JP2009525046A - アルファ−シヌクレインキナーゼ - Google Patents
アルファ−シヌクレインキナーゼ Download PDFInfo
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- JP2009525046A JP2009525046A JP2008553336A JP2008553336A JP2009525046A JP 2009525046 A JP2009525046 A JP 2009525046A JP 2008553336 A JP2008553336 A JP 2008553336A JP 2008553336 A JP2008553336 A JP 2008553336A JP 2009525046 A JP2009525046 A JP 2009525046A
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- synuclein
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- plk2
- kinases
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76400006P | 2006-01-31 | 2006-01-31 | |
| PCT/US2007/002685 WO2007089862A2 (en) | 2006-01-31 | 2007-01-30 | Alpha-synuclein kinase |
Publications (2)
| Publication Number | Publication Date |
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| JP2009525046A true JP2009525046A (ja) | 2009-07-09 |
| JP2009525046A5 JP2009525046A5 (enExample) | 2010-04-08 |
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| JP2008553336A Pending JP2009525046A (ja) | 2006-01-31 | 2007-01-30 | アルファ−シヌクレインキナーゼ |
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| US (3) | US7553639B2 (enExample) |
| EP (1) | EP1989330A4 (enExample) |
| JP (1) | JP2009525046A (enExample) |
| CA (1) | CA2641219A1 (enExample) |
| WO (1) | WO2007089862A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007089862A2 (en) | 2006-01-31 | 2007-08-09 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
| WO2009103010A2 (en) * | 2008-02-13 | 2009-08-20 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
| JP5747414B2 (ja) * | 2008-04-29 | 2015-07-15 | バイオアークティック ニューロサイエンス アーベー | α−シヌクレイン関連疾患についての治療および診断方法における使用のための抗体およびワクチン |
| US20100317646A1 (en) * | 2009-03-19 | 2010-12-16 | Medical Research Council Technology | Compounds |
| JP5894939B2 (ja) | 2010-02-26 | 2016-03-30 | バイオアークティック ニューロサイエンス アーベー | プロトフィブリル結合抗体ならびにパーキンソン病、レビー小体型認知症および他のα−シヌクレイノパチーの治療および診断方法におけるこれらの使用 |
| US9458463B2 (en) | 2010-09-03 | 2016-10-04 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for treatment of diabetes by a small molecule inhibitor for GRK5 |
| EP2426202A1 (en) * | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Kinases as targets for anti-diabetic therapy |
| WO2014132249A1 (en) * | 2013-02-26 | 2014-09-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for the assay of synucleins |
| WO2018057782A1 (en) * | 2016-09-23 | 2018-03-29 | University Of Utah Research Foundation | Methods of preventing stem cell differentiation using a pask inhibitor |
| KR102573778B1 (ko) | 2017-02-17 | 2023-08-31 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-시뉴클레인에 대한 항체 및 그의 용도 |
| US20210041461A1 (en) | 2018-03-14 | 2021-02-11 | Yissum Research Developmen Company Of The Hebrew University Of Jerusalem Ltd | Detection of phospho-serine 129 alpha-synuclein in blood cells as a biomarker for synucleinopathies |
| FI4172199T3 (fi) | 2020-06-26 | 2025-08-12 | Bioarctic Ab | Alfa-synukleiinin protofibrilliin sitoutuvat vasta-aineet |
| CN114601928B (zh) * | 2022-04-02 | 2023-03-17 | 首都医科大学 | 一种钙超载介导神经元死亡的标志物及应用 |
| CN115569202A (zh) * | 2022-10-19 | 2023-01-06 | 苏州捷乐思生物科技有限公司 | 一种帕金森综合征动物模型、药物筛选方法及治疗药物 |
Citations (2)
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| WO2001060794A2 (en) * | 2000-02-18 | 2001-08-23 | The Regents Of The University Of California | Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease |
| WO2004069175A2 (en) * | 2003-02-02 | 2004-08-19 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON’S DISEASE AND OTHER α-SYNUCLEINOPATHIES |
Family Cites Families (17)
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|---|---|---|---|---|
| CN1440420A (zh) * | 2000-07-07 | 2003-09-03 | 万能药制药公司 | 预防神经组织损伤和治疗α－共核蛋白疾病的方法 |
| RS95404A (sr) | 2002-05-03 | 2006-10-27 | Schering Aktiengesellschaft | Tiazolidinoni i njihova primena kao inhibitora polo like kinaze |
| US6861422B2 (en) | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE10351744A1 (de) | 2003-10-31 | 2005-06-16 | Schering Ag | Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel |
| US7566548B2 (en) | 2004-08-13 | 2009-07-28 | University Of Massachusetts | Methods for identifying therapeutic agents and for treating disease |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| EP1827473A4 (en) | 2004-12-01 | 2009-08-19 | Whitehead Biomedical Inst | MODULATOR OF ALPHA SYNNUCLEINE TOXICITY |
| JP2008524139A (ja) * | 2004-12-15 | 2008-07-10 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | メタ置換チアゾリノン類、それらの製造及び医薬としての使用 |
| DE102005005395A1 (de) | 2005-02-03 | 2006-08-10 | Schering Aktiengesellschaft | Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel |
| US20070010565A1 (en) | 2005-04-25 | 2007-01-11 | Olaf Prien | New thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents |
| DE102005020104A1 (de) | 2005-04-25 | 2006-10-26 | Schering Ag | Neue Thiazolidinone ohne basischen Stickstoff, deren Herstellung und Verwendung als Arzneimittel |
| EP1888095A4 (en) * | 2005-05-13 | 2009-08-26 | Whitehead Biomedical Inst | MODULATORS OF ALPHA-SYNUCLEIN INDUCED TOXICITY |
| US8017781B2 (en) | 2005-11-15 | 2011-09-13 | Vertex Pharmaceuticals Incorporated | Azaindazoles useful as inhibitors of kinases |
| CN101336244B (zh) | 2005-12-08 | 2011-11-30 | 雅培制药有限公司 | 用作蛋白激酶抑制剂的9元杂二环化合物 |
| TW201307354A (zh) | 2005-12-29 | 2013-02-16 | Abbott Lab | 蛋白質激酶抑制劑 |
| WO2007089862A2 (en) | 2006-01-31 | 2007-08-09 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
| WO2009103010A2 (en) | 2008-02-13 | 2009-08-20 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
-
2007
- 2007-01-30 WO PCT/US2007/002685 patent/WO2007089862A2/en not_active Ceased
- 2007-01-30 EP EP07762749A patent/EP1989330A4/en not_active Withdrawn
- 2007-01-30 US US11/669,093 patent/US7553639B2/en not_active Expired - Fee Related
- 2007-01-30 JP JP2008553336A patent/JP2009525046A/ja active Pending
- 2007-01-30 CA CA002641219A patent/CA2641219A1/en not_active Abandoned
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2008
- 2008-02-13 US US12/030,849 patent/US20080300206A1/en not_active Abandoned
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2010
- 2010-02-08 US US12/702,201 patent/US8148089B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001060794A2 (en) * | 2000-02-18 | 2001-08-23 | The Regents Of The University Of California | Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease |
| WO2004069175A2 (en) * | 2003-02-02 | 2004-08-19 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON’S DISEASE AND OTHER α-SYNUCLEINOPATHIES |
Also Published As
| Publication number | Publication date |
|---|---|
| US8148089B2 (en) | 2012-04-03 |
| US20080160011A1 (en) | 2008-07-03 |
| US20100143946A1 (en) | 2010-06-10 |
| US20080300206A1 (en) | 2008-12-04 |
| EP1989330A2 (en) | 2008-11-12 |
| US7553639B2 (en) | 2009-06-30 |
| CA2641219A1 (en) | 2007-08-09 |
| EP1989330A4 (en) | 2009-10-21 |
| WO2007089862A3 (en) | 2008-12-04 |
| WO2007089862A2 (en) | 2007-08-09 |
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