JP2009526795A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009526795A5 JP2009526795A5 JP2008554655A JP2008554655A JP2009526795A5 JP 2009526795 A5 JP2009526795 A5 JP 2009526795A5 JP 2008554655 A JP2008554655 A JP 2008554655A JP 2008554655 A JP2008554655 A JP 2008554655A JP 2009526795 A5 JP2009526795 A5 JP 2009526795A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- group
- independently
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 89
- 150000001875 compounds Chemical class 0.000 claims 52
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 46
- 229910052757 nitrogen Inorganic materials 0.000 claims 44
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 36
- 229910052760 oxygen Inorganic materials 0.000 claims 31
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 30
- 229910052717 sulfur Inorganic materials 0.000 claims 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 26
- 125000005842 heteroatom Chemical group 0.000 claims 24
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 19
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 19
- 239000001301 oxygen Substances 0.000 claims 19
- 239000011593 sulfur Substances 0.000 claims 19
- -1 N ( R31) Inorganic materials 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 238000004519 manufacturing process Methods 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 125000004122 cyclic group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 206010022489 Insulin Resistance Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 150000001299 aldehydes Chemical class 0.000 claims 2
- 150000001491 aromatic compounds Chemical class 0.000 claims 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000004129 fatty acid metabolism Effects 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 229930040373 Paraformaldehyde Natural products 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000883 anti-obesity agent Substances 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 229940125710 antiobesity agent Drugs 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004980 cyclopropylene group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 230000002140 halogenating effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229920002866 paraformaldehyde Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 150000003142 primary aromatic amines Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006007048 | 2006-02-15 | ||
| PCT/EP2007/001214 WO2007093366A1 (en) | 2006-02-15 | 2007-02-13 | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526795A JP2009526795A (ja) | 2009-07-23 |
| JP2009526795A5 true JP2009526795A5 (cg-RX-API-DMAC7.html) | 2010-04-02 |
Family
ID=38169583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554655A Pending JP2009526795A (ja) | 2006-02-15 | 2007-02-13 | 新規なアミノアルコール置換アリールジヒドロイソキノリノン、それらの製造方法及び薬剤としてそれらの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8501771B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1987006B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2009526795A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20080094699A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101384555A (cg-RX-API-DMAC7.html) |
| AR (1) | AR059522A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE495157T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007214711A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0707836A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2636617A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602007011897D1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL193339A0 (cg-RX-API-DMAC7.html) |
| MY (1) | MY149854A (cg-RX-API-DMAC7.html) |
| TW (1) | TW200800907A (cg-RX-API-DMAC7.html) |
| UY (1) | UY30165A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007093366A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
| ES2373792T3 (es) * | 2006-05-19 | 2012-02-08 | Abbott Laboratories | Derivados de alcanos azabicíclicos sustituidos con bicicloheterociclo condensado activos en el snc. |
| JP5198439B2 (ja) * | 2006-06-08 | 2013-05-15 | イーライ リリー アンド カンパニー | 新規なｍｃｈ受容体アンタゴニスト |
| MX2009007831A (es) | 2007-01-22 | 2010-01-15 | Gtx Inc | Agentes de union de receptor nuclear. |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
| US8344160B2 (en) | 2008-10-08 | 2013-01-01 | Bristol-Myers Squibb Company | Pyrrolone melanin concentrating hormone receptor-1 antagonists |
| EP2558094A4 (en) * | 2010-04-12 | 2013-09-25 | Merck Sharp & Dohme | pyridone derivatives |
| WO2011140190A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Tetrazolones as inhibitors of fatty acid synthase |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| TW201215387A (en) * | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| CN107108534B (zh) | 2014-08-29 | 2023-05-09 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| WO2021028935A1 (en) * | 2019-08-12 | 2021-02-18 | Dr Reddy's Institute Of Life Sciences | Heterocyclic compounds, and their use as allosteric modulators of 5-hydroxytryptamine 2c receptor (5-ht2cr) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10259176A (ja) * | 1997-03-17 | 1998-09-29 | Japan Tobacco Inc | 血管新生阻害作用を有する新規アミド誘導体及びその用途 |
