JP2009526856A - 抗体製剤 - Google Patents
抗体製剤 Download PDFInfo
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- JP2009526856A JP2009526856A JP2008555358A JP2008555358A JP2009526856A JP 2009526856 A JP2009526856 A JP 2009526856A JP 2008555358 A JP2008555358 A JP 2008555358A JP 2008555358 A JP2008555358 A JP 2008555358A JP 2009526856 A JP2009526856 A JP 2009526856A
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- formulation
- antibody
- buffer
- imc
- histidine
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US77410106P | 2006-02-15 | 2006-02-15 | |
| PCT/US2007/004050 WO2007095337A2 (en) | 2006-02-15 | 2007-02-15 | Antibody formulation |
Publications (2)
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| JP2009526856A true JP2009526856A (ja) | 2009-07-23 |
| JP2009526856A5 JP2009526856A5 (enExample) | 2010-01-07 |
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| EP (1) | EP1987067A4 (enExample) |
| JP (1) | JP2009526856A (enExample) |
| KR (1) | KR20080096827A (enExample) |
| CN (1) | CN101495136A (enExample) |
| AU (1) | AU2007215012A1 (enExample) |
| BR (1) | BRPI0707796A2 (enExample) |
| CA (1) | CA2642270A1 (enExample) |
| EA (1) | EA200870264A1 (enExample) |
| IL (1) | IL193408A0 (enExample) |
| MX (1) | MX2008010562A (enExample) |
| NO (1) | NO20083640L (enExample) |
| WO (1) | WO2007095337A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013523705A (ja) * | 2010-03-31 | 2013-06-17 | スタビリテック リミテッド | ミョウバンアジュバントおよびミョウバンアジュバント化ワクチンの保存方法 |
| US10029007B2 (en) | 2011-10-05 | 2018-07-24 | Stabilitech Biopharma Ltd | Stabilisation of polypeptides |
| US10206960B2 (en) | 2010-03-31 | 2019-02-19 | Stabilitech Biopharma Ltd | Stabilisation of viral particles |
| US10716859B2 (en) | 2010-03-31 | 2020-07-21 | Stabilitech Biopharma Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090021298A (ko) * | 2006-06-14 | 2009-03-02 | 임클론 시스템즈 인코포레이티드 | 항-ｅｇｆｒ 항체의 동결건조 제제 |
| EP2527364A1 (en) | 2007-03-29 | 2012-11-28 | Abbott Laboratories | Crystalline anti-human IL-12 antibodies |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| EP3011953A1 (en) * | 2008-10-29 | 2016-04-27 | Ablynx N.V. | Stabilised formulations of single domain antigen binding molecules |
| EP2346900A1 (en) | 2008-10-29 | 2011-07-27 | Wyeth LLC | Methods for purification of single domain antigen binding molecules |
| WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
| WO2011029823A1 (en) | 2009-09-09 | 2011-03-17 | Novartis Ag | Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells |
| EP2483301A1 (en) | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| JP2013543384A (ja) | 2010-10-05 | 2013-12-05 | ノバルティス アーゲー | 抗−ｉｌ１２ｒベータ１抗体ならびに自己免疫性および炎症性疾患の処置おけるその使用 |
| TWI486617B (zh) * | 2010-10-21 | 2015-06-01 | Iner Aec Executive Yuan | 一種測定對鎝（Ｔｃ－９９ｍ）與錸（Ｒｅ－１８６、Ｒｅ－１８８）具有穩定錯合力之含硫螯合劑在凍晶劑中之含量與均一性的固態樣品分析技術 |
| SG11201402661TA (en) * | 2011-11-28 | 2014-08-28 | Phasebio Pharmaceuticals Inc | Therapeutic agents comprising insulin amino acid sequences |
| US9029510B2 (en) | 2012-03-30 | 2015-05-12 | Sorrento Therapeutics, Inc. | Fully human antibodies that bind to VEGFR2 and methods of use thereof |
| EP2830663B1 (en) * | 2012-03-30 | 2019-02-06 | Sorrento Therapeutics Inc. | Fully human antibodies that bind to vegfr2 |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| AP2015008584A0 (en) | 2013-02-08 | 2015-07-31 | Novartis Ag | Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders |
| US9700485B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| US20170291939A1 (en) | 2014-06-25 | 2017-10-12 | Novartis Ag | Antibodies specific for il-17a fused to hyaluronan binding peptide tags |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| SI3370768T1 (sl) | 2015-11-03 | 2022-04-29 | Janssen Biotech, Inc. | Protitelesa, ki se specifično vežejo na PD-1, in njihove uporabe |
