JP2009518132A5 - - Google Patents
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- JP2009518132A5 JP2009518132A5 JP2008544482A JP2008544482A JP2009518132A5 JP 2009518132 A5 JP2009518132 A5 JP 2009518132A5 JP 2008544482 A JP2008544482 A JP 2008544482A JP 2008544482 A JP2008544482 A JP 2008544482A JP 2009518132 A5 JP2009518132 A5 JP 2009518132A5
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- acid
- polysaccharide
- polyester
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011159 matrix material Substances 0.000 claims 26
- 239000003795 chemical substances by application Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 18
- 229920000954 Polyglycolide Polymers 0.000 claims 15
- 229920000747 poly(lactic acid) Polymers 0.000 claims 15
- 229920000728 polyester Polymers 0.000 claims 15
- 239000004633 polyglycolic acid Substances 0.000 claims 15
- 239000004626 polylactic acid Substances 0.000 claims 15
- 229920001282 polysaccharide Polymers 0.000 claims 15
- 239000005017 polysaccharide Substances 0.000 claims 15
- 150000004804 polysaccharides Chemical class 0.000 claims 15
- 239000012528 membrane Substances 0.000 claims 11
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 6
- 229920002971 Heparan sulfate Polymers 0.000 claims 6
- 239000000853 adhesive Substances 0.000 claims 6
- 230000001070 adhesive effect Effects 0.000 claims 6
- 229920001577 copolymer Polymers 0.000 claims 6
- 229920002674 hyaluronan Polymers 0.000 claims 6
- 229960003160 hyaluronic acid Drugs 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 230000007547 defect Effects 0.000 claims 5
- 239000003102 growth factor Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- 102100027400 A disintegrin and metalloproteinase with thrombospondin motifs 4 Human genes 0.000 claims 3
- 101710100373 A disintegrin and metalloproteinase with thrombospondin motifs 4 Proteins 0.000 claims 3
- 108010059616 Activins Proteins 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 3
- 229920000045 Dermatan sulfate Polymers 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 3
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 3
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 3
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 3
- 108090000031 Hedgehog Proteins Proteins 0.000 claims 3
- 102000003693 Hedgehog Proteins Human genes 0.000 claims 3
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 3
- 102000015696 Interleukins Human genes 0.000 claims 3
- 108010063738 Interleukins Proteins 0.000 claims 3
- 229920000288 Keratan sulfate Polymers 0.000 claims 3
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 3
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 3
- 102000013275 Somatomedins Human genes 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 239000000488 activin Substances 0.000 claims 3
- 229960001126 alginic acid Drugs 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 239000000783 alginic acid Substances 0.000 claims 3
- 150000004781 alginic acids Chemical class 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 3
- 229940051593 dermatan sulfate Drugs 0.000 claims 3
- 229960002086 dextran Drugs 0.000 claims 3
- -1 dextran sulfate Polymers 0.000 claims 3
- 229960000633 dextran sulfate Drugs 0.000 claims 3
- 230000004069 differentiation Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 229940126864 fibroblast growth factor Drugs 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 210000003035 hyaline cartilage Anatomy 0.000 claims 3
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 102000005755 Intercellular Signaling Peptides and Proteins Human genes 0.000 claims 2
- 108010070716 Intercellular Signaling Peptides and Proteins Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000002188 osteogenic effect Effects 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74802705P | 2005-12-07 | 2005-12-07 | |
| PCT/US2006/046576 WO2007067637A2 (en) | 2005-12-07 | 2006-12-07 | Cartilage repair methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009518132A JP2009518132A (ja) | 2009-05-07 |
| JP2009518132A5 true JP2009518132A5 (cg-RX-API-DMAC10.html) | 2010-01-28 |
Family
ID=38123465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544482A Pending JP2009518132A (ja) | 2005-12-07 | 2006-12-07 | 軟骨修復方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8444968B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1973554B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2009518132A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2631520A1 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2528272T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2007067637A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69714035T2 (de) * | 1997-08-14 | 2003-03-06 | Sulzer Innotec Ag, Winterthur | Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| EP2335650B1 (en) | 2003-12-11 | 2012-10-03 | Isto Technologies Inc. | Particulate cartilage system |
