JP2009533317A5 - - Google Patents

Info

Publication number

JP2009533317A5

JP2009533317A5 JP2008553409A JP2008553409A JP2009533317A5 JP 2009533317 A5 JP2009533317 A5 JP 2009533317A5 JP 2008553409 A JP2008553409 A JP 2008553409A JP 2008553409 A JP2008553409 A JP 2008553409A JP 2009533317 A5 JP2009533317 A5 JP 2009533317A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

conjugate

composition

peptide

Prior art date

2007-02-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 25
• 125000003275 alpha amino acid group Chemical group 0.000 claims 15
• 206010028980 Neoplasm Diseases 0.000 claims 10
• 150000001413 amino acids Chemical class 0.000 claims 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 230000006378 damage Effects 0.000 claims 6
• 208000027418 Wounds and injury Diseases 0.000 claims 5
• 208000014674 injury Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 4
• 238000006467 substitution reaction Methods 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• 238000003384 imaging method Methods 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 102000004506 Blood Proteins Human genes 0.000 claims 1
• 108010017384 Blood Proteins Proteins 0.000 claims 1
• OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 claims 1
• 102000009123 Fibrin Human genes 0.000 claims 1
• 108010073385 Fibrin Proteins 0.000 claims 1
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
• 102000016359 Fibronectins Human genes 0.000 claims 1
• 108010067306 Fibronectins Proteins 0.000 claims 1
• GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical compound [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229950003499 fibrin Drugs 0.000 claims 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
• APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims 1
• 229940055742 indium-111 Drugs 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• -1 radionuclide Chemical compound 0.000 claims 1
• PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 230000008023 solidification Effects 0.000 claims 1
• 238000007711 solidification Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000004614 tumor growth Effects 0.000 claims 1