AU2007251239B2 - IL-1alpha immunization induces autoantibodies protective against atherosclerosis - Google Patents
IL-1alpha immunization induces autoantibodies protective against atherosclerosis Download PDFInfo
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- AU2007251239B2 AU2007251239B2 AU2007251239A AU2007251239A AU2007251239B2 AU 2007251239 B2 AU2007251239 B2 AU 2007251239B2 AU 2007251239 A AU2007251239 A AU 2007251239A AU 2007251239 A AU2007251239 A AU 2007251239A AU 2007251239 B2 AU2007251239 B2 AU 2007251239B2
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| CN109187944A (zh) * | 2005-08-02 | 2019-01-11 | 埃克斯生物科技公司 | 使用IL-1α自身抗体诊断、治疗和预防血管疾病 |
| US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| PT2109623E (pt) * | 2006-05-22 | 2012-01-12 | Xbiotech Inc | Tratamento de cancro com anticorpos anti-il-1 |
| CN105467136B (zh) | 2008-05-30 | 2018-02-16 | 埃克斯生物科技公司 | 白细胞介素‑1α抗体及使用方法 |
| WO2010030979A2 (en) | 2008-09-12 | 2010-03-18 | Xbiotech, Inc. | Targeting pathogenic monocytes |
| EP2569640A1 (en) | 2010-05-12 | 2013-03-20 | The University of Birmingham | Biomarker |
| JP6324720B2 (ja) | 2010-06-18 | 2018-05-16 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 関節炎治療 |
| KR102748255B1 (ko) | 2010-08-23 | 2024-12-31 | 엑스바이오테크 인코포레이티드 | 종양성 질병들에 대한 치료 |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| JP6204915B2 (ja) | 2011-09-23 | 2017-09-27 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 悪液質治療 |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| JP6456015B2 (ja) * | 2013-07-19 | 2019-01-23 | 国立大学法人三重大学 | 閉塞性動脈硬化症モデル動物、るい痩研究用モデル動物、及び全身性アミロイドーシスモデル動物としての非ヒト哺乳動物 |
| CN105175503A (zh) * | 2015-09-08 | 2015-12-23 | 苏州普罗达生物科技有限公司 | 因子viii抑制多肽及其应用 |
| CN105175504A (zh) * | 2015-09-08 | 2015-12-23 | 苏州普罗达生物科技有限公司 | 血管性血友病因子抑制多肽及其应用 |
| KR20190117579A (ko) | 2017-02-16 | 2019-10-16 | 엑스바이오테크, 인크. | 화농성 한선염의 치료 |
| US10975146B2 (en) | 2018-06-29 | 2021-04-13 | Cedars-Sinai Medical Center | Interleukin-1 inhibition for combination treatment of pancreatic cancer |
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|---|---|---|---|---|
| WO2004100987A2 (en) * | 2003-05-06 | 2004-11-25 | Regeneron Pharmaceuticals, Inc. | Methods of using il-1 antagonists to treat neointimal hyperplasia |
| AU2006298767A1 (en) * | 2005-09-28 | 2007-04-12 | Cytos Biotechnology Ag | Interleukin-1 conjugates and uses thereof |
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| SE9802402D0 (sv) * | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| US6555579B2 (en) * | 1998-08-13 | 2003-04-29 | The Wistar Institute | Methods for reducing atherosclerotic plaques |
| US20030040617A9 (en) * | 1999-03-12 | 2003-02-27 | Rosen Craig A. | Nucleic acids, proteins and antibodies |
| US20030232054A1 (en) * | 2000-01-25 | 2003-12-18 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| US20030026806A1 (en) * | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| HN2004000285A (es) * | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| CN109187944A (zh) * | 2005-08-02 | 2019-01-11 | 埃克斯生物科技公司 | 使用IL-1α自身抗体诊断、治疗和预防血管疾病 |
| CN105467136B (zh) * | 2008-05-30 | 2018-02-16 | 埃克斯生物科技公司 | 白细胞介素‑1α抗体及使用方法 |
| WO2010030979A2 (en) * | 2008-09-12 | 2010-03-18 | Xbiotech, Inc. | Targeting pathogenic monocytes |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004100987A2 (en) * | 2003-05-06 | 2004-11-25 | Regeneron Pharmaceuticals, Inc. | Methods of using il-1 antagonists to treat neointimal hyperplasia |
| AU2006298767A1 (en) * | 2005-09-28 | 2007-04-12 | Cytos Biotechnology Ag | Interleukin-1 conjugates and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| Svenson, M. et al. (2000) Journal of Immunological Methods, vol. 236, pp. 1-8 * |
Also Published As
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| ES2384278T3 (es) | 2012-07-03 |
| JP2009537507A (ja) | 2009-10-29 |
| WO2007132338A3 (en) | 2008-06-12 |
| WO2007132338A2 (en) | 2007-11-22 |
| CA2652274A1 (en) | 2007-11-22 |
| CN101448528A (zh) | 2009-06-03 |
| EP2021033A2 (en) | 2009-02-11 |
| EP2021033A4 (en) | 2010-02-24 |
| ATE551365T1 (de) | 2012-04-15 |
| US20090191149A1 (en) | 2009-07-30 |
| EP2021033B1 (en) | 2012-03-28 |
| AU2007251239A1 (en) | 2007-11-22 |
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