JP2009518038A5 - - Google Patents
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- Publication number
- JP2009518038A5 JP2009518038A5 JP2008544524A JP2008544524A JP2009518038A5 JP 2009518038 A5 JP2009518038 A5 JP 2009518038A5 JP 2008544524 A JP2008544524 A JP 2008544524A JP 2008544524 A JP2008544524 A JP 2008544524A JP 2009518038 A5 JP2009518038 A5 JP 2009518038A5
- Authority
- JP
- Japan
- Prior art keywords
- genome
- cassette
- synthetic
- kilobases
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 72
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 239000002773 nucleotide Substances 0.000 claims description 16
- 125000003729 nucleotide group Chemical group 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 108091034117 Oligonucleotide Proteins 0.000 claims description 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 230000010076 replication Effects 0.000 claims description 4
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 238000010367 cloning Methods 0.000 claims description 3
- 238000005215 recombination Methods 0.000 claims description 3
- 230000006798 recombination Effects 0.000 claims description 3
- 238000010276 construction Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000000592 Artificial Cell Substances 0.000 description 16
- 239000000047 product Substances 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000003362 replicative effect Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74254205P | 2005-12-06 | 2005-12-06 | |
| US60/742,542 | 2005-12-06 | ||
| PCT/US2006/046803 WO2008024129A2 (en) | 2005-12-06 | 2006-12-06 | Synthetic genomes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009518038A JP2009518038A (ja) | 2009-05-07 |
| JP2009518038A5 true JP2009518038A5 (https=) | 2010-01-28 |
| JP5106412B2 JP5106412B2 (ja) | 2012-12-26 |
Family
ID=39107256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008544524A Active JP5106412B2 (ja) | 2005-12-06 | 2006-12-06 | 合成ゲノム |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10041060B2 (https=) |
| EP (1) | EP1968994B1 (https=) |
| JP (1) | JP5106412B2 (https=) |
| CN (1) | CN101501207B (https=) |
| AU (1) | AU2006347573B2 (https=) |
| CA (1) | CA2643356A1 (https=) |
| DK (1) | DK1968994T3 (https=) |
| IL (1) | IL192041A (https=) |
| WO (1) | WO2008024129A2 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY143596A (en) | 2005-08-11 | 2011-06-15 | Synthetic Genomics Inc | In vitro recombination method |
| US20090017513A1 (en) * | 2007-07-13 | 2009-01-15 | Georgia Belle Plantation, Inc. | Process for producing hydrocarbon molecules from renewable biomass |
| US9267132B2 (en) | 2007-10-08 | 2016-02-23 | Synthetic Genomics, Inc. | Methods for cloning and manipulating genomes |
| AU2009214435C1 (en) * | 2008-02-15 | 2014-07-17 | Synthetic Genomics, Inc. | Methods for in vitro joining and combinatorial assembly of nucleic acid molecules |
| US10093552B2 (en) | 2008-02-22 | 2018-10-09 | James Weifu Lee | Photovoltaic panel-interfaced solar-greenhouse distillation systems |
| US9259662B2 (en) | 2008-02-22 | 2016-02-16 | James Weifu Lee | Photovoltaic panel-interfaced solar-greenhouse distillation systems |
| US8986963B2 (en) * | 2008-02-23 | 2015-03-24 | James Weifu Lee | Designer calvin-cycle-channeled production of butanol and related higher alcohols |
| DK2250276T3 (en) * | 2008-02-23 | 2017-02-13 | James Weifu Lee | DESIGN ORGANISMS FOR PHOTOBIOLOGICAL PRODUCTION OF BUTANOL FROM CARBON DIOXIDE AND WATER |
| EP2285948B1 (en) | 2008-03-03 | 2014-01-08 | Joule Unlimited Technologies, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| ES2560281T3 (es) | 2008-10-17 | 2016-02-18 | Joule Unlimited Technologies, Inc. | Producción de etanol por microorganismos |
