CA2643140C - System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits - Google Patents

System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits Download PDF

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Publication number
CA2643140C
CA2643140C CA2643140A CA2643140A CA2643140C CA 2643140 C CA2643140 C CA 2643140C CA 2643140 A CA2643140 A CA 2643140A CA 2643140 A CA2643140 A CA 2643140A CA 2643140 C CA2643140 C CA 2643140C
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CA
Canada
Prior art keywords
blood
citrate
fluid
filter
line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2643140A
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English (en)
French (fr)
Other versions
CA2643140A1 (en
Inventor
Balazs Szamosfalvi
Stanley Frinak
Jerry Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henry Ford Health System
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Henry Ford Health System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henry Ford Health System filed Critical Henry Ford Health System
Priority to CA2863264A priority Critical patent/CA2863264C/en
Publication of CA2643140A1 publication Critical patent/CA2643140A1/en
Application granted granted Critical
Publication of CA2643140C publication Critical patent/CA2643140C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3431—Substitution fluid path upstream of the filter
    • A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3441—Substitution rate control as a function of the ultrafiltration rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3458—Substitution fluids having electrolytes not present in the dialysate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3626—Gas bubble detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
    • A61M1/3656—Monitoring patency or flow at connection sites; Detecting disconnections
    • A61M1/3658—Indicating the amount of purified blood recirculating in the fistula or shunt
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A61M1/3675—Deactivation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/32—Controlling or regulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0028—Special media to be introduced, removed or treated fluid entering a filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7563—General characteristics of the apparatus with filters with means preventing clogging of filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/207—Blood composition characteristics hematocrit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/12—Addition of chemical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/24—Quality control
    • B01D2311/243—Electrical conductivity control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/24—Quality control
    • B01D2311/246—Concentration control

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
CA2643140A 2006-02-22 2007-02-22 System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits Expired - Fee Related CA2643140C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2863264A CA2863264C (en) 2006-02-22 2007-02-22 System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US77572906P 2006-02-22 2006-02-22
US77572806P 2006-02-22 2006-02-22
US60/775,728 2006-02-22
US60/775,729 2006-02-22
US79088206P 2006-04-11 2006-04-11
US79105506P 2006-04-11 2006-04-11
US60/791,055 2006-04-11
US60/790,882 2006-04-11
US84564606P 2006-09-19 2006-09-19
US60/845,646 2006-09-19
PCT/US2007/062589 WO2007101064A2 (en) 2006-02-22 2007-02-22 System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2863264A Division CA2863264C (en) 2006-02-22 2007-02-22 System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits

Publications (2)

Publication Number Publication Date
CA2643140A1 CA2643140A1 (en) 2007-09-07
CA2643140C true CA2643140C (en) 2014-12-09

Family

ID=38459734

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2643140A Expired - Fee Related CA2643140C (en) 2006-02-22 2007-02-22 System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits

Country Status (5)

