JP2009524678A - 炎症及び免疫関連用途のためのフェニル及びピリジル化合物 - Google Patents

炎症及び免疫関連用途のためのフェニル及びピリジル化合物 Download PDF

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JP2009524678A
JP2009524678A JP2008552424A JP2008552424A JP2009524678A JP 2009524678 A JP2009524678 A JP 2009524678A JP 2008552424 A JP2008552424 A JP 2008552424A JP 2008552424 A JP2008552424 A JP 2008552424A JP 2009524678 A JP2009524678 A JP 2009524678A
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methyl
phenyl
thiophen
halo
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JP2009524678A5 (enExample
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ジャン，ジュン
チャン，ジュンイ
フウ ボ，ニャ
チェン，ショウジュン
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シンタ ファーマシューティカルズ コーポレーション
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JP2008552424A 2006-01-25 2007-01-25 炎症及び免疫関連用途のためのフェニル及びピリジル化合物 Pending JP2009524678A (ja)

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US76201506P 2006-01-25 2006-01-25
US76193106P 2006-01-25 2006-01-25
PCT/US2007/002129 WO2007087429A2 (en) 2006-01-25 2007-01-25 Phenyl and pyridyl compounds for inflammation and immune-related uses

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532380A (ja) * 2007-06-29 2010-10-07 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用な化合物
JP2010535214A (ja) * 2007-08-01 2010-11-18 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途のための複素環−アリール化合物

