JP2009536616A5 - - Google Patents
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- Publication number
- JP2009536616A5 JP2009536616A5 JP2009505429A JP2009505429A JP2009536616A5 JP 2009536616 A5 JP2009536616 A5 JP 2009536616A5 JP 2009505429 A JP2009505429 A JP 2009505429A JP 2009505429 A JP2009505429 A JP 2009505429A JP 2009536616 A5 JP2009536616 A5 JP 2009536616A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- optionally substituted
- butyl
- compound
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *NS(c1cc(NC(c2ccccc2*C2=CC=C*(*3)C3=C2)=O)ccc1)(=O)=O Chemical compound *NS(c1cc(NC(c2ccccc2*C2=CC=C*(*3)C3=C2)=O)ccc1)(=O)=O 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N OC(c1ccccc1)=O Chemical compound OC(c1ccccc1)=O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79107906P | 2006-04-11 | 2006-04-11 | |
| US60/791,079 | 2006-04-11 | ||
| PCT/US2007/008818 WO2007120647A2 (en) | 2006-04-11 | 2007-04-11 | Compositions useful as inhibitors of voltage-gated sodium channels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009536616A JP2009536616A (ja) | 2009-10-15 |
| JP2009536616A5 true JP2009536616A5 (enExample) | 2011-05-12 |
| JP5438504B2 JP5438504B2 (ja) | 2014-03-12 |
Family
ID=38512589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505429A Active JP5438504B2 (ja) | 2006-04-11 | 2007-04-11 | 電位依存性ナトリウムチャンネル阻害剤として有用である組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8841483B2 (enExample) |
| EP (1) | EP2004596A2 (enExample) |
| JP (1) | JP5438504B2 (enExample) |
| KR (1) | KR20080109918A (enExample) |
| CN (1) | CN101466665B (enExample) |
| AU (1) | AU2007238857B2 (enExample) |
| CA (1) | CA2648202A1 (enExample) |
| MX (1) | MX2008013194A (enExample) |
| NO (1) | NO20084758L (enExample) |
| NZ (1) | NZ596413A (enExample) |
| RU (1) | RU2470012C2 (enExample) |
| WO (1) | WO2007120647A2 (enExample) |
| ZA (1) | ZA200808751B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008281877A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of CNS disorders |
| AU2008310663A1 (en) * | 2007-10-11 | 2009-04-16 | Vertex Pharmaceuticals Incorporated | Aryl amides useful as inhibitors of voltage-gated sodium channels |
| MX2010003864A (es) * | 2007-10-11 | 2010-06-01 | Vertex Pharma | Amidas utiles como inhibidores de canales de sodio dependientes de voltaje. |
| US20110064662A1 (en) * | 2007-10-31 | 2011-03-17 | Riken | Kit for producing molecular probe for pet screening for drug discovery |
| US20130039998A1 (en) * | 2008-12-24 | 2013-02-14 | University Of Washington | Compositions of modulators of the wnt/beta-catenin pathway and benzamide and/or hydroxamic acid derivatives to treat bipolar disorder |
| ES2879314T3 (es) | 2010-08-18 | 2021-11-22 | Biosplice Therapeutics Inc | Dicetonas e hidroxicetonas como activadores de la vía de señalización de catenina |
| US20140113898A1 (en) * | 2010-11-08 | 2014-04-24 | Zalicus Pharmaceuticals Ltd. | Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers |
| JP6014155B2 (ja) | 2011-10-31 | 2016-10-25 | ゼノン・ファーマシューティカルズ・インコーポレイテッドXenon Pharmaceuticals Inc. | ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用 |
| ES2586213T3 (es) | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
| BR112014029161A2 (pt) * | 2012-05-22 | 2017-06-27 | Genentech Inc | benzamidas n-substituídas e seu uso no tratamento de dor |
| BR112015000187A2 (pt) * | 2012-07-06 | 2017-06-27 | Genentech Inc | benzamidas substituídas com n e métodos de uso das mesmas |
| ES2857687T3 (es) | 2013-01-31 | 2021-09-29 | Vertex Pharma | Piridona amidas como moduladores de los canales de sodio |
| AR094668A1 (es) | 2013-01-31 | 2015-08-19 | Vertex Pharma | Amidas como moduladores de canales de sodio |
| CN105073738B (zh) | 2013-01-31 | 2018-01-05 | 沃泰克斯药物股份有限公司 | 作为钠通道调节剂的喹啉及喹喔啉酰胺类 |
