JP2009524051A5 - - Google Patents
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- Publication number
- JP2009524051A5 JP2009524051A5 JP2008551261A JP2008551261A JP2009524051A5 JP 2009524051 A5 JP2009524051 A5 JP 2009524051A5 JP 2008551261 A JP2008551261 A JP 2008551261A JP 2008551261 A JP2008551261 A JP 2008551261A JP 2009524051 A5 JP2009524051 A5 JP 2009524051A5
- Authority
- JP
- Japan
- Prior art keywords
- hoxa5
- calm
- test compound
- leukemia
- dot1l
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76070906P | 2006-01-20 | 2006-01-20 | |
| US60/760,709 | 2006-01-20 | ||
| PCT/US2006/046612 WO2007087015A1 (en) | 2006-01-20 | 2006-12-06 | Diagnostic and therapeutic targets for leukemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009524051A JP2009524051A (ja) | 2009-06-25 |
| JP2009524051A5 true JP2009524051A5 (https=) | 2010-01-28 |
| JP5167149B2 JP5167149B2 (ja) | 2013-03-21 |
Family
ID=38309541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551261A Expired - Fee Related JP5167149B2 (ja) | 2006-01-20 | 2006-12-06 | 白血病の診断および治療ターゲット |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8524467B2 (https=) |
| EP (2) | EP1974055A4 (https=) |
| JP (1) | JP5167149B2 (https=) |
| AU (1) | AU2006336552B2 (https=) |
| CA (1) | CA2623271A1 (https=) |
| WO (1) | WO2007087015A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130102477A1 (en) | 2010-06-23 | 2013-04-25 | Ryan D. Morin | Biomarkers for non-hodgkin lymphomas and uses thereof |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| BR112013005806B1 (pt) | 2010-09-10 | 2022-05-10 | Epizyme, Inc | Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2 |
| TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3363B1 (ar) | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| PT3184523T (pt) | 2012-04-13 | 2019-09-26 | Eisai R&D Man Co Ltd | Bromidrato de n-((4,6-dimetil-2-oxo-l,2-di-hidropiridin- 3-il)metil)-5-(etil(tetra-hidro-2h-piran-4-il)amino)-4- metil-4¿-(morfolinometil)-[l,1¿-bofenil]-3-carboxamida para utilização no tratamento de uma doença proliferativa celular do sistema hematológico |
| MX2015004721A (es) | 2012-10-15 | 2016-01-25 | Epizyme Inc | Compuestos de benceno sustituidos. |
| CA2920252A1 (en) * | 2013-08-02 | 2015-02-05 | Memorial Sloan-Kettering Cancer Center | Methods for the detection and treatment of leukemias that are responsive to dot1l inhibition |
| MA38949A1 (fr) | 2013-10-16 | 2017-07-31 | Eisai R&D Man Co Ltd | Forme saline d'hydrochlorure pour inhibition d'ezh2 |
| WO2020150326A1 (en) * | 2019-01-15 | 2020-07-23 | Ptc Therapeutics, Inc. | Method for treating an acute myeloid leukemia |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420328A (en) | 1992-09-11 | 1995-05-30 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5525734A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies N.V. | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5817751A (en) | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
| US6251594B1 (en) * | 1997-06-09 | 2001-06-26 | Usc/Norris Comprehensive Cancer Ctr. | Cancer diagnostic method based upon DNA methylation differences |
| US6555329B2 (en) * | 2000-06-09 | 2003-04-29 | Boehringer Ingelheim International Gmbh | Method for identifying compounds altering higher-order chromatin-dependent chromosome stability |
| AU2002329784A1 (en) | 2001-08-17 | 2003-03-03 | Incyte Genomics, Inc. | Molecules for disease detection and treatment |
| US7485414B2 (en) * | 2002-08-30 | 2009-02-03 | Rigel Pharmaceuticals, Inc. | Modulators of angiogenesis |
| US7442685B2 (en) | 2003-06-13 | 2008-10-28 | The University Of North Carolina At Chapel Hill | DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
| DE602004023766D1 (de) | 2004-08-31 | 2009-12-03 | Univ North Carolina | Dot1-histon-methyltransferasen als ziel zur identifizierung von therapeutika gegen leukämie |
-
2006
- 2006-12-06 JP JP2008551261A patent/JP5167149B2/ja not_active Expired - Fee Related
- 2006-12-06 AU AU2006336552A patent/AU2006336552B2/en not_active Ceased
- 2006-12-06 WO PCT/US2006/046612 patent/WO2007087015A1/en not_active Ceased
- 2006-12-06 EP EP06839119A patent/EP1974055A4/en not_active Withdrawn
- 2006-12-06 CA CA002623271A patent/CA2623271A1/en not_active Abandoned
- 2006-12-06 US US12/161,482 patent/US8524467B2/en not_active Expired - Fee Related
- 2006-12-06 EP EP13177872.2A patent/EP2730661A1/en not_active Withdrawn
-
2013
- 2013-07-29 US US13/953,190 patent/US20140044740A1/en not_active Abandoned
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