JP2009532053A - インヴィヴォでの核酸配列のエピジェネティック修飾用組成物および方法 - Google Patents

インヴィヴォでの核酸配列のエピジェネティック修飾用組成物および方法 Download PDF

Info

Publication number
JP2009532053A
JP2009532053A JP2009503661A JP2009503661A JP2009532053A JP 2009532053 A JP2009532053 A JP 2009532053A JP 2009503661 A JP2009503661 A JP 2009503661A JP 2009503661 A JP2009503661 A JP 2009503661A JP 2009532053 A JP2009532053 A JP 2009532053A
Authority
JP
Japan
Prior art keywords
cell
sequence
domain
molecule
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009503661A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009532053A5 (enExample
Inventor
ライク,ウルフ
モーガン,ヒュー
チャン,アンソニー,チュン‐フン
Original Assignee
セルセントリック・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セルセントリック・リミテッド filed Critical セルセントリック・リミテッド
Publication of JP2009532053A publication Critical patent/JP2009532053A/ja
Publication of JP2009532053A5 publication Critical patent/JP2009532053A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877Techniques for producing new mammalian cloned embryos
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009503661A 2006-04-07 2007-04-10 インヴィヴォでの核酸配列のエピジェネティック修飾用組成物および方法 Pending JP2009532053A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US79027306P 2006-04-07 2006-04-07
GBGB0607063.5A GB0607063D0 (en) 2006-04-07 2006-04-07 Compositions and methods for epigenetic modification of nucleic acid sequences in vivo
US79794206P 2006-05-05 2006-05-05
GBGB0623644.2A GB0623644D0 (en) 2006-04-07 2006-11-27 Compositions and methods for epigenetic modification of nucleic acid sequences in vivo
PCT/GB2007/001304 WO2007128982A2 (en) 2006-04-07 2007-04-10 Compositions and methods for epigenetic modification of nucleic acid sequences in vivo

Publications (2)

Publication Number Publication Date
JP2009532053A true JP2009532053A (ja) 2009-09-10
JP2009532053A5 JP2009532053A5 (enExample) 2010-05-27

Family

ID=36539563

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009503661A Pending JP2009532053A (ja) 2006-04-07 2007-04-10 インヴィヴォでの核酸配列のエピジェネティック修飾用組成物および方法

Country Status (5)

Country Link
US (2) US8298529B2 (enExample)
EP (1) EP2010660B1 (enExample)
JP (1) JP2009532053A (enExample)
GB (2) GB0607063D0 (enExample)
WO (1) WO2007128982A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020503040A (ja) * 2016-12-28 2020-01-30 トランジェーヌ、ソシエテ、アノニムTransgene S.A. 腫瘍溶解性ウイルスおよび治療用分子
JP2020132584A (ja) * 2019-02-21 2020-08-31 株式会社豊田中央研究所 エピゲノム状態を制御する融合タンパク質及びその利用
JP2021536229A (ja) * 2018-08-23 2021-12-27 サンガモ セラピューティクス, インコーポレイテッド 操作された標的特異的な塩基エディター
JPWO2022244544A1 (enExample) * 2021-05-20 2022-11-24

