JP2009539097A5 - - Google Patents
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- JP2009539097A5 JP2009539097A5 JP2009512704A JP2009512704A JP2009539097A5 JP 2009539097 A5 JP2009539097 A5 JP 2009539097A5 JP 2009512704 A JP2009512704 A JP 2009512704A JP 2009512704 A JP2009512704 A JP 2009512704A JP 2009539097 A5 JP2009539097 A5 JP 2009539097A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- igf
- tumor cells
- cell
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 102000004584 Somatomedin Receptors Human genes 0.000 claims 16
- 108010017622 Somatomedin Receptors Proteins 0.000 claims 16
- 210000004881 tumor cell Anatomy 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 9
- 238000004458 analytical method Methods 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 7
- 239000005557 antagonist Substances 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 238000010191 image analysis Methods 0.000 claims 4
- 239000006249 magnetic particle Substances 0.000 claims 4
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 2
- 102000011782 Keratins Human genes 0.000 claims 2
- 108010076876 Keratins Proteins 0.000 claims 2
- 239000006285 cell suspension Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000004163 cytometry Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical group O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 2
- 238000010820 immunofluorescence microscopy Methods 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 230000003595 spectral effect Effects 0.000 claims 2
- 230000007717 exclusion Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81081106P | 2006-06-02 | 2006-06-02 | |
| US60/810,811 | 2006-06-02 | ||
| PCT/IB2007/001483 WO2007141626A1 (en) | 2006-06-02 | 2007-05-29 | Circulating tumor cell assay |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009539097A JP2009539097A (ja) | 2009-11-12 |
| JP2009539097A5 true JP2009539097A5 (https=) | 2010-07-15 |
| JP4943504B2 JP4943504B2 (ja) | 2012-05-30 |
Family
ID=38476880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512704A Expired - Fee Related JP4943504B2 (ja) | 2006-06-02 | 2007-05-29 | 循環腫瘍細胞アッセイ |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US8940493B2 (https=) |
| EP (1) | EP2027470B1 (https=) |
| JP (1) | JP4943504B2 (https=) |
| KR (3) | KR20090023423A (https=) |
| CN (1) | CN101600966B (https=) |
| AU (1) | AU2007255110B8 (https=) |
| BR (1) | BRPI0712225A8 (https=) |
| CA (1) | CA2653745C (https=) |
| DK (1) | DK2027470T3 (https=) |
| ES (1) | ES2397971T3 (https=) |
| IL (1) | IL195577A (https=) |
| MX (1) | MX2008015425A (https=) |
| NZ (1) | NZ573187A (https=) |
| PL (1) | PL2027470T3 (https=) |
| PT (1) | PT2027470E (https=) |
| RU (1) | RU2429486C2 (https=) |
| SI (1) | SI2027470T1 (https=) |
| WO (1) | WO2007141626A1 (https=) |
| ZA (1) | ZA200810203B (https=) |
Families Citing this family (48)
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| AU2006292278B2 (en) | 2005-09-20 | 2012-03-08 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
| MX2008015425A (es) | 2006-06-02 | 2008-12-12 | Pfizer Prod Inc | Ensayo de celulas tumorales circulantes. |
| PE20090368A1 (es) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
| JP2010540960A (ja) | 2007-10-03 | 2010-12-24 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | インスリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー |
| JP2011501660A (ja) | 2007-10-03 | 2011-01-13 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | インスリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー |
| US20090258365A1 (en) | 2008-03-25 | 2009-10-15 | Terstappen Leon W M M | METHOD FOR DETECTING IGF1R/Chr 15 in CIRCULATING TUMOR CELLS USING FISH |
| NZ592151A (en) | 2008-12-12 | 2012-10-26 | Boehringer Ingelheim Int | Anti-igf antibodies |
