JP2009537147A5 - - Google Patents
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- JP2009537147A5 JP2009537147A5 JP2009511210A JP2009511210A JP2009537147A5 JP 2009537147 A5 JP2009537147 A5 JP 2009537147A5 JP 2009511210 A JP2009511210 A JP 2009511210A JP 2009511210 A JP2009511210 A JP 2009511210A JP 2009537147 A5 JP2009537147 A5 JP 2009537147A5
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- JP
- Japan
- Prior art keywords
- item
- influenza
- virus
- subtype
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003472 neutralizing effect Effects 0.000 claims description 65
- 238000000034 method Methods 0.000 claims description 55
- 241000712431 Influenza A virus Species 0.000 claims description 46
- 241001473385 H5N1 subtype Species 0.000 claims description 17
- 208000037797 influenza A Diseases 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 206010022000 influenza Diseases 0.000 claims description 4
- 238000002703 mutagenesis Methods 0.000 claims description 3
- 231100000350 mutagenesis Toxicity 0.000 claims description 3
- 101710154606 Hemagglutinin Proteins 0.000 claims 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 2
- 101710176177 Protein A56 Proteins 0.000 claims 2
- 239000000185 hemagglutinin Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 101710169105 Minor spike protein Proteins 0.000 description 4
- 101710081079 Minor spike protein H Proteins 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 241000197306 H1N1 subtype Species 0.000 description 2
- 241000197304 H2N2 subtype Species 0.000 description 2
- 241000252870 H3N2 subtype Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 241000271566 Aves Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000037432 silent mutation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80078706P | 2006-05-15 | 2006-05-15 | |
| US85567906P | 2006-10-30 | 2006-10-30 | |
| PCT/US2007/068983 WO2007134327A2 (en) | 2006-05-15 | 2007-05-15 | Neutralizing antibodies to influenza viruses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002320A Division JP2013067660A (ja) | 2006-05-15 | 2013-01-10 | インフルエンザウイルスに対する中和抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009537147A JP2009537147A (ja) | 2009-10-29 |
| JP2009537147A5 true JP2009537147A5 (enExample) | 2010-07-01 |
Family
ID=38694784
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511210A Pending JP2009537147A (ja) | 2006-05-15 | 2007-05-15 | インフルエンザウイルスに対する中和抗体 |
| JP2013002320A Pending JP2013067660A (ja) | 2006-05-15 | 2013-01-10 | インフルエンザウイルスに対する中和抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002320A Pending JP2013067660A (ja) | 2006-05-15 | 2013-01-10 | インフルエンザウイルスに対する中和抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20080014205A1 (enExample) |
| EP (2) | EP2522678A1 (enExample) |
| JP (2) | JP2009537147A (enExample) |
| CN (1) | CN103435697A (enExample) |
| AU (1) | AU2007249160B2 (enExample) |
| CA (1) | CA2652452C (enExample) |
| IL (3) | IL195225A (enExample) |
| WO (1) | WO2007134327A2 (enExample) |
Families Citing this family (70)
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|---|---|---|---|---|
| US8148085B2 (en) | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
| ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
| CN102046654A (zh) * | 2007-03-13 | 2011-05-04 | 胡马斯有限公司 | 针对甲型流感病毒h5n1株系的抗体 |
| EP2132312B1 (en) | 2007-03-27 | 2016-01-27 | Sea Lane Biotechnologies,llc. | Constructs and libraries comprising antibody surrogate light chain sequences |
| CA2684103A1 (en) * | 2007-04-11 | 2008-10-23 | Immuron Limited | Delivery of flu antibodies to surfaces in contact with air |
| MX2010006148A (es) | 2007-12-06 | 2011-02-23 | Dana Farber Cancer Inst Inc | Anti-cuerpos contra el virus de la influenza y metodos de uso de los mismos. |
| ITTO20080204A1 (it) * | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| WO2009121004A2 (en) * | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| ES2662519T3 (es) * | 2008-07-25 | 2018-04-06 | Institute For Research In Biomedicine | Anticuerpos neutralizantes contra el virus de la gripe A y usos de estos |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| GB0818356D0 (en) * | 2008-10-07 | 2008-11-12 | Istituto Superiore Di Sanito | Antibodies |
| US20110195079A1 (en) * | 2008-10-21 | 2011-08-11 | Dormitzer Philip | Immunization protocol for directed expansion and maturation |
| EP2848630A1 (en) | 2008-10-22 | 2015-03-18 | Institute for Research in Biomedicine | Methods for producing antibodies from plasma cells |
| ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| WO2010130636A1 (en) * | 2009-05-11 | 2010-11-18 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof |
| CN102482345A (zh) * | 2009-05-13 | 2012-05-30 | 航道生物技术有限责任公司 | 针对流感病毒的中和分子 |
| AU2010254136B2 (en) * | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| IT1395961B1 (it) | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| JP6050747B2 (ja) | 2010-06-17 | 2016-12-21 | トレリス バイオサイエンス リミテッド ライアビリティー カンパニー | インフルエンザ受動免疫化に有用な抗体 |
| US9534042B2 (en) | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| EP2436766A1 (en) * | 2010-09-29 | 2012-04-04 | Deutsches Krebsforschungszentrum | Means and methods for improved protein interaction screening |
| WO2012045001A2 (en) * | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
| EP2640831A1 (en) * | 2010-11-17 | 2013-09-25 | Sea Lane Biotechnologies,llc. | Influenza virus neutralizing agents that mimic the binding site of an influenza neutralizing antibody |
| CA2841551C (en) | 2011-07-18 | 2020-07-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| EP2736928B1 (en) | 2011-07-28 | 2019-01-09 | i2 Pharmaceuticals, Inc. | Sur-binding proteins against erbb3 |
| KR20140068205A (ko) | 2011-09-20 | 2014-06-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 백신 및 이의 용도 |
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| KR20130059721A (ko) * | 2011-11-29 | 2013-06-07 | (주)셀트리온 | 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자 |
| CN104302321A (zh) | 2011-12-05 | 2015-01-21 | 特瑞利斯生物科学有限责任公司 | 可用于被动流感免疫的抗体 |
| WO2013089496A1 (ko) * | 2011-12-15 | 2013-06-20 | (주)에이프로젠 | H1n1-감염된 환자들로부터 유도된 매우 잠재력 있는 넓은-스펙트럼 중화 단일클론 항체 및 이를 포함하는 바이러스의 치료용 조성물 |
| EP2793940B1 (en) | 2011-12-22 | 2018-11-14 | i2 Pharmaceuticals, Inc. | Surrogate binding proteins |
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| JP6628966B2 (ja) | 2012-06-14 | 2020-01-15 | 中外製薬株式会社 | 改変されたＦｃ領域を含む抗原結合分子 |
| KR20150104117A (ko) | 2012-12-18 | 2015-09-14 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 인플루엔자 바이러스 백신 및 그의 용도 |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| CN105209071A (zh) | 2013-03-14 | 2015-12-30 | 抗非特公司 | 用于提高疗效的基于鼻内递送中和抗体的组合物和方法 |
| US9101597B2 (en) | 2013-03-14 | 2015-08-11 | The Administration Of The Tulane Educational Fund | Immunoprotective primary mesenchymal stem cells and methods |
| JPWO2015025900A1 (ja) | 2013-08-23 | 2017-03-02 | 学校法人藤田学園 | 抗インフルエンザウイルス中和抗体 |
| JP6535675B2 (ja) | 2013-10-02 | 2019-06-26 | メディミューン，エルエルシー | 抗ａ型インフルエンザ抗体の中和及びその使用 |
| CN105940107B (zh) | 2013-11-11 | 2021-06-15 | 中外制药株式会社 | 含有改变了抗体可变区的抗原结合分子 |
| KR102344390B1 (ko) | 2014-02-04 | 2021-12-28 | 콘트라펙트 코포레이션 | 수동 인플루엔자 면역화에 유용한 항체, 및 이의 사용을 위한 조성물, 조합 및 방법 |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| DK3126384T3 (da) * | 2014-04-01 | 2021-01-18 | Adimab Llc | Multispecifikke antistofanaloger omfattende en fælles letkæde, og fremgangsmåder til deres fremstilling og anvendelse |
| CN113563462B (zh) | 2014-07-15 | 2024-08-13 | 免疫医疗有限责任公司 | 中和抗乙型流感抗体及其用途 |
| TWI740809B (zh) | 2014-11-11 | 2021-10-01 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| MX389708B (es) | 2015-06-01 | 2025-03-20 | Medimmune Llc | Neutralizacion de moleculas de union anti-influenza y usos de las mismas. |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| SG11201805001UA (en) | 2016-01-13 | 2018-07-30 | Medimmune Llc | Method of treating influenza a |
| EP3419663A1 (en) | 2016-02-24 | 2019-01-02 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| WO2017218624A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| GB201614485D0 (en) * | 2016-08-25 | 2016-10-12 | Univ Oxford Innovation Ltd | Immunogenic composition |
| KR102264642B1 (ko) * | 2016-10-31 | 2021-06-15 | 유니베르시태트 취리히 | 단백질 스크리닝 및 검출 방법 |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| EP3697437A4 (en) | 2017-10-20 | 2021-10-13 | Academia Sinica | METHOD OF HIGH-THROUGHPUT SCREENING OF NEUTRALIZING ANTIBODIES, NEUTRALIZING ANTIBODIES PRODUCED THEREOF AND THEIR USES |
| EP3720963A4 (en) * | 2017-12-05 | 2021-12-08 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULE WITH CHANGED BINDING OF THE VARIABLE ANTIBODY REGIONS CD3 AND CD137 |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| CN113286824A (zh) | 2018-08-03 | 2021-08-20 | 中外制药株式会社 | 包含两个彼此连接的抗原结合结构域的抗原结合分子 |
| EP3856789A4 (en) | 2018-09-28 | 2022-08-17 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULE WITH VARIABLE REGION OF AN ALTERED ANTIBODY |
| CN113924147A (zh) | 2019-03-25 | 2022-01-11 | 威特拉公司 | 用于治疗和预防流感的组合物和方法 |
| EP3959216A4 (en) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
| WO2021055679A1 (en) * | 2019-09-20 | 2021-03-25 | Academia Sinica | Chimeric hemagglutinin protein and a vaccine composition comprising the same |
| TWI799824B (zh) | 2020-03-31 | 2023-04-21 | 日商中外製藥股份有限公司 | Ｄｌｌ３靶向之多特異性抗原結合分子及其用途 |
| CN113121680B (zh) * | 2021-04-12 | 2022-03-29 | 华南农业大学 | 一种抗h5亚型禽流感纳米抗体蛋白及其编码基因与应用 |
| CN113355344B (zh) * | 2021-08-10 | 2021-11-02 | 北京溯本源和生物科技有限公司 | 一种流感病毒ns1蛋白的表达质粒、重组蛋白和特异性单克隆抗体及应用 |
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2007
- 2007-05-15 WO PCT/US2007/068983 patent/WO2007134327A2/en not_active Ceased
- 2007-05-15 EP EP20120165672 patent/EP2522678A1/en not_active Withdrawn
- 2007-05-15 EP EP07762203A patent/EP2024393A2/en not_active Withdrawn
- 2007-05-15 CA CA2652452A patent/CA2652452C/en not_active Expired - Fee Related
- 2007-05-15 AU AU2007249160A patent/AU2007249160B2/en not_active Ceased
- 2007-05-15 JP JP2009511210A patent/JP2009537147A/ja active Pending
- 2007-05-15 CN CN2013102549131A patent/CN103435697A/zh active Pending
- 2007-05-15 US US11/748,980 patent/US20080014205A1/en not_active Abandoned
-
2008
- 2008-11-11 IL IL195225A patent/IL195225A/en not_active IP Right Cessation
-
2010
- 2010-07-12 US US12/834,736 patent/US20100316654A1/en not_active Abandoned
-
2011
- 2011-08-10 US US13/207,083 patent/US20120107326A1/en not_active Abandoned
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2012
- 2012-10-30 IL IL222762A patent/IL222762A0/en unknown
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2013
- 2013-01-10 JP JP2013002320A patent/JP2013067660A/ja active Pending
- 2013-09-13 US US14/026,086 patent/US20140205614A1/en not_active Abandoned
-
2015
- 2015-05-27 IL IL239023A patent/IL239023A0/en unknown
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