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2274430T3 (pl) * 2008-04-30 2017-09-29 Sanbio Inc Komórki regenerujące nerwy ze zmianami w metylacji DNA
EP2128259A1 (en) 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Therapy delivery and monitoring using a gene of interest-reporter fusion protein and optical imaging
DK2414507T3 (da) * 2009-04-03 2014-08-25 Medical Res Council Mutanter af aktiveringsinduceret cytidin-deaminase (aid) og til anvendelsesfremgangsmåder
EP2258858A1 (en) * 2009-06-05 2010-12-08 Universitätsklinikum Freiburg Transgenic LSD1 animal model for cancer
US20110104787A1 (en) * 2009-11-05 2011-05-05 President And Fellows Of Harvard College Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
US20130011380A1 (en) * 2009-12-18 2013-01-10 Blau Helen M Use of Cytidine Deaminase-Related Agents to Promote Demethylation and Cell Reprogramming
EP3461896B1 (en) 2011-07-15 2023-11-29 The General Hospital Corporation Methods of transcription activator like effector assembly
US9890364B2 (en) 2012-05-29 2018-02-13 The General Hospital Corporation TAL-Tet1 fusion proteins and methods of use thereof
EP2906602B1 (en) 2012-10-12 2019-01-16 The General Hospital Corporation Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
US10676749B2 (en) 2013-02-07 2020-06-09 The General Hospital Corporation Tale transcriptional activators
US9721248B2 (en) 2014-03-04 2017-08-01 Bank Of America Corporation ATM token cash withdrawal
GB201418965D0 (enExample) 2014-10-24 2014-12-10 Ospedale San Raffaele And Fond Telethon
US10460367B2 (en) 2016-04-29 2019-10-29 Bank Of America Corporation System for user authentication based on linking a randomly generated number to the user and a physical item
US10268635B2 (en) 2016-06-17 2019-04-23 Bank Of America Corporation System for data rotation through tokenization
CN112334577B (zh) 2018-04-19 2023-10-17 加利福尼亚大学董事会 用于基因编辑的组合物和方法
US11680109B2 (en) 2019-05-29 2023-06-20 Duke University Compositions and methods for detection and measurement of RNA modifications through targeted RNA editing
CN113383749B (zh) * 2020-03-12 2025-11-18 中国医学科学院基础医学研究所 一种使用单个肿瘤细胞构建小鼠肿瘤模型的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534104A (ja) * 1999-01-12 2002-10-15 サンガモ バイオサイエンシーズ, インコーポレイテッド ジンクフィンガータンパク質を用いた、細胞における、内因性遺伝子発現の調節
JP2003527943A (ja) * 2000-03-29 2003-09-24 エイエム アセット マネジメント ピィティワイ リミテッド ゴルフボールをクリーニングするための装置および方法
WO2004106550A2 (en) * 2003-06-02 2004-12-09 The Babraham Institute Identification and/or analysis of nucleic acids and/or proteins associated with a chromosome location
JP2004537260A (ja) * 2000-12-07 2004-12-16 サンガモ バイオサイエンシーズ, インコーポレイテッド ジンクフィンガータンパク質による血管新生の調節
WO2006030126A2 (fr) * 2004-09-10 2006-03-23 Institut Necker Procédé pour l'accélération des mutations somatiques et son application en protéomique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
ES2195196T3 (es) 1996-12-30 2003-12-01 Univ Johns Hopkins Med Determinacion de la propensidad de un organo o un tejido al cancer por determinacion de su patron de impresion.
WO2000058480A1 (en) * 1999-03-29 2000-10-05 Kansai Technology Licensing Organization Co., Ltd. Novel cytidine deaminase
AU5391401A (en) * 2000-04-28 2001-11-12 Sangamo Biosciences Inc Targeted modification of chromatin structure
EP1303608A2 (en) 2000-07-21 2003-04-23 Syngenta Participations AG Zinc finger domain recognition code and uses thereof
EP1418949B1 (en) * 2001-07-31 2013-06-19 THE STATE OF OREGON acting by and through THE STATE BOARD OF HIGHER EDUCATION on behalf of THE UNIVERSITY OF OREGON Inhibitor of dna methylation
WO2003095636A2 (en) * 2002-05-10 2003-11-20 Medical Research Council Activation induced deaminase (aid)

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534104A (ja) * 1999-01-12 2002-10-15 サンガモ バイオサイエンシーズ, インコーポレイテッド ジンクフィンガータンパク質を用いた、細胞における、内因性遺伝子発現の調節
JP2003527943A (ja) * 2000-03-29 2003-09-24 エイエム アセット マネジメント ピィティワイ リミテッド ゴルフボールをクリーニングするための装置および方法
JP2004537260A (ja) * 2000-12-07 2004-12-16 サンガモ バイオサイエンシーズ, インコーポレイテッド ジンクフィンガータンパク質による血管新生の調節
WO2004106550A2 (en) * 2003-06-02 2004-12-09 The Babraham Institute Identification and/or analysis of nucleic acids and/or proteins associated with a chromosome location
WO2006030126A2 (fr) * 2004-09-10 2006-03-23 Institut Necker Procédé pour l'accélération des mutations somatiques et son application en protéomique

