JP2009518337A5 - - Google Patents
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- Publication number
- JP2009518337A5 JP2009518337A5 JP2008543720A JP2008543720A JP2009518337A5 JP 2009518337 A5 JP2009518337 A5 JP 2009518337A5 JP 2008543720 A JP2008543720 A JP 2008543720A JP 2008543720 A JP2008543720 A JP 2008543720A JP 2009518337 A5 JP2009518337 A5 JP 2009518337A5
- Authority
- JP
- Japan
- Prior art keywords
- piperidine
- disorder
- group
- compound
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000000825 pharmaceutical preparation Substances 0.000 claims 10
- 229940127557 pharmaceutical product Drugs 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 210000003169 central nervous system Anatomy 0.000 claims 6
- -1 4- (3-chloro-5-fluorophenyl) piperidine 4- (3-chloro-4-fluorophenyl) piperidine 4- (4-chloro-2-fluorophenyl) piperidine 2-fluoro-5-piperidin-4-yl -Benzonitrile 2-chloro-5-piperidin-4-yl-benzonitrile Chemical compound 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 208000015114 central nervous system disease Diseases 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 208000029364 generalized anxiety disease Diseases 0.000 claims 2
- 208000019906 panic disease Diseases 0.000 claims 2
- CECGTSSOVAKSAO-UHFFFAOYSA-N 4-[4-chloro-3-(trifluoromethyl)phenyl]piperidine Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(C2CCNCC2)=C1 CECGTSSOVAKSAO-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000012239 Developmental disease Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 208000029560 autism spectrum disease Diseases 0.000 claims 1
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Substances N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 201000001716 specific phobia Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 0 *c1cc(C2CCNCC2)cc(*)c1 Chemical compound *c1cc(C2CCNCC2)cc(*)c1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74807705P | 2005-12-07 | 2005-12-07 | |
| SE0502709 | 2005-12-07 | ||
| PCT/EP2006/011712 WO2007065655A1 (en) | 2005-12-07 | 2006-12-06 | Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518337A JP2009518337A (ja) | 2009-05-07 |
| JP2009518337A5 true JP2009518337A5 (enExample) | 2010-02-04 |
Family
ID=37909741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543720A Abandoned JP2009518337A (ja) | 2005-12-07 | 2006-12-06 | 皮質カテコールアミン作動性神経伝達のモジュレーターとしての二置換フェニルピペリジン |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080269286A1 (enExample) |
| EP (1) | EP1963268B1 (enExample) |
| JP (1) | JP2009518337A (enExample) |
| WO (1) | WO2007065655A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
| SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
| DE602005021641D1 (de) | 2004-06-08 | 2010-07-15 | Nsab, Filial Af Neurosearch Sweden Ab | Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission |
| ES2659577T3 (es) | 2004-10-13 | 2018-03-16 | Teva Pharmaceuticals International Gmbh | Proceso para la síntesis de 4-(3-metanosulfonilfenil)-1-N-propil-piperidina |
| SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
| UY34503A (es) | 2011-12-08 | 2013-07-31 | Ivax Int Gmbh | ?sal de bromhidrato de pridopidina? |
| US20130267552A1 (en) | 2012-04-04 | 2013-10-10 | IVAX International GmbH | Pharmaceutical compositions for combination therapy |
| HUE049278T2 (hu) | 2014-08-15 | 2020-09-28 | Janssen Pharmaceuticals Inc | Pirazolok |
| US11220487B2 (en) * | 2017-06-14 | 2022-01-11 | Bayer Aktiengesellschaft | Process for preparing 3,4-dichloro-n-(2-cyanophenyl)-5-isothiazolecarboxamide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1459013A (fr) * | 1964-08-05 | 1966-04-29 | Allen & Hanburys Ltd | Procédé de préparation de dérivés de la 4-phényl-pipéridine |
| US4415736A (en) | 1981-12-28 | 1983-11-15 | E. I. Du Pont De Nemours & Co. | Certain tetrahydropyridine intermediates |
| US5658590A (en) | 1995-01-11 | 1997-08-19 | Eli Lilly And Company | Treatment of attention-deficit/hyperactivity disorder |
| DE69817557T2 (de) | 1997-05-14 | 2004-06-17 | Neurosearch A/S | Piperidine derivate als inhibitoren der neurotransmitter-wiederaufbaunahme |
| IL146564A0 (en) * | 1999-05-24 | 2002-07-25 | Mitsubishi Pharma Corp | Phenoxypropylamine derivatives and pharmaceutical compositions containing the same |
| SE9904723D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
| US20080318999A1 (en) * | 2005-08-05 | 2008-12-25 | Methvin Isaac | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators |
-
2006
- 2006-12-06 EP EP06829342A patent/EP1963268B1/en not_active Not-in-force
- 2006-12-06 JP JP2008543720A patent/JP2009518337A/ja not_active Abandoned
- 2006-12-06 US US12/096,349 patent/US20080269286A1/en not_active Abandoned
- 2006-12-06 WO PCT/EP2006/011712 patent/WO2007065655A1/en not_active Ceased
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