ES2650974T3 - Sistema de solvatación de polisacáridos extracelulares antibacteriano - Google Patents
Sistema de solvatación de polisacáridos extracelulares antibacteriano Download PDFInfo
- Publication number
- ES2650974T3 ES2650974T3 ES07762011.0T ES07762011T ES2650974T3 ES 2650974 T3 ES2650974 T3 ES 2650974T3 ES 07762011 T ES07762011 T ES 07762011T ES 2650974 T3 ES2650974 T3 ES 2650974T3
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- Prior art keywords
- acid
- solvation system
- solvation
- metal ion
- sequestering agent
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
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- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (5)
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|---|---|---|---|
| US431495 | 1982-09-30 | ||
| US11/431,495 US20070264296A1 (en) | 2006-05-10 | 2006-05-10 | Biofilm extracellular polysachharide solvating system |
| US739508 | 2007-04-24 | ||
| US11/739,508 US7976873B2 (en) | 2006-05-10 | 2007-04-24 | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| PCT/US2007/068477 WO2007134055A1 (en) | 2006-05-10 | 2007-05-08 | Antibacterial extracellular polysaccharide solvating system |
Publications (1)
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| ES2650974T3 true ES2650974T3 (es) | 2018-01-23 |
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| ES07762011.0T Active ES2650974T3 (es) | 2006-05-10 | 2007-05-08 | Sistema de solvatación de polisacáridos extracelulares antibacteriano |
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| EP (1) | EP2029232B1 (enExample) |
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| KR (1) | KR101453011B1 (enExample) |
| CN (1) | CN104815328A (enExample) |
| AU (1) | AU2007249413B2 (enExample) |
| CA (1) | CA2651646C (enExample) |
| ES (1) | ES2650974T3 (enExample) |
| WO (1) | WO2007134055A1 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009525284A (ja) * | 2006-01-30 | 2009-07-09 | タイタン ファーマシューティカルズ インコーポレイテッド | バイオフィルム関連感染を処置するためのガリウムの使用 |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US20070264296A1 (en) | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US7976873B2 (en) | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| US8088095B2 (en) | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
| GB2463181B (en) | 2007-05-14 | 2013-03-27 | Univ New York State Res Found | Induction of a physiological dispersion response in bacterial cells in a biofilm |
| US20090054881A1 (en) * | 2007-06-14 | 2009-02-26 | Yosef Krespi | Mammalian biofilm treatment processes and instruments |
| CA2727432C (en) * | 2008-06-12 | 2016-10-11 | Medtronic Xomed, Inc. | Method for treating chronic wounds with an extracellular polymeric substance solvating system |
| US20100086576A1 (en) * | 2008-10-06 | 2010-04-08 | Myntti Matthew F | Antimicrobial composition and methods of making and using same |
| DE102008064481A1 (de) * | 2008-12-18 | 2010-08-12 | Bode Chemie Gmbh | Kombinierte Desinfektions- und Dekontaminationsmittel mit erhöhter Wirksamkeit |
| EP2706845B1 (en) | 2011-05-10 | 2021-06-23 | Next Science IP Holdings Pty Ltd | Antimicrobial solid and methods of making and using same |
| CA3254125A1 (en) | 2011-10-08 | 2025-07-08 | Next Science IP Holdings Pty Ltd | Antimicrobial compositions and methods employing same |
| CN103987664B (zh) | 2011-12-06 | 2017-03-08 | 德尔塔阀门公司 | 龙头中的臭氧分配 |
| US9707520B2 (en) | 2012-01-18 | 2017-07-18 | Nch Corporation | Composition, system, and method for treating water systems |
| EP2807323B1 (en) | 2012-01-18 | 2020-05-13 | NCH Corporation | Composition and method for treating water systems |
| US9716253B2 (en) * | 2012-03-23 | 2017-07-25 | Lg Chem, Ltd. | Battery case for secondary battery |