| EP3045918B1 (en) * | 2009-10-21 | 2017-12-06 | The Scripps Research Institute | Method of using non-rare cells to detect rare cells |
| WO2011083391A2 (en) * | 2010-01-05 | 2011-07-14 | Pfizer Inc. | Biomarkers for anti-igf-ir cancer therapy |
| TWI577389B (zh) * | 2010-10-14 | 2017-04-11 | 維里德克斯有限責任公司 | 使用多專一性捕捉及雞尾酒檢測試劑檢測胰臟病患之循環腫瘤細胞的方法及套組 |
| WO2012103025A2 (en) * | 2011-01-24 | 2012-08-02 | Epic Sciences, Inc. | Methods for obtaining single cells and applications of single cell omics |
| EP2702173A1 (en) | 2011-04-25 | 2014-03-05 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
| WO2013013222A1 (en) * | 2011-07-21 | 2013-01-24 | Veridex, Llc | Assay to capture and detect circulating multiple myeloma cells from blood |
| ES2930651T3 (es) * | 2011-09-06 | 2022-12-20 | Becton Dickinson Co | Métodos y composiciones para la detección citométrica de células tumorales circulantes en una muestra |
| AU2013302867A1 (en) | 2012-08-13 | 2015-02-26 | The Regents Of The University Of California | Methods and systems for detecting biological components |
| EP2903691B1 (en) | 2012-10-05 | 2019-05-22 | F.Hoffmann-La Roche Ag | Methods for diagnosing and treating inflammatory bowel disease |
| EP2912433B1 (en) * | 2012-10-26 | 2019-03-20 | Fluidigm Canada Inc. | Cell analysis by mass cytometry |
| US9396532B2 (en) * | 2012-11-15 | 2016-07-19 | Siemens Healthcare Diagnostics, Inc. | Cell feature-based automatic circulating tumor cell detection |
| GB2516196B (en) | 2013-01-25 | 2015-09-09 | Xcell Biosciences Inc | Methods, compositions, kits, and systems for selective enrichment of target cells |
| US20150233932A1 (en) * | 2013-02-19 | 2015-08-20 | Ching-Ping Tseng | Methods, Systems, and Compositions for Enrichment of Rare Cells |
| US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
| EP3502270B1 (en) | 2013-10-21 | 2020-03-18 | The General Hospital Corporation | Methods relating to circulating tumor cell clusters and the treatment of cancer |
| CN103630440A (zh) * | 2013-11-28 | 2014-03-12 | 武汉大学 | 一种循环肿瘤细胞的富集方法 |
| EA201691496A1 (ru) | 2014-01-27 | 2016-12-30 | Эпик Сайенсиз, Инк. | Диагностика биомаркеров рака предстательной железы с помощью циркулирующих опухолевых клеток |
| CN106061998B (zh) * | 2014-02-05 | 2020-12-11 | 弗吉瑞必欧诊断股份公司 | 用于检测恶性赘生性疾病的组合物和方法 |
| EA201691682A1 (ru) | 2014-02-21 | 2017-02-28 | Эпик Сайенсиз, Инк. | Способы анализирования редких циркулирующих в крови клеток |
| CN103940997B (zh) * | 2014-03-21 | 2017-01-04 | 上海柏慧康生物科技有限公司 | 一种乳腺癌循环肿瘤细胞检测系统及试剂盒 |
| KR101656037B1 (ko) * | 2014-04-30 | 2016-09-08 | 울산과학기술원 | 희소 세포 분리장치, 희소 세포 분리 방법 및 이를 이용한 희소 세포 검출 방법 |
| US10697007B2 (en) | 2014-06-27 | 2020-06-30 | The Regents Of The University Of California | PCR-activated sorting (PAS) |
| CA2959072C (en) * | 2014-08-25 | 2025-12-09 | Creatv Microtech, Inc. | Use of circulating cell biomarkers in the blood for detection and diagnosis of diseases and methods of isolating them |
| CN104345052B (zh) * | 2014-09-29 | 2017-10-20 | 南通市肿瘤医院 | 一种荧光负染法检测活细胞的方法 |
| US10434507B2 (en) | 2014-10-22 | 2019-10-08 | The Regents Of The University Of California | High definition microdroplet printer |
| CN115011670A (zh) | 2015-02-04 | 2022-09-06 | 加利福尼亚大学董事会 | 通过在离散实体中条形码化对核酸进行测序 |
| WO2016172427A1 (en) * | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| KR101701618B1 (ko) | 2015-06-23 | 2017-02-13 | 국립암센터 | 전도성 고분자를 이용한 세포 유리 ｄｎａ 검출용 구조체 및 이의 용도 |
| RU2616532C1 (ru) * | 2015-12-28 | 2017-04-17 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ оценки чувствительности опухоли к проводимой химиотерапии больных местно-распространенным раком молочной железы |
| KR102130872B1 (ko) | 2016-04-27 | 2020-07-06 | 주식회사 엘지화학 | 고체 시료의 수분 측정 장치, 고체 시료 수분 함량 측정 방법 및 이미드화율 분석 방법 |
| CN110088290A (zh) | 2016-08-10 | 2019-08-02 | 加利福尼亚大学董事会 | 在乳液微滴中结合多重置换扩增和pcr |
