JP2009536246A5 - - Google Patents

Info

Publication number

JP2009536246A5

JP2009536246A5 JP2009509690A JP2009509690A JP2009536246A5 JP 2009536246 A5 JP2009536246 A5 JP 2009536246A5 JP 2009509690 A JP2009509690 A JP 2009509690A JP 2009509690 A JP2009509690 A JP 2009509690A JP 2009536246 A5 JP2009536246 A5 JP 2009536246A5

Authority

JP

Japan

Prior art keywords

polymer

optionally substituted

amine

group

independently

Prior art date

2007-05-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
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• 229920000642 polymer Polymers 0.000 claims 18
• 150000001412 amines Chemical group 0.000 claims 10
• 125000004429 atom Chemical group 0.000 claims 8
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 125000003107 substituted aryl group Chemical group 0.000 claims 6
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• IBYHHJPAARCAIE-UHFFFAOYSA-N 1-bromo-2-chloroethane Chemical compound ClCCBr IBYHHJPAARCAIE-UHFFFAOYSA-N 0.000 claims 2
• -1 2-chloretyl Chemical group 0.000 claims 2
• 229910019142 PO4 Inorganic materials 0.000 claims 2
• 239000007983 Tris buffer Substances 0.000 claims 2
• 150000001450 anions Chemical class 0.000 claims 2
• 238000004132 cross linking Methods 0.000 claims 2
• 239000003431 cross linking reagent Substances 0.000 claims 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
• 239000010452 phosphate Substances 0.000 claims 2
• 125000000547 substituted alkyl group Chemical group 0.000 claims 2
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
• PAAZPARNPHGIKF-UHFFFAOYSA-N 1,2-dibromoethane Chemical compound BrCCBr PAAZPARNPHGIKF-UHFFFAOYSA-N 0.000 claims 1
• VEFLKXRACNJHOV-UHFFFAOYSA-N 1,3-dibromopropane Chemical compound BrCCCBr VEFLKXRACNJHOV-UHFFFAOYSA-N 0.000 claims 1
• VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims 1
• YMDZDFSUDFLGMX-UHFFFAOYSA-N 2-chloro-n-(2-chloroethyl)ethanamine;hydron;chloride Chemical compound [Cl-].ClCC[NH2+]CCCl YMDZDFSUDFLGMX-UHFFFAOYSA-N 0.000 claims 1
• 229940122720 Alkaline phosphatase inhibitor Drugs 0.000 claims 1
• 229940122502 Cholesterol absorption inhibitor Drugs 0.000 claims 1
• BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical group ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 1
• 229940123934 Reductase inhibitor Drugs 0.000 claims 1
• 125000002723 alicyclic group Chemical group 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 239000003613 bile acid Substances 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 claims 1
• 239000005516 coenzyme A Substances 0.000 claims 1
• 229940093530 coenzyme a Drugs 0.000 claims 1
• KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 201000005991 hyperphosphatemia Diseases 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• QZIQJVCYUQZDIR-UHFFFAOYSA-N mechlorethamine hydrochloride Chemical compound Cl.ClCCN(C)CCCl QZIQJVCYUQZDIR-UHFFFAOYSA-N 0.000 claims 1
• 229960002868 mechlorethamine hydrochloride Drugs 0.000 claims 1
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
• PJOLOHMGBICKJH-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-[2-[bis(3-aminopropyl)amino]ethyl]propane-1,3-diamine Chemical compound NCCCN(CCCN)CCN(CCCN)CCCN PJOLOHMGBICKJH-UHFFFAOYSA-N 0.000 claims 1
• LSHROXHEILXKHM-UHFFFAOYSA-N n'-[2-[2-[2-(2-aminoethylamino)ethylamino]ethylamino]ethyl]ethane-1,2-diamine Chemical compound NCCNCCNCCNCCNCCN LSHROXHEILXKHM-UHFFFAOYSA-N 0.000 claims 1
• 239000002694 phosphate binding agent Substances 0.000 claims 1
• 239000002516 radical scavenger Substances 0.000 claims 1
• AOCSUUGBCMTKJH-UHFFFAOYSA-N tert-butyl n-(2-aminoethyl)carbamate Chemical compound CC(C)(C)OC(=O)NCCN AOCSUUGBCMTKJH-UHFFFAOYSA-N 0.000 claims 1
• FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 claims 1
• MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 claims 1