| CN103484392A (zh) * | 2012-06-13 | 2014-01-01 | 中国海洋大学 | 用Pseudomonas fluorescens PGM37菌株生产葡甘聚糖 |
| JP6430490B2 (ja) | 2013-05-02 | 2018-11-28 | ネクスト サイエンス アイピー ホールディングス ピーティワイ エルティーディ | １以上の有機溶媒を含む高い浸透性の抗菌性組成物 |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| US9506016B2 (en) | 2013-11-06 | 2016-11-29 | Nch Corporation | Composition and method for treating water systems |
| US9441190B2 (en) | 2013-11-06 | 2016-09-13 | Nch Corporation | Composition and method for treating water systems |
| US9848604B2 (en) * | 2014-07-11 | 2017-12-26 | Medtronic Xomed, Inc. | Antimicrobial wash |
| US9744192B2 (en) | 2015-03-16 | 2017-08-29 | Lee A. Flippin | Methods of treating chronic rhinosinusitis |
| CN107920532A (zh) | 2015-07-17 | 2018-04-17 | 贴近科学Ip控股私人有限公司 | 具有抗内生孢子功效的抗微生物组合物 |
| BR112018002548A2 (pt) | 2015-08-07 | 2018-09-18 | Next Science IP Holdings Pty Ltd | composição antimicrobiana com eficácia contra endoesporos |
| CN115093008B (zh) | 2015-12-21 | 2024-05-14 | 德尔塔阀门公司 | 包括消毒装置的流体输送系统 |
| CN105770999B (zh) * | 2016-03-03 | 2019-01-29 | 宁夏大学 | 一种消除细菌生物被膜的复合生物材料 |
| CA3029601A1 (en) * | 2016-06-30 | 2018-01-04 | Next Science IP Holdings Pty Ltd | Antimicrobial compositions and methods employing same |
| EP3710030A4 (en) | 2017-11-19 | 2020-12-23 | Next Science IP Holdings Pty Ltd | COMPOSITIONS AND METHODS FOR TREATMENT OF INTERVERTEBRAL DISCS |
| WO2019213396A1 (en) * | 2018-05-03 | 2019-11-07 | Jaim Nulman | Formulations and delivery methods for reduction and elimination of pathogen induced inflammations in the human body |
| US11819229B2 (en) | 2019-06-19 | 2023-11-21 | Boston Scientific Scimed, Inc. | Balloon surface photoacoustic pressure wave generation to disrupt vascular lesions |
| US12402946B2 (en) | 2019-06-19 | 2025-09-02 | Boston Scientific Scimed, Inc. | Breakdown of laser pulse energy for breakup of vascular calcium |
| US11717139B2 (en) | 2019-06-19 | 2023-08-08 | Bolt Medical, Inc. | Plasma creation via nonaqueous optical breakdown of laser pulse energy for breakup of vascular calcium |
| US11660427B2 (en) | 2019-06-24 | 2023-05-30 | Boston Scientific Scimed, Inc. | Superheating system for inertial impulse generation to disrupt vascular lesions |
| US12280223B2 (en) | 2019-06-26 | 2025-04-22 | Boston Scientific Scimed, Inc. | Focusing element for plasma system to disrupt vascular lesions |
| US11583339B2 (en) | 2019-10-31 | 2023-02-21 | Bolt Medical, Inc. | Asymmetrical balloon for intravascular lithotripsy device and method |
| US12102384B2 (en) | 2019-11-13 | 2024-10-01 | Bolt Medical, Inc. | Dynamic intravascular lithotripsy device with movable energy guide |
| US12274497B2 (en) | 2019-12-18 | 2025-04-15 | Bolt Medical, Inc. | Multiplexer for laser-driven intravascular lithotripsy device |
| CN115426990A (zh) * | 2020-01-24 | 2022-12-02 | 斯皮拉尔诊疗有限公司 | 通过鼓膜进入中耳和内耳的微创工具和方法 |
| US12446961B2 (en) | 2020-02-10 | 2025-10-21 | Bolt Medical, Inc. | System and method for pressure monitoring within a catheter system |
| US11672599B2 (en) | 2020-03-09 | 2023-06-13 | Bolt Medical, Inc. | Acoustic performance monitoring system and method within intravascular lithotripsy device |
| US20210290286A1 (en) | 2020-03-18 | 2021-09-23 | Bolt Medical, Inc. | Optical analyzer assembly and method for intravascular lithotripsy device |
| US11707323B2 (en) | 2020-04-03 | 2023-07-25 | Bolt Medical, Inc. | Electrical analyzer assembly for intravascular lithotripsy device |
| US12295654B2 (en) | 2020-06-03 | 2025-05-13 | Boston Scientific Scimed, Inc. | System and method for maintaining balloon integrity within intravascular lithotripsy device with plasma generator |
| US12207870B2 (en) | 2020-06-15 | 2025-01-28 | Boston Scientific Scimed, Inc. | Spectroscopic tissue identification for balloon intravascular lithotripsy guidance |
| CA3198601A1 (en) | 2020-10-14 | 2022-04-21 | Next Science IP Holdings Pty Ltd | Hard surface disinfecting composition |
| US12016610B2 (en) | 2020-12-11 | 2024-06-25 | Bolt Medical, Inc. | Catheter system for valvuloplasty procedure |
| US11672773B2 (en) | 2020-12-13 | 2023-06-13 | Next Science IP Holdings Pty Ltd | Methods for treating ciliated cavities |
| US11672585B2 (en) | 2021-01-12 | 2023-06-13 | Bolt Medical, Inc. | Balloon assembly for valvuloplasty catheter system |
| WO2022154954A1 (en) | 2021-01-12 | 2022-07-21 | Bolt Medical, Inc. | Balloon assembly for valvuloplasty catheter system |
| US11648057B2 (en) | 2021-05-10 | 2023-05-16 | Bolt Medical, Inc. | Optical analyzer assembly with safety shutdown system for intravascular lithotripsy device |
| US11806075B2 (en) | 2021-06-07 | 2023-11-07 | Bolt Medical, Inc. | Active alignment system and method for laser optical coupling |
| US11839391B2 (en) | 2021-12-14 | 2023-12-12 | Bolt Medical, Inc. | Optical emitter housing assembly for intravascular lithotripsy device |
| EP4580751A2 (en) | 2022-09-29 | 2025-07-09 | Adora Animal Health Corporation | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions |
Family Cites Families (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB983130A (en) * | 1962-08-06 | 1965-02-10 | Mundipharma Ag | Improvements in preparations for the removal of wax from the ear |
| US4002775A (en) * | 1973-07-09 | 1977-01-11 | Kabara Jon J | Fatty acids and derivatives of antimicrobial agents |
| CA1052273A (en) * | 1975-12-18 | 1979-04-10 | Edwin B. Michaels | Antimicrobial compositions |
| SU1128917A1 (ru) | 1980-12-24 | 1984-12-15 | Кишиневский государственный медицинский институт | Способ лечени пародонтоза |
| US5166331A (en) | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US5208257A (en) * | 1986-04-21 | 1993-05-04 | Kabara Jon J | Topical antimicrobial pharmaceutical compositions and methods |
| CA1302280C (en) * | 1986-04-21 | 1992-06-02 | Jon Joseph Kabara | Topical antimicrobial pharmaceutical compositions and methods |
| US5017229A (en) * | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
| US5290552A (en) * | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5575815A (en) | 1988-08-24 | 1996-11-19 | Endoluminal Therapeutics, Inc. | Local polymeric gel therapy |
| US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| SU1699430A1 (ru) | 1989-03-03 | 1991-12-23 | Кишиневский государственный медицинский институт | Способ лечени пародонтита |
| EP0466397A3 (en) * | 1990-07-10 | 1992-05-06 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of inflammatory diseases with polyoxyethylenesorbitan mono-higher-fatty acid esters |
| US5662913A (en) * | 1991-04-10 | 1997-09-02 | Capelli; Christopher C. | Antimicrobial compositions useful for medical applications |
| EP0580803B1 (en) * | 1991-04-10 | 1999-07-07 | CAPELLI, Christopher C. | Antimicrobial compositions useful for medical applications |
| GB9204175D0 (en) * | 1992-02-27 | 1992-04-08 | Unilever Plc | Cleansing composition |
| US5229103A (en) * | 1992-04-30 | 1993-07-20 | Hydrodent Laboratories, Inc. | Antiplaque mouthwash concentrate |
| IT1260154B (it) * | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
| CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US5336163A (en) * | 1993-01-06 | 1994-08-09 | Smith & Nephew Richards, Inc. | Expandable nasal stent |
| US5994341A (en) * | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US5480658A (en) * | 1993-07-23 | 1996-01-02 | Melman; Steven A. | Ear and skin cleanser |
| FR2710529A1 (fr) | 1993-09-29 | 1995-04-07 | Zirinis Phedon | Gel aqueux à usage nasal, pellets, et leur procédé de préparation. |
| US6544761B2 (en) * | 1994-12-13 | 2003-04-08 | Human Genome Sciences, Inc. | Human tissue inhibitor of metalloproteinase-4 |
| US6086921A (en) * | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
| US5817303A (en) | 1995-05-05 | 1998-10-06 | Protein Polymer Technologies, Inc. | Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer |
| US5968542A (en) * | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| CN1301139C (zh) | 1995-08-29 | 2007-02-21 | 菲迪亚高级生物聚合物公司 | 包括透明质酸衍生物的用于预防手术后粘连的生物材料 |
| US5601594A (en) * | 1995-09-14 | 1997-02-11 | Best; Barry D. | Nasal stent |
| FI955389A0 (fi) | 1995-11-09 | 1995-11-09 | Antti Sakari Aaltonen | Tandskyddande profylaktisk preparat och administreringsmedlen emot mellanoerpatogener |
| US6423694B1 (en) * | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
| US5693065A (en) | 1996-06-25 | 1997-12-02 | Rains, Iii; B. Manrin | Frontal sinus stent |
| JPH1072342A (ja) * | 1996-06-27 | 1998-03-17 | Senju Pharmaceut Co Ltd | 界面活性剤の刺激性低下方法及び低刺激性水性組成物 |
| US6541460B2 (en) * | 1996-08-07 | 2003-04-01 | George D. Petito | Method for use of hyaluronic acid in wound management |
| US6063061A (en) * | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US6203822B1 (en) * | 1996-09-03 | 2001-03-20 | University Of Iowa Research Foundation | Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection |
| CO4910145A1 (es) | 1996-10-01 | 2000-04-24 | Smithkline Beecham Corp | Uso |
| AU724070B2 (en) | 1996-10-01 | 2000-09-14 | Smithkline Beecham Corporation | Use of mupirocin for the manufacture of a medicament for the treatment of bacterial infections associated with colonisation of the nasopharynx by pathogenic organisms |
| IT1287967B1 (it) * | 1996-10-17 | 1998-09-10 | Fidia Spa In Amministrazione S | Preparazioni farmaceutiche per uso anestetico locale |
| ZA9710342B (en) * | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
| US5709546A (en) * | 1996-11-27 | 1998-01-20 | Waggoner; Mark B. | Water sanitizing system and process |
| FR2756739B1 (fr) * | 1996-12-05 | 2000-04-28 | Astra Ab | Nouvelle formulation de budesonide |
| US6891037B1 (en) * | 1997-01-24 | 2005-05-10 | Schweiz. Serum- & Impfinstitut Bern | Method for the isolation of polysaccharides |
| US6869938B1 (en) * | 1997-06-17 | 2005-03-22 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use in reducing adhesions |
| US5925334A (en) * | 1997-08-27 | 1999-07-20 | Rubin; Bruce K. | Use of surface active agents to promote mucus clearance |
| US6638621B2 (en) * | 2000-08-16 | 2003-10-28 | Lyotropic Therapeutics, Inc. | Coated particles, methods of making and using |
| AU751182B2 (en) * | 1997-12-02 | 2002-08-08 | Archimedes Development Limited | Compositions for nasal administration |
| US5895781A (en) * | 1997-12-22 | 1999-04-20 | S. C. Johnson & Son, Inc. | Cleaning compositions for ceramic and porcelain surfaces and related methods |
| EP1054679B1 (en) * | 1997-12-24 | 2003-02-12 | Britannia Pharmaceuticals Limited | Use of surface active agent for the manufacture of a medicament for treatment of disorders of the middle ear |
| US6541116B2 (en) * | 1998-01-30 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device |
| IL123143A (en) * | 1998-02-02 | 2001-08-26 | Agis Ind 1983 Ltd | Pharmaceutical compositions containing mupirocin |
| US6623521B2 (en) | 1998-02-17 | 2003-09-23 | Md3, Inc. | Expandable stent with sliding and locking radial elements |
| US7691829B2 (en) | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
| US6824793B1 (en) | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
