JP2009532053A5 - - Google Patents
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- Publication number
- JP2009532053A5 JP2009532053A5 JP2009503661A JP2009503661A JP2009532053A5 JP 2009532053 A5 JP2009532053 A5 JP 2009532053A5 JP 2009503661 A JP2009503661 A JP 2009503661A JP 2009503661 A JP2009503661 A JP 2009503661A JP 2009532053 A5 JP2009532053 A5 JP 2009532053A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- sequence
- cell
- molecule
- cytidine deaminase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 102100026846 Cytidine deaminase Human genes 0.000 claims 7
- 108010031325 Cytidine deaminase Proteins 0.000 claims 7
- 230000004568 DNA-binding Effects 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 230000017858 demethylation Effects 0.000 claims 4
- 238000010520 demethylation reaction Methods 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000005937 nuclear translocation Effects 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000010374 somatic cell nuclear transfer Methods 0.000 claims 2
- 102000012758 APOBEC-1 Deaminase Human genes 0.000 claims 1
- 101150012656 APOBEC1 gene Proteins 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 108700008625 Reporter Genes Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000002257 embryonic structure Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79027306P | 2006-04-07 | 2006-04-07 | |
| GBGB0607063.5A GB0607063D0 (en) | 2006-04-07 | 2006-04-07 | Compositions and methods for epigenetic modification of nucleic acid sequences in vivo |
| US79794206P | 2006-05-05 | 2006-05-05 | |
| GBGB0623644.2A GB0623644D0 (en) | 2006-04-07 | 2006-11-27 | Compositions and methods for epigenetic modification of nucleic acid sequences in vivo |
| PCT/GB2007/001304 WO2007128982A2 (en) | 2006-04-07 | 2007-04-10 | Compositions and methods for epigenetic modification of nucleic acid sequences in vivo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009532053A JP2009532053A (ja) | 2009-09-10 |
| JP2009532053A5 true JP2009532053A5 (enExample) | 2010-05-27 |
Family
ID=36539563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503661A Pending JP2009532053A (ja) | 2006-04-07 | 2007-04-10 | インヴィヴォでの核酸配列のエピジェネティック修飾用組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8298529B2 (enExample) |
| EP (1) | EP2010660B1 (enExample) |
| JP (1) | JP2009532053A (enExample) |
| GB (2) | GB0607063D0 (enExample) |
| WO (1) | WO2007128982A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2274430T3 (pl) * | 2008-04-30 | 2017-09-29 | Sanbio Inc | Komórki regenerujące nerwy ze zmianami w metylacji DNA |
| EP2128259A1 (en) | 2008-05-27 | 2009-12-02 | Koninklijke Philips Electronics N.V. | Therapy delivery and monitoring using a gene of interest-reporter fusion protein and optical imaging |
| DK2414507T3 (da) * | 2009-04-03 | 2014-08-25 | Medical Res Council | Mutanter af aktiveringsinduceret cytidin-deaminase (aid) og til anvendelsesfremgangsmåder |
| EP2258858A1 (en) * | 2009-06-05 | 2010-12-08 | Universitätsklinikum Freiburg | Transgenic LSD1 animal model for cancer |
| US20110104787A1 (en) * | 2009-11-05 | 2011-05-05 | President And Fellows Of Harvard College | Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences |
| US20130011380A1 (en) * | 2009-12-18 | 2013-01-10 | Blau Helen M | Use of Cytidine Deaminase-Related Agents to Promote Demethylation and Cell Reprogramming |
| EP3461896B1 (en) | 2011-07-15 | 2023-11-29 | The General Hospital Corporation | Methods of transcription activator like effector assembly |
| US9890364B2 (en) | 2012-05-29 | 2018-02-13 | The General Hospital Corporation | TAL-Tet1 fusion proteins and methods of use thereof |
