JP2009531367A5 - - Google Patents
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- Publication number
- JP2009531367A5 JP2009531367A5 JP2009501968A JP2009501968A JP2009531367A5 JP 2009531367 A5 JP2009531367 A5 JP 2009531367A5 JP 2009501968 A JP2009501968 A JP 2009501968A JP 2009501968 A JP2009501968 A JP 2009501968A JP 2009531367 A5 JP2009531367 A5 JP 2009531367A5
- Authority
- JP
- Japan
- Prior art keywords
- inosine
- adenosine
- ratio
- combination
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 80
- 229930010555 Inosine Natural products 0.000 claims 41
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 41
- 229960003786 inosine Drugs 0.000 claims 41
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 40
- 229960005305 adenosine Drugs 0.000 claims 40
- 238000001802 infusion Methods 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 230000001154 acute effect Effects 0.000 claims 5
- 230000009692 acute damage Effects 0.000 claims 4
- 238000001990 intravenous administration Methods 0.000 claims 4
- 230000000747 cardiac effect Effects 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims 2
- 230000002537 thrombolytic effect Effects 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035965 Postoperative Complications Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 238000007887 coronary angioplasty Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000037891 myocardial injury Diseases 0.000 claims 1
- 230000036593 pulmonary vascular resistance Effects 0.000 claims 1
- 230000001698 pyrogenic effect Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78777106P | 2006-03-31 | 2006-03-31 | |
| PCT/EP2007/002905 WO2007112986A1 (en) | 2006-03-31 | 2007-03-30 | Compositions, methods, and kits using adenosine and inosine in combination for diagnosis and treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531367A JP2009531367A (ja) | 2009-09-03 |
| JP2009531367A5 true JP2009531367A5 (https=) | 2010-05-27 |
Family
ID=38197939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009501968A Withdrawn JP2009531367A (ja) | 2006-03-31 | 2007-03-30 | 診断および治療のためのアデノシンおよびイノシンを組み合わせて使用する組成物、方法およびキット |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080056993A1 (https=) |
| EP (1) | EP2004139A1 (https=) |
| JP (1) | JP2009531367A (https=) |
| KR (1) | KR20090010176A (https=) |
| CN (1) | CN101453984A (https=) |
| AU (1) | AU2007234006A1 (https=) |
| CA (1) | CA2647770A1 (https=) |
| IL (1) | IL194423A0 (https=) |
| NO (1) | NO20084599L (https=) |
| RU (1) | RU2008143202A (https=) |
| WO (1) | WO2007112986A1 (https=) |
| ZA (1) | ZA200808368B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2497489A1 (en) * | 2011-03-09 | 2012-09-12 | CSL Behring GmbH | Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs |
| HU227743B1 (en) | 2011-07-22 | 2012-02-28 | Debreceni Egyetem | Eardrop composition and process for producing this |
| CN105188750A (zh) | 2013-03-08 | 2015-12-23 | 德国杰特贝林生物制品有限公司 | 治疗和预防远端缺血-再灌注损伤 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231086A (en) * | 1985-09-24 | 1993-07-27 | Item Development Aktiebolag | Continuous administration adenosine to increase myocardial blood flow |
| DE3701497A1 (de) * | 1987-01-20 | 1988-07-28 | Frankhof Wolfgang | Arzneimittel, enthaltend lokalanaesthetika und nukleoside sowie dessen verwendung zur behandlung von muskelverletzungen |
| US5070877A (en) * | 1988-08-11 | 1991-12-10 | Medco Research, Inc. | Novel method of myocardial imaging |
| US5187162A (en) * | 1989-09-15 | 1993-02-16 | Gensia Pharmaceuticals | Methods of treating neurodegenerative conditions |
| US6180616B1 (en) * | 1990-05-10 | 2001-01-30 | Atsuo F. Fukunaga | Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function |
| US6004945A (en) * | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
| US5677290A (en) * | 1990-05-10 | 1997-10-14 | Fukunaga; Atsuo F. | Therapeutic use of adenosine compounds as surgical anesthetics |
| US5236908A (en) * | 1991-06-07 | 1993-08-17 | Gensia Pharmaceuticals, Inc. | Methods of treating injury to the central nervous system |
| US5443836A (en) * | 1993-03-15 | 1995-08-22 | Gensia, Inc. | Methods for protecting tissues and organs from ischemic damage |
