JP2009534306A5 - - Google Patents
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- Publication number
- JP2009534306A5 JP2009534306A5 JP2009501893A JP2009501893A JP2009534306A5 JP 2009534306 A5 JP2009534306 A5 JP 2009534306A5 JP 2009501893 A JP2009501893 A JP 2009501893A JP 2009501893 A JP2009501893 A JP 2009501893A JP 2009534306 A5 JP2009534306 A5 JP 2009534306A5
- Authority
- JP
- Japan
- Prior art keywords
- vpa
- pharmaceutically acceptable
- acceptable salt
- valproic acid
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 36
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 36
- 229960000604 valproic acid Drugs 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 15
- 239000013543 active substance Substances 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 230000000699 topical effect Effects 0.000 claims 6
- 208000002874 Acne Vulgaris Diseases 0.000 claims 5
- 206010000496 acne Diseases 0.000 claims 5
- 239000003242 anti bacterial agent Substances 0.000 claims 4
- 230000001186 cumulative effect Effects 0.000 claims 4
- 239000000417 fungicide Substances 0.000 claims 4
- 229940125697 hormonal agent Drugs 0.000 claims 4
- 230000003902 lesion Effects 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 229940088710 antibiotic agent Drugs 0.000 claims 3
- 206010015150 Erythema Diseases 0.000 claims 2
- 102000003964 Histone deacetylase Human genes 0.000 claims 2
- 108090000353 Histone deacetylase Proteins 0.000 claims 2
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 231100000321 erythema Toxicity 0.000 claims 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 2
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 229960005280 isotretinoin Drugs 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000004492 retinoid derivatives Chemical class 0.000 claims 1
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06006847A EP1839656A1 (en) | 2006-03-31 | 2006-03-31 | Use of valproic acid for the topical treatment of mild to moderate acne vulgaris |
| PCT/EP2007/002201 WO2007112832A1 (en) | 2006-03-31 | 2007-03-13 | Use of valproic acid for the topical treatment of mild to moderate acne vulgaris |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009534306A JP2009534306A (ja) | 2009-09-24 |
| JP2009534306A5 true JP2009534306A5 (https=) | 2010-03-18 |
Family
ID=36498743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501893A Withdrawn JP2009534306A (ja) | 2006-03-31 | 2007-03-13 | 軽度から中等度の尋常性ざ瘡の局所治療のためのバルプロ酸の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090186809A1 (https=) |
| EP (2) | EP1839656A1 (https=) |
| JP (1) | JP2009534306A (https=) |
| AT (1) | ATE476972T1 (https=) |
| DE (1) | DE602007008385D1 (https=) |
| WO (1) | WO2007112832A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8492438B2 (en) * | 2002-04-26 | 2013-07-23 | Asan Laboratories Company (Cayman), Limited | Treatment skin disorders |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| NZ589276A (en) | 2005-02-03 | 2012-06-29 | Topotarget Uk Ltd | Combination therapies using hdac inhibitors and erlotinib (tarceva) |
| CN101189003B (zh) | 2005-05-13 | 2012-02-08 | 托波塔吉特英国有限公司 | Hdac抑制剂的药物制剂 |
| JP5377968B2 (ja) * | 2005-11-10 | 2013-12-25 | トポターゲット ユーケー リミテッド | 癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤 |
| JP2010540426A (ja) * | 2007-09-25 | 2010-12-24 | トポターゲット ユーケー リミテッド | 特定のヒドロキサム酸化合物の合成方法 |
| AU2009220942B2 (en) * | 2008-03-07 | 2015-05-28 | Onxeo Dk, Branch Of Onxeo S.A., France | Methods of treatment employing prolonged continuous infusion of Belinostat |
| JP2012511048A (ja) | 2008-12-08 | 2012-05-17 | ノースウェスタン ユニバーシティ | Ｈｓｆ−１の改変方法 |
| GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
| WO2011097549A2 (en) * | 2010-02-05 | 2011-08-11 | Asan Laboratories Company (Cayman), Limited | Treatment skin disorders |
| KR101733189B1 (ko) * | 2010-10-06 | 2017-05-08 | (주)아모레퍼시픽 | 손톱 또는 발톱 성장 촉진용 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| ES2308065T3 (es) * | 2004-04-30 | 2008-12-01 | Topotarget Germany Ag | Formulacion que comprende un inhibidor de histona desacetilasa, que exhibe una liberacion bifasica. |
| JP5279268B2 (ja) * | 2004-07-28 | 2013-09-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としての置換されたプロペニルピペラジン誘導体 |
-
2006
- 2006-03-31 EP EP06006847A patent/EP1839656A1/en not_active Withdrawn
-
2007
- 2007-03-13 US US12/295,359 patent/US20090186809A1/en not_active Abandoned
- 2007-03-13 EP EP07711939A patent/EP2001458B1/en not_active Not-in-force
- 2007-03-13 AT AT07711939T patent/ATE476972T1/de not_active IP Right Cessation
- 2007-03-13 DE DE602007008385T patent/DE602007008385D1/de active Active
- 2007-03-13 WO PCT/EP2007/002201 patent/WO2007112832A1/en not_active Ceased
- 2007-03-13 JP JP2009501893A patent/JP2009534306A/ja not_active Withdrawn
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