CN114980926A - 一种抗il-4r抗体药物组合物及其用途 - Google Patents

一种抗il-4r抗体药物组合物及其用途 Download PDF

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Publication number
CN114980926A
CN114980926A CN202180009420.4A CN202180009420A CN114980926A CN 114980926 A CN114980926 A CN 114980926A CN 202180009420 A CN202180009420 A CN 202180009420A CN 114980926 A CN114980926 A CN 114980926A
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seq
antibody
histidine
pharmaceutical composition
antigen
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CN202180009420.4A
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吴婷婷
颜贞
刘洵
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Guangdong Jiangsu Hengrui Medicine Co ltd
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

提供一种抗IL‑4R抗体药物组合物及其用途，所述药物组合物包含在组氨酸‑醋酸缓冲剂中的抗IL‑4R抗体或其抗原结合片段，以及粘度调节剂、表面活性剂和稳定剂。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
CN202180009420.4A 2020-02-21 2021-02-19 一种抗il-4r抗体药物组合物及其用途 Pending CN114980926A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN202010107765 2020-02-21
CN2020101077650 2020-02-21
CN2021101454552 2021-02-02
CN202110145455 2021-02-02
PCT/CN2021/076854 WO2021164728A1 (zh) 2020-02-21 2021-02-19 一种抗il-4r抗体药物组合物及其用途

Publications (1)

Publication Number Publication Date
CN114980926A true CN114980926A (zh) 2022-08-30

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CN202180009420.4A Pending CN114980926A (zh) 2020-02-21 2021-02-19 一种抗il-4r抗体药物组合物及其用途

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Country Link
US (1) US20230088052A1 (zh)
EP (1) EP4104858A4 (zh)
JP (1) JP2023515423A (zh)
KR (1) KR20220143882A (zh)
CN (1) CN114980926A (zh)
AU (1) AU2021223128A1 (zh)
BR (1) BR112022016345A2 (zh)
CA (1) CA3169959A1 (zh)
MX (1) MX2022010217A (zh)
TW (1) TW202139974A (zh)
WO (1) WO2021164728A1 (zh)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
DK2990420T3 (en) 2000-05-26 2017-04-03 Immunex Corp USE OF INTERLEUKIN-4 RECEPTOR ANTIBODIES AND COMPOSITIONS THEREOF
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
ES2859825T3 (es) 2006-10-02 2021-10-04 Regeneron Pharma Anticuerpos humanos con alta afinidad para el receptor IL-4 humano
EA028945B1 (ru) * 2010-10-06 2018-01-31 Ридженерон Фармасьютикалз, Инк. СТАБИЛЬНЫЕ ЖИДКИЕ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ АНТИТЕЛА К АЛЬФА РЕЦЕПТОРУ ЧЕЛОВЕЧЕСКОГО ИНТЕРЛЕЙКИНА-4 (hIL-4Rα)
HUE064945T2 (hu) 2012-08-21 2024-04-28 Sanofi Biotechnology Eljárások asztma kezelésére vagy megelõzésére IL-4R antagonista beadásával
AU2015310879A1 (en) 2014-09-03 2017-03-02 Medimmune Limited Stable anti-IL-4R-alpha antibody formulation
CN111686247B (zh) * 2019-03-13 2022-07-29 苏州康乃德生物医药有限公司 包含人白介素-4受体α的抗体的液体组合物
CN114652853A (zh) * 2020-12-22 2022-06-24 江苏恒瑞医药股份有限公司 抗il-4r抗体-药物偶联物及医药用途

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Publication number Publication date
WO2021164728A1 (zh) 2021-08-26
EP4104858A1 (en) 2022-12-21
AU2021223128A1 (en) 2022-09-08
CA3169959A1 (en) 2021-08-26
MX2022010217A (es) 2022-09-19
EP4104858A4 (en) 2023-11-29
JP2023515423A (ja) 2023-04-13
BR112022016345A2 (pt) 2022-12-20
KR20220143882A (ko) 2022-10-25
US20230088052A1 (en) 2023-03-23
TW202139974A (zh) 2021-11-01

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