| WO1994023723A1 (en) * | 1993-04-15 | 1994-10-27 | New York University | Adenosine receptor agonists for the promotion of wound healing |
| SE9301324D0 (sv) * | 1993-04-21 | 1993-04-21 | Item Development Ab | New method of treatment |
| US6342484B1 (en) * | 1993-06-30 | 2002-01-29 | Board Of Regents, The University Of Texas Systems | Method and compositions for promotion of wound treatment |
| US5852000A (en) * | 1993-08-25 | 1998-12-22 | Otsuka Pharmaceutical Factory, Inc. | Cardiac rehabilitation agent |
| US5646156A (en) * | 1994-04-25 | 1997-07-08 | Merck & Co., Inc. | Inhibition of eosinophil activation through A3 adenosine receptor antagonism |
| SE9401499D0 (sv) * | 1994-05-02 | 1994-05-02 | Item Dev Ab | New method of treatment |
| US5629298A (en) * | 1995-03-13 | 1997-05-13 | University Of Massachusetts Medical Center | Adenosine as a positive inotrop in the compromised heart |
| US5733916A (en) * | 1995-03-24 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists |
| US5801159A (en) * | 1996-02-23 | 1998-09-01 | Galileo Laboratories, Inc. | Method and composition for inhibiting cellular irreversible changes due to stress |
| AU2603197A (en) * | 1996-04-10 | 1997-10-29 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Use of an a1 adenosine receptor agonist to treat cerebral ischaemia |
| US5873366A (en) * | 1996-11-07 | 1999-02-23 | Chim; Nicholas | Method for transmyocardial revascularization |
| US6211165B1 (en) * | 1997-05-09 | 2001-04-03 | The Trustees Of The University Of Pennsylvania | Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
| US6432986B2 (en) * | 1997-07-21 | 2002-08-13 | Bruce H. Levin | Compositions, kits, and methods for inhibiting cerebral neurovascular disorders and muscular headaches |
| US6440455B1 (en) * | 1997-09-02 | 2002-08-27 | Children's Medical Center Corporation | Methods for modulating the axonal outgrowth of central nervous system neurons |
| US5998386A (en) * | 1997-09-19 | 1999-12-07 | Feldman; Arthur M. | Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue |
| AU1363699A (en) * | 1997-10-23 | 1999-05-10 | National Institute Of Health | Methods for reducing ischemic injury of the heart via the sequential administ ration of monophosphoryl lipid a and adenosine receptor agents |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| EP1168912B1 (en) * | 1999-03-23 | 2007-05-09 | Hibernation Therapeutics Limited | Organ arrest, protection and preservation |
| US6103702A (en) * | 1999-05-24 | 2000-08-15 | Board Of Trustees Of The University Of Illinois | Use of adenosine deaminase inhibitors to treat systemic inflammatory response syndrome |
| US6586413B2 (en) * | 1999-11-05 | 2003-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
| US6492103B1 (en) * | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
| US6566371B2 (en) * | 2000-04-28 | 2003-05-20 | University Of Pittsburgh | Intraperitoneal administration of adenosine for the treatment of prevention of gastrointestinal of systemic diseases |
| US6599283B1 (en) * | 2001-05-04 | 2003-07-29 | Cv Therapeutics, Inc. | Method of preventing reperfusion injury |
| EP1575562B1 (en) * | 2002-11-26 | 2016-10-05 | Seacoast Neurosciene, Inc. | Buoyant polymer particles delivering therapeutic agents |
-
2007
- 2007-03-30 WO PCT/EP2007/002905 patent/WO2007112986A1/en not_active Ceased
- 2007-03-30 CN CNA2007800200114A patent/CN101453984A/zh active Pending
- 2007-03-30 AU AU2007234006A patent/AU2007234006A1/en not_active Abandoned
- 2007-03-30 ZA ZA200808368A patent/ZA200808368B/xx unknown
- 2007-03-30 EP EP07723846A patent/EP2004139A1/en not_active Withdrawn
- 2007-03-30 JP JP2009501968A patent/JP2009531367A/ja not_active Withdrawn
- 2007-03-30 US US11/693,967 patent/US20080056993A1/en not_active Abandoned
- 2007-03-30 KR KR1020087026487A patent/KR20090010176A/ko not_active Withdrawn
- 2007-03-30 CA CA002647770A patent/CA2647770A1/en not_active Abandoned
- 2007-03-30 RU RU2008143202/15A patent/RU2008143202A/ru not_active Application Discontinuation
-
2008
- 2008-09-28 IL IL194423A patent/IL194423A0/en unknown
- 2008-10-30 NO NO20084599A patent/NO20084599L/no not_active Application Discontinuation
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