| CA3047328A1 (en) | 2016-12-21 | 2018-06-28 | The Regents Of The University Of California | Single cell genomic sequencing using hydrogel based droplets |
| US11576424B2 (en) | 2017-04-05 | 2023-02-14 | Altria Client Services Llc | Susceptor for use with an inductively heated aerosol-generating device or system |
| CN115969102B (zh) | 2017-04-05 | 2025-12-12 | 菲利普莫里斯生产公司 | 与电感加热式气溶胶生成装置或系统一起使用的感受器 |
| US10501739B2 (en) | 2017-10-18 | 2019-12-10 | Mission Bio, Inc. | Method, systems and apparatus for single cell analysis |
| EP3540631A1 (de) | 2018-03-15 | 2019-09-18 | Siemens Healthcare GmbH | In-vitro-verfahren zum markierungsfreien bestimmen eines zelltyps einer weissen blutzelle |
| CN109406245A (zh) * | 2018-09-12 | 2019-03-01 | 中国辐射防护研究院 | 一种电子线照射对小鼠igf相关蛋白表达影响的检测方法 |
| CA3138806A1 (en) | 2019-05-22 | 2020-11-26 | Dalia Dhingra | Method and apparatus for simultaneous targeted sequencing of dna, rna and protein |
| WO2021003255A1 (en) | 2019-07-01 | 2021-01-07 | Mission Bio | Method and apparatus to normalize quantitative readouts in single-cell experiments |
| EP4501142A4 (en) | 2022-03-30 | 2026-01-21 | Japan Tobacco Inc | Aroma leaf for use in a non-combustible heating aroma inhalation device |
| EP4646208A1 (en) | 2023-01-06 | 2025-11-12 | Ideaya Biosciences, Inc. | Treatment of er+ breast cancer comprising homologous recombination deficiency using parg inhibitor |
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| US4551435A (en) | 1983-08-24 | 1985-11-05 | Immunicon, Inc. | Selective removal of immunospecifically recognizable substances from solution |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| US4925788A (en) | 1986-10-24 | 1990-05-15 | Immunicon Corporation | Immunoassay system and procedure based on precipitin-like interaction between immune complex and Clq or other non-immunospecific factor |
| US5108933A (en) | 1988-09-16 | 1992-04-28 | Immunicon Corporation | Manipulation of colloids for facilitating magnetic separations |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| CA2251186A1 (en) | 1996-04-05 | 1997-10-16 | The Johns Hopkins University | A method of enriching rare cells |
| US20010018192A1 (en) | 1998-02-12 | 2001-08-30 | Terstappen Leon W.M.M. | Labeled cells for use as an internal functional control in rare cell detection assays |
| US20020172987A1 (en) | 1998-02-12 | 2002-11-21 | Terstappen Leon W.M.M. | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
| WO1999041613A1 (en) | 1998-02-12 | 1999-08-19 | Immunivest | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
| DE19983691T1 (de) | 1998-10-29 | 2001-11-29 | Cell Works Inc | Charakterisierung mehrerer Marker von Einzelzellen |
| AU2876900A (en) | 1999-02-10 | 2000-08-29 | Cell Works Inc. | Class characterization of circulating cancer cells isolated from body fluids andmethods of use |
| JP2001041959A (ja) * | 1999-05-24 | 2001-02-16 | Toray Ind Inc | 癌細胞検出システムおよび癌細胞検出キット |
| BR0013388A (pt) | 1999-08-18 | 2002-08-27 | Gen Hospital Corp | Processos, composições e kits para promover a recuperação de lesões do sistema nervoso central |
| US7537938B2 (en) | 2000-04-28 | 2009-05-26 | Monogram Biosciences, Inc. | Biomarker detection in circulating cells |
| WO2002059558A2 (en) * | 2001-01-23 | 2002-08-01 | Primagen Holding B.V. | Means and methods for treatment evaluation |
| BR0207290A (pt) * | 2001-02-16 | 2005-06-07 | Immunivest Corp | Método para analisar um paciente quanto à presença de uma malignidade, célula maligna isolada das células cultivadas, vacina de tumor, molécula associada com diátese de tumor alterada, métodos para determinar alterações em moléculas associadas com diátese de tumor como um meio para predizer a eficácia da terapia, como um meio para analisar dosagem apropriada para terapia, como um meio para monitorar eficácia da terapia, como um meio para analisar progressão de câncer, para realizar uma biópsia de corpo inteiro em um paciente, e para identificar alterações em uma célula de tumor circulante relativamente a células presentes numa massa de tumor in situ, e, kit de teste para analisar uma amostra de paciente quanto à presença de uma célula maligna não-hematopoiética |
| EP1425294B2 (en) * | 2001-08-23 | 2012-12-12 | Veridex, LLC | Analysis of circulating tumor cells, fragments, and debris |
| US7863012B2 (en) | 2004-02-17 | 2011-01-04 | Veridex, Llc | Analysis of circulating tumor cells, fragments, and debris |
| US6670142B2 (en) * | 2001-10-26 | 2003-12-30 | The Regents Of The University Of California | Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells |
| DE60312639T2 (de) * | 2002-01-18 | 2007-11-29 | Pierre Fabre Médicament | Antikörper gegen igf-ir und ihre verwendungen |
| US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
| MXPA06001634A (es) | 2003-08-13 | 2006-04-28 | Pfizer Prod Inc | Anticuerpos humanos modificados igf-1r. |
| KR20070036130A (ko) * | 2004-07-16 | 2007-04-02 | 화이자 프로덕츠 인코포레이티드 | 항-아이지에프-1알 항체를 사용하는 비-혈액학적악성종양에 대한 조합 치료 |
| US20060045881A1 (en) * | 2004-08-26 | 2006-03-02 | Board Of Regents, The University Of Texas System | Anti-cancer vaccines |
| WO2006041453A1 (en) | 2004-09-30 | 2006-04-20 | Immunivest Corporation | Circulating tumor cells (ctc’s): apoptotic assessment in prostate cancer patients |
| CA2600225C (en) | 2005-03-14 | 2016-06-28 | Immunivest Corporation | A method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells |
| US20070037173A1 (en) | 2005-08-12 | 2007-02-15 | Allard Jeffrey W | Circulating tumor cells (CTC's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients |
| MX2008015425A (es) | 2006-06-02 | 2008-12-12 | Pfizer Prod Inc | Ensayo de celulas tumorales circulantes. |
| US9121801B2 (en) * | 2007-10-24 | 2015-09-01 | Biomarker Strategies, Llc | Methods and devices for cellular analysis |
-
2007
- 2007-05-29 MX MX2008015425A patent/MX2008015425A/es active IP Right Grant
- 2007-05-29 CN CN200780027121.3A patent/CN101600966B/zh not_active Expired - Fee Related
- 2007-05-29 KR KR1020087032034A patent/KR20090023423A/ko not_active Ceased
- 2007-05-29 PL PL07734765T patent/PL2027470T3/pl unknown
- 2007-05-29 SI SI200731093T patent/SI2027470T1/sl unknown
- 2007-05-29 DK DK07734765.6T patent/DK2027470T3/da active
- 2007-05-29 WO PCT/IB2007/001483 patent/WO2007141626A1/en not_active Ceased
- 2007-05-29 PT PT77347656T patent/PT2027470E/pt unknown
- 2007-05-29 AU AU2007255110A patent/AU2007255110B8/en not_active Ceased
- 2007-05-29 JP JP2009512704A patent/JP4943504B2/ja not_active Expired - Fee Related
- 2007-05-29 EP EP07734765A patent/EP2027470B1/en not_active Not-in-force
- 2007-05-29 RU RU2008147415/15A patent/RU2429486C2/ru not_active IP Right Cessation
- 2007-05-29 CA CA2653745A patent/CA2653745C/en not_active Expired - Fee Related
- 2007-05-29 BR BRPI0712225A patent/BRPI0712225A8/pt not_active Application Discontinuation
- 2007-05-29 KR KR1020147009331A patent/KR20140052081A/ko not_active Ceased
- 2007-05-29 US US12/303,243 patent/US8940493B2/en active Active
- 2007-05-29 KR KR1020137019896A patent/KR101467136B1/ko active Active
- 2007-05-29 ES ES07734765T patent/ES2397971T3/es active Active
- 2007-05-29 NZ NZ573187A patent/NZ573187A/en not_active IP Right Cessation
-
2008
- 2008-11-27 IL IL195577A patent/IL195577A/en active IP Right Grant
- 2008-12-01 ZA ZA2008/10203A patent/ZA200810203B/en unknown
-
2014
- 2014-12-22 US US14/580,019 patent/US20150177252A1/en not_active Abandoned
-
2017
- 2017-07-27 US US15/661,241 patent/US20180011103A1/en not_active Abandoned
-
2019
- 2019-07-08 US US16/505,085 patent/US20200191793A1/en not_active Abandoned
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