| CA2386474A1 (en) | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| AU2001249399A1 (en) | 2000-03-24 | 2001-10-08 | Cor Therapeutics, Inc. | Isoquinolone inhibitors of factor xa |
| JP2004504303A (ja) | 2000-07-05 | 2004-02-12 | シナプティック・ファーマスーティカル・コーポレーション | 選択的メラニン凝集ホルモン−１（ｍｃｈ１）受容体アンタゴニストおよびその使用 |
| AU7320701A (en) | 2000-07-05 | 2002-01-14 | Synaptic Pharmaceutical Corporation | DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof |
| IL153645A0 (en) | 2000-07-31 | 2003-07-06 | Smithkline Beecham Plc | Carboxamide compounds and their use as antagonists of a human 11cby receptor |
| US20030022891A1 (en) | 2000-12-01 | 2003-01-30 | Anandan Palani | MCH antagonists and their use in the treatment of obesity |
| CA2446351A1 (en) | 2001-05-04 | 2002-11-14 | Tularik Inc. | Fused heterocyclic compounds |
| GB0124627D0 (en) | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
| CZ2004634A3 (cs) | 2001-10-25 | 2004-10-13 | Takedaáchemicaláindustriesźáltd | Chinolinová sloučeninaŹ způsob výroby a použití a farmaceutický přípravek |
| US7084156B2 (en) | 2001-11-27 | 2006-08-01 | Merck & Co., Inc. | 2-Aminoquinoline compounds |
| AU2003222648A1 (en) | 2002-05-13 | 2003-12-02 | Eli Lilly And Company | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes |
| DE10238865A1 (de) | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| WO2004092181A1 (en) * | 2003-04-11 | 2004-10-28 | Smithkline Beecham Corporation | Heterocyclic mchr1 antagonists |
| US7390820B2 (en) | 2003-08-25 | 2008-06-24 | Amgen Inc. | Substituted quinolinone derivatives and methods of use |
| CA2543122A1 (en) * | 2003-10-23 | 2005-05-12 | Glaxo Group Limited | 3-(4-aminophenyl) thienopyrimid-4-one derivatives as mch r1 antagonists for the treatment of obesity, diabetes, depression and anxiety |
| WO2005047293A1 (en) | 2003-11-07 | 2005-05-26 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
| UA83416C2 (en) * | 2004-02-13 | 2008-07-10 | Баниу Фармасьютикал Ко., Лтд. | Fused ring 4-oxopyrimidine derivative |
| US20050256124A1 (en) | 2004-04-15 | 2005-11-17 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
-
2007
- 2007-02-13 JP JP2008554655A patent/JP2009526795A/ja active Pending
- 2007-02-13 DE DE602007011897T patent/DE602007011897D1/de active Active
- 2007-02-13 TW TW096105356A patent/TW200800907A/zh unknown
- 2007-02-13 WO PCT/EP2007/001214 patent/WO2007093366A1/en not_active Ceased
- 2007-02-13 MY MYPI20083055A patent/MY149854A/en unknown
- 2007-02-13 BR BRPI0707836-6A patent/BRPI0707836A2/pt not_active IP Right Cessation
- 2007-02-13 AT AT07722802T patent/ATE495157T1/de not_active IP Right Cessation
- 2007-02-13 CA CA002636617A patent/CA2636617A1/en not_active Abandoned
- 2007-02-13 AU AU2007214711A patent/AU2007214711A1/en not_active Abandoned
- 2007-02-13 CN CNA2007800057008A patent/CN101384555A/zh active Pending
- 2007-02-13 KR KR1020087020097A patent/KR20080094699A/ko not_active Withdrawn
- 2007-02-13 EP EP07722802A patent/EP1987006B1/en not_active Not-in-force
- 2007-02-15 AR ARP070100661A patent/AR059522A1/es not_active Application Discontinuation
- 2007-02-15 UY UY30165A patent/UY30165A1/es not_active Application Discontinuation
-
2008
- 2008-08-10 IL IL193339A patent/IL193339A0/en unknown
- 2008-08-14 US US12/191,697 patent/US8501771B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009526795A5 (cg-RX-API-DMAC7.html) | ||
| JP2009526793A5 (cg-RX-API-DMAC7.html) | ||
| JP2009526792A5 (cg-RX-API-DMAC7.html) | ||
| RU2008136898A (ru) | Азациклил-замещенные арилдигидроизохинолиноны, способ их получения и их применение в качестве лекарственных средств | |
| JP2009526794A5 (cg-RX-API-DMAC7.html) | ||
| JP6259855B2 (ja) | インフルエンザウイルス複製の阻害剤 | |
| ES2572803T3 (es) | Estimuladores de GCs | |
| TWI852872B (zh) | 三環性螺化合物之用途 | |
| CN102812006B (zh) | 新型抗疟疾试剂 | |
| JP2021527638A (ja) | Ｂ型肝炎カプシドアセンブリモジュレーター | |
| JP6557674B2 (ja) | 新規クラスのミュー−オピオイド受容体アゴニスト | |
| ES2573715T3 (es) | Ligandos sigma para la prevención y/o el tratamiento del vómito inducido por la quimioterapia o la radioterapia | |
| JP2006501202A5 (cg-RX-API-DMAC7.html) | ||
| JP2006517563A5 (cg-RX-API-DMAC7.html) | ||
| AU2021200164A1 (en) | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment | |
| DK3083592T3 (en) | SUBSTITU | |
| TW201605433A (zh) | ＮＳＡＩＤ與西克馬（ｓｉｇｍａ）受體配位體之組合 | |
| AU2009310807B2 (en) | Cyclohexane derivative and pharmaceutical use thereof | |
| JP2008531679A (ja) | オキシトシンアンタゴニストとしての１，２，４−トリアゾール誘導体とその使用 | |
| US9624198B2 (en) | Substituted piperidinyltetrahydroquinolines | |
| CA2934134A1 (en) | Substituted bipiperidinyl derivatives as adrenoreceptor alpha 2c antagonists | |
| JP2018016544A (ja) | 新規ジアザビシクロ［２．２．２］オクタン誘導体 | |
| ES2708577T3 (es) | Composición medicinal que mejora la resistencia a la leptina | |
| JP2022508217A (ja) | Ｔａｓｋ－１およびｔａｓｋ－３チャンネル阻害剤を含有する医薬投薬形態の製造方法、ならびに呼吸障害治療におけるその使用 | |
| AR120406A1 (es) | Compuestos de pirrolidina y piperidina |