JP2009519955A - 置換されたイミダゾキノリン、イミダゾナフチリジンおよびイミダゾピリジン、組成物ならびに方法 - Google Patents
置換されたイミダゾキノリン、イミダゾナフチリジンおよびイミダゾピリジン、組成物ならびに方法 Download PDFInfo
- Publication number
- JP2009519955A JP2009519955A JP2008545861A JP2008545861A JP2009519955A JP 2009519955 A JP2009519955 A JP 2009519955A JP 2008545861 A JP2008545861 A JP 2008545861A JP 2008545861 A JP2008545861 A JP 2008545861A JP 2009519955 A JP2009519955 A JP 2009519955A
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- tetrahydro
- pyran
- alkylenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*1=*CCCC1 Chemical compound C*1=*CCCC1 0.000 description 7
- ISFFAZPSGIHCHX-UHFFFAOYSA-N C(C1CCOCC1)[n]1c2c(cccc3)c3ncc2nc1Cc1ccccc1 Chemical compound C(C1CCOCC1)[n]1c2c(cccc3)c3ncc2nc1Cc1ccccc1 ISFFAZPSGIHCHX-UHFFFAOYSA-N 0.000 description 1
- YQSZBSHXGPXGSI-UHFFFAOYSA-N CC(C)CN(C)C(NC)=O Chemical compound CC(C)CN(C)C(NC)=O YQSZBSHXGPXGSI-UHFFFAOYSA-N 0.000 description 1
- QUBKYFDHQIGATA-UHFFFAOYSA-N CCOCc1nc(cnc2c3ccc(OCc4ccccc4)c2)c3[n]1CC1CCOCC1 Chemical compound CCOCc1nc(cnc2c3ccc(OCc4ccccc4)c2)c3[n]1CC1CCOCC1 QUBKYFDHQIGATA-UHFFFAOYSA-N 0.000 description 1
- OYDXPGOLPWMXEV-UHFFFAOYSA-N CCOCc1nc2cnc(C)c(C)c2[n]1NC1CCSCC1 Chemical compound CCOCc1nc2cnc(C)c(C)c2[n]1NC1CCSCC1 OYDXPGOLPWMXEV-UHFFFAOYSA-N 0.000 description 1
- LMPIVMUWXOHAHD-UHFFFAOYSA-N CCOCc1nc2cnc(cccc3)c3c2[n]1CC1CCCC1 Chemical compound CCOCc1nc2cnc(cccc3)c3c2[n]1CC1CCCC1 LMPIVMUWXOHAHD-UHFFFAOYSA-N 0.000 description 1
- TUEHSLHMQYVUBB-UHFFFAOYSA-N CCOCc1nc2cnc(cccc3)c3c2[n]1NC1CCOCC1 Chemical compound CCOCc1nc2cnc(cccc3)c3c2[n]1NC1CCOCC1 TUEHSLHMQYVUBB-UHFFFAOYSA-N 0.000 description 1
- QOEUNLQGZBSTBB-UHFFFAOYSA-N CN(CC1)C1=O Chemical compound CN(CC1)C1=O QOEUNLQGZBSTBB-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N CN(CCC1)C1=O Chemical compound CN(CCC1)C1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- NCBHOFSYIAZVJH-UHFFFAOYSA-N CN(CCCC1)C1O Chemical compound CN(CCCC1)C1O NCBHOFSYIAZVJH-UHFFFAOYSA-N 0.000 description 1
- MHSWCKAYODIGCG-UHFFFAOYSA-N CN(CCCO1)C1=O Chemical compound CN(CCCO1)C1=O MHSWCKAYODIGCG-UHFFFAOYSA-N 0.000 description 1
- QYMLJJASQZUTMJ-UHFFFAOYSA-N CN(CCN1I)C1=O Chemical compound CN(CCN1I)C1=O QYMLJJASQZUTMJ-UHFFFAOYSA-N 0.000 description 1
- AVFZOVWCLRSYKC-UHFFFAOYSA-N CN1CCCC1 Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- NRGWQNYIKGRALF-UHFFFAOYSA-N CNCCCCSO Chemical compound CNCCCCSO NRGWQNYIKGRALF-UHFFFAOYSA-N 0.000 description 1
- PGPMVVNIKFELAI-UHFFFAOYSA-N CNCCCS(=O)=O Chemical compound CNCCCS(=O)=O PGPMVVNIKFELAI-UHFFFAOYSA-N 0.000 description 1
- WCOSPOMNNFYBEF-UHFFFAOYSA-N COCCc1nc2cnc(cc(cc3)OCCOCCNC(CCN(C(C=C4)=O)C4=O)=O)c3c2[n]1CC1CCOCC1 Chemical compound COCCc1nc2cnc(cc(cc3)OCCOCCNC(CCN(C(C=C4)=O)C4=O)=O)c3c2[n]1CC1CCOCC1 WCOSPOMNNFYBEF-UHFFFAOYSA-N 0.000 description 1
- UQOOGKPMBUPRKU-UHFFFAOYSA-N COCCc1nc2cnc(ccc(-c3cccc(CO)c3)c3)c3c2[n]1CC1CCOCC1 Chemical compound COCCc1nc2cnc(ccc(-c3cccc(CO)c3)c3)c3c2[n]1CC1CCOCC1 UQOOGKPMBUPRKU-UHFFFAOYSA-N 0.000 description 1
- RYFAJLVNXKCDSR-UHFFFAOYSA-N COCCc1nc2cnc(ccc(-c3ccccc3OC)c3)c3c2[n]1CC1CCOCC1 Chemical compound COCCc1nc2cnc(ccc(-c3ccccc3OC)c3)c3c2[n]1CC1CCOCC1 RYFAJLVNXKCDSR-UHFFFAOYSA-N 0.000 description 1
- YYJODTBQGPUMDJ-UHFFFAOYSA-N COCCc1nc2cnc(ccc(OCc3ccccc3)c3)c3c2[n]1CC1CCOCC1 Chemical compound COCCc1nc2cnc(ccc(OCc3ccccc3)c3)c3c2[n]1CC1CCOCC1 YYJODTBQGPUMDJ-UHFFFAOYSA-N 0.000 description 1