Country Link
US (4) US8211048B2 (enExample)
EP (1) EP1998826B1 (enExample)
JP (1) JP5254043B2 (enExample)
CA (1) CA2643140C (enExample)
WO (1) WO2007101064A2 (enExample)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544179B2 (en) 2002-04-11 2009-06-09 Deka Products Limited Partnership System and method for delivering a target volume of fluid
AU2006325531B2 (en) 2005-12-13 2012-04-19 Exthera Medical Corporation Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood
US8133194B2 (en) * 2006-02-22 2012-03-13 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US10463774B2 (en) 2007-02-27 2019-11-05 Deka Products Limited Partnership Control systems and methods for blood or fluid handling medical devices
US9517295B2 (en) 2007-02-27 2016-12-13 Deka Products Limited Partnership Blood treatment systems and methods
US8888470B2 (en) 2007-02-27 2014-11-18 Deka Products Limited Partnership Pumping cassette
KR102160985B1 (ko) 2007-02-27 2020-09-29 데카 프로덕츠 리미티드 파트너쉽 혈액투석 시스템
US8562834B2 (en) 2007-02-27 2013-10-22 Deka Products Limited Partnership Modular assembly for a portable hemodialysis system
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
US9028691B2 (en) 2007-02-27 2015-05-12 Deka Products Limited Partnership Blood circuit assembly for a hemodialysis system
US8042563B2 (en) 2007-02-27 2011-10-25 Deka Products Limited Partnership Cassette system integrated apparatus
WO2008155683A1 (en) 2007-06-18 2008-12-24 Firmenich Sa Malodor counteracting compositions and method for their use
AT505690B1 (de) * 2007-08-31 2012-09-15 Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems Verfahren zum erfassen der ionenkonzentration bei citrat-antikoagulierter extrakorporaler blutreinigung
DE102007056475A1 (de) * 2007-11-22 2009-06-04 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zum Bestimmen der Rezirkulation in einer Fistel oder der kardiopulmonalen Rezirkulation sowie Blutbehandlungsvorrichtung mit einer Vorrichtung zur Bestimmung der Fistelrezirkulation oder des kardiopulmonalen Rezirkulationsanteils
WO2010029401A2 (en) 2008-09-09 2010-03-18 Gambro Lundia Ab A procedure and a device for extracorporeal blood treatment using citrate anticoagulation
AU2010230239B2 (en) * 2009-03-31 2014-08-07 Gambro Lundia Ab A multipart fluid system and a system for regional citrate anticoagulation in an extracorporeal blood circuit
WO2010112223A1 (de) * 2009-03-31 2010-10-07 Fresenius Medical Care Deutschland Gmbh Vorrichtung und verfahren zur ermittlung und regelung der konzentration mindestens eines gelösten stoffes in einem fluidkreislauf
US8845571B2 (en) 2009-06-17 2014-09-30 Fresenius Medical Care Holdings, Inc. Methods of regional citrate anticoagulation dialysis
EP2449129B1 (en) * 2009-07-01 2014-04-16 Board Of Regents, The University Of Texas System Methods of determining the presence and/or concentration of an analyte in a sample
CA2782311C (en) 2009-12-01 2017-06-27 Robert S. Ward Method for removing cytokines from blood with surface immobilized polysaccharides
DE102009060668A1 (de) * 2009-12-28 2011-06-30 Fresenius Medical Care Deutschland GmbH, 61352 Vorrichtung und Verfahren zur Überwachung einer extrakorporalen Blutbehandlung
DE102010007464B4 (de) * 2010-02-10 2016-09-29 Fresenius Medical Care Deutschland Gmbh Medizinische Funktionseinrichtung, Behandlungsvorrichtung sowie Verfahren
DE102010007914A1 (de) 2010-02-12 2012-12-27 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zur Überwachung eines Gefäßzugangs für eine extrakorporale Blutbehandlung
JP5548001B2 (ja) * 2010-03-25 2014-07-16 日機装株式会社 血液浄化装置
