JP2009527343A5 - - Google Patents

Info

Publication number

JP2009527343A5

JP2009527343A5 JP2008556544A JP2008556544A JP2009527343A5 JP 2009527343 A5 JP2009527343 A5 JP 2009527343A5 JP 2008556544 A JP2008556544 A JP 2008556544A JP 2008556544 A JP2008556544 A JP 2008556544A JP 2009527343 A5 JP2009527343 A5 JP 2009527343A5

Authority

JP

Japan

Prior art keywords

blood

filter

mmol

line

infusion

Prior art date

2007-02-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008280 blood Substances 0.000 claims 68
• 210000004369 blood Anatomy 0.000 claims 68
• 238000001802 infusion Methods 0.000 claims 56
• 238000011045 prefiltration Methods 0.000 claims 26
• 239000000243 solution Substances 0.000 claims 23
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 18
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 18
• BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 15
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 14
• 239000011575 calcium Substances 0.000 claims 14
• 229910052791 calcium Inorganic materials 0.000 claims 14
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 12
• 238000005534 hematocrit Methods 0.000 claims 12
• 239000002699 waste material Substances 0.000 claims 12
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 9
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 9
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 9
• 239000011777 magnesium Substances 0.000 claims 9
• 229910052749 magnesium Inorganic materials 0.000 claims 9
• 239000011734 sodium Substances 0.000 claims 9
• 229910052708 sodium Inorganic materials 0.000 claims 9
• 238000011144 upstream manufacturing Methods 0.000 claims 7
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
• 229910000147 aluminium phosphate Inorganic materials 0.000 claims 6
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 5
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 5
• 239000003146 anticoagulant agent Substances 0.000 claims 5
• 229940127219 anticoagulant drug Drugs 0.000 claims 5
• 238000010790 dilution Methods 0.000 claims 5
• 239000012895 dilution Substances 0.000 claims 5
• 239000012530 fluid Substances 0.000 claims 5
• 239000011591 potassium Substances 0.000 claims 5
• 229910052700 potassium Inorganic materials 0.000 claims 5
• 230000017531 blood circulation Effects 0.000 claims 4
• 239000008103 glucose Substances 0.000 claims 4
• 230000002792 vascular Effects 0.000 claims 4
• 229910019142 PO4 Inorganic materials 0.000 claims 3
• 239000012141 concentrate Substances 0.000 claims 3
• 238000001914 filtration Methods 0.000 claims 3
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 3
• 239000010452 phosphate Substances 0.000 claims 3
• 239000011780 sodium chloride Substances 0.000 claims 3
• 230000009885 systemic effect Effects 0.000 claims 3
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
• 239000002253 acid Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 239000008174 sterile solution Substances 0.000 claims 2
• 230000001954 sterilising effect Effects 0.000 claims 2
• 238000004659 sterilization and disinfection Methods 0.000 claims 2
• 102000009027 Albumins Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 229920001202 Inulin Polymers 0.000 claims 1
• HSMNQINEKMPTIC-UHFFFAOYSA-N N-(4-aminobenzoyl)glycine Chemical compound NC1=CC=C(C(=O)NCC(O)=O)C=C1 HSMNQINEKMPTIC-UHFFFAOYSA-N 0.000 claims 1
• 230000002378 acidificating effect Effects 0.000 claims 1
• 210000001367 artery Anatomy 0.000 claims 1
• 238000004891 communication Methods 0.000 claims 1
• 239000008121 dextrose Substances 0.000 claims 1
• 238000000502 dialysis Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
• 229910000397 disodium phosphate Inorganic materials 0.000 claims 1
• 235000019800 disodium phosphate Nutrition 0.000 claims 1
• 230000009977 dual effect Effects 0.000 claims 1
• 238000001631 haemodialysis Methods 0.000 claims 1
• 230000000322 hemodialysis Effects 0.000 claims 1
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 1
• 229940029339 inulin Drugs 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 229910052751 metal Inorganic materials 0.000 claims 1
• 239000002184 metal Substances 0.000 claims 1
• 150000002739 metals Chemical class 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 235000019799 monosodium phosphate Nutrition 0.000 claims 1
• 238000012545 processing Methods 0.000 claims 1
• AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
• 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
• 229910021654 trace metal Inorganic materials 0.000 claims 1
• 238000012546 transfer Methods 0.000 claims 1