JP2009528544A5 - - Google Patents
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- JP2009528544A5 JP2009528544A5 JP2008557381A JP2008557381A JP2009528544A5 JP 2009528544 A5 JP2009528544 A5 JP 2009528544A5 JP 2008557381 A JP2008557381 A JP 2008557381A JP 2008557381 A JP2008557381 A JP 2008557381A JP 2009528544 A5 JP2009528544 A5 JP 2009528544A5
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- JP
- Japan
- Prior art keywords
- adma
- sdma
- ions
- sample
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 117
- 150000002500 ions Chemical class 0.000 claims 80
- HVPFXCBJHIIJGS-LURJTMIESA-N N(omega),N'(omega)-dimethyl-L-arginine Chemical compound CN\C(=N/C)NCCC[C@H](N)C(O)=O HVPFXCBJHIIJGS-LURJTMIESA-N 0.000 claims 58
- YDGMGEXADBMOMJ-LURJTMIESA-N N(g)-dimethylarginine Chemical compound CN(C)C(\N)=N\CCC[C@H](N)C(O)=O YDGMGEXADBMOMJ-LURJTMIESA-N 0.000 claims 51
- YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 claims 40
- 239000000523 sample Substances 0.000 claims 33
- 206010059245 Angiopathy Diseases 0.000 claims 16
- 239000012472 biological sample Substances 0.000 claims 16
- 208000019553 vascular disease Diseases 0.000 claims 16
- NWGZOALPWZDXNG-LURJTMIESA-N (2s)-5-(diaminomethylideneamino)-2-(dimethylamino)pentanoic acid Chemical class CN(C)[C@H](C(O)=O)CCCNC(N)=N NWGZOALPWZDXNG-LURJTMIESA-N 0.000 claims 14
- 230000002503 metabolic effect Effects 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 10
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims 10
- 206010020772 Hypertension Diseases 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 8
- 208000024172 Cardiovascular disease Diseases 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 201000011461 pre-eclampsia Diseases 0.000 claims 7
- 239000004475 Arginine Substances 0.000 claims 5
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 5
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 5
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 5
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 5
- 229960002173 citrulline Drugs 0.000 claims 5
- 235000013477 citrulline Nutrition 0.000 claims 5
- 229960003624 creatine Drugs 0.000 claims 5
- 239000006046 creatine Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 238000003745 diagnosis Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000013074 reference sample Substances 0.000 claims 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- 238000004949 mass spectrometry Methods 0.000 claims 3
- 150000007524 organic acids Chemical class 0.000 claims 3
- 230000008085 renal dysfunction Effects 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 206010036790 Productive cough Diseases 0.000 claims 2
- 210000004381 amniotic fluid Anatomy 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 210000002751 lymph Anatomy 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 210000003097 mucus Anatomy 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000004243 sweat Anatomy 0.000 claims 2
- 210000001138 tear Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 238000004885 tandem mass spectrometry Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77848306P | 2006-03-02 | 2006-03-02 | |
| PCT/US2007/005279 WO2007103124A2 (en) | 2006-03-02 | 2007-03-02 | Methods for distinguishing isomers using mass spectrometry |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009528544A JP2009528544A (ja) | 2009-08-06 |
| JP2009528544A5 true JP2009528544A5 (https=) | 2010-04-15 |
Family
ID=38475391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557381A Pending JP2009528544A (ja) | 2006-03-02 | 2007-03-02 | 質量分析法を用いて異性体を識別するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080073500A1 (https=) |
| EP (1) | EP1996923B1 (https=) |
| JP (1) | JP2009528544A (https=) |
| CN (1) | CN101438148B (https=) |
| AU (1) | AU2007224240B2 (https=) |
| BR (1) | BRPI0708485A2 (https=) |
| CA (1) | CA2644499A1 (https=) |
| DK (1) | DK1996923T3 (https=) |
| ES (1) | ES2392629T3 (https=) |
| WO (1) | WO2007103124A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005056408B4 (de) * | 2005-05-28 | 2007-05-31 | Esa Patentverwertungsagentur Sachsen-Anhalt Gmbh | Verfahren zur Bestimmung der Konzentration von asymmetrischem Dimethylarginin (ADMA) |
| JP2010540911A (ja) * | 2007-10-01 | 2010-12-24 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | アルコール消費の複合化した代謝産物の分析 |