| US20030079758A1 (en) * | 1998-06-03 | 2003-05-01 | Siegel Phyllis B. | Process and composition for removing biofilm |
| US20020022588A1 (en) * | 1998-06-23 | 2002-02-21 | James Wilkie | Methods and compositions for sealing tissue leaks |
| US6706290B1 (en) * | 1998-07-06 | 2004-03-16 | Olvai E. Kajander | Methods for eradication of nanobacteria |
| US6632457B1 (en) | 1998-08-14 | 2003-10-14 | Incept Llc | Composite hydrogel drug delivery systems |
| US6395746B1 (en) * | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
| GB9822170D0 (en) | 1998-10-13 | 1998-12-02 | Danbioyst Uk Ltd | Novel formulations of fexofenadine |
| WO2000027438A1 (en) * | 1998-11-06 | 2000-05-18 | Universite De Montreal | Improved bactericidal and non-bactericidal solutions for removing biofilms |
| US8197461B1 (en) * | 1998-12-04 | 2012-06-12 | Durect Corporation | Controlled release system for delivering therapeutic agents into the inner ear |
| US6375963B1 (en) * | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
| US20020061281A1 (en) | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US6576224B1 (en) | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US6372229B1 (en) * | 1999-09-15 | 2002-04-16 | Cryolife, Inc. | Vascular coating composition |
| PL201130B1 (pl) * | 1999-09-24 | 2009-03-31 | Alcon Inc | Kompozycje zawiesinowe zawierające ciprofloksacynę i deksametazon do podawania miejscowego do oczu, uszu lub nosa |
| US6533749B1 (en) * | 1999-09-24 | 2003-03-18 | Medtronic Xomed, Inc. | Angled rotary tissue cutting instrument with flexible inner member |
| US6156294A (en) * | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| US6676930B2 (en) * | 1999-11-28 | 2004-01-13 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| GB0002229D0 (en) * | 2000-02-01 | 2000-03-22 | Reckitt & Colman Inc | Improvements in or relating to organic compositions |
| DE60103023T2 (de) * | 2000-02-28 | 2005-01-27 | The Procter & Gamble Company, Cincinnati | Saure antimikrobielle zusammensetzungen zur behandlung von lebensmitteln und lebensmittel-kontaktflächen und verfahren zu ihrer anwendung |
| US6379382B1 (en) * | 2000-03-13 | 2002-04-30 | Jun Yang | Stent having cover with drug delivery capability |
| US20030009213A1 (en) * | 2000-03-13 | 2003-01-09 | Jun Yang | Stent having cover with drug delivery capability |
| CA2410796C (en) | 2000-06-05 | 2007-05-01 | S.C. Johnson & Son, Inc. | Biocidal cleaning method |
| US20020029015A1 (en) * | 2000-07-04 | 2002-03-07 | Edoardo Camenzind | Device for administering a composition in a duct of a human or animal body |
| US6953772B2 (en) | 2000-07-18 | 2005-10-11 | Lopes John A | Concentrated sanitizing compositions for cleaning food and food contact surfaces |
| AUPQ893200A0 (en) * | 2000-07-21 | 2000-08-17 | Whiteley, Reginald K. | Medical residue treatment |
| US20030133883A1 (en) * | 2001-06-14 | 2003-07-17 | Finnegan Mary Beth | Oral care compositions containing grapefruit seed extract |
| GB0100761D0 (en) * | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| US6623513B2 (en) * | 2001-01-19 | 2003-09-23 | Advanced Photodynamic Technologies, Inc. | Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin |
| DE10105592A1 (de) * | 2001-02-06 | 2002-08-08 | Achim Goepferich | Platzhalter zur Arzneistofffreigabe in der Stirnhöhle |
| KR100492644B1 (ko) * | 2001-02-26 | 2005-06-02 | 미쓰비시 지도샤 고교(주) | 배기 가스 정화용 촉매 |
| US6610314B2 (en) * | 2001-03-12 | 2003-08-26 | Kimberly-Clark Worldwide, Inc. | Antimicrobial formulations |
| US6682695B2 (en) | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
| WO2002094854A2 (en) | 2001-05-21 | 2002-11-28 | The Brigham And Women's Hospital, Inc. | P.aeruginosa mucoid exopolysaccharide specific binding peptides |
| WO2003023074A1 (en) * | 2001-09-13 | 2003-03-20 | Ak Properties, Inc. | Method of continuously casting electrical steel strip with controlled spray cooling |
| DK1429780T3 (da) | 2001-09-21 | 2006-02-13 | Fremgangsmåde til behandling af mellemoreinfektioner | |
| US20030064000A1 (en) * | 2001-09-24 | 2003-04-03 | Wilson Burgess | Methods of sterilizing biological mixtures using stabilizer mixtures |
| WO2003061579A2 (en) | 2002-01-18 | 2003-07-31 | Emory University | Phthalocyanine and porphyrazine pharmaceutical compositions |
| US20050042240A1 (en) * | 2002-01-28 | 2005-02-24 | Utterberg David S. | High viscosity antibacterials |
| US20030180181A1 (en) | 2002-02-01 | 2003-09-25 | Teri Greib | Methods for sterilizing tissue |
| RU2228203C2 (ru) | 2002-04-12 | 2004-05-10 | ООО "Наука-Сервис-Центр" | Ранозаживляющий материал |
| EP1499341A4 (en) | 2002-04-18 | 2010-10-27 | Univ Iowa Res Found | METHOD FOR INHIBITING AND TREATING BACTERIAL BIOFILMS WITH METAL CHELATE IMAGES |
| US6919348B2 (en) * | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
| EP1374856A1 (en) | 2002-06-18 | 2004-01-02 | Impetus AG | Oily thixotropic nasal spray |
| US7105175B2 (en) | 2002-06-19 | 2006-09-12 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled delivery of a therapeutic agent |
| AU2003272517A1 (en) * | 2002-09-13 | 2004-04-30 | Zicam, Llc. | Compositions to reduce congestion and methods for application thereof to the nasal membrane |
| US20050064508A1 (en) * | 2003-09-22 | 2005-03-24 | Semzyme | Peptide mediated synthesis of metallic and magnetic materials |
| AU2003279067A1 (en) | 2002-09-23 | 2004-04-08 | Genta Inc. | Tri(alkylcarboxylato) gallium (iii) products and pharmaceutical compositions containing them |
| US6770729B2 (en) * | 2002-09-30 | 2004-08-03 | Medtronic Minimed, Inc. | Polymer compositions containing bioactive agents and methods for their use |
| BR0314952A (pt) * | 2002-09-30 | 2005-08-02 | Bausch & Lomb | Método para inibir a aderência de bactérias a uma superfìcie de um dispositivo biomédico |
| EP1567101A4 (en) | 2002-10-22 | 2009-06-03 | Nucryst Pharm Corp | PROPHYLACTIC TREATMENT METHODS |
| US20040101506A1 (en) * | 2002-11-25 | 2004-05-27 | Fust Charles A. | Composition for the prevention and treatment of inflammation of the ear |
| US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| US7491234B2 (en) * | 2002-12-03 | 2009-02-17 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agents |
| GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
| CA2518960C (en) * | 2003-03-14 | 2013-08-27 | Sinexus, Inc. | Sinus delivery of sustained release therapeutics |
| US20040214753A1 (en) | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
| US20040213758A1 (en) | 2003-04-23 | 2004-10-28 | Rimon Therapeutics Ltd. | Hydroxyamate-containing materials for the inhibition of matrix metalloproteinases |
| US7090882B2 (en) | 2003-06-12 | 2006-08-15 | Cargill, Incorporated | Antimicrobial salt solutions for food safety applications |
| US20050003007A1 (en) * | 2003-07-02 | 2005-01-06 | Michele Boix | Method of sterilization of polymeric microparticles |
| US7341983B2 (en) | 2003-08-04 | 2008-03-11 | Ecolab Inc. | Antimicrobial compositions including carboxylic acids and alkoxylated amines |
| CA2535846A1 (en) * | 2003-08-15 | 2005-02-24 | Qlt Usa, Inc. | Adhesive bioerodible transmucosal drug delivery system |
| US20050080396A1 (en) | 2003-10-03 | 2005-04-14 | Michael Rontal | Method and apparatus for the ultrasonic cleaning of biofilm coated surfaces |
| DE10347994A1 (de) | 2003-10-15 | 2005-06-16 | Pari GmbH Spezialisten für effektive Inhalation | Wässrige Aerosol-Zubereitung |
