JP2009526600A - 骨誘導性リン酸カルシウム - Google Patents
骨誘導性リン酸カルシウム Download PDFInfo
- Publication number
- JP2009526600A JP2009526600A JP2008555181A JP2008555181A JP2009526600A JP 2009526600 A JP2009526600 A JP 2009526600A JP 2008555181 A JP2008555181 A JP 2008555181A JP 2008555181 A JP2008555181 A JP 2008555181A JP 2009526600 A JP2009526600 A JP 2009526600A
- Authority
- JP
- Japan
- Prior art keywords
- calcium phosphate
- tcp
- porous
- ceramic
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 228
- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 115
- 235000011010 calcium phosphates Nutrition 0.000 title claims abstract description 105
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims abstract description 102
- 239000000463 material Substances 0.000 claims abstract description 80
- 230000002138 osteoinductive effect Effects 0.000 claims abstract description 36
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 112
- 239000002245 particle Substances 0.000 claims description 96
- 239000000843 powder Substances 0.000 claims description 80
- 238000000034 method Methods 0.000 claims description 49
- 108090000623 proteins and genes Proteins 0.000 claims description 47
- 102000004169 proteins and genes Human genes 0.000 claims description 47
- 210000000988 bone and bone Anatomy 0.000 claims description 39
- 239000007943 implant Substances 0.000 claims description 39
- 239000002002 slurry Substances 0.000 claims description 38
- 239000004068 calcium phosphate ceramic Substances 0.000 claims description 35
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 31
- 239000012091 fetal bovine serum Substances 0.000 claims description 28
- 238000001179 sorption measurement Methods 0.000 claims description 28
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 26
- 239000011859 microparticle Substances 0.000 claims description 24
- 239000011148 porous material Substances 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 20
- 238000005245 sintering Methods 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 19
- 239000004604 Blowing Agent Substances 0.000 claims description 12
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 12
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000013078 crystal Substances 0.000 claims description 10
- 229910052586 apatite Inorganic materials 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000001788 irregular Effects 0.000 claims description 8
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 6
- 230000002051 biphasic effect Effects 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000005187 foaming Methods 0.000 claims description 5
- 239000004088 foaming agent Substances 0.000 claims description 5
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims description 4
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000002407 tissue scaffold Substances 0.000 claims description 2
- 239000000919 ceramic Substances 0.000 description 106
- 229960001714 calcium phosphate Drugs 0.000 description 69
- 235000013339 cereals Nutrition 0.000 description 58
- 239000011575 calcium Substances 0.000 description 26
- 239000000243 solution Substances 0.000 description 25
- 230000011164 ossification Effects 0.000 description 15
- 238000001000 micrograph Methods 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 10
- 238000002513 implantation Methods 0.000 description 9
