JP2009536666A5 - - Google Patents
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- Publication number
- JP2009536666A5 JP2009536666A5 JP2009510146A JP2009510146A JP2009536666A5 JP 2009536666 A5 JP2009536666 A5 JP 2009536666A5 JP 2009510146 A JP2009510146 A JP 2009510146A JP 2009510146 A JP2009510146 A JP 2009510146A JP 2009536666 A5 JP2009536666 A5 JP 2009536666A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- metal ion
- ion sequestering
- sequestering agent
- gallium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003352 sequestering agent Substances 0.000 claims 19
- 230000021148 sequestering of metal ion Effects 0.000 claims 17
- 238000007614 solvation Methods 0.000 claims 15
- 239000002253 acid Substances 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 6
- 230000001580 bacterial effect Effects 0.000 claims 6
- 229910052733 gallium Inorganic materials 0.000 claims 6
- 210000000959 ear middle Anatomy 0.000 claims 5
- 239000004094 surface-active agent Substances 0.000 claims 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 claims 4
- 210000003027 ear inner Anatomy 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 4
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims 4
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 239000000872 buffer Substances 0.000 claims 3
- 239000006172 buffering agent Substances 0.000 claims 3
- 210000003928 nasal cavity Anatomy 0.000 claims 3
- 210000003695 paranasal sinus Anatomy 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000002888 zwitterionic surfactant Substances 0.000 claims 3
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims 2
- UTNSTTZHNMPBEE-UHFFFAOYSA-N 2-chloro-2-hydroxy-2-phenylacetic acid Chemical compound OC(=O)C(O)(Cl)C1=CC=CC=C1 UTNSTTZHNMPBEE-UHFFFAOYSA-N 0.000 claims 2
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 2
- HABHUTWTLGRDDU-UHFFFAOYSA-N 2-oxopimelic acid Chemical compound OC(=O)CCCCC(=O)C(O)=O HABHUTWTLGRDDU-UHFFFAOYSA-N 0.000 claims 2
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 2
- 239000005711 Benzoic acid Substances 0.000 claims 2
- 239000004135 Bone phosphate Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 claims 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- 229960000583 acetic acid Drugs 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 239000001361 adipic acid Substances 0.000 claims 2
- 235000011037 adipic acid Nutrition 0.000 claims 2
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- 235000010233 benzoic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 2
- 239000004327 boric acid Substances 0.000 claims 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000003093 cationic surfactant Substances 0.000 claims 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims 2
- 229940106681 chloroacetic acid Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960005215 dichloroacetic acid Drugs 0.000 claims 2
- 235000019253 formic acid Nutrition 0.000 claims 2
- 229940013688 formic acid Drugs 0.000 claims 2
- 239000001530 fumaric acid Substances 0.000 claims 2
- CHPZKNULDCNCBW-UHFFFAOYSA-N gallium nitrate Chemical compound [Ga+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O CHPZKNULDCNCBW-UHFFFAOYSA-N 0.000 claims 2
- 229940097043 glucuronic acid Drugs 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- 239000011976 maleic acid Substances 0.000 claims 2
- 229960002510 mandelic acid Drugs 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims 2
- 210000001331 nose Anatomy 0.000 claims 2
- 235000006408 oxalic acid Nutrition 0.000 claims 2
- 229940116315 oxalic acid Drugs 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 2
- 229940107700 pyruvic acid Drugs 0.000 claims 2
- 229960004889 salicylic acid Drugs 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 229910002601 GaN Inorganic materials 0.000 claims 1
- JMASRVWKEDWRBT-UHFFFAOYSA-N Gallium nitride Chemical compound [Ga]#N JMASRVWKEDWRBT-UHFFFAOYSA-N 0.000 claims 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 229940044658 gallium nitrate Drugs 0.000 claims 1
- 229910000373 gallium sulfate Inorganic materials 0.000 claims 1
- UPWPDUACHOATKO-UHFFFAOYSA-K gallium trichloride Chemical compound Cl[Ga](Cl)Cl UPWPDUACHOATKO-UHFFFAOYSA-K 0.000 claims 1
- SRVXDMYFQIODQI-UHFFFAOYSA-K gallium(iii) bromide Chemical compound Br[Ga](Br)Br SRVXDMYFQIODQI-UHFFFAOYSA-K 0.000 claims 1
- DWRNSCDYNYYYHT-UHFFFAOYSA-K gallium(iii) iodide Chemical compound I[Ga](I)I DWRNSCDYNYYYHT-UHFFFAOYSA-K 0.000 claims 1
- ZGAZQDZRSBOHRX-UHFFFAOYSA-N gallium;phosphite Chemical compound [Ga+3].[O-]P([O-])[O-] ZGAZQDZRSBOHRX-UHFFFAOYSA-N 0.000 claims 1
- SBDRYJMIQMDXRH-UHFFFAOYSA-N gallium;sulfuric acid Chemical compound [Ga].OS(O)(=O)=O SBDRYJMIQMDXRH-UHFFFAOYSA-N 0.000 claims 1