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Publication number Priority date Publication date Assignee Title
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
WO2007087427A2 (en) * 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Thiazole and thiadiazole compounds for inflammation and immune-related uses
EP1984337B1 (en) * 2006-01-25 2014-04-30 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
TW200806641A (en) * 2006-01-25 2008-02-01 Synta Pharmaceuticals Corp Substituted aromatic compounds for inflammation and immune-related uses
EP1998612A4 (en) * 2006-01-25 2010-11-24 Synta Pharmaceuticals Corp SUBSTITUTED BIARYL COMPOUNDS FOR USE AGAINST INFLAMMATION AND IMMUNE DISORDERS
US8119643B2 (en) * 2006-03-20 2012-02-21 Synta Pharmaceuticals Corp. Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses
WO2008024390A2 (en) 2006-08-24 2008-02-28 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders
US8236835B2 (en) 2006-09-22 2012-08-07 Novartis Ag Heterocyclic inhibitors of stearoyl-CoA desaturase
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
JP2010513403A (ja) 2006-12-20 2010-04-30 ノバルティス アーゲー Ｓｃｄ阻害剤としての２−置換５員ヘテロ環
US8263641B2 (en) 2007-09-10 2012-09-11 Calcimedica, Inc. Compounds that modulate intracellular calcium
US8389567B2 (en) 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
MX2011000150A (es) 2008-06-30 2011-04-05 Cylene Pharmaceuticals Inc Compuestos de oxoindol.
CA2734500A1 (en) 2008-08-27 2010-03-11 Calcimedica Inc. Compounds that modulate intracellular calcium
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
AU2009300317A1 (en) * 2008-10-01 2010-04-08 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
WO2011034962A2 (en) 2009-09-16 2011-03-24 Calcimedica Inc. Compounds that modulate intracellular calcium
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
CA2779948A1 (en) 2009-11-05 2011-05-12 Piramal Life Sciences Limited Carboxy oxazole or thiazole compounds as dgat-1 inhibitors useful for the treatment of obesity
HUE029570T2 (en) 2010-04-27 2017-03-28 Calcimedica Inc Intracellular calcium modifying compounds
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
US8754219B2 (en) 2010-04-27 2014-06-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN114591311A (zh) 2010-08-27 2022-06-07 钙医学公司 调节细胞内钙的化合物
EP2632906B1 (en) 2010-10-30 2016-04-06 Lupin Limited Oxazoline and isoxazoline derivatives as crac modulators
US20140051661A1 (en) * 2011-02-16 2014-02-20 The Texas A&M University System Novel lipogenic inhibitors and uses thereof
WO2012170931A2 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9399638B2 (en) 2012-05-02 2016-07-26 Lupin Limited Substituted pyridine compounds as CRAC modulators
AU2013255441B2 (en) 2012-05-02 2017-11-09 Lupin Limited Substituted pyrazole compounds as CRAC modulators
JP6225178B2 (ja) 2012-05-31 2017-11-01 フェネックス ファーマシューティカルス アーゲー オーファン核内受容体ＲＯＲγの調整剤としてのカルボキサミドまたはスルホンアミド置換されたチアゾールおよび関連する誘導体
WO2014043715A1 (en) * 2012-09-17 2014-03-20 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP3010586A1 (en) 2013-06-21 2016-04-27 Lupin Limited Substituted heterocyclic compounds as crac modulators
US9790231B2 (en) 2013-06-24 2017-10-17 Lupin Limited Chromane and chromene derivatives and their use as CRAC modulators
US20170114060A1 (en) * 2014-06-03 2017-04-27 The Trustees Of The University Of Pennsylvania Novel effective antiviral compounds and methods using same
KR20250004174A (ko) 2014-06-27 2025-01-07 노그라 파마 리미티드 아릴 수용체 조정제, 및 그의 제조 및 사용 방법
CN114712513A (zh) 2015-02-27 2022-07-08 钙医学公司 胰腺炎治疗
CA2995094A1 (en) 2015-08-07 2017-02-16 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
CN108774220B (zh) * 2018-05-27 2019-04-23 西安培华学院 用于治疗心肌缺血的化合物及其应用
BR112021004893A2 (pt) 2018-09-14 2021-06-01 Rhizen Pharmaceuticals A G composições compreendendo um inibidor de crac e um corticosteroide e métodos de uso dos mesmos
AU2021207804A1 (en) 2020-01-13 2022-09-01 Verge Analytics, Inc. Substituted pyrazolo-pyrimidines and uses thereof
CN118084860A (zh) * 2024-02-06 2024-05-28 中国药科大学 芳酰胺类化合物及其药物组合物和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064558A2 (en) * 2001-02-14 2002-08-22 Sankyo Company, Limited Oxazole derivatives, their preparation and their use as cytokine inhibitors
JP2002528533A (ja) * 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー 酵素ｉｍｐｄｈの新規なインヒビター
WO2003051876A1 (en) * 2001-12-14 2003-06-26 Japan Tobacco Inc. Pyrazolopyridine derivatives and medicinal use thereof
WO2005032493A2 (en) * 2003-10-07 2005-04-14 Renovis, Inc. Amide compounds as ion channel ligands and uses thereof
WO2005111033A2 (en) * 2004-05-19 2005-11-24 Neurosearch A/S Novel azabicyclic aryl derivatives
JP2005539005A (ja) * 2002-08-05 2005-12-22 オックスフォード グリコサイエンシィズ（ユーケイ）リミテッド ヘパラナーゼ阻害物質としてのフランチアゾール誘導体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852503A (en) * 1953-12-31 1958-09-16 American Cyanamid Co 2, 5-bis (p-aminophenyl) furan azo derivatives
CH484918A (de) * 1965-10-28 1970-01-31 Ciba Geigy Verfahren zur Herstellung heterocyclischer, Aethylendoppelbindungen enthaltender Verbindungen
DE3021599A1 (de) * 1980-06-09 1981-12-24 Hoechst Ag, 6000 Frankfurt 2-(halogenmethyl-phenyl)-4-halogenoxazol-derivate, ein verfahren zu ihrer herstellung und sie enthaltende strahlungsempfindliche massen
US6420403B1 (en) * 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
US7420055B2 (en) * 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US20060111351A1 (en) * 2002-11-18 2006-05-25 Solomon Ungashe Aryl sulfonamides
EP2256116A3 (en) * 2002-11-18 2011-11-16 ChemoCentryx, Inc. Aryl sulfonamides
DE602004030689D1 (de) * 2003-07-23 2011-02-03 Synta Pharmaceuticals Corp Verbindungen gegen entzündungen und immun-relevante verwendungen
US6984652B2 (en) * 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
EP1998612A4 (en) * 2006-01-25 2010-11-24 Synta Pharmaceuticals Corp SUBSTITUTED BIARYL COMPOUNDS FOR USE AGAINST INFLAMMATION AND IMMUNE DISORDERS
TW200806641A (en) * 2006-01-25 2008-02-01 Synta Pharmaceuticals Corp Substituted aromatic compounds for inflammation and immune-related uses
WO2007087427A2 (en) * 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Thiazole and thiadiazole compounds for inflammation and immune-related uses
EP1984337B1 (en) * 2006-01-25 2014-04-30 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002528533A (ja) * 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー 酵素ｉｍｐｄｈの新規なインヒビター
WO2002064558A2 (en) * 2001-02-14 2002-08-22 Sankyo Company, Limited Oxazole derivatives, their preparation and their use as cytokine inhibitors
WO2003051876A1 (en) * 2001-12-14 2003-06-26 Japan Tobacco Inc. Pyrazolopyridine derivatives and medicinal use thereof
JP2005539005A (ja) * 2002-08-05 2005-12-22 オックスフォード グリコサイエンシィズ（ユーケイ）リミテッド ヘパラナーゼ阻害物質としてのフランチアゾール誘導体
WO2005032493A2 (en) * 2003-10-07 2005-04-14 Renovis, Inc. Amide compounds as ion channel ligands and uses thereof
WO2005111033A2 (en) * 2004-05-19 2005-11-24 Neurosearch A/S Novel azabicyclic aryl derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010532380A (ja) * 2007-06-29 2010-10-07 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用な化合物
JP2010535214A (ja) * 2007-08-01 2010-11-18 シンタ ファーマシューティカルズ コーポレーション 炎症および免疫関連用途のための複素環−アリール化合物

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