- 230000002188 osteogenic effect Effects 0.000 description 9
- 241000282472 Canis lupus familiaris Species 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 7
- 238000001878 scanning electron micrograph Methods 0.000 description 7
- 210000003205 muscle Anatomy 0.000 description 6
- 239000012798 spherical particle Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 4
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 4
- 229910052753 mercury Inorganic materials 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 210000002449 bone cell Anatomy 0.000 description 3
- 239000000316 bone substitute Substances 0.000 description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 235000019691 monocalcium phosphate Nutrition 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 2
- JUQPZRLQQYSMEQ-UHFFFAOYSA-N CI Basic red 9 Chemical compound [Cl-].C1=CC(N)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[NH2+])C=C1 JUQPZRLQQYSMEQ-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 239000005574 MCPA Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- WHKUVVPPKQRRBV-UHFFFAOYSA-N Trasan Chemical compound CC1=CC(Cl)=CC=C1OCC(O)=O WHKUVVPPKQRRBV-UHFFFAOYSA-N 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 229940052223 basic fuchsin Drugs 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- VEJCUEBBRSCJRP-UHFFFAOYSA-L calcium;hydron;phosphonato phosphate Chemical compound [Ca+2].OP(O)(=O)OP([O-])([O-])=O VEJCUEBBRSCJRP-UHFFFAOYSA-L 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000000462 isostatic pressing Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000002731 protein assay Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- ZRMMVODKVLXCBB-UHFFFAOYSA-N 1-n-cyclohexyl-4-n-phenylbenzene-1,4-diamine Chemical compound C1CCCCC1NC(C=C1)=CC=C1NC1=CC=CC=C1 ZRMMVODKVLXCBB-UHFFFAOYSA-N 0.000 description 1
- 239000004135 Bone phosphate Substances 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 239000004134 Dicalcium diphosphate Substances 0.000 description 1
- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010049811 Extraskeletal ossification Diseases 0.000 description 1
- 208000034970 Heterotopic Ossification Diseases 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 235000019815 calcium dihydrogen diphosphate Nutrition 0.000 description 1
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- ROPDWRCJTIRLTR-UHFFFAOYSA-L calcium metaphosphate Chemical compound [Ca+2].[O-]P(=O)=O.[O-]P(=O)=O ROPDWRCJTIRLTR-UHFFFAOYSA-L 0.000 description 1
- 229910000394 calcium triphosphate Inorganic materials 0.000 description 1
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229910000393 dicalcium diphosphate Inorganic materials 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium phosphate dihydrate Substances O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 1
- OLSDWRNWUGHKSY-UHFFFAOYSA-J dicalcium;phosphonato phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O OLSDWRNWUGHKSY-UHFFFAOYSA-J 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 229940077441 fluorapatite Drugs 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229910000150 monocalcium phosphate Inorganic materials 0.000 description 1
