JP2009533024A5 - - Google Patents

Info

Publication number

JP2009533024A5

JP2009533024A5 JP2009504337A JP2009504337A JP2009533024A5 JP 2009533024 A5 JP2009533024 A5 JP 2009533024A5 JP 2009504337 A JP2009504337 A JP 2009504337A JP 2009504337 A JP2009504337 A JP 2009504337A JP 2009533024 A5 JP2009533024 A5 JP 2009533024A5

Authority

JP

Japan

Prior art keywords

transcobalamin

cell

amount

antibody

receptor

Prior art date

2007-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010023603 Transcobalamins Proteins 0.000 claims description 55
• 102000011409 Transcobalamins Human genes 0.000 claims description 55
• 108010083125 transcobalamin receptor Proteins 0.000 claims description 52
• 102100025240 CD320 antigen Human genes 0.000 claims description 50
• 238000000034 method Methods 0.000 claims description 40
• 229920001184 polypeptide Polymers 0.000 claims description 36
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 36
• FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 32
• 239000012634 fragment Substances 0.000 claims description 28
• 108091033319 polynucleotide Proteins 0.000 claims description 14
• 239000002157 polynucleotide Substances 0.000 claims description 14
• 102000040430 polynucleotide Human genes 0.000 claims description 14
• 208000012902 Nervous system disease Diseases 0.000 claims description 10
• 208000025966 Neurological disease Diseases 0.000 claims description 9
• 108091034117 Oligonucleotide Proteins 0.000 claims description 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
• 230000000295 complement effect Effects 0.000 claims description 6
• 230000002401 inhibitory effect Effects 0.000 claims description 6
• 206010061218 Inflammation Diseases 0.000 claims description 5
• 206010028980 Neoplasm Diseases 0.000 claims description 5
• 201000010099 disease Diseases 0.000 claims description 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
• 230000004054 inflammatory process Effects 0.000 claims description 5
• 108091081021 Sense strand Proteins 0.000 claims description 4
• 239000003112 inhibitor Substances 0.000 claims description 4
• 239000002773 nucleotide Substances 0.000 claims description 4
• 125000003729 nucleotide group Chemical group 0.000 claims description 4
• 229920002477 rna polymer Polymers 0.000 claims description 4
• 241001465754 Metazoa Species 0.000 claims description 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
• 230000000692 anti-sense effect Effects 0.000 claims description 2
• 230000003053 immunization Effects 0.000 claims description 2
• 230000002163 immunogen Effects 0.000 claims description 2
• 238000010348 incorporation Methods 0.000 claims description 2
• 108020004999 messenger RNA Proteins 0.000 claims description 2
• 230000001737 promoting effect Effects 0.000 claims description 2
• 230000009261 transgenic effect Effects 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 14
• 238000000338 in vitro Methods 0.000 claims 5
• 101710094819 Vitamin B12 transporter BtuB Proteins 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 description 1