| EP2906602B1 (en) | 2012-10-12 | 2019-01-16 | The General Hospital Corporation | Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins |
| US10676749B2 (en) | 2013-02-07 | 2020-06-09 | The General Hospital Corporation | Tale transcriptional activators |
| US9721248B2 (en) | 2014-03-04 | 2017-08-01 | Bank Of America Corporation | ATM token cash withdrawal |
| GB201418965D0 (enExample) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| US10460367B2 (en) | 2016-04-29 | 2019-10-29 | Bank Of America Corporation | System for user authentication based on linking a randomly generated number to the user and a physical item |
| US10268635B2 (en) | 2016-06-17 | 2019-04-23 | Bank Of America Corporation | System for data rotation through tokenization |
| ES2905478T3 (es) * | 2016-12-28 | 2022-04-08 | Transgene Sa | Virus oncolíticos y moléculas terapéuticas |
| CN112334577B (zh) | 2018-04-19 | 2023-10-17 | 加利福尼亚大学董事会 | 用于基因编辑的组合物和方法 |
| JP7541508B2 (ja) * | 2018-08-23 | 2024-08-28 | サンガモ セラピューティクス， インコーポレイテッド | 操作された標的特異的な塩基エディター |
| JP7059965B2 (ja) * | 2019-02-21 | 2022-04-26 | 株式会社豊田中央研究所 | エピゲノム状態を制御する融合タンパク質及びその利用 |
| US11680109B2 (en) | 2019-05-29 | 2023-06-20 | Duke University | Compositions and methods for detection and measurement of RNA modifications through targeted RNA editing |
| CN113383749B (zh) * | 2020-03-12 | 2025-11-18 | 中国医学科学院基础医学研究所 | 一种使用单个肿瘤细胞构建小鼠肿瘤模型的方法 |
| WO2022244544A1 (ja) * | 2021-05-20 | 2022-11-24 | 国立大学法人群馬大学 | エピゲノムが改変された動植物の親系統の製造に用いるための組成物およびその用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| ES2195196T3 (es) | 1996-12-30 | 2003-12-01 | Univ Johns Hopkins Med | Determinacion de la propensidad de un organo o un tejido al cancer por determinacion de su patron de impresion. |
| US6534261B1 (en) * | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| WO2000058480A1 (en) * | 1999-03-29 | 2000-10-05 | Kansai Technology Licensing Organization Co., Ltd. | Novel cytidine deaminase |
| AUPQ655100A0 (en) * | 2000-03-29 | 2000-04-20 | Am Asset Management Pty Ltd | Device and method for cleaning golf balls |
| AU5391401A (en) * | 2000-04-28 | 2001-11-12 | Sangamo Biosciences Inc | Targeted modification of chromatin structure |
| EP1303608A2 (en) | 2000-07-21 | 2003-04-23 | Syngenta Participations AG | Zinc finger domain recognition code and uses thereof |
| US7026462B2 (en) * | 2000-12-07 | 2006-04-11 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| EP1418949B1 (en) * | 2001-07-31 | 2013-06-19 | THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON | Inhibitor of dna methylation |
| WO2003095636A2 (en) * | 2002-05-10 | 2003-11-20 | Medical Research Council | Activation induced deaminase (aid) |
| GB0312676D0 (en) * | 2003-06-02 | 2003-07-09 | Babraham Inst | Binding assay |
| FR2875239B1 (fr) * | 2004-09-10 | 2007-07-20 | Inst Necker Ass Loi De 1901 | Procede pour l'acceleration des mutations somatiques et son application en proteomique |
-
2006
- 2006-04-07 GB GBGB0607063.5A patent/GB0607063D0/en not_active Ceased
- 2006-11-27 GB GBGB0623644.2A patent/GB0623644D0/en not_active Ceased
-
2007
- 2007-04-10 JP JP2009503661A patent/JP2009532053A/ja active Pending
- 2007-04-10 US US12/226,094 patent/US8298529B2/en not_active Expired - Fee Related
- 2007-04-10 EP EP07732348.3A patent/EP2010660B1/en not_active Not-in-force
- 2007-04-10 WO PCT/GB2007/001304 patent/WO2007128982A2/en not_active Ceased
-
2012
- 2012-10-05 US US13/646,008 patent/US8658393B2/en not_active Expired - Fee Related
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