- CVPJXKJISAFJDU-UHFFFAOYSA-A nonacalcium;magnesium;hydrogen phosphate;iron(2+);hexaphosphate Chemical compound [Mg+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Fe+2].OP([O-])([O-])=O.OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O CVPJXKJISAFJDU-UHFFFAOYSA-A 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 210000005009 osteogenic cell Anatomy 0.000 description 1
- 230000004819 osteoinduction Effects 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- -1 phosphate anion Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229940045916 polymetaphosphate Drugs 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- LFULEKSKNZEWOE-UHFFFAOYSA-N propanil Chemical compound CCC(=O)NC1=CC=C(Cl)C(Cl)=C1 LFULEKSKNZEWOE-UHFFFAOYSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229910052591 whitlockite Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Porous Artificial Stone Or Porous Ceramic Products (AREA)
- Compositions Of Oxide Ceramics (AREA)
Abstract
【選択図】なし
Description
本発明は、骨誘導性物質、該物質を調製する方法及びそのように製造された物質に関係する。
患者の自身の骨から採取された自己由来の骨は、大きな骨欠損の修復にとっての究極の骨代用物である。しかしながら、患者から採取可能な自己由来の骨の量は限定され、そして骨の引き抜きそれ自身が重大な健康リスクを生じ且つ残っている骨の構造的完全性の喪失を結果する。
本発明の多孔性リン酸カルシウムに関する。
−リン酸α−トリカルシウム(α−TCP、α−Ca3(PO4)2、同義語:ウィットロッカイト、リン酸トリカルシウム、リン酸カルシウムトリベーシック)、無水又は水和物として;
−リン酸β−トリカルシウム(β−TCP、β−Ca3(PO4)2、同義語:ウィットロッカイト、リン酸トリカルシウム、リン酸カルシウムトリベーシック)無水又は水和物として;
−非晶質リン酸カルシウム(ACP、Ca3(PO4)2・nH2O、n=3〜4.5、Ca/P比=1.5)
−アパタイト(カルシウムフルオロ−ホスフェート、Ca5(F、Cl、OH)(PO4)3)
−カルシウムジハイドロジェンホスフェート(Ca(H2PO4)2);
−カルシウムジハイドロジェンホスフェートハイドレート(Ca(H2PO4)2・H2O)
−カルシウムハイドロジェンホスフェートハイドレート(CaHPO4・2H2O);
−カルシウムハイドロジェンホスフェート、無水物(CaHPO4)、
−カルシウム欠損ヒドロキシアパタイト又は沈降ヒドロキシアパタイト(PHA)1.5〜1.67のCa/P比を有するCa10−X(HPO4)X(PO4)6−X(OH)2−X(0≦X≦1)
−カーボネートアパタイト(Ca5(PO4、CO3)3F)
−リン酸ジカルシウム無水物(DCPA、CaHPO4)
−リン酸ジカルシウム二水和物(DCPD、CaHPO4・2H2O);
−フルオロアパタイト(FA、Ca5(PO4)3F);
−ヒドロキシアパタイト(HA、Ca5(PO4)3OH、同義語;(ペンタ)カルシウムトリホスフェート);
−リン酸モノカルシウム無水物(MCPA、Ca(H2PO4)2);
−リン酸モノカルシウムモノハイドレート(MCPM、Ca(H2PO4)2・H2O);
−リン酸オクタカルシウム(OCP、Ca8H2(PO4)6・5H2O);
−オキシアパタイト(Ca10(PO4)6O);
−リン酸テトラカルシウム(TTCP、Ca4(PO4)2O);
−上記の2以上の混合物、例えばMCPM又はMCPAと他のCaP、例えばリン酸α−トリカルシウム又はリン酸β−トリカルシウム、及び
−上記の2以上の複合物、例えばβ−TCPとヒドロキシアパタイト(Ca/P−1.67)、例えば二相性リン酸カルシウム(BCP)
である。
−グレインサイズ(約10〜20μm×5〜15μmの面積を表す該物質の表面の顕微鏡写真の拡大及び検査に基づく、例えば図6において示されるようなSEM顕微鏡写真において見られるとおり、連続したマトリックスを形成する、最大の個々に認識できる「粒子群」、すなわち該セラミック物質中に埋め込まれ且つ他のグレインとその中で構造的に連結されたようなグレインの少なくとも10の平均直径);
−ミクロ孔サイズ(約10〜20μm×5〜15μmの該物質の表面領域の拡大及び検査に基づき、例えば図7において示されたような、SEM顕微鏡写真において見られるとおりの最大のミクロ孔の少なくとも10の平均直径);
−ミクロ孔の面積百分率(例えば、デジタル画像中における、選ばれた表面領域の画素の総数の百分率としての、ミクロ孔に関する画素数:該物質の断面図におけるミクロ孔の面積百分率);及び
−タンパク質吸着(例えば、25ppmのNaN3における3mlの1%ウシ胎仔血清(FBS)溶液中に浸されたときに、37℃で24時間のインキュベーション後での、多孔性セラミックの1mlの体積により吸収されたタンパク質の量、そして溶液中に残る量から吸収された量を、例えばBCA(商標)Protein Assay Kit(Pierce Biotechnology Inc., Rockford, Il, USA)を用いて決定する)。
それ故に、リン酸トリカルシウムセラミックの骨誘導的特性を改善する為に、焼結温度は、好ましくは1100℃を超えないべきであり、好ましくは約1050〜1075℃であるべきであることが結論付けられる。
Claims (24)
- 0.1〜1.50μmの範囲の平均グレイン(grain)サイズを有し、多孔度が0.1〜1.50μmのサイズ範囲のミクロ孔を含み且つ10〜40%の範囲のミクロ孔の表面積百分率を有する多孔性骨誘導性リン酸カルシウム物質。
- 少なくとも40%のタンパク質吸着能力を有し、ここで該能力は、25ppmのアジ化ナトリウム(NaN3)の存在下におけるウシ胎仔血清(FBS)の1%水溶液の3mlの体積から、該リン酸カルシウムの1mlの体積により37℃で24時間後に吸収されたタンパク質の百分率として表される、請求項1に記載の多孔性リン酸カルシウム。
- 実質的にミクロ孔だけから成る多孔度を有する、請求項1又は2に記載の多孔性リン酸カルシウム。
- 該物質が、約50〜約1500μmの粒子サイズを有する微小粒子の形態である、請求項1〜3のいずれか1項に記載の多孔性リン酸カルシウム。
- 該微小粒子が、約200〜約300μm、好ましくは212〜300μmの粒子サイズを有する、請求項4に記載の多孔性リン酸カルシウム。
- 該リン酸カルシウムが、リン酸オクタカルシウム、アパタイト、例えばヒドロキシアパタイト及びカーボネートアパタイト、ウィットロッカイト、例えばリン酸β−トリカルシウム及びリン酸α−トリカルシウム、及びそれらの組み合わせから成る群から選ばれる、請求項1〜5のいずれか1項に記載の多孔性リン酸カルシウム。
- 該リン酸カルシウムが吸収可能な二相性リン酸カルシウム(BCP)又は吸収可能なリン酸トリカルシウム、好ましくはリン酸β−トリカルシウムである、請求項1〜6のいずれか1項に記載の多孔性リン酸カルシウム。
- 医療的移植物材料又は組織足場として用いる為の、請求項1〜7のいずれか1項に記載の多孔性リン酸カルシウム。
- 生きている生物中の骨組織の形成を誘導する為に、請求項1〜8のいずれか1項に定義された多孔性リン酸カルシウムを使用する方法。
- 非骨部分における自己由来の骨の産生の為に、移植物材料として単独で又は成長因子若しくは/及び細胞と組合せて、請求項1〜8のいずれか1項に定義された多孔性リン酸カルシウムを使用する方法。
- 医療的移植物又は装置の製造の為に、請求項1〜8のいずれか1項に定義された多孔性リン酸カルシウムを単独で又は成長因子若しくは/及び細胞と組合せて使用する方法。
- 歯科の手術における、請求項9〜11のいずれか1項に記載の使用方法。
- 多孔性骨誘導性リン酸カルシウムセラミックを製造する方法であって、水中に、1.0〜8.0μm、好ましくは2.0〜4.0μmの粒子サイズを有するリン酸カルシウム粉、発泡剤及び任意的に孔形成剤の水性スラリーを用意すること;該スラリーの発泡を引き起こす条件に該スラリーを付すること;得られた発泡したスラリーを乾燥し、任意的に孔形成剤を除去して、多孔性の素地を用意すること、及び1050℃〜1150℃の温度で該多孔性の素地を焼結して多孔性の焼結リン酸カルシウムを用意すること;並びに任意的に該焼結リン酸カルシウムを粒子へと粉砕しそして約50〜約1500μmの粒子サイズを有する粒子を集めることを含む、上記方法。
- 該粒子が、212及び300μmのふるいを用いて集められる、請求項13に記載の方法。
- 該リン酸カルシウム粉が、0.01〜1.0μm、好ましくは0.05〜0.50μmの結晶サイズを有する結晶から構成される、請求項13又は14に記載の方法。
- 該発泡剤が過酸化水素である、請求項13〜15のいずれか1項に記載の方法。
- 該孔形成剤がナフタレン粒子を含み、且つ該孔形成剤が80〜110℃で蒸発により除去される、請求項13〜16のいずれか1項に記載の方法。
- 該スラリーの発泡を引き起こす該条件が、約50〜70℃へ該スラリーを加熱することを含む、請求項13〜17のいずれか1項に記載の方法。
- 該スラリーの発泡が多孔性の素地を産生する、請求項13〜18のいずれか1項に記載の方法。
- 該乾燥され且つ発泡されたスラリーが、TCPの場合には1050〜1100℃の温度で焼結され、又はHA及び/若しくはBCPの場合には1100〜1150℃の温度で焼結される、請求項13〜19のいずれか1項に記載の方法。
- 該リン酸カルシウム粉が、TCP又はBCP粉である、請求項13〜20のいずれか1項に記載の方法。
- 該集められた微小粒子が次に、アセトン、エタノール及び/又は水により超音波的に洗浄され、そして任意的に乾燥され及び滅菌される、請求項13〜21のいずれか1項に記載の方法。
- 該リン酸カルシウム粉が、不規則な形を有する、オーブン乾燥され粉砕された粉である、請求項13〜21のいずれか1項に記載の方法。
- 請求項13〜23のいずれか1項に記載の方法により入手可能である多孔性骨誘導性リン酸カルシウム。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77484006P | 2006-02-17 | 2006-02-17 | |
EP06075368.8 | 2006-02-17 | ||
US60/774,840 | 2006-02-17 | ||
EP06075368A EP1829564A1 (en) | 2006-02-17 | 2006-02-17 | Osteoinductive calcium phosphate |
PCT/NL2007/050069 WO2007094672A1 (en) | 2006-02-17 | 2007-02-19 | Osteoinductive calcium phosphates |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009526600A true JP2009526600A (ja) | 2009-07-23 |
JP2009526600A5 JP2009526600A5 (ja) | 2010-01-21 |
JP5201510B2 JP5201510B2 (ja) | 2013-06-05 |
Family
ID=38022844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008555181A Active JP5201510B2 (ja) | 2006-02-17 | 2007-02-19 | 骨誘導性リン酸カルシウム |
Country Status (7)
Country | Link |
---|---|
US (3) | US7942934B2 (ja) |
EP (1) | EP1993624B1 (ja) |
JP (1) | JP5201510B2 (ja) |
KR (1) | KR101391846B1 (ja) |
AU (1) | AU2007215625B2 (ja) |
CA (1) | CA2642830A1 (ja) |
WO (1) | WO2007094672A1 (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110020419A1 (en) * | 2006-02-17 | 2011-01-27 | Huipin Yuan | Osteoinductive calcium phosphates |
JP5201510B2 (ja) * | 2006-02-17 | 2013-06-05 | プロゲンティクス オーソバイオロジー ビー.ブイ. | 骨誘導性リン酸カルシウム |
GB0801935D0 (en) | 2008-02-01 | 2008-03-12 | Apatech Ltd | Porous biomaterial |
AU2010275697B2 (en) | 2009-07-23 | 2014-01-30 | Progentix Orthobiology B.V. | Injectable and moldable osteoinductive ceramic materials |
US20110307074A1 (en) * | 2010-05-24 | 2011-12-15 | University Of The Witwatersrand, Johannesburg | Biomaterials for use in methods of bone replacement therapy |
US20120021008A1 (en) * | 2010-07-23 | 2012-01-26 | Joost Dick De Bruijn | Injectable and moldable ceramic materials |
US9272072B1 (en) | 2012-10-19 | 2016-03-01 | Nuvasive, Inc. | Osteoinductive bone graft substitute |
NL2011195C2 (en) | 2013-07-18 | 2015-01-21 | Xpand Biotechnology B V | Method for producing an osteoinductive calcium phosphate and products thus obtained. |
EP3735204B1 (en) | 2018-01-02 | 2023-09-06 | Cartiheal (2009) Ltd. | Implantation tool for optimized solid substrates promoting cell and tissue growth |
WO2021194477A1 (en) * | 2020-03-24 | 2021-09-30 | Secada Medical, Llc Dba Ventris Medical, Llc | Methods of producing an osteoinductive calcium phosphate material for bone grafting |
US10786597B1 (en) | 2020-03-24 | 2020-09-29 | Secada Medical Llc | Methods of producing an osteoinductive calcium phosphate material for bone grafting |
US11083557B1 (en) | 2020-05-01 | 2021-08-10 | Secada Medical Llc | Bone graft containment system |
NL2027599B1 (en) | 2021-02-19 | 2022-09-19 | Instructure Labs B V | Biocompatible polymeric implant material having a textured surface |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62281953A (ja) * | 1986-05-28 | 1987-12-07 | 旭光学工業株式会社 | 骨補填材 |
JPS63125259A (ja) * | 1986-11-14 | 1988-05-28 | 旭光学工業株式会社 | リン酸カルシウム系多孔質骨補填材 |
JP2000500110A (ja) * | 1995-11-07 | 2000-01-11 | エテックス コーポレイション | 低温リン酸カルシウムアパタイト及びその製造方法 |
JP2000093504A (ja) * | 1998-09-15 | 2000-04-04 | Isotis Bv | 骨誘発生体適合材料 |
WO2004091435A2 (en) * | 2003-04-11 | 2004-10-28 | Etex Corporation | Osteoinductive bone material |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4693986A (en) * | 1985-06-25 | 1987-09-15 | Orthomatrix, Inc. | Ceramic process and products |
JP2572606B2 (ja) * | 1987-09-14 | 1997-01-16 | 旭光学工業株式会社 | 表面多孔質なリン酸カルシウム系セラミックスの製造法 |
JPH04212369A (ja) | 1991-01-04 | 1992-08-03 | Asahi Optical Co Ltd | 骨補填材の製造方法 |
US20020098222A1 (en) * | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
CA2285430C (en) * | 1997-04-01 | 2008-11-18 | Cap Biotechnology, Inc. | Calcium phosphate microcarriers and microspheres |
NL1008582C2 (nl) * | 1998-01-05 | 1999-07-06 | Vrije Universiteit | Botmateriaal. |
WO2001081243A1 (fr) * | 2000-04-26 | 2001-11-01 | Ecole Polytechnique Federale De Lausanne (Epfl) | Microgranules phosphocalciques |
JP4212369B2 (ja) | 2003-01-22 | 2009-01-21 | 中国電力株式会社 | 電力供給サービス方法およびシステム |
TWI230058B (en) * | 2003-08-05 | 2005-04-01 | Univ Nat Taiwan | Hydroxylapatite powder, porous body and method for preparing thereof |
US8029755B2 (en) * | 2003-08-06 | 2011-10-04 | Angstrom Medica | Tricalcium phosphates, their composites, implants incorporating them, and method for their production |
EP1716873A1 (en) * | 2005-04-25 | 2006-11-02 | Progentix B.V. i.o. | Method of improving the osteoinductivity of bioactive materials |
US20060257492A1 (en) * | 2005-05-13 | 2006-11-16 | Depuy Products, Inc. | Suspension of calcium phosphate particulates for local delivery of therapeutic agents |
US7901650B2 (en) * | 2005-06-22 | 2011-03-08 | Skeletal Kinectics, LLC | Porous beta-tricalcium phosphate and methods for producing the same |
US20110020419A1 (en) | 2006-02-17 | 2011-01-27 | Huipin Yuan | Osteoinductive calcium phosphates |
JP5201510B2 (ja) * | 2006-02-17 | 2013-06-05 | プロゲンティクス オーソバイオロジー ビー.ブイ. | 骨誘導性リン酸カルシウム |
EP1829564A1 (en) * | 2006-02-17 | 2007-09-05 | Progentix B.V. i.o. | Osteoinductive calcium phosphate |
-
2007
- 2007-02-19 JP JP2008555181A patent/JP5201510B2/ja active Active
- 2007-02-19 KR KR1020087022635A patent/KR101391846B1/ko active IP Right Grant
- 2007-02-19 EP EP07715889A patent/EP1993624B1/en active Active
- 2007-02-19 CA CA002642830A patent/CA2642830A1/en not_active Abandoned
- 2007-02-19 AU AU2007215625A patent/AU2007215625B2/en active Active
- 2007-02-19 WO PCT/NL2007/050069 patent/WO2007094672A1/en active Application Filing
-
2009
