JP2009528131A5 - - Google Patents

Info

Publication number

JP2009528131A5

JP2009528131A5 JP2008557341A JP2008557341A JP2009528131A5 JP 2009528131 A5 JP2009528131 A5 JP 2009528131A5 JP 2008557341 A JP2008557341 A JP 2008557341A JP 2008557341 A JP2008557341 A JP 2008557341A JP 2009528131 A5 JP2009528131 A5 JP 2009528131A5

Authority

JP

Japan

Prior art keywords

tissue

tumor

agent

applying

administered

Prior art date

2007-03-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
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• 239000003795 chemical substances by application Substances 0.000 claims 14
• 206010028980 Neoplasm Diseases 0.000 claims 13
• 238000004520 electroporation Methods 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 8
• 108091030071 RNAI Proteins 0.000 claims 6
• 230000000692 anti-sense effect Effects 0.000 claims 6
• 210000004027 cell Anatomy 0.000 claims 6
• 230000009368 gene silencing by RNA Effects 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 6
• 102000039446 nucleic acids Human genes 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 108010006654 Bleomycin Proteins 0.000 claims 3
• 102000019034 Chemokines Human genes 0.000 claims 3
• 108010012236 Chemokines Proteins 0.000 claims 3
• 102000004127 Cytokines Human genes 0.000 claims 3
• 108090000695 Cytokines Proteins 0.000 claims 3
• 241000124008 Mammalia Species 0.000 claims 3
• -1 antibody Proteins 0.000 claims 3
• 229960001561 bleomycin Drugs 0.000 claims 3
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 3
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 3
• 229960004316 cisplatin Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 239000007788 liquid Substances 0.000 claims 3
• 229920002643 polyglutamic acid Polymers 0.000 claims 3
• 239000000243 solution Substances 0.000 claims 3
• 230000004565 tumor cell growth Effects 0.000 claims 3
• 230000004614 tumor growth Effects 0.000 claims 3
• 208000007660 Residual Neoplasm Diseases 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 208000000453 Skin Neoplasms Diseases 0.000 claims 1
• 230000005540 biological transmission Effects 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 238000002271 resection Methods 0.000 claims 1
• 201000000849 skin cancer Diseases 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1