- PUQGHYPTSCZFCL-UHFFFAOYSA-N COCCc1nc2cnc(cccc3)c3c2[n]1CC1CCOCC1 Chemical compound COCCc1nc2cnc(cccc3)c3c2[n]1CC1CCOCC1 PUQGHYPTSCZFCL-UHFFFAOYSA-N 0.000 description 1
- HCVRCGKQLAJWJY-UHFFFAOYSA-N Cc1nc2cnc(cccc3)c3c2[n]1NC1CCOCC1 Chemical compound Cc1nc2cnc(cccc3)c3c2[n]1NC1CCOCC1 HCVRCGKQLAJWJY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75139205P | 2005-12-16 | 2005-12-16 | |
PCT/US2006/048017 WO2007075468A1 (fr) | 2005-12-16 | 2006-12-15 | Imidazoquinoléines, imidazonaphtyridines et imidazopyridines substituées, compositions et procédés correspondants |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2009519955A true JP2009519955A (ja) | 2009-05-21 |
Family
ID=38218311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008545861A Pending JP2009519955A (ja) | 2005-12-16 | 2006-12-15 | 置換されたイミダゾキノリン、イミダゾナフチリジンおよびイミダゾピリジン、組成物ならびに方法 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1968587A1 (fr) |
JP (1) | JP2009519955A (fr) |
KR (1) | KR20080077982A (fr) |
CN (1) | CN101330916A (fr) |
AU (2) | AU2006332000A1 (fr) |
CA (1) | CA2634017A1 (fr) |
IL (1) | IL191846A0 (fr) |
MX (1) | MX2008007864A (fr) |
NO (1) | NO20082757L (fr) |
WO (1) | WO2007075468A1 (fr) |
ZA (1) | ZA200805105B (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013510124A (ja) * | 2009-11-05 | 2013-03-21 | グラクソスミスクライン エルエルシー | ブロモドメイン阻害剤としてのイミダゾ[4,5−c]キノリン誘導体 |
JP2013535446A (ja) * | 2010-07-16 | 2013-09-12 | ピラマル エンタープライジーズ リミテッド | キナーゼ阻害剤としての置換イミダゾキノリン誘導体 |
JP2013537204A (ja) * | 2010-09-16 | 2013-09-30 | ハチソン メディファーマ リミテッド | 縮合ヘテロアリールおよびその使用 |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007502293A (ja) | 2003-08-12 | 2007-02-08 | スリーエム イノベイティブ プロパティズ カンパニー | ヒドロキシルアミン置換イミダゾ含有化合物 |
RU2006105101A (ru) | 2003-08-27 | 2007-10-10 | 3М Инновейтив Пропертиз Компани (US) | Арилокси и арилалкиленокси замещенные имидазохинолины |
CA2537763A1 (fr) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Traitement pour le lymphome a cellules b cd5<sp>+</sp> |
AU2004278014B2 (en) | 2003-10-03 | 2011-04-28 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
JP2007511527A (ja) | 2003-11-14 | 2007-05-10 | スリーエム イノベイティブ プロパティズ カンパニー | オキシム置換イミダゾ環化合物 |
US8598192B2 (en) | 2003-11-14 | 2013-12-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazoquinolines |
WO2005051317A2 (fr) | 2003-11-25 | 2005-06-09 | 3M Innovative Properties Company | Systèmes cycliques d'imidazo substitués et procédés |
WO2005066170A1 (fr) | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Imidazoquinolines a substitution arylalcenyle et arylalkynyle |
CA2551399A1 (fr) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle |
US8697873B2 (en) | 2004-03-24 | 2014-04-15 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
US8017779B2 (en) | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
US7897609B2 (en) | 2004-06-18 | 2011-03-01 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
US7915281B2 (en) | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
US8026366B2 (en) | 2004-06-18 | 2011-09-27 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
JP5313502B2 (ja) | 2004-12-30 | 2013-10-09 | スリーエム イノベイティブ プロパティズ カンパニー | 置換キラル縮合[1,2]イミダゾ[4,5−c]環状化合物 |
JP5543068B2 (ja) | 2004-12-30 | 2014-07-09 | スリーエム イノベイティブ プロパティズ カンパニー | キラル縮合[1,2]イミダゾ[4,5−c]環状化合物 |
JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
AU2006213746A1 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods |
WO2006107853A2 (fr) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines et analogues associes |
AU2006232375A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
WO2008008432A2 (fr) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants |
KR20140015162A (ko) | 2010-01-12 | 2014-02-06 | 에프. 호프만-라 로슈 아게 | 트라이사이클릭 헤테로사이클릭 화합물, 조성물 및 이의 사용 방법 |
JP5863058B2 (ja) * | 2010-05-17 | 2016-02-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 1H−イミダゾ[4,5−c]キノリン |
CN103124731B (zh) * | 2010-09-16 | 2016-01-20 | 和记黄埔医药(上海)有限公司 | 稠合的杂芳基化合物及其应用 |
GB201106799D0 (en) * | 2011-04-21 | 2011-06-01 | Glaxosmithkline Llc | Novel compounds |
GB201114103D0 (en) | 2011-08-17 | 2011-09-28 | Glaxosmithkline Llc | Novel compounds |
US9227969B2 (en) | 2013-08-14 | 2016-01-05 | Novartis Ag | Compounds and compositions as inhibitors of MEK |
EP3992191A1 (fr) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Dérivés d'imidazo[4,5-c]quinoline et leur utilisation en tant qu'inhibiteurs de kinase atm |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7091214B2 (en) * | 2002-12-20 | 2006-08-15 | 3M Innovative Properties Co. | Aryl substituted Imidazoquinolines |
JP2007502293A (ja) * | 2003-08-12 | 2007-02-08 | スリーエム イノベイティブ プロパティズ カンパニー | ヒドロキシルアミン置換イミダゾ含有化合物 |
JP2007513170A (ja) * | 2003-12-04 | 2007-05-24 | スリーエム イノベイティブ プロパティズ カンパニー | スルホン置換イミダゾ環エーテル |
CA2551399A1 (fr) * | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle |
-
2006
- 2006-12-15 AU AU2006332000A patent/AU2006332000A1/en not_active Abandoned
- 2006-12-15 KR KR1020087014349A patent/KR20080077982A/ko not_active Application Discontinuation
- 2006-12-15 JP JP2008545861A patent/JP2009519955A/ja active Pending
- 2006-12-15 EP EP06845602A patent/EP1968587A1/fr not_active Withdrawn
- 2006-12-15 MX MX2008007864A patent/MX2008007864A/es unknown
- 2006-12-15 CN CNA2006800474919A patent/CN101330916A/zh active Pending
- 2006-12-15 WO PCT/US2006/048017 patent/WO2007075468A1/fr active Application Filing
- 2006-12-15 CA CA002634017A patent/CA2634017A1/fr not_active Abandoned
-
2008
- 2008-05-29 IL IL191846A patent/IL191846A0/en unknown
- 2008-06-11 ZA ZA200805105A patent/ZA200805105B/xx unknown
- 2008-06-18 NO NO20082757A patent/NO20082757L/no not_active Application Discontinuation
-
2011
- 2011-04-04 AU AU2011201519A patent/AU2011201519A1/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013510124A (ja) * | 2009-11-05 | 2013-03-21 | グラクソスミスクライン エルエルシー | ブロモドメイン阻害剤としてのイミダゾ[4,5−c]キノリン誘導体 |
JP2013535446A (ja) * | 2010-07-16 | 2013-09-12 | ピラマル エンタープライジーズ リミテッド | キナーゼ阻害剤としての置換イミダゾキノリン誘導体 |
JP2013537204A (ja) * | 2010-09-16 | 2013-09-30 | ハチソン メディファーマ リミテッド | 縮合ヘテロアリールおよびその使用 |
Also Published As
Publication number | Publication date |
---|---|
AU2006332000A1 (en) | 2007-07-05 |
MX2008007864A (es) | 2009-03-04 |
CN101330916A (zh) | 2008-12-24 |
AU2011201519A1 (en) | 2011-04-21 |
CA2634017A1 (fr) | 2007-07-05 |
EP1968587A1 (fr) | 2008-09-17 |
ZA200805105B (en) | 2009-06-24 |
NO20082757L (no) | 2008-09-04 |
KR20080077982A (ko) | 2008-08-26 |
WO2007075468A1 (fr) | 2007-07-05 |
IL191846A0 (en) | 2008-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090413 |