- 2009-10-28 US US12/607,874 patent/US7942934B2/en active Active
-
2015
- 2015-07-06 US US14/792,305 patent/US10532131B2/en active Active
-
2019
- 2019-12-05 US US16/704,580 patent/US11590263B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62281953A (ja) * | 1986-05-28 | 1987-12-07 | 旭光学工業株式会社 | 骨補填材 |
JPS63125259A (ja) * | 1986-11-14 | 1988-05-28 | 旭光学工業株式会社 | リン酸カルシウム系多孔質骨補填材 |
JP2000500110A (ja) * | 1995-11-07 | 2000-01-11 | エテックス コーポレイション | 低温リン酸カルシウムアパタイト及びその製造方法 |
JP2000093504A (ja) * | 1998-09-15 | 2000-04-04 | Isotis Bv | 骨誘発生体適合材料 |
WO2004091435A2 (en) * | 2003-04-11 | 2004-10-28 | Etex Corporation | Osteoinductive bone material |
Also Published As
Publication number | Publication date |
---|---|
CA2642830A1 (en) | 2007-08-23 |
AU2007215625A1 (en) | 2007-08-23 |
KR20090017470A (ko) | 2009-02-18 |
AU2007215625B2 (en) | 2012-06-28 |
EP1993624A1 (en) | 2008-11-26 |
WO2007094672A1 (en) | 2007-08-23 |
EP1993624B1 (en) | 2011-05-04 |
US20100034865A1 (en) | 2010-02-11 |
US20160067382A1 (en) | 2016-03-10 |
KR101391846B1 (ko) | 2014-05-19 |
JP5201510B2 (ja) | 2013-06-05 |
US11590263B2 (en) | 2023-02-28 |
US10532131B2 (en) | 2020-01-14 |
US7942934B2 (en) | 2011-05-17 |
US20200108180A1 (en) | 2020-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11590263B2 (en) | Osteoinductive calcium phosphates | |
US20230158213A1 (en) | Osteoinductive Calcium Phosphates | |
US20110020419A1 (en) | Osteoinductive calcium phosphates | |
AU2004241740B2 (en) | Inorganic resorbable bone substitute material | |
Stastny et al. | Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro | |
JP5759370B2 (ja) | 組織工学および骨の再生のための、構造化された多孔率を有するモネタイトの三次元マトリクス、および、当該三次元マトリクスの調製方法 | |
EP3021878B1 (en) | Method for producing an osteoinductive calcium phosphate and products thus obtained | |
US10583222B2 (en) | Composite biomaterials with improved bioactivity and their use for bone substitute | |
JP2018523632A (ja) | 天然の構造の生物の形態に似せた変換によって得られる活性ハイドロキシアパタイトから作られる大きな三次元多孔性足場材料、およびこれを得るためのプロセス | |
Mao et al. | Preparation and properties of α-calcium sulphate hemihydrate and β-tricalcium phosphate bone substitute | |
KR102636183B1 (ko) | 골 대체 물질의 콜라겐 기질 또는 그래뉼레이트 블렌드 | |
Prince et al. | Yolk-porous shell biphasic bioceramic granules enhancing bone regeneration and repair beyond homogenous hybrid | |
US10195306B2 (en) | Modified ceramics with improved bioactivity and their use for bone substitute | |
Sano et al. | The In Vitro and In Vivo Biodegradable Behavior of Hydroxyapatite Granules in the Presence of Different Crystals | |
Piccinini | Porous calcium phosphate granules for biomedical applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091127 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20091127 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120605 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120830 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120906 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121004 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121012 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121105 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130109 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130201 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5201510 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160222 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |