JP2009530399A5 - - Google Patents

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Publication number
JP2009530399A5
JP2009530399A5 JP2009501576A JP2009501576A JP2009530399A5 JP 2009530399 A5 JP2009530399 A5 JP 2009530399A5 JP 2009501576 A JP2009501576 A JP 2009501576A JP 2009501576 A JP2009501576 A JP 2009501576A JP 2009530399 A5 JP2009530399 A5 JP 2009530399A5
Authority
JP
Japan
Prior art keywords
lower alkyl
substituted
compound
pharmaceutically acceptable
occurrence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009501576A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009530399A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/007228 external-priority patent/WO2007111994A2/en
Publication of JP2009530399A publication Critical patent/JP2009530399A/ja
Publication of JP2009530399A5 publication Critical patent/JP2009530399A5/ja
Pending legal-status Critical Current

Links

JP2009501576A 2006-03-22 2007-03-22 Erストレスに関連する疾病の治療のための化合物及び方法 Pending JP2009530399A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US78533506P 2006-03-22 2006-03-22
US78503406P 2006-03-22 2006-03-22
US78515406P 2006-03-22 2006-03-22
US78500706P 2006-03-22 2006-03-22
US78532806P 2006-03-22 2006-03-22
US78518206P 2006-03-22 2006-03-22
US78523506P 2006-03-22 2006-03-22
US78518506P 2006-03-22 2006-03-22
US78503506P 2006-03-22 2006-03-22
US78533806P 2006-03-22 2006-03-22
PCT/US2007/007228 WO2007111994A2 (en) 2006-03-22 2007-03-22 Compounds and methods for treatment of disorders associated with er stress

Publications (2)

Publication Number Publication Date
JP2009530399A JP2009530399A (ja) 2009-08-27
JP2009530399A5 true JP2009530399A5 (OSRAM) 2010-05-13

Family

ID=38541676

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009501576A Pending JP2009530399A (ja) 2006-03-22 2007-03-22 Erストレスに関連する疾病の治療のための化合物及び方法

Country Status (6)

Country Link
US (1) US20090131384A1 (OSRAM)
EP (1) EP2001897A2 (OSRAM)
JP (1) JP2009530399A (OSRAM)
AU (1) AU2007230991A1 (OSRAM)
CA (1) CA2681639A1 (OSRAM)
WO (1) WO2007111994A2 (OSRAM)

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EA201270666A1 (ru) 2007-11-27 2012-12-28 Ардеа Биосайнсиз Инк. Соединения и фармацевтические композиции для снижения уровня мочевой кислоты
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
US8242154B2 (en) 2008-09-04 2012-08-14 Ardea Biosciences, Inc. Compounds, compositions and methods of using same for modulating uric acid levels
EP2367839A4 (en) * 2008-11-03 2012-07-04 Univ Tufts METHOD AND COMPOSITIONS FOR INHIBITING CLOSTRIDIUM DIFFICILE SPORTS NUTRITION AND GROWTH
EP2255813A1 (en) * 2009-05-29 2010-12-01 The Royal College of Surgeons in Ireland Derivatives of ursodeoxycholic acid for the treatment of diarrhoea
EP2519100B1 (en) 2009-12-29 2017-03-15 Mapi Pharma Limited Intermediate compounds and processes for the preparation of tapentadol and related compounds
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CA2797118C (en) 2010-04-22 2021-03-30 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
AR081930A1 (es) 2010-06-16 2012-10-31 Ardea Biosciences Inc Compuestos de tioacetato
EP2582664A4 (en) 2010-06-16 2014-07-09 Ardea Biosciences Inc PHENYL THIOACETATE COMPOUNDS AND COMPOSITIONS AND METHOD FOR THEIR USE
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
UA114304C2 (uk) 2011-11-03 2017-05-25 Ардеа Біосайєнсіс, Інк. Спосіб зниження сироваткових рівнів сечової кислоти у людини
US9084826B2 (en) 2012-05-01 2015-07-21 Catabasis Pharmaceuticals, Inc. Fatty acid conjugates of statin and FXR agonists; compositions and method of uses
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN111529534A (zh) 2012-09-27 2020-08-14 儿童医学中心公司 用于治疗肥胖症的化合物和其使用方法
JP6422452B2 (ja) * 2013-03-14 2018-11-14 ユニバーシティ オブ マカオUniversity Of Macau ヤクチ(益智(alpiniaeoxyphyllaefructus))およびその全合成から単離される新規な抗神経変性天然化合物
CA2944140C (en) 2014-04-15 2022-10-04 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
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KR20170099909A (ko) 2014-11-26 2017-09-01 이난타 파마슈티칼스, 인코포레이티드 Fxr/tgr5 작용제로서의 담즙산 유사체 및 이의 이용 방법
US11578097B2 (en) 2014-11-26 2023-02-14 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
CN107249594A (zh) 2015-02-11 2017-10-13 英安塔制药有限公司 作为fxr/tgr5激动剂的胆汁酸类似物及其使用方法
SG10201910670RA (en) 2015-03-31 2020-01-30 Enanta Pharm Inc Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
WO2017147137A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
US10364267B2 (en) 2016-02-23 2019-07-30 Enanta Pharmaceuticals, Inc. Deuterated bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2017147174A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof
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JP7057783B2 (ja) 2016-11-29 2022-04-20 エナンタ ファーマシューティカルズ インコーポレイテッド スルホニル尿素胆汁酸誘導体の調製方法
US10472386B2 (en) 2017-02-14 2019-11-12 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR agonists and methods of use thereof
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CN117751130A (zh) * 2021-07-26 2024-03-22 沙裴隆有限公司 一种抑制TNF-α生成和炎症小体活性的新型化合物及其制备方法

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AU5322601A (en) * 2000-04-07 2001-10-23 Univ Maryland Bile acid containing prodrugs with enhanced bioavailability
WO2002032376A2 (en) * 2000-10-06 2002-04-25 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs

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