| BR112018014150A2 (en) | 2016-01-11 | 2018-12-11 | Novartis Ag | immunostimulating humanized monoclonal antibodies to human interleukin-2, and fusion proteins thereof |
| CN106188296B (zh) * | 2016-07-19 | 2018-05-08 | 康融东方（广东）医药有限公司 | 一类抗血管内皮生长因子受体vegfr2的单克隆抗体及其编码基因和应用 |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| EP3684332A1 (en) * | 2017-09-18 | 2020-07-29 | Amgen Inc. | Vegfr-fc fusion protein formulations |
| US12398209B2 (en) * | 2018-01-22 | 2025-08-26 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-PD-1 antibodies |
| MX2021009851A (es) | 2019-02-18 | 2021-09-10 | Lilly Co Eli | Formulacion de anticuerpos terapeuticos. |
| CN110646618B (zh) * | 2019-09-17 | 2022-11-01 | 广州市伊川生物科技有限公司 | 一种c反应蛋白测定试剂盒及其制备方法和应用 |
| CN114980926A (zh) * | 2020-02-21 | 2022-08-30 | 江苏恒瑞医药股份有限公司 | 一种抗il-4r抗体药物组合物及其用途 |
| US11773160B1 (en) | 2022-08-05 | 2023-10-03 | Anaveon AG | Immune-stimulating IL-2 fusion proteins |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH04217630A (ja) * | 1990-03-20 | 1992-08-07 | Akzo Nv | 安定化されたゴナドトロピンを含有する調製品 |
| JP2004292455A (ja) * | 2002-02-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | 抗体含有溶液製剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5270057A (en) * | 1990-03-20 | 1993-12-14 | Akzo N.V. | Stabilized gonadotropin containing preparations |
| EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| ATE454137T1 (de) * | 2001-07-25 | 2010-01-15 | Facet Biotech Corp | Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab |
-
2007
- 2007-02-15 CN CNA2007800092016A patent/CN101495136A/zh active Pending
- 2007-02-15 JP JP2008555358A patent/JP2009526856A/ja active Pending
- 2007-02-15 MX MX2008010562A patent/MX2008010562A/es unknown
- 2007-02-15 CA CA002642270A patent/CA2642270A1/en not_active Abandoned
- 2007-02-15 US US12/224,122 patent/US20090306348A1/en not_active Abandoned
- 2007-02-15 BR BRPI0707796-3A patent/BRPI0707796A2/pt not_active IP Right Cessation
- 2007-02-15 AU AU2007215012A patent/AU2007215012A1/en not_active Abandoned
- 2007-02-15 WO PCT/US2007/004050 patent/WO2007095337A2/en not_active Ceased
- 2007-02-15 EA EA200870264A patent/EA200870264A1/ru unknown
- 2007-02-15 KR KR1020087022255A patent/KR20080096827A/ko not_active Withdrawn
- 2007-02-15 EP EP07750858A patent/EP1987067A4/en not_active Withdrawn
-
2008
- 2008-08-12 IL IL193408A patent/IL193408A0/en unknown
- 2008-08-22 NO NO20083640A patent/NO20083640L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04217630A (ja) * | 1990-03-20 | 1992-08-07 | Akzo Nv | 安定化されたゴナドトロピンを含有する調製品 |
| JP2004292455A (ja) * | 2002-02-14 | 2004-10-21 | Chugai Pharmaceut Co Ltd | 抗体含有溶液製剤 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013523705A (ja) * | 2010-03-31 | 2013-06-17 | スタビリテック リミテッド | ミョウバンアジュバントおよびミョウバンアジュバント化ワクチンの保存方法 |
| US9101607B2 (en) | 2010-03-31 | 2015-08-11 | Stabilitech Ltd. | Method for preserving alum adjuvants and alum-adjuvanted vaccines |
| US10206960B2 (en) | 2010-03-31 | 2019-02-19 | Stabilitech Biopharma Ltd | Stabilisation of viral particles |
| US10716859B2 (en) | 2010-03-31 | 2020-07-21 | Stabilitech Biopharma Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
| US10029007B2 (en) | 2011-10-05 | 2018-07-24 | Stabilitech Biopharma Ltd | Stabilisation of polypeptides |
Also Published As
| Publication number | Publication date |
|---|---|
| IL193408A0 (en) | 2011-08-01 |
| BRPI0707796A2 (pt) | 2011-05-10 |
| KR20080096827A (ko) | 2008-11-03 |
| WO2007095337A2 (en) | 2007-08-23 |
| AU2007215012A1 (en) | 2007-08-23 |
| US20090306348A1 (en) | 2009-12-10 |
| MX2008010562A (es) | 2009-03-05 |
| CN101495136A (zh) | 2009-07-29 |
| CA2642270A1 (en) | 2007-08-23 |
| NO20083640L (no) | 2008-11-17 |
| EP1987067A2 (en) | 2008-11-05 |
| EP1987067A4 (en) | 2012-01-25 |
| EA200870264A1 (ru) | 2009-02-27 |
| WO2007095337A3 (en) | 2008-11-27 |
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