| CN102421358A (zh) | 2009-03-10 | 2012-04-18 | 杜克大学 | 对冠心病和心血管事件风险的预测 |
| AU2015258285B2 (en) * | 2009-03-10 | 2017-09-07 | Duke University | Predicting coronary artery disease and risk of cardiovascular events |
| WO2010108180A2 (en) * | 2009-03-20 | 2010-09-23 | The Cleveland Clinic Foundation | Citrulline, a risk indicator for cardiovascular disease |
| EP2436025A1 (en) * | 2009-05-27 | 2012-04-04 | DH Technologies Development Pte. Ltd. | Linear ion trap for msms |
| JP5746154B2 (ja) * | 2009-05-28 | 2015-07-08 | ザ クリーブランド クリニック ファウンデーションＴｈｅ Ｃｌｅｖｅｌａｎｄ ＣｌｉｎｉｃＦｏｕｎｄａｔｉｏｎ | 疾患の診断および予測のためのトリメチルアミン含有化合物 |
| EP2438441B1 (en) * | 2009-06-02 | 2014-05-21 | BIOCRATES Life Sciences AG | New biomarkers for assessing kidney diseases |
| EP2443456A4 (en) * | 2009-06-15 | 2013-02-20 | Cleveland Clinic Foundation | METABOLITES OF ARGININE METHYLATES AS PREDICTORS OF CARDIOVASCULAR DISEASE RISK |
| CN102893156A (zh) * | 2009-12-21 | 2013-01-23 | 爱尔兰国立科克大学 | 子痫前期风险的检测 |
| US8703424B2 (en) * | 2010-03-22 | 2014-04-22 | Stemina Biomarker Discovery, Inc. | Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics |
| CN107064330B (zh) * | 2010-12-28 | 2022-02-25 | 探索诊断投资公司 | 通过质谱法定量胰岛素 |
| CN102154444B (zh) * | 2010-12-30 | 2013-09-25 | 北京九强生物技术股份有限公司 | 测定不对称二甲基精氨酸浓度的方法及诊断试剂盒 |
| AU2012271718A1 (en) * | 2011-06-16 | 2014-01-09 | Baylor Research Institute | Analysis of total homocysteine and methylmalonic acid in plasma by LC-MS/MS from a plasma separator device (PSD) |
| WO2013140785A1 (ja) * | 2012-03-18 | 2013-09-26 | 国立大学法人九州大学 | 疾患サンプル分析装置、分析システム及び分析方法 |
| CN103207173B (zh) * | 2013-03-13 | 2015-06-17 | 北大工学院绍兴技术研究院 | 一种酶学检测方法 |
| WO2015044958A1 (en) | 2013-09-25 | 2015-04-02 | Council Of Scientific & Industrial Research | Quantitation of structural isomers using maldi ms/ms |
| JP6647224B2 (ja) | 2014-06-13 | 2020-02-14 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 質量分析を用いる脂質の分析のための方法 |
| EP3259593B1 (en) * | 2015-02-20 | 2022-10-05 | IDEXX Laboratories, Inc. | Homogenous immunoassay with compensation for background signal |
| WO2016149220A1 (en) | 2015-03-13 | 2016-09-22 | Duke University | Compositions and methods for metabolic profiling in subjects with heart failure with preserved ejection fraction |
| CN104849298B (zh) * | 2015-05-26 | 2017-10-31 | 衢州普林千叶电子科技有限公司 | 一种用于核磁分析的样品检测分析仪和方法 |
| CN105628623B (zh) * | 2015-12-25 | 2018-08-24 | 北京市农林科学院 | 一种鉴别光学异构化合物旋光性的方法 |
| CN107764891B (zh) * | 2017-10-16 | 2020-03-13 | 杭州先导医药科技有限责任公司 | 一种恩替卡韦手性异构体的区分测定方法 |
| US10854438B2 (en) * | 2018-03-19 | 2020-12-01 | Agilent Technologies, Inc. | Inductively coupled plasma mass spectrometry (ICP-MS) with improved signal-to-noise and signal-to-background ratios |
| US11694886B2 (en) * | 2018-11-02 | 2023-07-04 | National University Corporation Kobe University | Analysis method, adsorption prevention agent, and analysis kit |
| US20220276263A1 (en) * | 2021-02-19 | 2022-09-01 | Idexx Laboratories, Inc. | Mass spectrometric analysis of biomarkers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3055142B2 (ja) * | 1989-11-24 | 2000-06-26 | 株式会社島津製作所 | 質量分析方法 |
| JP2000111526A (ja) * | 1998-09-30 | 2000-04-21 | Hitachi Ltd | 質量分析計 |
| US20040191819A1 (en) * | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corporation | Expression profiles for breast cancer and methods of use |
| GB0308967D0 (en) * | 2003-04-17 | 2003-05-28 | Univ London | Screen for pre-eclampsia |
| DE102005056408B4 (de) * | 2005-05-28 | 2007-05-31 | Esa Patentverwertungsagentur Sachsen-Anhalt Gmbh | Verfahren zur Bestimmung der Konzentration von asymmetrischem Dimethylarginin (ADMA) |
-
2007
- 2007-03-02 CA CA002644499A patent/CA2644499A1/en not_active Abandoned
- 2007-03-02 CN CN200780016028.2A patent/CN101438148B/zh active Active
- 2007-03-02 JP JP2008557381A patent/JP2009528544A/ja active Pending
- 2007-03-02 AU AU2007224240A patent/AU2007224240B2/en active Active
- 2007-03-02 EP EP07752007A patent/EP1996923B1/en active Active
- 2007-03-02 BR BRPI0708485-4A patent/BRPI0708485A2/pt not_active IP Right Cessation
- 2007-03-02 US US11/681,744 patent/US20080073500A1/en not_active Abandoned
- 2007-03-02 DK DK07752007.0T patent/DK1996923T3/da active
- 2007-03-02 ES ES07752007T patent/ES2392629T3/es active Active
- 2007-03-02 WO PCT/US2007/005279 patent/WO2007103124A2/en not_active Ceased
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