| AU2005287402B2 (en) * | 2004-07-12 | 2011-03-03 | Isto Technologies Ii, Llc | Tissue matrix system |
| US8512730B2 (en) * | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20090319045A1 (en) | 2004-10-12 | 2009-12-24 | Truncale Katherine G | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| JP5292533B2 (ja) | 2005-08-26 | 2013-09-18 | ジンマー・インコーポレイテッド | インプラントおよび関節疾患の治療、置換および治療方法 |
| CA2623106C (en) | 2005-09-19 | 2013-12-24 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
| EP1764117A1 (en) | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
| ES2528272T3 (es) | 2005-12-07 | 2015-02-06 | Isto Technologies Inc. | Métodos de reparación de cartílago |
| US20080138414A1 (en) * | 2006-12-08 | 2008-06-12 | Smith & Nephew, Inc. | Methods of Regenerating Cartilage |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| EP2134297B1 (en) | 2007-04-12 | 2017-03-08 | Zimmer, Inc. | Apparatus for tissue repair |
| US8464125B2 (en) * | 2009-12-10 | 2013-06-11 | Intel Corporation | Instruction-set architecture for programmable cyclic redundancy check (CRC) computations |
| US9119605B2 (en) | 2010-05-06 | 2015-09-01 | Zimmer, Inc. | Synthetic polymer adhesives and methods for making, using and delivering the same |
| EP2726603B1 (en) | 2011-06-29 | 2020-04-01 | Biorestorative Therapies, Inc. | Brown fat cell compositions and methods |
| US9272079B2 (en) * | 2011-10-13 | 2016-03-01 | Kci Licensing, Inc. | Stimulation of cartilage formation using reduced pressure treatment |
| US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| ES2859548T3 (es) | 2013-04-19 | 2021-10-04 | Biorestorative Therapies Inc | Células madre derivadas de tejido adiposo marrón humano y sus usos |
| WO2015155651A1 (en) * | 2014-04-08 | 2015-10-15 | Antonio Sambusseti | Resorbable device for the reconstruction of cartilage |
| CA2962223C (en) | 2014-09-23 | 2020-08-25 | Cytex Therapeutics, Inc. | Articular cartilage repair |
| US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| US10524774B2 (en) | 2015-04-02 | 2020-01-07 | Arthrex, Inc. | Method of repairing cartilage defects |
| US10524775B2 (en) | 2015-07-02 | 2020-01-07 | Arthrex, Inc. | Methods of repairing cartilage defects |
| KR102355223B1 (ko) | 2016-05-16 | 2022-01-25 | 아스렉스, 인코퍼레이티드 | 무릎 관절낭 파열 및 복구 |
| US10022231B2 (en) | 2016-07-22 | 2018-07-17 | Cytex Therapeutics, Inc. | Articular cartilage repair |
| US12303534B2 (en) | 2018-06-05 | 2025-05-20 | Medipost Co., Ltd | Pharmaceutical composition comprising mesenchymal stem cells as effective ingredient for prevention or treatment of inflammatory disease |
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| US4438102A (en) | 1982-08-10 | 1984-03-20 | Ciro's Touch, Ltd. | Method of promoting tissue growth |
| US4692371A (en) | 1985-07-30 | 1987-09-08 | Kimberly-Clark Corporation | High temperature method of making elastomeric materials and materials obtained thereby |
| IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| US5041138A (en) * | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
| US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
| US5290552A (en) | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| DK0591392T3 (da) | 1991-06-21 | 1996-09-30 | Genetics Inst | Farmaceutiske formuleringer af osteogene proteiner |
| IT1260154B (it) | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
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| FI20045223L (fi) | 2004-06-15 | 2005-12-16 | Bioretec Oy | Monitoiminen biohajoava komposiitti ja kirurginen implantti, joka käsittää mainitun komposiitin |
| WO2005046746A2 (en) | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
| US7316822B2 (en) * | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
| US7446131B1 (en) | 2004-06-10 | 2008-11-04 | The United States Of America As Represented By The Secretary Of Agriculture | Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making |
| AU2005287402B2 (en) * | 2004-07-12 | 2011-03-03 | Isto Technologies Ii, Llc | Tissue matrix system |
| ATE524121T1 (de) | 2004-11-24 | 2011-09-15 | Abdou Samy | Vorrichtungen zur platzierung eines orthopädischen intervertebralen implantats |
| ES2528272T3 (es) | 2005-12-07 | 2015-02-06 | Isto Technologies Inc. | Métodos de reparación de cartílago |
-
2006
- 2006-12-07 ES ES06839104.4T patent/ES2528272T3/es active Active
- 2006-12-07 US US11/635,265 patent/US8444968B2/en active Active
- 2006-12-07 EP EP06839104.4A patent/EP1973554B1/en active Active
- 2006-12-07 JP JP2008544482A patent/JP2009518132A/ja active Pending
- 2006-12-07 CA CA002631520A patent/CA2631520A1/en not_active Abandoned
- 2006-12-07 WO PCT/US2006/046576 patent/WO2007067637A2/en not_active Ceased
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