| CN1901801B (zh) * | 2003-12-04 | 2013-01-16 | 衣阿华大学研究基金会 | 镓抑制生物膜形成 |
| ZA200605583B (en) | 2003-12-17 | 2009-06-24 | Titan Pharmaceuticals Inc | Use of gallium to treat inflammatory arthritis |
| EP2286791B1 (en) * | 2003-12-30 | 2014-03-26 | Durect Corporation | Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents |
| US7541320B2 (en) * | 2004-01-23 | 2009-06-02 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Mild, viscous cleansing composition with versatile compatibility and enhanced conditioning |
| US20100016267A1 (en) | 2004-03-15 | 2010-01-21 | Felix Theeuwes | Pharmaceutical compositions for administraton to a sinus |
| EP1737378A2 (en) * | 2004-04-02 | 2007-01-03 | Baylor College of Medicine | Novel modification of medical prostheses |
| US7803150B2 (en) * | 2004-04-21 | 2010-09-28 | Acclarent, Inc. | Devices, systems and methods useable for treating sinusitis |
| US7410480B2 (en) * | 2004-04-21 | 2008-08-12 | Acclarent, Inc. | Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders |
| US20050282722A1 (en) | 2004-06-16 | 2005-12-22 | Mcreynolds Kent B | Two part cleaning composition |
| US7494963B2 (en) * | 2004-08-11 | 2009-02-24 | Delaval Holding Ab | Non-chlorinated concentrated all-in-one acid detergent and method for using the same |
| US20060045850A1 (en) * | 2004-08-30 | 2006-03-02 | Qpharma, Llc | Nasal delivery of cyclodextrin complexes of anti-inflammatory steroids |
| US9028852B2 (en) * | 2004-09-07 | 2015-05-12 | 3M Innovative Properties Company | Cationic antiseptic compositions and methods of use |
| US20080248558A1 (en) | 2004-09-10 | 2008-10-09 | Novozymes A/S | Methods For Preventing, Removing, Reducing, or Disrupting Biofilm |
| US20060079420A1 (en) * | 2004-10-08 | 2006-04-13 | Wagner Julie A | Multi-phase personal cleansing composition |
| CN101137359B (zh) * | 2005-03-10 | 2011-01-12 | 3M创新有限公司 | 治疗耳感染的方法 |
| WO2006099386A2 (en) | 2005-03-11 | 2006-09-21 | Massachusetts Institute Of Technology | Synthesis and use of colloidal iii-v nanoparticles |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| US7976873B2 (en) | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
| US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
| US7998404B2 (en) * | 2006-07-13 | 2011-08-16 | Advanced Cardiovascular Systems, Inc. | Reduced temperature sterilization of stents |
| WO2008097317A1 (en) | 2007-02-08 | 2008-08-14 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use |
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2007
- 2007-04-24 US US11/739,508 patent/US7976873B2/en active Active
- 2007-05-08 AU AU2007249413A patent/AU2007249413B2/en not_active Ceased
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- 2007-05-08 ES ES07762011.0T patent/ES2650974T3/es active Active
- 2007-05-08 WO PCT/US2007/068477 patent/WO2007134055A1/en not_active Ceased
- 2007-05-08 CN CN201510116539.8A patent/CN104815328A/zh active Pending
- 2007-05-08 KR KR1020087027422A patent/KR101453011B1/ko not_active Expired - Fee Related
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2014
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| EP2029232A1 (en) | 2009-03-04 |
| JP2014240419A (ja) | 2014-12-25 |
| CA2651646A1 (en) | 2007-11-22 |
| AU2007249413A1 (en) | 2007-11-22 |
| EP2029232B1 (en) | 2017-09-20 |
| US20070264353A1 (en) | 2007-11-15 |
| CA2651646C (en) | 2015-01-27 |
| KR20090005162A (ko) | 2009-01-12 |
| US7976873B2 (en) | 2011-07-12 |
| KR101453011B1 (ko) | 2014-10-21 |
| JP5912218B2 (ja) | 2016-04-27 |
| JP2009536666A (ja) | 2009-10-15 |
| CN104815328A (zh) | 2015-08-05 |
| WO2007134055A1 (en) | 2007-11-22 |
| AU2007249413B2 (en) | 2012-08-30 |
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