EP2591385B1 (en) 2010-07-07 2017-10-11 DEKA Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
KR101466459B1 (ko) * 2010-07-14 2014-11-28 아사히 가세이 메디컬 가부시키가이샤 혈액 투석 장치
US9603989B2 (en) 2010-08-24 2017-03-28 Fenwal, Inc. Methods for anticoagulating blood
JP5750601B2 (ja) * 2010-08-31 2015-07-22 高野 晉 イオン化カルシウムの定量のための計算方法
PL2433662T3 (pl) * 2010-09-27 2014-10-31 Gambro Lundia Ab Urządzenie do pozaustrojowego oczyszczania krwi
DE102011010406A1 (de) * 2011-02-04 2012-08-09 Fresenius Medical Care Deutschland Gmbh Verfahren zum Steuern einer Blutbehandlungvorrichtung, Steuereinrichtung, Zugabeeinrichtung und Blutbehandlungsvorrichtung
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
WO2012135746A2 (en) * 2011-04-01 2012-10-04 Aethlon Medical, Inc. Methods and devices comprising extracorporeal blood flow
EP2696961B1 (en) 2011-04-13 2019-02-13 Fenwal, Inc. Systems for use and control of an automated separator with adsorption columns
US20140072288A1 (en) 2011-05-12 2014-03-13 Nxstage Medical, Inc. Fluid heating apparatuses, systems, and methods
US9999717B2 (en) 2011-05-24 2018-06-19 Deka Products Limited Partnership Systems and methods for detecting vascular access disconnection
US20120316498A1 (en) * 2011-06-09 2012-12-13 Frank Dos Santos Intravenous fluid monitoring device
DE102011078700A1 (de) * 2011-07-05 2013-01-10 Charité - Universitätsmedizin Berlin Dialyseverfahren zur Entfernung proteingebundener Toxine aus dem Blut von akut oder chronisch-niereninsuffizienten Patienten
CN103889481B (zh) * 2011-08-02 2016-03-09 美敦力公司 带有具有可控的顺应性容积的流动路径的血液透析系统
PL2564885T3 (pl) 2011-08-30 2014-11-28 Gambro Lundia Ab Urządzenie do pozaustrojowego oczyszczania krwi oraz sposób obliczania założonych natężeń przepływu w urządzeniu medycznym dla podawania lub pobierania płynów
DE102011053200A1 (de) * 2011-09-01 2013-03-07 Fresenius Medical Care Deutschland Gmbh Dialysatfluss-Regelung
US20130085439A1 (en) * 2011-09-30 2013-04-04 Tyco Healthcare Group Lp Device to encourage blood circulation between dialysis
DE102011116262A1 (de) * 2011-10-19 2013-04-25 Fresenius Medical Care Deutschland Gmbh Verfahren sowie Vorrichtungen zum retrograden Befüllen wenigstens einer Calciumleitung eines extrakorporalen Blutkreislaufs
EP2861273B1 (en) 2012-06-13 2017-08-23 ExThera Medical Corporation Use of heparin and carbohydrates to treat cancer
US9579444B2 (en) 2012-07-05 2017-02-28 LenJam AB Blood collection system and method
US8803090B2 (en) * 2012-11-09 2014-08-12 Fenwal, Inc. Citrate detector for blood processing system
AU2013201546B2 (en) * 2012-12-18 2014-10-23 Gambro Lundia Ab Dialysis composition
DE102012025052A1 (de) * 2012-12-20 2014-06-26 Fresenius Medical Care Deutschland Gmbh Hämodiafiltrationsverfahren
US11154648B2 (en) 2013-01-09 2021-10-26 Medtronic, Inc. Fluid circuits for sorbent cartridge with sensors
US9713666B2 (en) 2013-01-09 2017-07-25 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US10850016B2 (en) 2013-02-01 2020-12-01 Medtronic, Inc. Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection
US9623164B2 (en) 2013-02-01 2017-04-18 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
AU2014234479B2 (en) * 2013-03-20 2018-08-02 Gambro Lundia Ab Monitoring of cardiac arrest in a patient connected to an extracorporeal blood processing apparatus
DK2884896T3 (en) 2013-04-17 2016-08-22 Fluisense Aps Improved fluid sampling system
CN104334168A (zh) * 2013-04-30 2015-02-04 甘布罗伦迪亚股份公司 包含柠檬酸盐和磷酸盐的抗凝流体
EP2991640B1 (en) 2013-04-30 2018-12-05 Gambro Lundia AB A multipart fluid system and a system for citrate anticoagualation in an extracorporeal blood circuit
