JP2009522246A5 - - Google Patents
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- Publication number
- JP2009522246A5 JP2009522246A5 JP2008548055A JP2008548055A JP2009522246A5 JP 2009522246 A5 JP2009522246 A5 JP 2009522246A5 JP 2008548055 A JP2008548055 A JP 2008548055A JP 2008548055 A JP2008548055 A JP 2008548055A JP 2009522246 A5 JP2009522246 A5 JP 2009522246A5
- Authority
- JP
- Japan
- Prior art keywords
- derivatives
- receptor antagonists
- muscarinic receptor
- discloses
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000014415 Muscarinic acetylcholine receptor family Human genes 0.000 description 9
- 108050003473 Muscarinic acetylcholine receptor family Proteins 0.000 description 9
- 239000002464 receptor antagonist Substances 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000002194 synthesizing Effects 0.000 description 3
- XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical compound C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 description 2
- 230000001022 anti-muscarinic Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- -1 cyclohexylmethyl piperidinylmethyl Chemical group 0.000 description 2
- 102000016979 Other receptors Human genes 0.000 description 1
- 230000003042 antagnostic Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 229960005434 oxybutynin Drugs 0.000 description 1
- 150000003235 pyrrolidines Chemical class 0.000 description 1
- 229960004045 tolterodine Drugs 0.000 description 1
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
- 125000001834 xanthenyl group Chemical class C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Description
ＷＯ０４／００５２５２は、ムスカリン性レセプターアンタゴニストとして記述されるアザビシクロ誘導体を開示している。ＷＯ０４／００４６２９、ＷＯ０４／０５２８５７、ＷＯ０４／０６７５１０、ＷＯ０４／０１４８５３、ＷＯ０４／０１４３６３は、有用なムスカリン性レセプターアンタゴニストとして記述される、３，６−二置換アザビシクロ［３．１．０］ヘキサン誘導体を開示している。ＷＯ０４／０５６８１１は、ムスカリン性レセプターアンタゴニストとして、フラキサバート誘導体を開示している。ＷＯ０４／０５６８１０は、ムスカリン性レセプターアンタゴニストとしてキサンテン誘導体を開示している。ＷＯ０４／０５６７６７は、ムスカリン性レセプターアンタゴニストとして、１−置換−３−ピロリジン誘導体を開示している。ＷＯ９９／１４２００、ＷＯ０３／０２７０６０、米国特許第６，２００，９９１号およびＷＯ００／５６７１８は、ムスカリン性レセプターアンタゴニストとして、複素環誘導体を開示している。ＷＯ０４／０８９３６３、ＷＯ０４／０８９８９８、ＷＯ０４／０６９８３５号、ＷＯ０４／０８９９００およびＷＯ０４／０８９３６４号は、ムスカリン性レセプターアンタゴニストとして、置換アザビシクロヘキサン誘導体を開示している。ＷＯ０６／０１８７０８、ムスカリン性レセプターアンタゴニストとしてピロリジン誘導体を開示している。ＷＯ０６／３５３０３号は、ムスカリン性レセプターアンタゴニストとしてアザビシクロ誘導体を開示している。Ｊ．Ｍｅｄ．Ｃｈｅｍ．，４４．ｐ．９８４（２００２）は、他のレセプターサブタイプに対して区別される選択的Ｍ3アンタゴニストとして、シクロヘキシルメチルピペリジニル−トリフェニルプロピオンアミド誘導体を記述している。Ｊ．Ｍｅｄ．Ｃｈｅｍ．，３６，ｐ．６１０（１９９３）は、ある１−シクロアルキル−１−ヒドロキシ−１−フェニル−３−（４−置換−ピペラジニル）−２−プロピオン酸塩および関連化合物の合成および抗ムスカリン活性を記述している。Ｊ．Ｍｅｄ．Ｃｈｅｍ．，３４，ｐ．３０６５（１９９１）は、オキシブチニンの類似体、ある置換７−アミノ−１−ヒドロキシ−５−ヘプチン−２−オンおよび関連化合物の合成および抗ムスカリン活性を記述している。Ｂｉｏ−Ｏｒｇ．Ｍｅｄ．Ｃｈｅｍ．Ｌｅｔｔ．，１５，ｐ．２０９３（２００５）は、オキシブチニンおよびトルテロジンの類似体の合成および活性を記述している。Ｃｈｅｍ．Ｐｈａｒｍ．Ｂｕｌｌ．，５３（４），４３７，２００５は、チアゾールカルボキシアミド誘導体を開示している。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3521DE2005 | 2005-12-30 | ||
| IN1557DE2006 | 2006-07-03 | ||
| PCT/IB2006/055010 WO2007077510A2 (en) | 2005-12-30 | 2006-12-21 | Muscarinic receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009522246A JP2009522246A (ja) | 2009-06-11 |
| JP2009522246A5 true JP2009522246A5 (ja) | 2010-01-14 |
Family
ID=38038504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548055A Pending JP2009522246A (ja) | 2005-12-30 | 2006-12-21 | ムスカリン性レセプターアンタゴニスト |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100222393A1 (ja) |
| EP (1) | EP1968945A2 (ja) |
| JP (1) | JP2009522246A (ja) |
| KR (1) | KR20080089461A (ja) |
| AP (1) | AP2008004537A0 (ja) |
| AU (1) | AU2006334107A1 (ja) |
| BR (1) | BRPI0620844A2 (ja) |
| CA (1) | CA2635335A1 (ja) |
| EA (1) | EA200801591A1 (ja) |
| WO (1) | WO2007077510A2 (ja) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6471115B1 (en) | 1990-02-19 | 2002-10-29 | Hitachi, Ltd. | Process for manufacturing electronic circuit devices |
| US6227436B1 (en) | 1990-02-19 | 2001-05-08 | Hitachi, Ltd. | Method of fabricating an electronic circuit device and apparatus for performing the method |
| EP2111861A1 (en) * | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
| PT2417106T (pt) | 2009-04-09 | 2017-02-13 | Novartis Ag | Processo para preparação de sais de pirrolidínio |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2953565A (en) * | 1956-12-13 | 1960-09-20 | Sahyun Melville | Pyrimidyl, imidazolyl and diazepinyl acetals and glycolates |
| DK534178A (da) * | 1977-12-16 | 1979-06-17 | Interx Research Corp | Anticholinerge midler med sektrtionshaemmende virkning |
| JPS55100338A (en) * | 1979-01-23 | 1980-07-31 | Sumitomo Chem Co Ltd | New carboxylic acid ester, their preparation and insecticide and miticide containing the same |
| EP0117462A3 (en) * | 1983-02-28 | 1986-08-20 | American Cyanamid Company | N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides |
| NL8301550A (nl) * | 1983-05-03 | 1984-12-03 | Gist Brocades Nv | Imidazolethanol esters. |
| DE4314407A1 (de) * | 1993-05-03 | 1994-11-10 | Zuckerindustrie Verein | 3-(Aminoacyl-amino)-saccharide und Verfahren zu ihrer Herstellung |
| AUPN862996A0 (en) * | 1996-03-13 | 1996-04-04 | Fujisawa Pharmaceutical Co., Ltd. | A novel substituted-acetamide compound |
| US6011155A (en) * | 1996-11-07 | 2000-01-04 | Novartis Ag | N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
| CN1270582A (zh) | 1997-09-18 | 2000-10-18 | 三菱东京制药株式会社 | 咪唑啉化合物 |
| FR2771093B1 (fr) | 1997-11-19 | 2000-01-21 | Synthelabo | Derives d'imidazole, leur preparation et leur application en therapeutique |
| JP2003286266A (ja) | 1999-03-24 | 2003-10-10 | Mitsubishi-Tokyo Pharmaceuticals Inc | イミダゾール化合物 |
| EP1294699B1 (en) * | 2000-05-12 | 2016-04-13 | Genzyme Corporation | Modulators of tnf- alpha signalling |
| WO2002004402A1 (fr) * | 2000-07-11 | 2002-01-17 | Banyu Pharmaceutical Co., Ltd. | Derives d'ester |
| MY129677A (en) * | 2000-09-20 | 2007-04-30 | Schering Corp | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
| MXPA03007699A (es) * | 2001-02-28 | 2004-03-16 | Melacure Therapeutics Ab | Esteres de diaminoquinazolina para utilizarse como inhibidores de dihidrofolato reductasa. |
| ATE381539T1 (de) * | 2001-06-20 | 2008-01-15 | Merck & Co Inc | Dipeptidylpeptidase-hemmer zur behandlung von diabetes |
| UA74912C2 (en) * | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| JPWO2003027060A1 (ja) | 2001-09-20 | 2005-05-12 | 杏林製薬株式会社 | ジフェニルブタンアミド誘導体 |
| CA2492121A1 (en) | 2002-07-08 | 2004-01-15 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| AU2002368152A1 (en) | 2002-07-31 | 2004-02-25 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo (3.1.0)hexane derivatives useful as muscarinic receptor antagonists |
| US6875774B2 (en) * | 2002-08-06 | 2005-04-05 | The University Of North Carolina | Aza-bridged bicyclic amine derivatives for use as novel cholinergic receptor ligands |
| EP1545508A4 (en) | 2002-08-09 | 2009-11-25 | Ranbaxy Lab Ltd | 3,6-DISUBSTITUTED AZABICYCLO ¬3.1.0 HEXANE DERIVATIVES AS USEFUL AS MUSCARINIC RECEPTOR AGONISTS |
| ATE423769T1 (de) * | 2002-08-23 | 2009-03-15 | Ranbaxy Lab Ltd | Fluor- und sulfonylaminohaltige, 3,6- disubstituierte azabicyclo 3.1.0 hexanderivate als muscarinrezeptorantagonisten |
| EP2177511A2 (en) | 2002-12-10 | 2010-04-21 | Ranbaxy Laboratories Limited | Process for preparing 3,6-disubstituted azabicyclo derivatives |
| EP1581522B1 (en) | 2002-12-23 | 2008-02-20 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
| US7465751B2 (en) | 2002-12-23 | 2008-12-16 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| AU2002356369A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | Xanthine derivatives as muscarinic receptor antagonists |
| US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| US20070010568A1 (en) | 2003-02-07 | 2007-01-11 | Anita Mehta | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| CA2515717A1 (en) * | 2003-02-10 | 2004-08-19 | Banyu Pharmaceutical Co., Ltd. | Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient |
| US7517905B2 (en) | 2003-04-09 | 2009-04-14 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| AU2003214535B2 (en) | 2003-04-10 | 2009-09-03 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| JP2006522787A (ja) * | 2003-04-11 | 2006-10-05 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体 |
| UA87854C2 (en) * | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| US20080262075A1 (en) | 2004-08-19 | 2008-10-23 | Ranbaxy Laboratories Limited | Pyrrolidine Derivatives as Muscarinic Receptor Antagonists |
| US20090105221A1 (en) | 2004-09-29 | 2009-04-23 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
-
2006
- 2006-12-21 AP AP2008004537A patent/AP2008004537A0/xx unknown
- 2006-12-21 EA EA200801591A patent/EA200801591A1/ru unknown
- 2006-12-21 AU AU2006334107A patent/AU2006334107A1/en not_active Abandoned
- 2006-12-21 KR KR1020087018663A patent/KR20080089461A/ko not_active Application Discontinuation
- 2006-12-21 BR BRPI0620844-4A patent/BRPI0620844A2/pt not_active IP Right Cessation
- 2006-12-21 EP EP06842663A patent/EP1968945A2/en not_active Withdrawn
- 2006-12-21 US US12/159,505 patent/US20100222393A1/en not_active Abandoned
- 2006-12-21 JP JP2008548055A patent/JP2009522246A/ja active Pending
- 2006-12-21 CA CA002635335A patent/CA2635335A1/en not_active Abandoned
- 2006-12-21 WO PCT/IB2006/055010 patent/WO2007077510A2/en active Application Filing
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