CN101426550B - 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的方法和装置 - Google Patents

用于治疗在外科切除术后残留在组织中的微小残余肿瘤的方法和装置 Download PDF

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Publication number
CN101426550B
CN101426550B CN2007800143130A CN200780014313A CN101426550B CN 101426550 B CN101426550 B CN 101426550B CN 2007800143130 A CN2007800143130 A CN 2007800143130A CN 200780014313 A CN200780014313 A CN 200780014313A CN 101426550 B CN101426550 B CN 101426550B
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CN
China
Prior art keywords
tissue
tumor
electroporation
electrodes
array
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Expired - Fee Related
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CN2007800143130A
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English (en)
Chinese (zh)
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CN101426550A (zh
Inventor
保罗·戈德法布
戴尔特墨·拉布塞
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Hongnian Development Co ltd
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Genetronics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN2007800143130A 2006-03-03 2007-03-02 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的方法和装置 Expired - Fee Related CN101426550B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77874006P 2006-03-03 2006-03-03
US60/778,740 2006-03-03
PCT/US2007/005133 WO2007103070A2 (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210397694.8A Division CN102921102B (zh) 2006-03-03 2007-03-02 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的装置

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Publication Number Publication Date
CN101426550A CN101426550A (zh) 2009-05-06
CN101426550B true CN101426550B (zh) 2012-10-31

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CN2007800143130A Expired - Fee Related CN101426550B (zh) 2006-03-03 2007-03-02 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的方法和装置
CN201210397694.8A Expired - Fee Related CN102921102B (zh) 2006-03-03 2007-03-02 用于治疗在外科切除术后残留在组织中的微小残余肿瘤的装置

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US (4) US9037230B2 (enExample)
EP (2) EP3845269A1 (enExample)
JP (3) JP2009528131A (enExample)
KR (2) KR101529448B1 (enExample)
CN (2) CN101426550B (enExample)
AU (1) AU2007224275B2 (enExample)
CA (1) CA2644163C (enExample)
DK (1) DK1991303T3 (enExample)
ES (1) ES2874482T3 (enExample)
NO (2) NO344476B1 (enExample)
PL (1) PL1991303T3 (enExample)
WO (1) WO2007103070A2 (enExample)

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US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
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JP2009528131A (ja) 2009-08-06
US20120143120A1 (en) 2012-06-07
KR20090004890A (ko) 2009-01-12
NO344476B1 (no) 2020-01-13
CN101426550A (zh) 2009-05-06
JP2015213778A (ja) 2015-12-03
US20170216585A1 (en) 2017-08-03
US11007365B2 (en) 2021-05-18
EP3845269A1 (en) 2021-07-07
US20070239099A1 (en) 2007-10-11
US20210308451A1 (en) 2021-10-07
NO20084148L (no) 2008-11-13
CA2644163C (en) 2020-05-05
ES2874482T3 (es) 2021-11-05
WO2007103070A2 (en) 2007-09-13
NO20191102A1 (no) 2008-11-13
EP1991303A4 (en) 2012-01-18
PL1991303T3 (pl) 2021-10-11
WO2007103070A3 (en) 2008-08-28
AU2007224275B2 (en) 2012-04-12
CA2644163A1 (en) 2007-09-13
KR101444471B1 (ko) 2014-09-24
CN102921102B (zh) 2015-06-10
CN102921102A (zh) 2013-02-13
KR101529448B1 (ko) 2015-06-18
KR20140081894A (ko) 2014-07-01
AU2007224275A1 (en) 2007-09-13
EP1991303A2 (en) 2008-11-19
US9037230B2 (en) 2015-05-19
JP2013127000A (ja) 2013-06-27
JP6174632B2 (ja) 2017-08-02
DK1991303T3 (da) 2021-06-07
US12324913B2 (en) 2025-06-10
EP1991303B1 (en) 2021-05-05

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CF01 Termination of patent right due to non-payment of annual fee