US10463779B2 (en) 2013-04-30 2019-11-05 Gambro Lundia Ab Multipart fluid system and a system for regional citrate anticoagulation with a phosphate comprising anticoagulation fluid
US10004762B2 (en) 2013-05-08 2018-06-26 Gambro Lundia Ab Dialysis formulation
US9414812B2 (en) * 2013-05-14 2016-08-16 Acist Medical Systems, Inc. System and method for monitoring device engagement
EP3013445B1 (en) 2013-06-24 2019-11-06 ExThera Medical Corporation Blood filtration system containing mannose coated substrate
MX382486B (es) 2013-11-08 2025-03-13 Exthera Medical Corp Métodos para diagnosticar enfermedades infecciosas usando medio de adsorción.
US10537875B2 (en) 2013-11-26 2020-01-21 Medtronic, Inc. Precision recharging of sorbent materials using patient and session data
US9884145B2 (en) 2013-11-26 2018-02-06 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
JP6728536B2 (ja) 2014-03-31 2020-07-22 ゾール メディカル コーポレイションＺＯＬＬ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ 蘇生後症候群を治療するための炎症性バイオマーカーの血液濾過
JP2017513636A (ja) 2014-04-24 2017-06-01 エクスセラ メディカル コーポレイション 高流量を用いて血液から細菌を除去するための方法
US10172991B2 (en) 2014-06-24 2019-01-08 Medtronic, Inc. Modular dialysate regeneration assembly
US10357757B2 (en) 2014-06-24 2019-07-23 Medtronic, Inc. Stacked sorbent assembly
JPWO2016006409A1 (ja) * 2014-07-09 2017-04-27 凸版印刷株式会社 液剤注入装置
JP6533826B2 (ja) 2014-08-29 2019-06-19 フレゼニウス カービ ドイチュラント ゲーエムベーハー 血液処理装置において用いるチューブセット
US10857283B2 (en) 2014-09-22 2020-12-08 Exthera Medical Corporation Wearable hemoperfusion device
DE102014113728B4 (de) 2014-09-23 2023-08-17 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtungen zum Vorbereiten eines extrakorporalen Blutkreislaufs für die Blutbehandlung
EP3015124B1 (en) 2014-10-31 2017-08-16 B. Braun Avitum AG System for flexible citrate anticoagulation during extracorporeal blood treatment using feed-forward control
CN104383618B (zh) * 2014-12-03 2017-02-22 北京迈淩医疗技术发展有限公司 一种能够同时进行前后补液的血液透析滤过机
DE102014119445A1 (de) * 2014-12-22 2016-06-23 Fresenius Medical Care Deutschland Gmbh Infusionsleitung mit Einrichtung zum Begünstigen einer Vermischung einer Infusionslösung mit einem weiteren Fluid, Vorrichtungen und Verfahren
US20180050148A1 (en) * 2015-04-23 2018-02-22 Aethlon Medical, Inc. Methods for delivering regional citrate anticoagulation (rca) during extracorporeal blood treatments
WO2017011024A1 (en) * 2015-07-13 2017-01-19 Noah Mark Minskoff Surgical suction device that uses positive pressure gas
CN105517490B (zh) * 2015-09-15 2018-08-10 薛迎风 全自动枸橼酸局部抗凝机
JP6909506B2 (ja) 2016-02-01 2021-07-28 リベルディーアイ，リミテッド コネクタを備えた透析システムポンプ
US10786615B2 (en) 2016-03-02 2020-09-29 Exthera Medical Corporation Method for treating drug intoxication
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
EP3238756B1 (en) 2016-04-26 2019-09-04 Gambro Lundia AB Apparatus for determining a parameter indicative of the progress of an extracorporeal blood treatment
DE102016117974A1 (de) 2016-09-23 2018-03-29 Fresenius Medical Care Deutschland Gmbh Einsatzstück für einen Blutschlauchsatz zum Begünstigen einer Vermischung einer Infusionslösung mit einem weiteren Fluid
DE102016119259A1 (de) * 2016-10-10 2018-04-12 B. Braun Avitum Ag Vorrichtung und Verfahren zur Rezirkulationsmessung
US10981148B2 (en) 2016-11-29 2021-04-20 Medtronic, Inc. Zirconium oxide module conditioning
CN110099704B (zh) 2016-12-22 2022-09-30 甘布罗伦迪亚股份公司 用于体外血液处理的装置
US11167068B2 (en) 2016-12-22 2021-11-09 Gambro Lundia Ab Apparatus for extracorporeal blood treatment
CN110234371A (zh) 2017-02-01 2019-09-13 利比迪公司 智能腹膜透析设备
EP3590563B1 (en) * 2017-03-02 2020-09-23 Asahi Kasei Medical Co., Ltd. Blood purification device
