JP2009534440A - カリウムチャンネルモジュレーターとしてのｃｂｘカンナビノイド受容体モジュレーターの使用 - Google Patents

カリウムチャンネルモジュレーターとしてのｃｂｘカンナビノイド受容体モジュレーターの使用 Download PDF

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Publication number
JP2009534440A
JP2009534440A JP2009507043A JP2009507043A JP2009534440A JP 2009534440 A JP2009534440 A JP 2009534440A JP 2009507043 A JP2009507043 A JP 2009507043A JP 2009507043 A JP2009507043 A JP 2009507043A JP 2009534440 A JP2009534440 A JP 2009534440A
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JP
Japan
Prior art keywords
phenyl
chloro
carboxylic acid
dichloro
dihydro
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Pending
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JP2009507043A
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English (en)
Japanese (ja)
Inventor
アンテル ヨッヘン
グレゴリー ペーター−コリン
フーベルトゥス マリア ランゲ ヨセフス
フィルンゲス ミハエル
ライヒェ ダニア
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Abbott Products GmbH
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Solvay Pharmaceuticals GmbH
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Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Publication of JP2009534440A publication Critical patent/JP2009534440A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009507043A 2006-04-27 2007-04-20 カリウムチャンネルモジュレーターとしてのｃｂｘカンナビノイド受容体モジュレーターの使用 Pending JP2009534440A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06113190 2006-04-27
PCT/EP2007/053915 WO2007125049A1 (fr) 2006-04-27 2007-04-20 Utilisation de modulateurs de récepteurs aux cannabinoïdes cbx en tant que modulateurs de canaux potassium

Publications (1)

Publication Number Publication Date
JP2009534440A true JP2009534440A (ja) 2009-09-24

Family

ID=36808728

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009507043A Pending JP2009534440A (ja) 2006-04-27 2007-04-20 カリウムチャンネルモジュレーターとしてのｃｂｘカンナビノイド受容体モジュレーターの使用

Country Status (10)

Country Link
EP (1) EP2012775A1 (fr)
JP (1) JP2009534440A (fr)
CN (1) CN101431994A (fr)
AR (1) AR060626A1 (fr)
AU (1) AU2007245734A1 (fr)
CA (1) CA2650567A1 (fr)
MX (1) MX2008013285A (fr)
RU (1) RU2008146591A (fr)
TW (1) TW200812576A (fr)
WO (1) WO2007125049A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013047701A1 (fr) * 2011-09-29 2013-04-04 小野薬品工業株式会社 Dérivé phényle
JP2015521193A (ja) * 2012-05-31 2015-07-27 フェネックス ファーマシューティカルス アーゲー オーファン核内受容体ＲＯＲγの調整剤としてのカルボキサミドまたはスルホンアミド置換されたチアゾールおよび関連する誘導体
US9676719B2 (en) 2013-03-26 2017-06-13 Ono Pharmaceutical Co., Ltd. Phenyl derivative

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
TW200836719A (en) 2007-02-12 2008-09-16 Astrazeneca Ab Chemical compounds
AU2011329636B2 (en) * 2010-11-18 2016-05-19 Jenrin Discovery Cannabinoid receptor antagonists-inverse agonists useful for treating metabolic disorders, including obesity and diabetes
CN106138053B (zh) * 2015-04-28 2019-04-09 上海市同济医院 一种化合物在制备治疗帕金森病的药物中的应用
EP3109237A1 (fr) 2015-06-22 2016-12-28 AnaMar AB Nouveaux antagonistes de 5-ht2
WO2021087127A1 (fr) * 2019-10-29 2021-05-06 Corbus Pharmaceuticals, Inc. Cannabinoïdes et utilisations associées

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003063758A2 (fr) * 2002-01-31 2003-08-07 Pharmos Corporation Ligands du recepteur cannabinoide cb2 bicyclique
GB0402356D0 (en) * 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013047701A1 (fr) * 2011-09-29 2013-04-04 小野薬品工業株式会社 Dérivé phényle
KR20140077891A (ko) * 2011-09-29 2014-06-24 오노 야꾸힝 고교 가부시키가이샤 페닐 유도체
US8975409B2 (en) 2011-09-29 2015-03-10 Ono Pharmaceutical Co., Ltd. Phenyl derivative
JPWO2013047701A1 (ja) * 2011-09-29 2015-03-26 小野薬品工業株式会社 フェニル誘導体
US9340499B2 (en) 2011-09-29 2016-05-17 Ono Pharmaceutical Co., Ltd. Phenyl derivative
JP2017036309A (ja) * 2011-09-29 2017-02-16 小野薬品工業株式会社 フェニル誘導体
US9820980B2 (en) 2011-09-29 2017-11-21 Ono Pharmaceutical Co., Ltd. Phenyl derivative
US10117861B2 (en) 2011-09-29 2018-11-06 Ono Pharmaceutical Co., Ltd. Phenyl derivative
KR101972619B1 (ko) 2011-09-29 2019-04-25 오노 야꾸힝 고교 가부시키가이샤 페닐 유도체
US10835520B2 (en) 2011-09-29 2020-11-17 Ono Pharmaceutical Co., Ltd. Phenyl derivative
JP2015521193A (ja) * 2012-05-31 2015-07-27 フェネックス ファーマシューティカルス アーゲー オーファン核内受容体ＲＯＲγの調整剤としてのカルボキサミドまたはスルホンアミド置換されたチアゾールおよび関連する誘導体
US9676719B2 (en) 2013-03-26 2017-06-13 Ono Pharmaceutical Co., Ltd. Phenyl derivative

Also Published As

Publication number Publication date
CA2650567A1 (fr) 2007-11-08
EP2012775A1 (fr) 2009-01-14
AU2007245734A1 (en) 2007-11-08
WO2007125049A1 (fr) 2007-11-08
RU2008146591A (ru) 2010-06-10
TW200812576A (en) 2008-03-16
CN101431994A (zh) 2009-05-13
AR060626A1 (es) 2008-07-02
MX2008013285A (es) 2008-10-24

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