| EP3257942B1 (en) | 2008-12-18 | 2020-07-22 | ITI Scotland Limited | Method for assembly of polynucleic acid sequences |
| SG10201400436PA (en) * | 2009-03-06 | 2014-06-27 | Synthetic Genomics Inc | Methods For Cloning And Manipulating Genomes |
| US7794969B1 (en) | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
| CA3056664A1 (en) | 2009-09-25 | 2011-03-31 | Alfred Gaertner | Production of fatty acid derivatives in recombinant bacterial cells expressing an ester synthase variant |
| MX2012005069A (es) * | 2009-10-30 | 2012-07-17 | Synthetic Genomics Inc | Codificar texto hacia secuencias de acido nucleico. |
| US20110269119A1 (en) | 2009-10-30 | 2011-11-03 | Synthetic Genomics, Inc. | Encoding text into nucleic acid sequences |
| WO2011109031A1 (en) * | 2010-03-05 | 2011-09-09 | Synthetic Genomics, Inc. | Methods for cloning and manipulating genomes |
| GB2481425A (en) | 2010-06-23 | 2011-12-28 | Iti Scotland Ltd | Method and device for assembling polynucleic acid sequences |
| US20120135486A1 (en) | 2010-09-14 | 2012-05-31 | C/O Joule Unlimited Technologies, Inc. | Methods and Compositions for the Extracellular Transport of Biosynthetic Hydrocarbons and Other Molecules |
| US8349587B2 (en) | 2011-10-31 | 2013-01-08 | Ginkgo Bioworks, Inc. | Methods and systems for chemoautotrophic production of organic compounds |
| US8790901B2 (en) | 2011-12-14 | 2014-07-29 | Pronutria, Inc. | Microorganisms and methods for producing unsaturated fatty acids |
| US9700071B2 (en) | 2012-03-26 | 2017-07-11 | Axcella Health Inc. | Nutritive fragments, proteins and methods |
| EP2831098A4 (en) | 2012-03-26 | 2016-12-07 | Axcella Health Inc | LOADED NUTRIENT PROTEINS AND METHODS |
| EP2831100A4 (en) | 2012-03-26 | 2016-02-10 | Pronutria Inc | NUTRIENT PROTEINS AND METHOD |
| RU2634407C2 (ru) | 2012-03-26 | 2017-10-26 | Эксселла Хелт Инк. | Фрагменты пищевых белков и способы их применения |
| GB201219989D0 (en) | 2012-11-06 | 2012-12-19 | Discuva Ltd | Bacterial engineering |
| WO2014089436A1 (en) | 2012-12-07 | 2014-06-12 | Ginkgo Bioworks, Inc. | Methods and systems for methylotrophic production of organic compounds |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| WO2015048339A2 (en) | 2013-09-25 | 2015-04-02 | Pronutria, Inc. | Compositions and formulations for non-human nutrition and methods of production and use thereof |
| RU2016110800A (ru) | 2013-09-25 | 2017-10-30 | Пронутриа Биосайенсис, Инк. | Составы и композиции для поддержания и увеличения мышечной массы, силы и результативности, и способы их производства и использования |
| WO2015054507A1 (en) | 2013-10-10 | 2015-04-16 | Pronutria, Inc. | Nutritive polypeptide production systems, and methods of manufacture and use thereof |
| GB201413202D0 (en) | 2014-07-25 | 2014-09-10 | Discuva Ltd | Process for producing bacterial mutants |
| US10538746B2 (en) | 2016-03-17 | 2020-01-21 | INVISTA North America S.à r.l. | Polypeptides and variants having improved activity, materials and processes relating thereto |
| EP3433354B1 (en) | 2016-03-23 | 2023-12-27 | Synthetic Genomics, Inc. | Generation of synthetic genomes |
| US11345938B2 (en) | 2017-02-02 | 2022-05-31 | Cargill, Incorporated | Genetically modified cells that produce C6-C10 fatty acid derivatives |
| WO2019191761A1 (en) | 2018-03-30 | 2019-10-03 | Invista North America S.A.R.L. | Method for controlling dissolved oxygen concentration in a continuous aerobic fermentation |
| CN111936623B (zh) | 2018-03-30 | 2023-08-25 | 英威达纺织（英国）有限公司 | 用于生物合成制造庚二酸的材料与方法和合成多肽的利用 |
| US12065636B2 (en) | 2018-03-30 | 2024-08-20 | Inv Nylon Chemicals Americas, Llc | High hydrogen utilization and gas recycle |
