T Active DE502007003020D1 (de) | 2006-06-08 | 2007-05-30 | Wirkstoffpartikelhaltiges transdermales therapeutisches system mit erhöhtem wirkstofffluss |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10292942B2 (https=) |
| EP (1) | EP2029121B1 (https=) |
| JP (1) | JP5757682B2 (https=) |
| CN (1) | CN101466361B (https=) |
| AT (1) | ATE459345T1 (https=) |
| BR (1) | BRPI0712420A2 (https=) |
| CA (1) | CA2652216C (https=) |
| DE (2) | DE102006026578B4 (https=) |
| DK (1) | DK2029121T3 (https=) |
| ES (1) | ES2340732T3 (https=) |
| PL (1) | PL2029121T3 (https=) |
| PT (1) | PT2029121E (https=) |
| WO (1) | WO2007140909A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| US8369942B2 (en) * | 2008-03-20 | 2013-02-05 | The Invention Science Fund I, Llc | Subdermal material delivery device |
| CA2662499A1 (en) * | 2008-04-16 | 2009-10-16 | Nitto Denko Corporation | Transdermal drug administration device |
| US20110033545A1 (en) * | 2009-08-06 | 2011-02-10 | Absize, Inc. | Topical pharmaceutical preparations having both a nanoparticle solution and a nanoparticle suspension and methods for the treatment of acute and chronic pain therewith |
| DE102011100619A1 (de) | 2010-05-05 | 2012-01-05 | Amw Gmbh | Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum |
| CN103052380B (zh) | 2010-08-23 | 2015-11-25 | 塔科达有限责任公司 | 包含治疗活性物质的湿润颗粒 |
| DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
| WO2014195352A1 (en) * | 2013-06-04 | 2014-12-11 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system |
| EP3209389B1 (en) | 2014-10-21 | 2019-10-02 | The Procter and Gamble Company | Kit for improving skin appearance |
| CN104758181A (zh) * | 2015-04-09 | 2015-07-08 | 史祎 | 一种无溶剂贴敷剂制备工艺 |
| CN108348788B (zh) | 2015-10-22 | 2021-11-05 | 宝洁公司 | 发泡膜的阻隔贴片和改善皮肤外观的方法 |
| CN108136230B (zh) | 2015-10-22 | 2022-05-13 | 宝洁公司 | 发泡膜的阻隔贴片和改善皮肤外观的方法 |
| EP3565641B1 (en) * | 2017-01-09 | 2021-06-23 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| US10751265B2 (en) * | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
| US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| EP3641952B1 (en) * | 2017-06-22 | 2023-08-02 | The Procter & Gamble Company | Beauty care films including a water-soluble layer and a vapor-deposited coating |
| KR102524880B1 (ko) * | 2017-12-21 | 2023-04-21 | 한양대학교 산학협력단 | 하이드로콜로이드 조성물 및 이를 포함하는 바이오 패치 |
| US10751266B2 (en) | 2018-03-19 | 2020-08-25 | The Procter & Gamble Company | Method of making a barrier patch with soluble film |
| US12491166B2 (en) | 2020-08-31 | 2025-12-09 | Wacker Chemie Ag | Method of delivering an active compound and delivery device for use in the same |
| US12201733B2 (en) * | 2021-03-08 | 2025-01-21 | Nikita Patel | Transdermal delivery system |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0186019A2 (de) * | 1984-12-22 | 1986-07-02 | Schwarz Pharma Ag | Wirkstoffpflaster |
| DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
| EP0481443A1 (en) * | 1990-10-17 | 1992-04-22 | Vectorpharma International S.P.A. | Transdermal therapeutic compositions |
| EP0739626A2 (en) * | 1995-04-28 | 1996-10-30 | Lead Chemical Company Ltd. | Release controlled transdermal therapeutic system |
| DE19844079A1 (de) * | 1998-05-22 | 1999-11-25 | Novosis Pharma Ag | Biphasische Transdermalsysteme |
| WO2000047191A1 (de) * | 1999-02-10 | 2000-08-17 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige laminate für transdermalsysteme |
| DE10136784A1 (de) * | 2001-07-27 | 2003-02-20 | Lohmann Therapie Syst Lts | Darreichungsformen mit wirkstoffhaltigen Partikeln, zur Anwendung auf der Haut oder Schleimhaut |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US3965482A (en) * | 1974-11-12 | 1976-06-22 | Rca Corporation | Velocity correction circuit for video discs |
| US4460372A (en) | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
| US4687481A (en) | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
| GB8629640D0 (en) | 1986-12-11 | 1987-01-21 | Beecham Group Plc | Composition & method |
| US5059189A (en) | 1987-09-08 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Method of preparing adhesive dressings containing a pharmaceutically active ingredient |
