HRP20200585T1 - Poboljšani test za dijagnozu alergije na kikiriki - Google Patents
Poboljšani test za dijagnozu alergije na kikiriki Download PDFInfo
- Publication number
- HRP20200585T1 HRP20200585T1 HRP20200585TT HRP20200585T HRP20200585T1 HR P20200585 T1 HRP20200585 T1 HR P20200585T1 HR P20200585T T HRP20200585T T HR P20200585TT HR P20200585 T HRP20200585 T HR P20200585T HR P20200585 T1 HRP20200585 T1 HR P20200585T1
- Authority
- HR
- Croatia
- Prior art keywords
- ara
- seq
- antibody
- isotype
- antibodies
- Prior art date
Links
- 206010016946 Food allergy Diseases 0.000 title claims 6
- 208000008267 Peanut Hypersensitivity Diseases 0.000 title claims 6
- 238000003745 diagnosis Methods 0.000 title claims 6
- 201000010853 peanut allergy Diseases 0.000 title claims 6
- 238000003556 assay Methods 0.000 title 1
- 210000004899 c-terminal region Anatomy 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 241001553178 Arachis glabrata Species 0.000 claims 4
- 230000000172 allergic effect Effects 0.000 claims 4
- 208000010668 atopic eczema Diseases 0.000 claims 4
- 235000020232 peanut Nutrition 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000017060 Arachis glabrata Nutrition 0.000 claims 1
- 235000010777 Arachis hypogaea Nutrition 0.000 claims 1
- 235000018262 Arachis monticola Nutrition 0.000 claims 1
- 238000000018 DNA microarray Methods 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000005580 one pot reaction Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000011895 specific detection Methods 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/415—Assays involving biological materials from specific organisms or of a specific nature from plants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Rehabilitation Therapy (AREA)
Claims (15)
1. Dijagnostički koristan nosač koji sadrži sredstvo za specifično hvatanje protutijela na epitop C-terminalnog kraja Ara h 7 izotipa 7.0201, pri čemu C-terminalni kraj sadrži SEQ ID NO 6 i pri čemu epitop sadrži SEQ ID NO 8, u uzorku od subjekta,
pri čemu je nosač odabran iz skupine koja sadrži kuglice, test traku, mikrotitarsku ploču, microarray, čvrsti polimer dobiven iz celuloze, blot iz skupine koja sadrži line blot i dot blot, staklenu površinu, klizač i biočip, te je najpoželjnije mikrotitarska ploča ili line blot,
pri čemu je sredstvo za specifično hvatanje protutijela polipeptid koji sadrži ili obuhvaća antigen na koji se veže protutijelo koje se treba uhvatiti ili detektirati ili njegova varijanta koja ima aktivnost vezanja protutijela.
2. Dijagnostički koristan nosač prema patentnom zahtjevu 1, naznačen time što nosač nadalje sadrži sredstvo za specifično hvatanje protutijela na jedan ili više daljnjih antigena iz skupine koja sadrži Ara h 2, Ara h 6, Ara h 1, Ara h 3, Ara h 9, Ara h 8 i Ara h 5, poželjnije iz skupine koja sadrži Ara h 2, Ara h 6, Ara h 1, Ara h 3, Ara h 9, poželjnije protutijelo na Ara h 2 i/ili protutijelo na Ara h 6, najpoželjnije protutijelo na Ara h 2.
3. Komplet naznačen time što sadrži dijagnostički koristan nosač prema bilo kojem od patentnih zahtjeva 1 do 2, kao i sredstvo za specifično otkrivanje uhvaćenog protutijela.
4. Komplet prema patentnom zahtjevu 3,
naznačen time što sredstvo za specifično hvatanje protutijela na epitop C-terminalnog kraja Ara h 7 izotipa 7.0201 pri čemu se C-terminalni kraj sastoji od SEQ ID NO 6 i pri čemu epitop sadrži SEQ ID NO 8, te je sredstvo za specifično hvatanje protutijela na jedan ili više daljnjih antigena na odvojenim nosačima ili
pri čemu sredstvo za specifično hvatanje protutijela na epitop C-terminalnog kraja Ara h 7 izotipa 7.0201 gdje C-terminalni kraj sadrži SEQ ID NO 6 i pri čemu epitop sadrži SEQ ID NO 8, te je sredstvo za specifično hvatanje protutijela na jedan ili više daljnjih antigena vezano na jednom, poželjno kovalentno vezano na jednom nosaču.
5. Postupak za dijagnozu alergije na kikiriki naznačen time što obuhvaća korak otkrivanja u uzorku od subjekta prisutnosti protutijela na epitopu C-terminalnog kraja Ara h 7 izotipa 7.0201, pri čemu C-terminalni kraj sadrži SEQ ID NO 6 i pri čemu epitop sadrži SEQ ID NO 8.
6. Postupak prema patentnom zahtjevu 5, naznačen time što nadalje obuhvaća korak otkrivanja u uzorku subjekta prisutnosti protutijela na jednom ili više daljnjih antigena, poželjno odabranih iz skupine koja sadrži Ara h 2, Ara h 6, Ara h 1, Ara h 3, Ara h 9, Ara h 8 i Ara h 5, poželjnije iz skupine koja sadrži Ara h 2, Ara h 6, Ara h 1, Ara h 3 i Ara h 9, najpoželjnije Ara h 2 i/ili Ara h 6.
7. Postupak prema bilo kojem od patentnih zahtjeva 5 do 6, naznačen time što se istovremeno određuje prisutnost protutijela na epitopu C-terminalnog kraja Ara h 7 izotipa 7.0201 koji sadrži SEQ ID NO 8 i prisutnost protutijela na jednom ili više daljnjih antigena, poželjno Ara h 2 i/ili Ara h 6.
8. Postupak prema bilo kojem od patentnih zahtjeva 5 do 7, naznačen time što se prisutnost protutijela na epitopu C-terminalnog kraja Ara h 7 izotipa 7.0201 koji sadrži SEQ ID NO 8 i prisutnost protutijela na jednom ili više daljnjih antigena određuju u prostorno odvojenim reakcijama vezivanja.
9. Postupak prema bilo kojem od patentnih zahtjeva 5 do 8, naznačen time što se prisutnost protutijela na epitopu C-terminalnog kraja Ara h 7 izotipa 7.0201 koji sadrži SEQ ID NO 8 i prisutnost protutijela na jednom ili više daljnjih antigena određuju reakcijom u jednoj posudi.
10. Nosač, komplet ili postupak prema bilo kojem od patentnih zahtjeva 1 do 9, naznačen time što je protutijelo na izotipu 7.0201 protutijelo monospecifično prema SEQ ID NO 6, poželjnije prema sekvenci iz skupine koja sadrži SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9 i SEQ ID NO 10, najpoželjnije SEQ ID NO 8.
11. Uporaba polipeptida koji sadrži SEQ ID NO 8, poželjnije sekvence iz skupine koja sadrži SEQ ID NO 6, SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9 i SEQ ID NO 10, poželjnije SEQ ID NO 6, najpoželjnije Ara h 7 izotip 7.0201 ili njegova varijanta koja se veže na protutijelo na Ara h 7 izotip 7.0201 od subjekta alergičnog na kikiriki, pri čemu je polipeptid rekombinantni, imobilizirani pročišćeni ili fuzijski protein, poželjno pročišćeni i rekombinantni i imobilizirani, te nosača prema bilo kojem od patentnih zahtjeva 1 do 2 ili kompleta prema bilo kojem od patentnih zahtjeva 3 do 4 naznačena time što je za povećanje osjetljivosti dijagnoze alergije na kikiriki.
12. Uporaba polipeptida koji sadrži SEQ ID NO 8, poželjnije sekvence iz skupine koja sadrži SEQ ID NO 6, SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9 i SEQ ID NO 10, poželjnije SEQ ID NO 6, najpoželjnije Ara h 7 izotip 7.0201 ili njegova varijanta koja se veže na protutijelo na Ara h 7 izotip 7.0201 od subjekta alergičnog na kikiriki, pri čemu je polipeptid rekombinantni, imobilizirani pročišćeni ili fuzijski protein, poželjno pročišćeni i rekombinantni i imobilizirani, naznačena time što je za proizvodnju kompleta za dijagnozu alergije na kikiriki.
13. Uporaba prema bilo kojem od patentnih zahtjeva 11 do 12, naznačena time što je polipeptid koji sadrži SEQ ID NO 8, poželjnije sekvencu iz skupine koja sadrži SEQ ID NO 6, SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9 i SEQ ID NO 10, poželjnije SEQ ID NO 6, najpoželjnije Ara h 7 izotip 7.0201 ili njegova varijanta koja se veže na protutijelo na Ara h 7 izotip 7.0201 od subjekta alergičnog na kikiriki u pripravku koji sadrži navedeni polipeptid i Ara h 2 i/ili Ara h 6 ili njegovu varijantu koja se veže na protutijelo na Ara h 2 ili Ara h 6 od subjekta alergičnog na kikiriki, redom.
14. Protutijelo, poželjno protutijelo razreda IgE, IgG1 i IgG4, koje se specifično veže za SEQ ID NO 6, poželjnije na sekvencu iz skupine koja sadrži SEQ ID NO 7, SEQ ID NO 8, SEQ ID NO 9 i SEQ ID NO 10, najpoželjnije na SEQ ID NO 8, pri čemu je poželjno protutijelo izolirano.
15. Uporaba protutijela prema patentnom zahtjevu 14 naznačena time što je za dijagnozu alergije na kikiriki ili za proizvodnju kompleta za dijagnozu alergije na kikiriki.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17000245.5A EP3244212A1 (en) | 2017-02-15 | 2017-02-15 | An improved assay for the diagnosis of peanut allergy |
| EP17001081 | 2017-06-26 | ||
| EP18156555.7A EP3364193B1 (en) | 2017-02-15 | 2018-02-13 | Improved assay for the diagnosis of peanut allergy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200585T1 true HRP20200585T1 (hr) | 2020-07-10 |
Family
ID=61163617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200585TT HRP20200585T1 (hr) | 2017-02-15 | 2020-04-10 | Poboljšani test za dijagnozu alergije na kikiriki |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10871493B2 (hr) |
| EP (1) | EP3364193B1 (hr) |
| JP (1) | JP6940427B2 (hr) |
| KR (1) | KR102228185B1 (hr) |
| CN (2) | CN113777325A (hr) |
| AU (1) | AU2017279647B2 (hr) |
| BR (1) | BR102017026619A2 (hr) |
| CA (1) | CA2992044C (hr) |
| ES (1) | ES2788389T3 (hr) |
| HK (1) | HK1263291A1 (hr) |
| HR (1) | HRP20200585T1 (hr) |
| LT (1) | LT3364193T (hr) |
| PL (1) | PL3364193T3 (hr) |
| SI (1) | SI3364193T1 (hr) |
| WO (1) | WO2018149927A1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201223256D0 (en) | 2012-12-21 | 2013-02-06 | Microtest Matrices Ltd | Immunoassay |
| CN112142836A (zh) * | 2019-06-28 | 2020-12-29 | 中国食品发酵工业研究院有限公司 | 一种原肌球蛋白抗原的表位肽及其应用 |
| CN112986578B (zh) * | 2021-02-04 | 2023-03-10 | 南昌大学 | 一种用于血清特异性Ig E筛查的试纸条及其制备方法 |
| EP4057009A1 (en) | 2021-03-08 | 2022-09-14 | Euroimmun Medizinische Labordiagnostika AG | Methods and reagents for detecting an antibody to a sesame nsltp |
| EP4134674A1 (en) | 2021-08-13 | 2023-02-15 | Euroimmun Medizinische Labordiagnostika AG | Methods and reagents for detecting an antibody to a ses ipr-10 allergen |
| WO2023190098A1 (ja) * | 2022-03-31 | 2023-10-05 | 日本ハム株式会社 | 落花生アレルゲンの検査用キットおよび検査方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5043077Y2 (hr) | 1973-12-03 | 1975-12-09 | ||
| DE69922293T2 (de) | 1998-06-09 | 2005-12-01 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Verfahren zur Kontrolle der Produktion einer mit einer Linse versehenen Photofilmeinheit |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| AU2003208817A1 (en) | 2002-02-27 | 2003-09-09 | Merck Patent Gmbh | Method for producing hypoallergenic major birch pollen allergens rbet v 1 |
| ATE307141T1 (de) | 2003-01-21 | 2005-11-15 | Biomay Prod & Handel | Verfahren zur vorbereitung von hypoallergenen mosaikproteine |
| EP1731907B1 (en) | 2004-03-05 | 2010-10-13 | Prima Meat Packers, Ltd. | Method of detecting allergen |
| US20060115499A1 (en) | 2004-09-27 | 2006-06-01 | Alk-Abello A/S | Liquid allergy vaccine formulation for oromucosal administration |