JP6848044B2 (ja) * 2017-03-02 2021-03-24 旭化成メディカル株式会社 血液浄化装置
US10960381B2 (en) 2017-06-15 2021-03-30 Medtronic, Inc. Zirconium phosphate disinfection recharging and conditioning
EP3421061A1 (en) 2017-06-28 2019-01-02 Fresenius Medical Care Deutschland GmbH Another insert piece for a blood tubing set to promote mixing an infusion solution with a further fluid
US11045589B2 (en) 2017-09-22 2021-06-29 Becton, Dickinson And Company 4% trisodium citrate solution for use as a catheter lock solution
DE102017122540A1 (de) * 2017-09-28 2019-03-28 B. Braun Avitum Ag Mehrfachsensorvorrichtung
EP3723608B1 (en) 2017-12-15 2023-10-11 Gastroklenz Inc. Sensor monitoring system for in-dwelling catheter based treatments
WO2019169508A1 (en) 2018-03-09 2019-09-12 1929803 Ontario Corp. D/B/A Flosonics Medical Dynamically controllable patient fluid control device
JP7098433B2 (ja) * 2018-06-20 2022-07-11 日機装株式会社 血液浄化装置及び血液浄化装置による血漿流量取得方法
US11109831B2 (en) 2018-07-17 2021-09-07 1929803 Ontario Corp, (o/a FloSonics Medical) Ultrasound patch for detecting fluid flow
US12285552B2 (en) 2018-08-14 2025-04-29 Mozarc Medical Us Llc Precision dialysis therapy based on sorbent effluent analysis
US11213616B2 (en) 2018-08-24 2022-01-04 Medtronic, Inc. Recharge solution for zirconium phosphate
WO2020120004A1 (en) * 2018-12-11 2020-06-18 Gambro Lundia Ab Performance monitoring of regional citrate anticoagulation
DE102019101774A1 (de) * 2019-01-24 2020-07-30 Fresenius Medical Care Deutschland Gmbh Vorrichtung zur extrakorporalen Blutbehandlung
EP3873343A4 (en) 2019-03-26 2022-01-05 Nuwellis, Inc. NEONATAL AND PEDIATRIC BLOOD FILTRATION SYSTEM
JP2022534191A (ja) 2019-05-16 2022-07-28 エクスセラ メディカル コーポレイション 内皮糖衣構造を調節するための方法
USD984637S1 (en) 2019-06-26 2023-04-25 Gastroklenz Inc. Measurement vessel
USD903126S1 (en) 2019-06-26 2020-11-24 Gastroklenz Inc. Monitoring device
CA3144280A1 (en) 2019-06-26 2020-12-30 Gastroklenz Inc. Systems, devices, and methods for fluid monitoring
JP7367425B2 (ja) * 2019-09-24 2023-10-24 株式会社ジェイ・エム・エス 血液浄化装置
CN112675375B (zh) * 2019-10-18 2022-01-07 上海市松江区中心医院（上海交通大学附属第一人民医院松江分院） 带有高精度rca功能的crrt机器
MX2022007091A (es) * 2019-12-10 2022-07-11 Baxter Int Metodo y sistema de administracion combinada extracorporea y de farmacos.
KR20220113996A (ko) * 2019-12-11 2022-08-17 에피센트알엑스, 인코포레이티드 약제 주입 디바이스, 시스템 및 방법
ES3026213T3 (en) 2019-12-23 2025-06-10 Gambro Lundia Ab Apparatus for extracorporeal blood treatment
CN113616204B (zh) * 2020-05-06 2024-06-11 上海交通大学医学院附属第九人民医院 一种可用于crrt的在线实时监测血液离子钙动态变化的装置
WO2022008970A1 (en) 2020-07-06 2022-01-13 1929803 Ontario Corp. D/B/A Flosonics Medical Ultrasound patch with integrated flexible transducer assembly
CN111973196B (zh) * 2020-09-22 2022-05-27 深圳市金迈得医疗科技有限公司 一种肝功能指标的检测与重分析装置
IT202000026212A1 (it) * 2020-11-03 2022-05-03 Gambro Lundia Ab Apparecchio per il trattamento extracorporeo del sangue e processo di calcolo delle portate impostate in un apparecchio medico per il trattamento extracorporeo del sangue
US20220193319A1 (en) * 2020-12-18 2022-06-23 Fluid-O-Tech S.R.L. Blood filtering device, particularly for hemodialysis and/or haemofiltration apparatuses
CN113018546B (zh) * 2021-03-17 2023-03-21 上海溯湃医疗科技有限公司 一种局部枸橼酸抗凝输注系统及控制方法、系统、介质
US12397093B2 (en) 2021-05-18 2025-08-26 Mozarc Medical Us Llc Sorbent cartridge designs
CN115252936B (zh) * 2022-07-18 2025-05-09 健帆生物科技集团股份有限公司 一种血液净化设备及存储介质
CN115252932B (zh) * 2022-08-01 2024-12-13 天津达伟医疗科技有限公司 一种血液透析滤过用干粉装置
US20240066190A1 (en) * 2022-08-31 2024-02-29 Fenwal, Inc. System and method for preventing donor reactions during blood donation

