JP2009517015A5 - - Google Patents
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- Publication number
- JP2009517015A5 JP2009517015A5 JP2008541846A JP2008541846A JP2009517015A5 JP 2009517015 A5 JP2009517015 A5 JP 2009517015A5 JP 2008541846 A JP2008541846 A JP 2008541846A JP 2008541846 A JP2008541846 A JP 2008541846A JP 2009517015 A5 JP2009517015 A5 JP 2009517015A5
- Authority
- JP
- Japan
- Prior art keywords
- tsh receptor
- prokaryotic host
- host cell
- fusion protein
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003911 Thyrotropin Receptors Human genes 0.000 claims 65
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims 65
- 210000004027 cell Anatomy 0.000 claims 33
- 108020001507 fusion proteins Proteins 0.000 claims 29
- 102000037865 fusion proteins Human genes 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 208000023275 Autoimmune disease Diseases 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 19
- 230000028993 immune response Effects 0.000 claims 18
- 230000004044 response Effects 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 239000006166 lysate Substances 0.000 claims 12
- 230000015572 biosynthetic process Effects 0.000 claims 9
- 210000000805 cytoplasm Anatomy 0.000 claims 9
- 230000035772 mutation Effects 0.000 claims 9
- 102000005720 Glutathione transferase Human genes 0.000 claims 8
- 108010070675 Glutathione transferase Proteins 0.000 claims 8
- 239000013060 biological fluid Substances 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 230000002934 lysing effect Effects 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- 230000001131 transforming effect Effects 0.000 claims 6
- 238000002965 ELISA Methods 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 238000000684 flow cytometry Methods 0.000 claims 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
- 238000001114 immunoprecipitation Methods 0.000 claims 2
- 238000001699 lithographically induced self-assembly Methods 0.000 claims 2
- 238000003127 radioimmunoassay Methods 0.000 claims 2
- 238000001262 western blot Methods 0.000 claims 2
- 108010024636 Glutathione Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229960003180 glutathione Drugs 0.000 claims 1
- 230000008105 immune reaction Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000012123 point-of-care testing Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73802105P | 2005-11-21 | 2005-11-21 | |
| PCT/IB2006/003394 WO2007057778A2 (en) | 2005-11-21 | 2006-11-21 | Recombinant polypeptides and methods for detecting and/or quantifying autoantibodies against tsh receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517015A JP2009517015A (ja) | 2009-04-30 |
| JP2009517015A5 true JP2009517015A5 (enExample) | 2010-01-14 |
Family
ID=37998447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541846A Withdrawn JP2009517015A (ja) | 2005-11-21 | 2006-11-21 | 組換えポリペプチドならびにｔｓｈレセプターに対する自己抗体を検出及び／又は定量化する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080305098A1 (enExample) |
| EP (2) | EP2080772A3 (enExample) |
| JP (1) | JP2009517015A (enExample) |
| WO (1) | WO2007057778A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8470554B2 (en) * | 2008-12-22 | 2013-06-25 | St. Jude Children's Research Hospital | Prokaryotic expression of soluble, active Dkk |
| EP2617735A3 (en) * | 2008-12-24 | 2013-10-16 | Rsr Limited | Human anti tshr antibodies |
| JP2011136911A (ja) * | 2009-12-25 | 2011-07-14 | Tosoh Corp | 甲状腺刺激ホルモンレセプターの安定化方法 |
| US20130189707A1 (en) * | 2010-01-26 | 2013-07-25 | Svetlana Alexandrovna Sergeeva | Method of determination of autoantibody level by means of enzyme immunoassay |
| JP5908590B2 (ja) | 2011-09-09 | 2016-04-26 | クイデル コーポレーション | 自己抗体を検出するための組成物および方法 |
| JP6472789B2 (ja) | 2013-05-14 | 2019-02-20 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | 受容体含有安定化液剤 |
| GB201314052D0 (en) * | 2013-08-06 | 2013-09-18 | Apitope Int Nv | Peptides |
| RU2728963C2 (ru) * | 2014-12-24 | 2020-08-03 | Эпитоп Интернэшнл Нв | Композиция |
| CN114601913B (zh) * | 2022-03-09 | 2025-03-04 | 陕西慧普德泰生物科技有限责任公司 | 人TSHR A亚基在预防Graves病中的应用 |
| CN119192331A (zh) * | 2024-11-11 | 2024-12-27 | 郑州伊美诺生物技术有限公司 | 促甲状腺激素受体的突变体及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030022826A1 (en) * | 1987-09-08 | 2003-01-30 | Duke University | Use of synthetic peptides to induce tolerance to pathogenic T and B cell epitopes of autoantigens or infectious agents |
| JPH0789991A (ja) * | 1993-09-28 | 1995-04-04 | Mitsubishi Chem Corp | 新規なポリペプチドおよびそれを用いるｔｓｈ受容体抗体の測定法 |
| EP1078986B1 (en) | 1999-08-24 | 2007-02-28 | Tosoh Corporation | Secretory thyroid stimulating hormone receptor (TSHR), and method for assaying anti-TSHR antibody using the same |
| ES2732276T3 (es) * | 2001-08-23 | 2019-11-21 | Rsr Ltd | Regiones del epítopo de un receptor de tirotropina (TSH), usos del mismo y anticuerpos para el mismo |
| US8110664B2 (en) * | 2002-11-29 | 2012-02-07 | Rsr Limited | Binding partners for the thyrotropin receptor and uses thereof |
-
2006
- 2006-11-21 US US12/094,533 patent/US20080305098A1/en not_active Abandoned
- 2006-11-21 WO PCT/IB2006/003394 patent/WO2007057778A2/en not_active Ceased
- 2006-11-21 EP EP09005494A patent/EP2080772A3/en not_active Withdrawn
- 2006-11-21 JP JP2008541846A patent/JP2009517015A/ja not_active Withdrawn
- 2006-11-21 EP EP06820995A patent/EP1951753A2/en not_active Withdrawn
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