| PL2968249T3 (pl) | 2013-02-22 | 2019-06-28 | Samumed, Llc | Gamma-diketony jako aktywatory szlaku sygnałowego Wnt/beta-kateniny |
| WO2014134306A1 (en) | 2013-03-01 | 2014-09-04 | Zalicus Pharmaceuticals, Ltd. | Heterocyclic inhibitors of the sodium channel |
| BR112015022488A2 (pt) | 2013-03-14 | 2017-07-18 | Genentech Inc | triazolopiridinas substituídas e métodos de uso das mesmas |
| BR112015023397A2 (pt) | 2013-03-15 | 2017-07-18 | Genentech Inc | benzoxazois substituídos e métodos de uso dos mesmos |
| PE20160548A1 (es) * | 2013-07-19 | 2016-05-21 | Vertex Pharma | Sulfonamidas como moduladores de canales de sodio |
| CR20160296A (es) | 2013-11-27 | 2016-09-20 | Genentech Inc | Benzamidas sustituidas y métodos para usarlas |
| CA2931550C (en) | 2013-12-13 | 2023-09-26 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
| EP3166939B1 (en) | 2014-07-07 | 2019-06-05 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| US9795550B2 (en) | 2014-08-20 | 2017-10-24 | Samumed, Llc | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
| CA2976449C (en) | 2015-02-11 | 2022-08-09 | Icahn School Of Medicine At Mount Sinai | Benzenesulfonamide upregulators of npc1 for neimann-pick disease and other lysosomal storage disorders |
| WO2016191312A1 (en) | 2015-05-22 | 2016-12-01 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| EP3101009A1 (en) * | 2015-06-05 | 2016-12-07 | Lead Pharma Cel Models IP B.V. | Ror gamma (rory) modulators |
| MA42683A (fr) | 2015-08-27 | 2018-07-04 | Genentech Inc | Composés thérapeutiques et leurs méthodes utilisation |
| PE20181003A1 (es) | 2015-09-28 | 2018-06-26 | Genentech Inc | Compuestos terapeuticos y sus metodos de uso |
| CN108495851A (zh) | 2015-11-25 | 2018-09-04 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
| EP3854782A1 (en) | 2016-03-30 | 2021-07-28 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| WO2018017896A1 (en) * | 2016-07-20 | 2018-01-25 | Amgen Inc. | Pyridine sulfonamides |
| SG11201903348UA (en) | 2016-10-17 | 2019-05-30 | Genentech Inc | Therapeutic compounds and methods of use thereof |
| US11117858B2 (en) | 2017-01-11 | 2021-09-14 | The General Hospital Corporation | Voltage gated sodium channel imaging agents |
| IT201700028127A1 (it) | 2017-03-14 | 2018-09-14 | Fondazione St Italiano Tecnologia | Composti e composizioni per il trattamento della fibrosi cistica |
| WO2018175707A1 (en) | 2017-03-24 | 2018-09-27 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| EP3625214B1 (en) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| CA3069720A1 (en) | 2017-07-11 | 2019-01-17 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2019157505A1 (en) | 2018-02-12 | 2019-08-15 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
| EP3759098A1 (en) | 2018-02-26 | 2021-01-06 | Genentech, Inc. | Pyridine-sulfonamide compounds and their use against pain and related conditions |
| EP3774801A1 (en) | 2018-03-30 | 2021-02-17 | F. Hoffmann-La Roche AG | Fused ring hydro-pyrido compounds as sodium channel inhibitors |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| KR102860523B1 (ko) * | 2018-11-02 | 2025-09-16 | 머크 샤프 앤드 돔 엘엘씨 | Nav1.8 억제제로서의 2-아미노-n-헤테로아릴-니코틴아미드 |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| TWI770607B (zh) * | 2019-09-12 | 2022-07-11 | 大陸商上海濟煜醫藥科技有限公司 | 吡啶氮氧化合物及其製備方法和用途 |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| WO2022121805A1 (zh) * | 2020-12-07 | 2022-06-16 | 成都康弘药业集团股份有限公司 | 作为Nav1.8抑制剂的并环化合物及其用途 |
| CN112457294B (zh) * | 2021-01-27 | 2021-06-04 | 上海济煜医药科技有限公司 | 一种作为NaV1.8阻滞剂的化合物及其制备方法和用途 |
| CN117794920A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂 |
| JP2025513455A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| CN116947713B (zh) * | 2022-04-25 | 2026-03-27 | 中国科学院上海药物研究所 | 并环类化合物及其应用 |
