KR20040095347A - 염증 질환을 치료하기 위한 ｃｃｒ３ 길항제로서의ｎ-｛[(2ｓ)-4-(3,4-디플루오로벤질)모르폴린-2-일]메틸｝-2-｛3-[(메틸설포닐)아미노]페닐｝아세트아미드 - Google Patents

염증 질환을 치료하기 위한 ｃｃｒ３ 길항제로서의ｎ-｛[(2ｓ)-4-(3,4-디플루오로벤질)모르폴린-2-일]메틸｝-2-｛3-[(메틸설포닐)아미노]페닐｝아세트아미드 Download PDF

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Publication number
KR20040095347A
KR20040095347A KR10-2004-7015447A KR20047015447A KR20040095347A KR 20040095347 A KR20040095347 A KR 20040095347A KR 20047015447 A KR20047015447 A KR 20047015447A KR 20040095347 A KR20040095347 A KR 20040095347A
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South Korea
Prior art keywords
formula
compound
compounds
suitably
amino
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Withdrawn
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KR10-2004-7015447A
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English (en)
Korean (ko)
Inventor
레이첼 앤 앤클리프
캐롤라인 메리 쿡
콜린 데이비드 엘드레드
폴 마틴 고어
리 앤드류 해리슨
마틴 알리스테어 헤이스
사이먼 틴비 호즈슨
던캔 브루스 주드
수잔 앨라인 캘링
샤오 킹 리웰
게일 마일스
그레엄 마이클 로버트슨
스티븐 스완슨
앤드류 존 워커
마크 윌킨슨
Original Assignee
글락소 그룹 리미티드
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Publication of KR20040095347A publication Critical patent/KR20040095347A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR10-2004-7015447A 2002-03-28 2003-03-27 염증 질환을 치료하기 위한 ｃｃｒ３ 길항제로서의ｎ-｛[(2ｓ)-4-(3,4-디플루오로벤질)모르폴린-2-일]메틸｝-2-｛3-[(메틸설포닐)아미노]페닐｝아세트아미드 Withdrawn KR20040095347A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0207449.0 2002-03-28
GBGB0207449.0A GB0207449D0 (en) 2002-03-28 2002-03-28 Novel compounds
PCT/EP2003/003339 WO2003082291A1 (en) 2002-03-28 2003-03-27 N-{´ (2s) -4- (3, 4-difluorobenzyl) morpholin-2yl!methyl} -2-{3-' (methylsulphonyl) amino! phenyl}acetamide as ccr3 antagonist for the treatment of inflammatory conditions

Publications (1)

Publication Number Publication Date
KR20040095347A true KR20040095347A (ko) 2004-11-12

Family

ID=9933998

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7015447A Withdrawn KR20040095347A (ko) 2002-03-28 2003-03-27 염증 질환을 치료하기 위한 ｃｃｒ３ 길항제로서의ｎ-｛[(2ｓ)-4-(3,4-디플루오로벤질)모르폴린-2-일]메틸｝-2-｛3-[(메틸설포닐)아미노]페닐｝아세트아미드

Country Status (22)

Country Link
US (1) US20060058299A1 (https=)
EP (1) EP1487453B1 (https=)
JP (1) JP4490110B2 (https=)
KR (1) KR20040095347A (https=)
CN (1) CN1642553A (https=)
AR (1) AR039177A1 (https=)
AT (1) ATE454892T1 (https=)
AU (1) AU2003216905A1 (https=)
BR (1) BR0308719A (https=)
CA (1) CA2479910A1 (https=)
DE (1) DE60330952D1 (https=)
ES (1) ES2339436T3 (https=)
GB (1) GB0207449D0 (https=)
IL (1) IL163648A0 (https=)
IS (1) IS7415A (https=)
MX (1) MXPA04009458A (https=)
NO (1) NO20044098L (https=)
PL (1) PL372930A1 (https=)
RU (1) RU2004126145A (https=)
TW (1) TW200400823A (https=)
WO (1) WO2003082291A1 (https=)
ZA (1) ZA200406990B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003275257A1 (en) 2002-09-26 2004-04-19 Bristol-Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
EP1919884A1 (en) * 2005-07-21 2008-05-14 AstraZeneca AB N-benzyl-morpholine derivatives as modulators of the chemokine receptor
AU2006293635A1 (en) * 2005-09-22 2007-03-29 Sanofi-Aventis Amino-alkyl-amide derivatives as CCR3 receptor liquids
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
HUP0800478A2 (en) * 2008-07-31 2010-03-01 Sanofi Aventis Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands
RU2014126070A (ru) * 2011-12-01 2016-01-27 Глэксо Груп Лимитед Способы лечения и предотвращения глазных заболеваний

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS562929A (en) * 1979-06-21 1981-01-13 Sumitomo Chem Co Ltd Preparation of optically active cyclopentenolone
US4870074A (en) * 1986-04-30 1989-09-26 Dainippon Pharmaceutical Co., Ltd. Substituted benzamide derivatives, for enhancing gastrointestinal motility
JPH01117882A (ja) * 1987-10-30 1989-05-10 Dainippon Pharmaceut Co Ltd 複素環式カルボン酸アミド誘導体
JPH03291274A (ja) * 1990-04-09 1991-12-20 Yoshitomi Pharmaceut Ind Ltd アミノアルキルモルホリン誘導体の製造法
JPH04270272A (ja) * 1991-02-25 1992-09-25 Yoshitomi Pharmaceut Ind Ltd アミノアルキルモルホリン誘導体の製造法
TW223629B (https=) * 1992-03-06 1994-05-11 Hoffmann La Roche
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
US6031097A (en) * 1997-10-27 2000-02-29 Neurogen Corporation 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands
AU2056800A (en) * 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Heterocyclic piperidines as modulators of chemokine receptor activity
JP4717306B2 (ja) * 1999-09-14 2011-07-06 アベンティスユービー・セカンド・インコーポレイテッド Ｄ４拮抗剤として有用なチエノイソキサゾールフェノキシ非置換エチルおよびプロピル誘導体
IL155093A0 (en) * 2000-09-29 2003-10-31 Glaxo Group Ltd Morpholin-acetamide derivatives for the treatment on inflammatory diseases
IL155092A0 (en) * 2000-09-29 2003-10-31 Glaxo Group Ltd Compounds useful in the treatment of inflammatory diseases

Also Published As

Publication number Publication date
TW200400823A (en) 2004-01-16
AU2003216905A1 (en) 2003-10-13
RU2004126145A (ru) 2005-06-27
MXPA04009458A (es) 2005-07-27
DE60330952D1 (de) 2010-03-04
CN1642553A (zh) 2005-07-20
ES2339436T3 (es) 2010-05-20
PL372930A1 (en) 2005-08-08
GB0207449D0 (en) 2002-05-08
JP2005525390A (ja) 2005-08-25
AR039177A1 (es) 2005-02-09
EP1487453A1 (en) 2004-12-22
CA2479910A1 (en) 2003-10-09
BR0308719A (pt) 2005-01-04
EP1487453B1 (en) 2010-01-13
JP4490110B2 (ja) 2010-06-23
IS7415A (is) 2004-08-19
WO2003082291A1 (en) 2003-10-09
ZA200406990B (en) 2005-11-08
IL163648A0 (en) 2005-12-18
ATE454892T1 (de) 2010-01-15
US20060058299A1 (en) 2006-03-16
NO20044098L (no) 2004-10-04

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Date Code Title Description
PA0105 International application

Patent event date: 20040925

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid