JP2009516534A5 - - Google Patents
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- Publication number
- JP2009516534A5 JP2009516534A5 JP2008539609A JP2008539609A JP2009516534A5 JP 2009516534 A5 JP2009516534 A5 JP 2009516534A5 JP 2008539609 A JP2008539609 A JP 2008539609A JP 2008539609 A JP2008539609 A JP 2008539609A JP 2009516534 A5 JP2009516534 A5 JP 2009516534A5
- Authority
- JP
- Japan
- Prior art keywords
- methacetin
- breath
- derivative
- salt
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XVAIDCNLVLTVFM-UHFFFAOYSA-N methacetin Chemical compound COC1=CC=C(NC(C)=O)C=C1 XVAIDCNLVLTVFM-UHFFFAOYSA-N 0.000 claims 46
- 238000000034 method Methods 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 25
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical class CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 20
- 238000012544 monitoring process Methods 0.000 claims 16
- 230000005817 liver abnormality Effects 0.000 claims 9
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 8
- 239000002207 metabolite Substances 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- 206010016654 Fibrosis Diseases 0.000 claims 6
- 230000004761 fibrosis Effects 0.000 claims 6
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 4
- 230000000155 isotopic effect Effects 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 235000012054 meals Nutrition 0.000 claims 2
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 230000003908 liver function Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- QVGXLLKOCUKJST-NJFSPNSNSA-N oxygen-18 atom Chemical compound [18O] QVGXLLKOCUKJST-NJFSPNSNSA-N 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73547905P | 2005-11-11 | 2005-11-11 | |
| PCT/IL2006/001296 WO2007054940A2 (en) | 2005-11-11 | 2006-11-12 | Breath test device and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009516534A JP2009516534A (ja) | 2009-04-23 |
| JP2009516534A5 true JP2009516534A5 (https=) | 2010-01-07 |
Family
ID=38023667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539609A Pending JP2009516534A (ja) | 2005-11-11 | 2006-11-12 | 呼気試験装置および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8622920B2 (https=) |
| EP (1) | EP1960004A4 (https=) |
| JP (1) | JP2009516534A (https=) |
| WO (1) | WO2007054940A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2527595T3 (es) | 2005-06-25 | 2015-01-27 | Freie Universität Berlin | Solución acuosa de metacetina 13C |
| US8512258B2 (en) * | 2005-11-11 | 2013-08-20 | Exalenz Bioscience Ltd. | Breath test device and method |
| DE102006018862A1 (de) * | 2006-03-17 | 2007-09-20 | Charité - Universitätsmedizin Berlin | Vorrichtung zur spektroskopischen Analyse eines Gases |
| US9585613B2 (en) * | 2009-02-26 | 2017-03-07 | Universite D'angers | Diagnosis of liver fibrosis and cirrhosis |
| DE102009055320B4 (de) | 2009-12-24 | 2011-09-01 | Humedics Gmbh | Messvorrichtung und Verfahren zur Untersuchung eines Probegases mittels Infrarot-Absorptionsspektroskopie |
| US8753889B1 (en) * | 2010-04-01 | 2014-06-17 | Beverly L. Roeder | Methods for diagnosing and treating disease in animals by the analysis of isotopes in elements such as carbon and nitrogen in animal substrate |
| DE102011007310A1 (de) * | 2011-04-13 | 2012-10-18 | Humedics Gmbh | Verfahren zur Bestimmung der metabolischen Leistung mindestens eines Enzyms |
| CN103764026B (zh) | 2011-04-14 | 2016-10-19 | 艾伦斯生物科技有限公司 | 用于肝细胞癌的诊断、预后、监测和治疗的方法 |
| US8512676B1 (en) * | 2012-03-07 | 2013-08-20 | Wisconsin Alumni Research Foundation | Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios |
| US20170181686A1 (en) * | 2014-04-02 | 2017-06-29 | Exalenz Bioscience Ltd. | Breath test for assessing liver disease |
| CN115267100A (zh) * | 2021-04-30 | 2022-11-01 | 北京华亘安邦科技有限公司 | 13c美沙西汀颗粒剂及其制备方法和应用 |
| CN116688160B (zh) * | 2023-07-10 | 2025-07-25 | 北京华亘安邦科技有限公司 | 一种13c美沙西汀口崩片及其制备方法与应用 |
| CN116966323B (zh) * | 2023-07-10 | 2026-02-27 | 北京华亘安邦科技有限公司 | 一种13c美沙西汀注射用冻干粉针剂及其制备方法与应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59304180D1 (de) * | 1992-07-22 | 1996-11-21 | Mannesmann Ag | Nichtdispersives Infrarotspektrometer |
| US5386832A (en) * | 1993-06-11 | 1995-02-07 | New England Deaconess Hospital | Liver function breath test using aromatic amino acids |
| US6186958B1 (en) * | 1997-02-26 | 2001-02-13 | Oridion Medical | Breath test analyzer |
| USRE38728E1 (en) * | 1997-09-11 | 2005-04-19 | Oridion Medical, LTD | Breath test analyzer |
| JP3340391B2 (ja) * | 1997-09-11 | 2002-11-05 | 東京瓦斯株式会社 | 肝手術評価用試薬 |
| ES2319344T3 (es) | 1997-09-11 | 2009-05-06 | Oridion Breathid Ltd. | Analizador de test de aliento. |
| CA2249173C (en) * | 1997-10-06 | 2008-12-16 | Tokyo Gas Co., Ltd. | Diagnostic agent for liver function |
| JP4007669B2 (ja) * | 1997-10-21 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| JP4007664B2 (ja) * | 1998-01-16 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| JP4007660B2 (ja) * | 1997-12-11 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| JP4007647B2 (ja) * | 1997-10-06 | 2007-11-14 | 東京瓦斯株式会社 | 肝機能診断剤 |
| CA2250485C (en) * | 1997-10-21 | 2008-04-29 | Tokyo Gas Co., Ltd. | Diagnostic agent for diabetes |
| US6656127B1 (en) * | 1999-06-08 | 2003-12-02 | Oridion Breathid Ltd. | Breath test apparatus and methods |
| US6486474B1 (en) * | 1999-08-13 | 2002-11-26 | Regents Of The University Of Minnesota | Infrared spectrometer for the measurement of isotopic ratios |
| GB0106923D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Dundee | Liver function test |
| US20040253637A1 (en) * | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| JP2005503205A (ja) * | 2001-08-23 | 2005-02-03 | オリディオン ブレシド リミティド | 胃腸障害の管理 |
| US6778269B2 (en) * | 2001-09-04 | 2004-08-17 | Board Of Regents, The University Of Texas System | Detecting isotopes and determining isotope ratios using raman spectroscopy |
| IL148468A (en) * | 2002-03-03 | 2012-12-31 | Exalenz Bioscience Ltd | Breath collection system |
| US7490085B2 (en) * | 2002-12-18 | 2009-02-10 | Ge Medical Systems Global Technology Company, Llc | Computer-assisted data processing system and method incorporating automated learning |
| US8778299B2 (en) * | 2005-01-26 | 2014-07-15 | The Regents Of The University Of Colorado, A Body Corporate | Methods for diagnosis and intervention of hepatic disorders |
| EP1702558A1 (en) * | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| JP2008538275A (ja) * | 2005-04-16 | 2008-10-23 | 大塚製薬株式会社 | 呼気試験を用いたチトクロムｐ４５０２ｄ６アイソザイム活性を評価するための方法と組成物 |
| ES2527595T3 (es) * | 2005-06-25 | 2015-01-27 | Freie Universität Berlin | Solución acuosa de metacetina 13C |
| US8512258B2 (en) * | 2005-11-11 | 2013-08-20 | Exalenz Bioscience Ltd. | Breath test device and method |
| US7662105B2 (en) * | 2005-12-14 | 2010-02-16 | Cardiac Pacemakers, Inc. | Systems and methods for determining respiration metrics |
-
2006
- 2006-11-12 US US12/084,629 patent/US8622920B2/en active Active
- 2006-11-12 WO PCT/IL2006/001296 patent/WO2007054940A2/en not_active Ceased
- 2006-11-12 JP JP2008539609A patent/JP2009516534A/ja active Pending
- 2006-11-12 EP EP06809856A patent/EP1960004A4/en not_active Ceased
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