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032615A (en) 1989-10-31 1991-07-16 The Regents Of The University Of California Continuous hemodialysis using citrate
FR2680975B1 (fr) * 1991-09-10 1998-12-31 Hospal Ind Rein artificiel muni de moyens pour doser une substance dans le sang.
US5817042A (en) * 1992-03-04 1998-10-06 Cobe Laboratories, Inc. Method and apparatus for controlling concentrations in vivos and in tubing systems
US5910252A (en) * 1993-02-12 1999-06-08 Cobe Laboratories, Inc. Technique for extracorporeal treatment of blood
US6212424B1 (en) 1998-10-29 2001-04-03 Rio Grande Medical Technologies, Inc. Apparatus and method for determination of the adequacy of dialysis by non-invasive near-infrared spectroscopy
JP4293474B2 (ja) 1996-04-16 2009-07-08 ノバルティス アクチエンゲゼルシャフト 光学的イオンセンサーとしての共有結合固定化フルオロイオノフォア
AU4553700A (en) * 1999-04-26 2000-11-10 Pe Chou Chang Substitution infusion fluid and citrate anticoagulation
US7186420B2 (en) 1999-04-26 2007-03-06 Edwards Lifesciences Corporation Multi-part substitution infusion fluids and matching anticoagulants
US8105258B2 (en) 1999-04-26 2012-01-31 Baxter International Inc. Citrate anticoagulation system for extracorporeal blood treatments
ATE380563T1 (de) 2000-07-07 2007-12-15 Fresenius Medical Care De Gmbh Vorrichtung zur hämodialyse
US6627177B2 (en) 2000-12-05 2003-09-30 The Regents Of The University Of California Polyhydroxyl-substituted organic molecule sensing optical in vivo method utilizing a boronic acid adduct and the device thereof
US7300674B2 (en) 2000-12-20 2007-11-27 Sheldon Tobe Sterile low bicarbonate dialysis concentrate solutions
EP1343489A2 (en) 2000-12-20 2003-09-17 Dialysis Solutions Inc. Sterile bicarbonate-free dialysis concentrate solutions
DE10114283C2 (de) 2000-12-22 2003-04-24 Fresenius Medical Care De Gmbh Verfahren zur Ermittlung der Ionenkonzentration des Blutes eines Patienten bei der citrat-antikoagulierten Hämodialyse und/oder Hämofiltration; Dialysegerät
US7445801B2 (en) 2002-06-07 2008-11-04 Baxter International Inc. Stable bicarbonate-based solution in a single container
US7351218B2 (en) * 2002-12-20 2008-04-01 Gambro Lundia Ab Device and process for extracorporeal treatment by citrate anticoagulant
US7174198B2 (en) 2002-12-27 2007-02-06 Igor Trofimov Non-invasive detection of analytes in a complex matrix
ITMI20030212A1 (it) * 2003-02-07 2004-08-08 Gambro Lundia Ab Metodo per il trattamento extracorporeo di sangue
US7326576B2 (en) 2003-04-09 2008-02-05 Prescient Medical, Inc. Raman spectroscopic monitoring of hemodialysis
US7053059B2 (en) 2003-07-25 2006-05-30 Baxter International Inc. Dialysis solutions with reduced levels of glucose degradation products
US7029456B2 (en) 2003-10-15 2006-04-18 Baxter International Inc. Medical fluid therapy flow balancing and synchronization system
US8029454B2 (en) 2003-11-05 2011-10-04 Baxter International Inc. High convection home hemodialysis/hemofiltration and sorbent system
CN1946441B (zh) 2004-05-07 2011-04-13 甘布罗伦迪亚股份公司 血液处理设备和用来控制注入的方法
US7209773B2 (en) 2004-06-18 2007-04-24 In Technology Holdings Llc Method and apparatus for performing in-vivo blood analysis using raman spectrum
US7374677B2 (en) 2004-08-20 2008-05-20 Kkj, Inc. Two stage hemofiltration that generates replacement fluid
US7468033B2 (en) 2004-09-08 2008-12-23 Medtronic Minimed, Inc. Blood contacting sensor
US7651851B2 (en) 2005-01-27 2010-01-26 Prescient Medical, Inc. Handheld Raman body fluid analyzer
US8372025B2 (en) * 2005-09-22 2013-02-12 Baxter International Inc. Automation and optimization of CRRT treatment using regional citrate anticoagulation
WO2007056587A2 (en) 2005-11-09 2007-05-18 The General Hospital Corporation Predicting diabetic nephropathy (dn)
US7884132B2 (en) 2005-11-14 2011-02-08 The Uab Research Foundation Process for metabolic control and high solute clearance and solutions for use therein
EP1954190A4 (en) 2005-11-15 2010-10-13 Luminous Medical Inc BLUTANALYTBESTIMMUNGEN
US8133194B2 (en) 2006-02-22 2012-03-13 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits

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