CA2644163C - Method and device for treating microscopic residual tumors remaining in tissues following surgical resection - Google Patents

Method and device for treating microscopic residual tumors remaining in tissues following surgical resection Download PDF

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Publication number
CA2644163C
CA2644163C CA2644163A CA2644163A CA2644163C CA 2644163 C CA2644163 C CA 2644163C CA 2644163 A CA2644163 A CA 2644163A CA 2644163 A CA2644163 A CA 2644163A CA 2644163 C CA2644163 C CA 2644163C
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CA
Canada
Prior art keywords
tumor
tissue
margin
expressible gene
bleomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2644163A
Other languages
English (en)
French (fr)
Other versions
CA2644163A1 (en
Inventor
Paul Goldfarb
Dietmar Rabussay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grand Decade Developments Ltd
Original Assignee
OncoSec Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OncoSec Medical Inc filed Critical OncoSec Medical Inc
Publication of CA2644163A1 publication Critical patent/CA2644163A1/en
Application granted granted Critical
Publication of CA2644163C publication Critical patent/CA2644163C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CA2644163A 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection Active CA2644163C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77874006P 2006-03-03 2006-03-03
US60/778,740 2006-03-03
PCT/US2007/005133 WO2007103070A2 (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Publications (2)

Publication Number Publication Date
CA2644163A1 CA2644163A1 (en) 2007-09-13
CA2644163C true CA2644163C (en) 2020-05-05

Family

ID=38475369

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2644163A Active CA2644163C (en) 2006-03-03 2007-03-02 Method and device for treating microscopic residual tumors remaining in tissues following surgical resection

Country Status (12)

Country Link
US (4) US9037230B2 (enExample)
EP (2) EP3845269A1 (enExample)
JP (3) JP2009528131A (enExample)
KR (2) KR101444471B1 (enExample)
CN (2) CN101426550B (enExample)
AU (1) AU2007224275B2 (enExample)
CA (1) CA2644163C (enExample)
DK (1) DK1991303T3 (enExample)
ES (1) ES2874482T3 (enExample)
NO (2) NO344476B1 (enExample)
PL (1) PL1991303T3 (enExample)
WO (1) WO2007103070A2 (enExample)

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Also Published As

Publication number Publication date
CN101426550B (zh) 2012-10-31
DK1991303T3 (da) 2021-06-07
KR20090004890A (ko) 2009-01-12
ES2874482T3 (es) 2021-11-05
US9037230B2 (en) 2015-05-19
NO344476B1 (no) 2020-01-13
EP1991303A2 (en) 2008-11-19
KR101529448B1 (ko) 2015-06-18
NO20191102A1 (no) 2008-11-13
CN102921102A (zh) 2013-02-13
US12324913B2 (en) 2025-06-10
US20120143120A1 (en) 2012-06-07
JP6174632B2 (ja) 2017-08-02
AU2007224275A1 (en) 2007-09-13
US20210308451A1 (en) 2021-10-07
US20070239099A1 (en) 2007-10-11
KR101444471B1 (ko) 2014-09-24
CN102921102B (zh) 2015-06-10
US20170216585A1 (en) 2017-08-03
WO2007103070A2 (en) 2007-09-13
WO2007103070A3 (en) 2008-08-28
CN101426550A (zh) 2009-05-06
AU2007224275B2 (en) 2012-04-12
CA2644163A1 (en) 2007-09-13
EP1991303A4 (en) 2012-01-18
NO20084148L (no) 2008-11-13
KR20140081894A (ko) 2014-07-01
US11007365B2 (en) 2021-05-18
EP3845269A1 (en) 2021-07-07
PL1991303T3 (pl) 2021-10-11
JP2009528131A (ja) 2009-08-06
EP1991303B1 (en) 2021-05-05
JP2015213778A (ja) 2015-12-03
JP2013127000A (ja) 2013-06-27

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