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012063342; J Biol Chem Vol.279 No.50 Page.52353-52360 (2004.12.10) *
JPN6012063344; Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1975-80. *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020503040A (ja) * 2016-12-28 2020-01-30 トランジェーヌ、ソシエテ、アノニムTransgene S.A. 腫瘍溶解性ウイルスおよび治療用分子
JP7110203B2 (ja) 2016-12-28 2022-08-01 トランジェーヌ 腫瘍溶解性ウイルスおよび治療用分子
JP2021536229A (ja) * 2018-08-23 2021-12-27 サンガモ セラピューティクス, インコーポレイテッド 操作された標的特異的な塩基エディター
JP7541508B2 (ja) 2018-08-23 2024-08-28 サンガモ セラピューティクス, インコーポレイテッド 操作された標的特異的な塩基エディター
JP2020132584A (ja) * 2019-02-21 2020-08-31 株式会社豊田中央研究所 エピゲノム状態を制御する融合タンパク質及びその利用
JP7059965B2 (ja) 2019-02-21 2022-04-26 株式会社豊田中央研究所 エピゲノム状態を制御する融合タンパク質及びその利用
US11479780B2 (en) 2019-02-21 2022-10-25 Kabushiki Kaisha Toyota Chuo Kenkyusho Fusion protein for controlling epigenomic state, and use thereof
JPWO2022244544A1 (enExample) * 2021-05-20 2022-11-24
WO2022244544A1 (ja) * 2021-05-20 2022-11-24 国立大学法人群馬大学 エピゲノムが改変された動植物の親系統の製造に用いるための組成物およびその用途

Also Published As

Publication number Publication date
EP2010660A2 (en) 2009-01-07
US20130034881A1 (en) 2013-02-07
WO2007128982A2 (en) 2007-11-15
US8658393B2 (en) 2014-02-25
US20110138491A1 (en) 2011-06-09
US8298529B2 (en) 2012-10-30
GB0607063D0 (en) 2006-05-17
EP2010660B1 (en) 2013-06-05
WO2007128982A3 (en) 2008-02-21
GB0623644D0 (en) 2007-01-03

Similar Documents

Publication Publication Date Title
EP2010660B1 (en) Compositions and methods for epigenetic modification of nucleic acid sequences in vivo
JP7731156B2 (ja) Dnaが編集された真核細胞を製造する方法、および当該方法に用いられるキット
JP7257062B2 (ja) ゲノム編集方法
JP6700306B2 (ja) 受精前の卵細胞、受精卵、及び標的遺伝子の改変方法
CN108291218B (zh) 核酸酶非依赖性靶向基因编辑平台及其用途
KR102531016B1 (ko) 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
JP6815986B2 (ja) 大型家畜の接合体における標的化ゲノム編集
JP7219972B2 (ja) Dna二本鎖切断に非依存的な標的化遺伝子編集プラットフォームおよびその用途
CN102625655B (zh) 使用锌指核酸酶在大鼠中进行基因组编辑
JP7063885B2 (ja) 標的にされた増大するdna脱メチル化
US20110023157A1 (en) Equine genome editing with zinc finger nucleases
US20150156996A1 (en) Livestock with genetically modified prolactin receptor
MX2014015204A (es) Metodos y composiciones para generar alelos con inactivacion condicional.
JPWO2008072540A1 (ja) Tol1因子のトランスポザーゼ及びそれを用いたDNA導入システム
CN108347908A (zh) 具有增加的热耐受性的经遗传修饰的动物
JP2018531003A6 (ja) 向上した耐暑性を有する遺伝子改変動物
US20040141994A1 (en) Viral recombinases, related articles, and methods of use thereof
JP2001523449A (ja) レスポンダー表現型に関わる核酸およびその適用
Jin et al. Haploid male germ cell‐and oocyte‐specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse
Uh Maintaining Proper Levels of DNA Methylation Marks Through the TET Family is Critical for Normal Embryo Development in Pigs
EA040859B1 (ru) Способ получения эукариотических клеток с отредактированной днк и набор, используемый в этом способе
HK40021189B (zh) Dna被编辑了的真核细胞的制造方法、和在该方法中使用的试剂盒
Yang Expression and methylation patterns of imprinted genes in deceased newborn clones and surviving adult clones in cattle
HK1258288B (en) Nuclease-independent targeted gene editing platform and uses thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100412

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121206

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130304

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130311

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130405

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130412

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130801