| IT1230566B (it) | 1988-10-17 | 1991-10-28 | Vectorpharma Int | Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione |
| US5270358A (en) * | 1989-12-28 | 1993-12-14 | Minnesota Mining And Manufacturing Company | Composite of a disperesed gel in an adhesive matrix |
| DE4332093C2 (de) | 1993-09-22 | 1995-07-13 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung |
| US6238700B1 (en) | 1995-12-01 | 2001-05-29 | Alza Corporation | Method for preventing crystal formation in a dispersion of a liquid in a matrix |
| DE19652196A1 (de) | 1996-12-16 | 1998-06-18 | Jenapharm Gmbh | Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen |
| EP1021241B1 (de) * | 1997-10-06 | 2001-08-29 | Adalbert-Raps-Stiftung | Verfahren zur herstellung eines pulverförmigen produktes aus einem flüssigen stoff oder stoffgemisch |
| FI20010115A0 (fi) * | 2001-01-18 | 2001-01-18 | Orion Corp | Menetelmä nanopartikkelien valmistamiseksi |
| DE10234673B4 (de) | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
| DE102006026578B4 (de) * | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
-
2006
- 2006-06-08 DE DE102006026578A patent/DE102006026578B4/de not_active Expired - Fee Related
-
2007
- 2007-05-30 AT AT07725656T patent/ATE459345T1/de active
- 2007-05-30 BR BRPI0712420-1A patent/BRPI0712420A2/pt not_active IP Right Cessation
- 2007-05-30 US US12/302,065 patent/US10292942B2/en active Active
- 2007-05-30 DE DE502007003020T patent/DE502007003020D1/de active Active
- 2007-05-30 ES ES07725656T patent/ES2340732T3/es active Active
- 2007-05-30 EP EP07725656A patent/EP2029121B1/de not_active Revoked
- 2007-05-30 JP JP2009513577A patent/JP5757682B2/ja not_active Expired - Fee Related
- 2007-05-30 WO PCT/EP2007/004765 patent/WO2007140909A1/de not_active Ceased
- 2007-05-30 PT PT07725656T patent/PT2029121E/pt unknown
- 2007-05-30 DK DK07725656.8T patent/DK2029121T3/da active
- 2007-05-30 CN CN200780021134XA patent/CN101466361B/zh not_active Expired - Fee Related
- 2007-05-30 PL PL07725656T patent/PL2029121T3/pl unknown
- 2007-05-30 CA CA2652216A patent/CA2652216C/en active Active
-
2019
- 2019-04-10 US US16/380,069 patent/US10596126B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0186019A2 (de) * | 1984-12-22 | 1986-07-02 | Schwarz Pharma Ag | Wirkstoffpflaster |
| DE3910543A1 (de) * | 1989-04-01 | 1990-10-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung |
| US5230898A (en) * | 1989-04-01 | 1993-07-27 | Lts Lohmann Therapie-Systeme Gmbh & Co. K.G. | Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof |
| EP0481443A1 (en) * | 1990-10-17 | 1992-04-22 | Vectorpharma International S.P.A. | Transdermal therapeutic compositions |
| EP0739626A2 (en) * | 1995-04-28 | 1996-10-30 | Lead Chemical Company Ltd. | Release controlled transdermal therapeutic system |
| DE19844079A1 (de) * | 1998-05-22 | 1999-11-25 | Novosis Pharma Ag | Biphasische Transdermalsysteme |
| WO2000047191A1 (de) * | 1999-02-10 | 2000-08-17 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige laminate für transdermalsysteme |
| DE10136784A1 (de) * | 2001-07-27 | 2003-02-20 | Lohmann Therapie Syst Lts | Darreichungsformen mit wirkstoffhaltigen Partikeln, zur Anwendung auf der Haut oder Schleimhaut |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009539786A (ja) | 2009-11-19 |
| US10596126B2 (en) | 2020-03-24 |
| US10292942B2 (en) | 2019-05-21 |
| US20190231710A1 (en) | 2019-08-01 |
| ATE459345T1 (de) | 2010-03-15 |
| CA2652216A1 (en) | 2007-12-13 |
| EP2029121A1 (de) | 2009-03-04 |
| US20090258062A1 (en) | 2009-10-15 |
| ES2340732T3 (es) | 2010-06-08 |
| CA2652216C (en) | 2016-02-16 |
| EP2029121B1 (de) | 2010-03-03 |
| DE502007003020D1 (de) | 2010-04-15 |
| PT2029121E (pt) | 2010-05-11 |
| PL2029121T3 (pl) | 2010-06-30 |
| CN101466361B (zh) | 2012-01-04 |
| DE102006026578A1 (de) | 2007-12-13 |
| DK2029121T3 (da) | 2010-06-07 |
| CN101466361A (zh) | 2009-06-24 |
| WO2007140909A1 (de) | 2007-12-13 |
| BRPI0712420A2 (pt) | 2012-09-04 |
| JP5757682B2 (ja) | 2015-07-29 |
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| R119 | Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee |