JP2005525390A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005525390A5 JP2005525390A5 JP2003579828A JP2003579828A JP2005525390A5 JP 2005525390 A5 JP2005525390 A5 JP 2005525390A5 JP 2003579828 A JP2003579828 A JP 2003579828A JP 2003579828 A JP2003579828 A JP 2003579828A JP 2005525390 A5 JP2005525390 A5 JP 2005525390A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- amino group
- protected amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207449.0A GB0207449D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| PCT/EP2003/003339 WO2003082291A1 (en) | 2002-03-28 | 2003-03-27 | N-{´ (2s) -4- (3, 4-difluorobenzyl) morpholin-2yl!methyl} -2-{3-' (methylsulphonyl) amino! phenyl}acetamide as ccr3 antagonist for the treatment of inflammatory conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005525390A JP2005525390A (ja) | 2005-08-25 |
| JP2005525390A5 true JP2005525390A5 (https=) | 2006-05-18 |
| JP4490110B2 JP4490110B2 (ja) | 2010-06-23 |
Family
ID=9933998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003579828A Expired - Lifetime JP4490110B2 (ja) | 2002-03-28 | 2003-03-27 | 炎症性症状の治療のためのｃｃｒ３拮抗薬としての、ｎ−｛［（２ｓ）−４−（３，４−ジフルオロベンジル）モルホリン−２−イル］メチル｝−２−｛３−［（メチルスルホニル）アミノ］フェニル｝アセトアミド |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20060058299A1 (https=) |
| EP (1) | EP1487453B1 (https=) |
| JP (1) | JP4490110B2 (https=) |
| KR (1) | KR20040095347A (https=) |
| CN (1) | CN1642553A (https=) |
| AR (1) | AR039177A1 (https=) |
| AT (1) | ATE454892T1 (https=) |
| AU (1) | AU2003216905A1 (https=) |
| BR (1) | BR0308719A (https=) |
| CA (1) | CA2479910A1 (https=) |
| DE (1) | DE60330952D1 (https=) |
| ES (1) | ES2339436T3 (https=) |
| GB (1) | GB0207449D0 (https=) |
| IL (1) | IL163648A0 (https=) |
| IS (1) | IS7415A (https=) |
| MX (1) | MXPA04009458A (https=) |
| NO (1) | NO20044098L (https=) |
| PL (1) | PL372930A1 (https=) |
| RU (1) | RU2004126145A (https=) |
| TW (1) | TW200400823A (https=) |
| WO (1) | WO2003082291A1 (https=) |
| ZA (1) | ZA200406990B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004028530A1 (en) | 2002-09-26 | 2004-04-08 | Bristol-Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| WO2007011292A1 (en) * | 2005-07-21 | 2007-01-25 | Astrazeneca Ab | N-benzyl-morpholine derivatives as modulators of the chemokine receptor |
| HUP0500886A2 (en) * | 2005-09-23 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use |
| HUP0500877A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
| BRPI0616150A2 (pt) * | 2005-09-22 | 2011-06-07 | Sanofi Aventis | derivados de amino-alquil-amida como lìquidos receptores de ccr3 |
| HUP0800478A2 (en) * | 2008-07-31 | 2010-03-01 | Sanofi Aventis | Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands |
| EP2785338A1 (en) * | 2011-12-01 | 2014-10-08 | Glaxo Group Limited | Methods of treatment and prevention of eye diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562929A (en) * | 1979-06-21 | 1981-01-13 | Sumitomo Chem Co Ltd | Preparation of optically active cyclopentenolone |
| CZ284687B6 (cs) * | 1986-04-30 | 1999-02-17 | Dainippon Pharmaceutical Co., Ltd. | Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi |
| JPH01117882A (ja) * | 1987-10-30 | 1989-05-10 | Dainippon Pharmaceut Co Ltd | 複素環式カルボン酸アミド誘導体 |
| JPH03291274A (ja) * | 1990-04-09 | 1991-12-20 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| JPH04270272A (ja) * | 1991-02-25 | 1992-09-25 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| TW223629B (https=) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US6031097A (en) * | 1997-10-27 | 2000-02-29 | Neurogen Corporation | 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands |
| US6331545B1 (en) * | 1998-12-18 | 2001-12-18 | Soo S. Ko | Heterocycyclic piperidines as modulators of chemokine receptor activity |
| HUP0202712A3 (en) * | 1999-09-14 | 2004-12-28 | Aventis Pharmaceuticals Inc Br | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing the compounds |
| EP1324990B1 (en) * | 2000-09-29 | 2014-10-29 | Glaxo Group Limited | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
| BR0114321A (pt) * | 2000-09-29 | 2003-07-01 | Glaxo Group Ltd | Composto, composição farmacêutica, uso de um composto, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar um composto |
-
2002
- 2002-03-28 GB GBGB0207449.0A patent/GB0207449D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106782A patent/TW200400823A/zh unknown
- 2003-03-27 KR KR10-2004-7015447A patent/KR20040095347A/ko not_active Withdrawn
- 2003-03-27 CN CNA038068656A patent/CN1642553A/zh active Pending
- 2003-03-27 DE DE60330952T patent/DE60330952D1/de not_active Expired - Lifetime
- 2003-03-27 BR BR0308719-0A patent/BR0308719A/pt not_active Application Discontinuation
- 2003-03-27 PL PL03372930A patent/PL372930A1/xx not_active Application Discontinuation
- 2003-03-27 CA CA002479910A patent/CA2479910A1/en not_active Abandoned
- 2003-03-27 AR ARP030101090A patent/AR039177A1/es unknown
- 2003-03-27 RU RU2004126145/04A patent/RU2004126145A/ru not_active Application Discontinuation
- 2003-03-27 ES ES03712117T patent/ES2339436T3/es not_active Expired - Lifetime
- 2003-03-27 AU AU2003216905A patent/AU2003216905A1/en not_active Abandoned
- 2003-03-27 IL IL16364803A patent/IL163648A0/xx unknown
- 2003-03-27 WO PCT/EP2003/003339 patent/WO2003082291A1/en not_active Ceased
- 2003-03-27 EP EP03712117A patent/EP1487453B1/en not_active Expired - Lifetime
- 2003-03-27 US US10/509,417 patent/US20060058299A1/en not_active Abandoned
- 2003-03-27 AT AT03712117T patent/ATE454892T1/de not_active IP Right Cessation
- 2003-03-27 JP JP2003579828A patent/JP4490110B2/ja not_active Expired - Lifetime
- 2003-03-27 MX MXPA04009458A patent/MXPA04009458A/es unknown
-
2004
- 2004-08-19 IS IS7415A patent/IS7415A/is unknown
- 2004-09-01 ZA ZA200406990A patent/ZA200406990B/en unknown
- 2004-09-27 NO NO20044098A patent/NO20044098L/no not_active Application Discontinuation