| EP3775241A1 (en) | 2018-03-30 | 2021-02-17 | INVISTA Textiles (U.K.) Limited | Methods for controlling oxygen concentration during aerobic biosynthesis |
| EP3788148A1 (en) | 2018-05-02 | 2021-03-10 | INVISTA Textiles (U.K.) Limited | Materials and methods for maximizing biosynthesis through alteration of pyruvate-acetyl-coa-tca balance in species of the genera ralstonia and cupriavidus and organisms related thereto |
| WO2019213118A1 (en) | 2018-05-02 | 2019-11-07 | Invista North America S.A.R.L. | Methods for controlling pha biosynthesis in cupriavidus or ralstonia |
| CN115807021A (zh) * | 2022-08-01 | 2023-03-17 | 深圳大学 | 一种莱茵衣藻人工叶绿体基因组合成组装与功能测试的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750380A (en) | 1981-06-30 | 1998-05-12 | City Of Hope Research Institute | DNA polymerase mediated synthesis of double stranded nucleic acids |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| US5976846A (en) | 1996-01-13 | 1999-11-02 | Passmore; Steven E. | Method for multifragment in vivo cloning and mutation mapping |
| IL120338A0 (en) * | 1997-02-27 | 1997-06-10 | Gesher Israel Advanced Biotecs | Single step DNA fragments assembly |
| PT1015576E (pt) * | 1997-09-16 | 2005-09-30 | Egea Biosciences Llc | Metodo para a sintese quimica completa e montagem de genes e de genomas |
| US6670127B2 (en) * | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| JP3131633B1 (ja) | 1999-11-26 | 2001-02-05 | 農林水産省食品総合研究所長 | Ｐｃｒ法による植物遺伝子の検出方法 |
| CN1384203A (zh) | 2001-04-30 | 2002-12-11 | 香港科技创业股份有限公司 | 具有高度延伸专一性的dna低温循环延伸反应方法 |
| US7267984B2 (en) * | 2002-10-31 | 2007-09-11 | Rice University | Recombination assembly of large DNA fragments |
| US20040185449A1 (en) | 2003-03-20 | 2004-09-23 | Quinn John J. | Method for preparing assay samples |
| WO2004113534A1 (en) * | 2003-05-22 | 2004-12-29 | University Of California | Method for producing a synthetic gene or other dna sequence |
| KR100624452B1 (ko) | 2004-12-21 | 2006-09-18 | 삼성전자주식회사 | 고정화된 히드로겔 또는 ｐｅｇ－히드로겔 공중합체를이용한 핵산의 분리 및 정제 방법 |
| EP2239327B1 (en) * | 2005-08-11 | 2015-02-25 | Synthetic Genomics, Inc. | Method for in vitro recombination |
| MY143596A (en) | 2005-08-11 | 2011-06-15 | Synthetic Genomics Inc | In vitro recombination method |
| US20090305233A1 (en) | 2007-07-03 | 2009-12-10 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona | Methods and Reagents for Polynucleotide Assembly |
| AU2009214435C1 (en) | 2008-02-15 | 2014-07-17 | Synthetic Genomics, Inc. | Methods for in vitro joining and combinatorial assembly of nucleic acid molecules |
| WO2010042007A1 (en) | 2008-10-10 | 2010-04-15 | Jonas Tegenfeldt | Method for the mapping of the local at/gc ratio along dna |
| DK2885408T5 (da) | 2012-08-16 | 2024-10-14 | Synthetic Genomics Inc | Digital til biologisk konverter |
| AU2013359293B2 (en) | 2012-12-13 | 2017-11-02 | Synthetic Genomics, Inc. | PEG-mediated assembly of nucleic acid molecules |
-
2006
- 2006-12-06 US US11/635,355 patent/US10041060B2/en active Active
- 2006-12-06 AU AU2006347573A patent/AU2006347573B2/en active Active
- 2006-12-06 WO PCT/US2006/046803 patent/WO2008024129A2/en not_active Ceased
- 2006-12-06 JP JP2008544524A patent/JP5106412B2/ja active Active
- 2006-12-06 CN CN200680052444.3A patent/CN101501207B/zh active Active
- 2006-12-06 EP EP06851474.4A patent/EP1968994B1/en active Active
- 2006-12-06 CA CA002643356A patent/CA2643356A1/en not_active Abandoned
- 2006-12-06 DK DK06851474.4T patent/DK1968994T3/da active
-
2008
- 2008-06-10 IL IL192041A patent/IL192041A/en active IP Right Grant
-
2018
- 2018-08-06 US US16/056,343 patent/US20180340165A1/en not_active Abandoned
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