| EP2694966A4 (en) * | 2011-03-20 | 2014-12-24 | Univ Colorado Regents | METHOD FOR PREDICTING THE GRAVITY OF AN ALLERGIC REACTION |
| DE202011106093U1 (de) | 2011-09-24 | 2011-10-19 | Euroimmun Medizinische Labordiagnostika Ag | Kalibrationsstreifen für einen Immunoblot |
| DK3482771T3 (da) | 2013-03-14 | 2023-03-20 | Nestle Sa | Fremstilling af jordnøddeformuleringer til oral desensibilisering |
| WO2014182932A1 (en) * | 2013-05-08 | 2014-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of testing for allergen sensitivity |
| US9688977B2 (en) * | 2013-08-05 | 2017-06-27 | Greenlight Biosciences, Inc. | Engineered phosphoglucose isomerase proteins with a protease cleavage site |
| CN103554245B (zh) * | 2013-10-15 | 2014-12-31 | 北京大学 | 一种融合标签蛋白 |
| EP3256158A4 (en) * | 2015-02-13 | 2018-11-07 | Virtici, LLC | Tolerance therapeutic for treating polypeptide induced allergy |
| TW201709926A (zh) * | 2015-04-23 | 2017-03-16 | 賽諾菲公司 | 用於舌下投藥之吡喃葡萄糖基脂ａ及過敏原調配物 |
| EP3088414A1 (de) | 2015-04-30 | 2016-11-02 | Euroimmun Medizinische Labordiagnostika AG | Verbesserter nachweis von nussallergien |
| EP3196209B1 (en) | 2016-01-25 | 2019-10-23 | Euroimmun Medizinische Labordiagnostika AG | A macadamia allergen |
-
2017
- 2017-12-11 BR BR102017026619A patent/BR102017026619A2/pt active Search and Examination
- 2017-12-20 AU AU2017279647A patent/AU2017279647B2/en active Active
- 2017-12-29 CN CN202111066218.3A patent/CN113777325A/zh active Pending
- 2017-12-29 CN CN201711468054.0A patent/CN108427001B/zh active Active
-
2018
- 2018-01-16 CA CA2992044A patent/CA2992044C/en active Active
- 2018-02-13 EP EP18156555.7A patent/EP3364193B1/en active Active
- 2018-02-13 KR KR1020180017527A patent/KR102228185B1/ko active IP Right Grant
- 2018-02-13 ES ES18156555T patent/ES2788389T3/es active Active
- 2018-02-13 LT LTEP18156555.7T patent/LT3364193T/lt unknown
- 2018-02-13 SI SI201830049T patent/SI3364193T1/sl unknown
- 2018-02-13 PL PL18156555T patent/PL3364193T3/pl unknown
- 2018-02-14 JP JP2018023758A patent/JP6940427B2/ja active Active
- 2018-02-15 WO PCT/EP2018/053806 patent/WO2018149927A1/en active Application Filing
- 2018-02-15 US US15/898,074 patent/US10871493B2/en active Active
-
2019
- 2019-01-30 HK HK19101670.4A patent/HK1263291A1/zh unknown
-
2020
- 2020-04-10 HR HRP20200585TT patent/HRP20200585T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3364193A1 (en) | 2018-08-22 |
| PL3364193T3 (pl) | 2020-11-02 |
| CN108427001A (zh) | 2018-08-21 |
| JP6940427B2 (ja) | 2021-09-29 |
| KR20180094487A (ko) | 2018-08-23 |
| SI3364193T1 (sl) | 2020-07-31 |
| KR102228185B1 (ko) | 2021-03-18 |
| CN113777325A (zh) | 2021-12-10 |
| US10871493B2 (en) | 2020-12-22 |
| CN108427001B (zh) | 2021-10-15 |
| ES2788389T3 (es) | 2020-10-21 |
| HK1263291A1 (zh) | 2020-03-27 |
| CA2992044C (en) | 2021-10-19 |
| BR102017026619A2 (pt) | 2018-10-30 |
| WO2018149927A1 (en) | 2018-08-23 |
| AU2017279647A1 (en) | 2018-08-30 |
| AU2017279647B2 (en) | 2022-05-26 |
| CA2992044A1 (en) | 2018-08-15 |
| EP3364193B1 (en) | 2020-04-01 |
| US20180231567A1 (en) | 2018-08-16 |
| JP2018132525A (ja) | 2018-08-23 |
| LT3364193T (lt) | 2020-06-10 |
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