JP2009537507A5 - - Google Patents
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- Publication number
- JP2009537507A5 JP2009537507A5 JP2009510567A JP2009510567A JP2009537507A5 JP 2009537507 A5 JP2009537507 A5 JP 2009537507A5 JP 2009510567 A JP2009510567 A JP 2009510567A JP 2009510567 A JP2009510567 A JP 2009510567A JP 2009537507 A5 JP2009537507 A5 JP 2009537507A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- mammal
- atherosclerosis
- disease
- related disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000124008 Mammalia Species 0.000 claims description 18
- 201000001320 Atherosclerosis Diseases 0.000 claims description 15
- 239000002671 adjuvant Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 201000010099 disease Diseases 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 14
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 208000005764 Peripheral Arterial Disease Diseases 0.000 description 4
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 102000013918 Apolipoproteins E Human genes 0.000 description 2
- 108010025628 Apolipoproteins E Proteins 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 229960001005 tuberculin Drugs 0.000 description 2
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80002906P | 2006-05-15 | 2006-05-15 | |
| PCT/IB2007/001264 WO2007132338A2 (en) | 2006-05-15 | 2007-05-15 | IL-1α IMMUNIZATION INDUCES AUTOANTIBODIES PROTECTIVE AGAINST ATHEROSCLEROSIS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009537507A JP2009537507A (ja) | 2009-10-29 |
| JP2009537507A5 true JP2009537507A5 (enExample) | 2010-07-01 |
Family
ID=38694276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510567A Pending JP2009537507A (ja) | 2006-05-15 | 2007-05-15 | アテローム性動脈硬化症に対して保護的な自己抗体を誘導するＩＬ−１α免疫法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090191149A1 (enExample) |
| EP (1) | EP2021033B1 (enExample) |
| JP (1) | JP2009537507A (enExample) |
| CN (1) | CN101448528A (enExample) |
| AT (1) | ATE551365T1 (enExample) |
| AU (1) | AU2007251239B2 (enExample) |
| CA (1) | CA2652274A1 (enExample) |
| ES (1) | ES2384278T3 (enExample) |
| WO (1) | WO2007132338A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1915620T3 (da) | 2005-08-02 | 2010-10-04 | Xbiotech Inc | Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistoffer |
| US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| CN102580086A (zh) * | 2006-05-22 | 2012-07-18 | 埃克斯生物科技公司 | 使用抗IL-1α抗体治疗癌症 |
| HUE029003T2 (en) | 2008-05-30 | 2017-01-30 | Xbiotech Inc | IL-1 alpha antibodies |
| JP5976319B2 (ja) * | 2008-09-12 | 2016-08-23 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 病原性単球の標的化 |
| EP2569640A1 (en) | 2010-05-12 | 2013-03-20 | The University of Birmingham | Biomarker |
| CN102946904A (zh) | 2010-06-18 | 2013-02-27 | 埃克斯生物科技公司 | 关节炎治疗 |
| PH12013500316A1 (en) | 2010-08-23 | 2016-09-02 | Janssen Biotech Inc | Treatment for neoplastic diseases |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| PT2750709T (pt) | 2011-09-23 | 2018-11-22 | Xbiotech Inc | Tratamento da caquexia |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| JP6456015B2 (ja) * | 2013-07-19 | 2019-01-23 | 国立大学法人三重大学 | 閉塞性動脈硬化症モデル動物、るい痩研究用モデル動物、及び全身性アミロイドーシスモデル動物としての非ヒト哺乳動物 |
| CN105175504A (zh) * | 2015-09-08 | 2015-12-23 | 苏州普罗达生物科技有限公司 | 血管性血友病因子抑制多肽及其应用 |
| CN105175503A (zh) * | 2015-09-08 | 2015-12-23 | 苏州普罗达生物科技有限公司 | 因子viii抑制多肽及其应用 |
| JP7145162B2 (ja) | 2017-02-16 | 2022-09-30 | ヤンセン バイオテク，インコーポレイテッド | 化膿性汗腺炎の処置 |
| US10975146B2 (en) | 2018-06-29 | 2021-04-13 | Cedars-Sinai Medical Center | Interleukin-1 inhibition for combination treatment of pancreatic cancer |
| CA3095675A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin 1 alpha (il-1a) |
| CA3095740A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin alpha (il-1a) |
| CA3095679A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleuken 1 alpha (il-1a) |
| CA3095676A1 (en) | 2020-10-07 | 2022-04-07 | Xbiotech Inc. | True human antibody specific for interleukin 1 alpha (il-1a) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9802402D0 (sv) * | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| US6555579B2 (en) * | 1998-08-13 | 2003-04-29 | The Wistar Institute | Methods for reducing atherosclerotic plaques |
| US20030040617A9 (en) * | 1999-03-12 | 2003-02-27 | Rosen Craig A. | Nucleic acids, proteins and antibodies |
| US20030232054A1 (en) * | 2000-01-25 | 2003-12-18 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| US20030026806A1 (en) * | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| US20040224893A1 (en) * | 2003-05-06 | 2004-11-11 | Li-Hsien Wang | Methods of using IL-1 antagonists to treat neointimal hyperplasia |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| DK1915620T3 (da) * | 2005-08-02 | 2010-10-04 | Xbiotech Inc | Diagnose, behandling og prævention af vaskulære sygdomme ved hjælp af IL-1alpha-autoantistoffer |
| BRPI0616446A2 (pt) * | 2005-09-28 | 2011-06-21 | Cytos Biotechnology Ag | composição contendo conjugados de interleucina-1, vacina, uso da vacina, composição farmacêutica, processo para a produção da composição ou da vacina, bem como medicamento |
| HUE029003T2 (en) * | 2008-05-30 | 2017-01-30 | Xbiotech Inc | IL-1 alpha antibodies |
| JP5976319B2 (ja) * | 2008-09-12 | 2016-08-23 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 病原性単球の標的化 |
-
2007
- 2007-05-15 EP EP07734572A patent/EP2021033B1/en active Active
- 2007-05-15 WO PCT/IB2007/001264 patent/WO2007132338A2/en not_active Ceased
- 2007-05-15 ES ES07734572T patent/ES2384278T3/es active Active
- 2007-05-15 AT AT07734572T patent/ATE551365T1/de active
- 2007-05-15 JP JP2009510567A patent/JP2009537507A/ja active Pending
- 2007-05-15 US US12/300,712 patent/US20090191149A1/en not_active Abandoned
- 2007-05-15 CN CNA2007800186140A patent/CN101448528A/zh active Pending
- 2007-05-15 AU AU2007251239A patent/AU2007251239B2/en active Active
- 2007-05-15 CA CA002652274A patent/CA2652274A1/en not_active Abandoned
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