JP2009520010A5 - - Google Patents
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- Publication number
- JP2009520010A5 JP2009520010A5 JP2008546592A JP2008546592A JP2009520010A5 JP 2009520010 A5 JP2009520010 A5 JP 2009520010A5 JP 2008546592 A JP2008546592 A JP 2008546592A JP 2008546592 A JP2008546592 A JP 2008546592A JP 2009520010 A5 JP2009520010 A5 JP 2009520010A5
- Authority
- JP
- Japan
- Prior art keywords
- diisopropyl
- compound
- use according
- pain
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000005062 synaptic transmission Effects 0.000 claims 3
- QNJVELOLCDKQBN-UHFFFAOYSA-N 4-bromo-2,6-di(propan-2-yl)phenol Chemical compound CC(C)C1=CC(Br)=CC(C(C)C)=C1O QNJVELOLCDKQBN-UHFFFAOYSA-N 0.000 claims 2
- JMJHJCFWTNRPEI-UHFFFAOYSA-N 4-iodopropofol Chemical compound CC(C)C1=CC(I)=CC(C(C)C)=C1O JMJHJCFWTNRPEI-UHFFFAOYSA-N 0.000 claims 2
- 239000004471 Glycine Substances 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- YYVIACQIJLPZFT-UHFFFAOYSA-N 4-bromo-3,5-di(propan-2-yl)phenol Chemical compound CC(C)C1=CC(O)=CC(C(C)C)=C1Br YYVIACQIJLPZFT-UHFFFAOYSA-N 0.000 claims 1
- ZRTAKZQCHCQFAB-UHFFFAOYSA-N 4-chloro-2,6-di(propan-2-yl)phenol Chemical compound CC(C)C1=CC(Cl)=CC(C(C)C)=C1O ZRTAKZQCHCQFAB-UHFFFAOYSA-N 0.000 claims 1
- BAHYFNRLSGHTRP-UHFFFAOYSA-N 4-fluoro-2,6-di(propan-2-yl)phenol Chemical compound CC(C)C1=CC(F)=CC(C(C)C)=C1O BAHYFNRLSGHTRP-UHFFFAOYSA-N 0.000 claims 1
- VJUMNSVYUGRAEN-UHFFFAOYSA-N 4-fluoro-3,5-di(propan-2-yl)phenol Chemical compound CC(C)C1=CC(O)=CC(C(C)C)=C1F VJUMNSVYUGRAEN-UHFFFAOYSA-N 0.000 claims 1
- ZUAUTJASOBMZKX-UHFFFAOYSA-N 4-iodo-3,5-di(propan-2-yl)phenol Chemical compound CC(C)C1=CC(O)=CC(C(C)C)=C1I ZUAUTJASOBMZKX-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75155905P | 2005-12-19 | 2005-12-19 | |
| US60/751,559 | 2005-12-19 | ||
| US79627006P | 2006-04-27 | 2006-04-27 | |
| US60/796,270 | 2006-04-27 | ||
| PCT/GB2006/004762 WO2007071967A2 (en) | 2005-12-19 | 2006-12-19 | Substituted phenol derivatives as analgesics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009520010A JP2009520010A (ja) | 2009-05-21 |
| JP2009520010A5 true JP2009520010A5 (https=) | 2010-02-12 |
| JP5537033B2 JP5537033B2 (ja) | 2014-07-02 |
Family
ID=37909696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546592A Expired - Fee Related JP5537033B2 (ja) | 2005-12-19 | 2006-12-19 | 無痛覚 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20070142477A1 (https=) |
| EP (1) | EP1965780B1 (https=) |
| JP (1) | JP5537033B2 (https=) |
| AU (1) | AU2006328198B2 (https=) |
| CA (1) | CA2632561C (https=) |
| WO (1) | WO2007071967A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1965780B1 (en) * | 2005-12-19 | 2017-03-08 | The University Of Liverpool | Propofol derivatives as analgesics |
| BRPI0811220A2 (pt) | 2007-05-09 | 2014-10-29 | Pharmacofore Inc | Compostos terapêuticos |
| MX2009012125A (es) * | 2007-05-09 | 2010-02-18 | Pharmacofore Inc | Compuestos terapeuticos. |
| GB0822486D0 (en) * | 2008-12-10 | 2009-01-14 | Univ Liverpool | Compounds for use in the treatment of pain |
| US20130005718A1 (en) * | 2009-08-11 | 2013-01-03 | Tibbs Gareth R | Compositions and methods of treating chronic pain by administering propofol derivatives |
| CN103896743B (zh) * | 2012-12-28 | 2017-04-05 | 四川海思科制药有限公司 | 一种2，6‑二异丙基‑4‑氟苯酚的制备方法 |
| GB201322905D0 (en) | 2013-12-23 | 2014-02-12 | Univ Liverpool | Pharmacologically active compounds |
| US10449198B2 (en) | 2016-07-01 | 2019-10-22 | The University Of Liverpool | Method for treating pain |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2087019B1 (es) * | 1994-02-08 | 1997-03-16 | Bobel246 S L | Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. |
| US6518315B1 (en) * | 1997-10-21 | 2003-02-11 | The University Of Sydney | Medicinal uses of phenylaikanols and derivatives |
| US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| WO2000054588A1 (en) * | 1999-03-15 | 2000-09-21 | John Claude Krusz | Treatment of acute headaches and chronic pain using rapidly-cleared anesthetic drug at sub-anesthetic dosages |
| MXPA03004862A (es) * | 2000-12-04 | 2005-02-14 | Hoffmann La Roche | Derivados de feniletenilo o feniletinilo como antagonistas del receptor de glutamato. |
| JP4334229B2 (ja) * | 2001-03-20 | 2009-09-30 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | プロポフォール及びスルホアルキルエーテルシクロデキストリン含有製剤 |
| US20040038874A1 (en) * | 2002-08-22 | 2004-02-26 | Osemwota Omoigui | Method of treatment of persistent pain |
| US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
| US7261882B2 (en) * | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| WO2005033279A2 (en) * | 2003-09-29 | 2005-04-14 | University Of Virginia Patent Foundation | Discovery of novel soluble crystalline anesthetics |
| DE102005033496A1 (de) * | 2005-07-19 | 2007-01-25 | Bayer Healthcare Ag | Desinfektionsmittel |
| EP1965780B1 (en) * | 2005-12-19 | 2017-03-08 | The University Of Liverpool | Propofol derivatives as analgesics |
-
2006
- 2006-12-19 EP EP06842182.5A patent/EP1965780B1/en not_active Not-in-force
- 2006-12-19 AU AU2006328198A patent/AU2006328198B2/en not_active Ceased
- 2006-12-19 JP JP2008546592A patent/JP5537033B2/ja not_active Expired - Fee Related
- 2006-12-19 CA CA2632561A patent/CA2632561C/en not_active Expired - Fee Related
- 2006-12-19 US US11/612,623 patent/US20070142477A1/en not_active Abandoned
- 2006-12-19 WO PCT/GB2006/004762 patent/WO2007071967A2/en not_active Ceased
-
2015
- 2015-11-24 US US14/951,003 patent/US20160095823A1/en not_active Abandoned
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