- 150000002366 halogen compounds Chemical class 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- DGMJZELBSFOPHH-KVTDHHQDSA-N mannite hexanitrate Chemical compound [O-][N+](=O)OC[C@@H](O[N+]([O-])=O)[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)CO[N+]([O-])=O DGMJZELBSFOPHH-KVTDHHQDSA-N 0.000 claims 1
- 229950003934 mannite hexanitrate Drugs 0.000 claims 1
- 150000001451 organic peroxides Chemical class 0.000 claims 1
- 150000002927 oxygen compounds Chemical class 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 150000003460 sulfonic acids Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/431,495 US20070264296A1 (en) | 2006-05-10 | 2006-05-10 | Biofilm extracellular polysachharide solvating system |
| US11/431,495 | 2006-05-10 | ||
| US11/739,508 | 2007-04-24 | ||
| US11/739,508 US7976873B2 (en) | 2006-05-10 | 2007-04-24 | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| PCT/US2007/068477 WO2007134055A1 (en) | 2006-05-10 | 2007-05-08 | Antibacterial extracellular polysaccharide solvating system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014173789A Division JP2014240419A (ja) | 2006-05-10 | 2014-08-28 | 抗細菌性細胞外多糖溶媒和系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536666A JP2009536666A (ja) | 2009-10-15 |
| JP2009536666A5 true JP2009536666A5 (enExample) | 2010-06-24 |
| JP5912218B2 JP5912218B2 (ja) | 2016-04-27 |
Family
ID=38458463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009510146A Expired - Fee Related JP5912218B2 (ja) | 2006-05-10 | 2007-05-08 | 抗細菌性細胞外多糖溶媒和系 |
| JP2014173789A Pending JP2014240419A (ja) | 2006-05-10 | 2014-08-28 | 抗細菌性細胞外多糖溶媒和系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014173789A Pending JP2014240419A (ja) | 2006-05-10 | 2014-08-28 | 抗細菌性細胞外多糖溶媒和系 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7976873B2 (enExample) |
| EP (1) | EP2029232B1 (enExample) |
| JP (2) | JP5912218B2 (enExample) |
| KR (1) | KR101453011B1 (enExample) |
| CN (1) | CN104815328A (enExample) |
| AU (1) | AU2007249413B2 (enExample) |
| CA (1) | CA2651646C (enExample) |
| ES (1) | ES2650974T3 (enExample) |
| WO (1) | WO2007134055A1 (enExample) |
Families Citing this family (56)
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| JP2009525284A (ja) * | 2006-01-30 | 2009-07-09 | タイタン ファーマシューティカルズ インコーポレイテッド | バイオフィルム関連感染を処置するためのガリウムの使用 |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US20070264296A1 (en) | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US7976873B2 (en) | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| US8088095B2 (en) | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| GB2463181B (en) | 2007-05-14 | 2013-03-27 | Univ New York State Res Found | Induction of a physiological dispersion response in bacterial cells in a biofilm |
| US20090054881A1 (en) * | 2007-06-14 | 2009-02-26 | Yosef Krespi | Mammalian biofilm treatment processes and instruments |
| CA2727432C (en) * | 2008-06-12 | 2016-10-11 | Medtronic Xomed, Inc. | Method for treating chronic wounds with an extracellular polymeric substance solvating system |
| US20100086576A1 (en) * | 2008-10-06 | 2010-04-08 | Myntti Matthew F | Antimicrobial composition and methods of making and using same |
| DE102008064481A1 (de) * | 2008-12-18 | 2010-08-12 | Bode Chemie Gmbh | Kombinierte Desinfektions- und Dekontaminationsmittel mit erhöhter Wirksamkeit |
| EP2706845B1 (en) | 2011-05-10 | 2021-06-23 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
| CA3254125A1 (en) | 2011-10-08 | 2025-07-08 | Next Science IP Holdings Pty Ltd | Antimicrobial compositions and methods employing same |
| CN103987664B (zh) | 2011-12-06 | 2017-03-08 | 德尔塔阀门公司 | 龙头中的臭氧分配 |
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| EP2807323B1 (en) | 2012-01-18 | 2020-05-13 | NCH Corporation | Composition and method for treating water systems |
| US9716253B2 (en) * | 2012-03-23 | 2017-07-25 | Lg Chem, Ltd. | Battery case for secondary battery |
| CN103484392A (zh) * | 2012-06-13 | 2014-01-01 | 中国海洋大学 | 用Pseudomonas fluorescens PGM37菌株生产葡甘聚糖 |
| JP6430490B2 (ja) | 2013-05-02 | 2018-11-28 | ネクスト サイエンス アイピー ホールディングス ピーティワイ エルティーディ | １以上の有機溶媒を含む高い浸透性の抗菌性組成物 |
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| US9441190B2 (en) | 2013-11-06 | 2016-09-13 | Nch Corporation | Composition and method for treating water systems |
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| BR112018002548A2 (pt) | 2015-08-07 | 2018-09-18 | Next Science IP Holdings Pty Ltd | composição antimicrobiana com eficácia contra endoesporos |
| CN115093008B (zh) | 2015-12-21 | 2024-05-14 | 德尔塔阀门公司 | 包括消毒装置的流体输送系统 |
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