| EP4570788A1 (en) | 2022-08-12 | 2025-06-18 | Guangzhou Fermion Technology Co., Ltd. | Compound as voltage-gated sodium channel inhibitor |
| KR20250173577A (ko) * | 2023-04-19 | 2025-12-10 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | Nav1.8억제제 및 이의 제조 방법 및 용도 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130154C (enExample) * | 1957-05-29 | |||
| DE2966048D1 (en) | 1978-07-20 | 1983-09-15 | Basf Ag | N-arylsulfonyl pyrroles, their preparation and medicaments containing them |
| US4228449A (en) * | 1978-12-26 | 1980-10-14 | Hughes Aircraft Company | Semiconductor diode array liquid crystal device |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| DE19804251A1 (de) * | 1998-02-04 | 1999-08-05 | Hoechst Marion Roussel De Gmbh | Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| DE19830430A1 (de) * | 1998-07-08 | 2000-01-13 | Hoechst Marion Roussel De Gmbh | Schwefelsubstituierte Sulfonylamino-carbonsäure-N-arylamide, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| US6620849B2 (en) * | 2000-07-26 | 2003-09-16 | Icafen, Inc. | Potassium channel inhibitors |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| DE60235114D1 (de) | 2001-11-01 | 2010-03-04 | Icagen Inc | Pyrazolamide zur anwendung in der behandlung von schmerz |
| SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| WO2004106324A1 (en) | 2003-05-27 | 2004-12-09 | E.I. Dupont De Nemours And Company | Azolecarboxamide herbicides |
| TW200524888A (en) * | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| TW200628159A (en) | 2004-11-10 | 2006-08-16 | Synta Pharmaceuticals Corp | IL-12 modulatory compounds |
| JP2007045850A (ja) * | 2005-08-05 | 2007-02-22 | Tonengeneral Sekiyu Kk | 潤滑油組成物 |
| PE20110118A1 (es) | 2005-10-04 | 2011-03-08 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| JP5565999B2 (ja) * | 2007-01-31 | 2014-08-06 | Jx日鉱日石エネルギー株式会社 | 潤滑油組成物 |
| JP5483662B2 (ja) * | 2008-01-15 | 2014-05-07 | Jx日鉱日石エネルギー株式会社 | 潤滑油組成物 |
| JP5800448B2 (ja) * | 2008-03-25 | 2015-10-28 | Jx日鉱日石エネルギー株式会社 | 潤滑油基油及びその製造方法並びに潤滑油組成物 |
| JP5800449B2 (ja) * | 2008-03-25 | 2015-10-28 | Jx日鉱日石エネルギー株式会社 | 潤滑油基油及びその製造方法並びに潤滑油組成物 |
| JP5806794B2 (ja) * | 2008-03-25 | 2015-11-10 | Jx日鉱日石エネルギー株式会社 | 内燃機関用潤滑油組成物 |
| SG194403A1 (en) * | 2008-10-07 | 2013-11-29 | Jx Nippon Oil & Energy Corp | Lubricant base oil and a process for producing the same,and lubricating oil composition |
| JP2010090251A (ja) * | 2008-10-07 | 2010-04-22 | Nippon Oil Corp | 潤滑油基油及びその製造方法、潤滑油組成物 |
| US8563486B2 (en) * | 2008-10-07 | 2013-10-22 | Jx Nippon Oil & Energy Corporation | Lubricant composition and method for producing same |
| JP5395453B2 (ja) * | 2009-02-16 | 2014-01-22 | Jx日鉱日石エネルギー株式会社 | 無段変速機油組成物 |
-
2007
- 2007-04-11 MX MX2008013194A patent/MX2008013194A/es active IP Right Grant
- 2007-04-11 AU AU2007238857A patent/AU2007238857B2/en not_active Ceased
- 2007-04-11 CA CA002648202A patent/CA2648202A1/en not_active Abandoned
- 2007-04-11 KR KR1020087027549A patent/KR20080109918A/ko not_active Ceased
- 2007-04-11 US US11/786,166 patent/US8841483B2/en active Active
- 2007-04-11 NZ NZ596413A patent/NZ596413A/xx not_active IP Right Cessation
- 2007-04-11 WO PCT/US2007/008818 patent/WO2007120647A2/en not_active Ceased
- 2007-04-11 CN CN2007800213612A patent/CN101466665B/zh not_active Expired - Fee Related
- 2007-04-11 EP EP07755180A patent/EP2004596A2/en not_active Withdrawn
- 2007-04-11 JP JP2009505429A patent/JP5438504B2/ja active Active
- 2007-04-11 RU RU2008144415/04A patent/RU2470012C2/ru not_active IP Right Cessation
-
2008
- 2008-10-14 ZA ZA2008/08751A patent/ZA200808751B/en unknown
- 2008-11-11 NO NO20084758A patent/NO20084758L/no not_active Application Discontinuation
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