JP2009515987A - 肝臓の健康状態を改善するための植物を主体とした製剤 - Google Patents
肝臓の健康状態を改善するための植物を主体とした製剤 Download PDFInfo
- Publication number
- JP2009515987A JP2009515987A JP2008541325A JP2008541325A JP2009515987A JP 2009515987 A JP2009515987 A JP 2009515987A JP 2008541325 A JP2008541325 A JP 2008541325A JP 2008541325 A JP2008541325 A JP 2008541325A JP 2009515987 A JP2009515987 A JP 2009515987A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- formulation
- root
- liver
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 83
- 238000009472 formulation Methods 0.000 title claims abstract description 63
- 210000004185 liver Anatomy 0.000 title claims abstract description 58
- 230000036541 health Effects 0.000 title claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 71
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 70
- 230000006378 damage Effects 0.000 claims abstract description 35
- 102000004190 Enzymes Human genes 0.000 claims abstract description 29
- 108090000790 Enzymes Proteins 0.000 claims abstract description 29
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 16
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 16
- 235000009337 Spinacia oleracea Nutrition 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 15
- 235000013628 Lantana involucrata Nutrition 0.000 claims abstract description 14
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 claims abstract description 14
- 240000003291 Armoracia rusticana Species 0.000 claims abstract description 13
- 235000011330 Armoracia rusticana Nutrition 0.000 claims abstract description 13
- 239000009759 San-Chi Substances 0.000 claims abstract description 11
- 241000208296 Datura Species 0.000 claims abstract description 10
- 244000003416 Asparagus officinalis Species 0.000 claims abstract description 9
- 235000005340 Asparagus officinalis Nutrition 0.000 claims abstract description 9
- 230000001939 inductive effect Effects 0.000 claims abstract description 8
- 241000208340 Araliaceae Species 0.000 claims abstract description 6
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 6
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 6
- 235000008434 ginseng Nutrition 0.000 claims abstract description 6
- 240000007673 Origanum vulgare Species 0.000 claims abstract 9
- 238000000034 method Methods 0.000 claims description 42
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims description 22
- 241000234479 Narcissus Species 0.000 claims description 12
- 239000004615 ingredient Substances 0.000 claims description 8
- 244000000626 Daucus carota Species 0.000 claims description 7
- 235000002767 Daucus carota Nutrition 0.000 claims description 7
- 208000027418 Wounds and injury Diseases 0.000 claims description 7
- 208000014674 injury Diseases 0.000 claims description 7
- 235000020710 ginseng extract Nutrition 0.000 claims description 5
- 241000219315 Spinacia Species 0.000 claims 8
- 241000207199 Citrus Species 0.000 claims 3
- 235000020971 citrus fruits Nutrition 0.000 claims 3
- 244000019459 Cynara cardunculus Species 0.000 claims 1
- 235000019106 Cynara scolymus Nutrition 0.000 claims 1
- 235000016520 artichoke thistle Nutrition 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 17
- 241000180649 Panax notoginseng Species 0.000 abstract description 13
- 235000003143 Panax notoginseng Nutrition 0.000 abstract description 13
- 244000300264 Spinacia oleracea Species 0.000 abstract description 7
- 239000000835 fiber Substances 0.000 abstract description 7
- 241000196324 Embryophyta Species 0.000 abstract description 6
- 239000000469 ethanolic extract Substances 0.000 abstract description 5
- 238000002360 preparation method Methods 0.000 abstract description 4
- 244000230712 Narcissus tazetta Species 0.000 abstract 1
- 244000209700 shan ge teng Species 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 48
- 210000003494 hepatocyte Anatomy 0.000 description 42
- 239000000523 sample Substances 0.000 description 41
- 235000019441 ethanol Nutrition 0.000 description 34
- 230000000694 effects Effects 0.000 description 33
- 210000004027 cell Anatomy 0.000 description 27
- 230000007850 degeneration Effects 0.000 description 23
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 19
- 238000007619 statistical method Methods 0.000 description 19
- 241001465754 Metazoa Species 0.000 description 18
- 238000003556 assay Methods 0.000 description 16
- 238000002474 experimental method Methods 0.000 description 16
- 238000011156 evaluation Methods 0.000 description 14
- 238000000540 analysis of variance Methods 0.000 description 12
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 11
- 229940118019 malondialdehyde Drugs 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 239000000411 inducer Substances 0.000 description 10
- 230000006698 induction Effects 0.000 description 10
- 231100000915 pathological change Toxicity 0.000 description 10
- 230000036285 pathological change Effects 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 230000017074 necrotic cell death Effects 0.000 description 9
- 102000004960 NAD(P)H dehydrogenase (quinone) Human genes 0.000 description 8
- 108020000284 NAD(P)H dehydrogenase (quinone) Proteins 0.000 description 8
- 241000700159 Rattus Species 0.000 description 8
- 230000037396 body weight Effects 0.000 description 8
- 230000001086 cytosolic effect Effects 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- 150000002632 lipids Chemical class 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- SUVMJBTUFCVSAD-UHFFFAOYSA-N sulforaphane Chemical compound CS(=O)CCCCN=C=S SUVMJBTUFCVSAD-UHFFFAOYSA-N 0.000 description 8
- 150000003626 triacylglycerols Chemical class 0.000 description 8
- 229960003180 glutathione Drugs 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 206010067125 Liver injury Diseases 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 230000002159 abnormal effect Effects 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 238000001784 detoxification Methods 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 230000009466 transformation Effects 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 6
- 108010024636 Glutathione Proteins 0.000 description 5
- 240000005183 Lantana involucrata Species 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000001338 necrotic effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 description 4
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 4
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 231100000002 MTT assay Toxicity 0.000 description 4
- 238000000134 MTT assay Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 235000002791 Panax Nutrition 0.000 description 4
- 241000208343 Panax Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 244000195452 Wasabia japonica Species 0.000 description 4
- 235000000760 Wasabia japonica Nutrition 0.000 description 4
- 238000004166 bioassay Methods 0.000 description 4
- 239000006143 cell culture medium Substances 0.000 description 4
- 230000030833 cell death Effects 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 230000003833 cell viability Effects 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 230000002706 hydrostatic effect Effects 0.000 description 4
- 230000003859 lipid peroxidation Effects 0.000 description 4
- 230000003908 liver function Effects 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 229960005559 sulforaphane Drugs 0.000 description 4
- 235000015487 sulforaphane Nutrition 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- KIUMMUBSPKGMOY-UHFFFAOYSA-N 3,3'-Dithiobis(6-nitrobenzoic acid) Chemical compound C1=C([N+]([O-])=O)C(C(=O)O)=CC(SSC=2C=C(C(=CC=2)[N+]([O-])=O)C(O)=O)=C1 KIUMMUBSPKGMOY-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000000805 cytoplasm Anatomy 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 231100000234 hepatic damage Toxicity 0.000 description 3
- 231100000753 hepatic injury Toxicity 0.000 description 3
- 230000008818 liver damage Effects 0.000 description 3
- 210000005228 liver tissue Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 238000013268 sustained release Methods 0.000 description 3
- 239000012730 sustained-release form Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 125000003831 tetrazolyl group Chemical group 0.000 description 3
- WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 description 2
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 2
- 244000308180 Brassica oleracea var. italica Species 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229940127463 Enzyme Inducers Drugs 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 231100000416 LDH assay Toxicity 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000320380 Silybum Species 0.000 description 2
- 235000010841 Silybum marianum Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 230000005779 cell damage Effects 0.000 description 2
- 238000003570 cell viability assay Methods 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229960001701 chloroform Drugs 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 238000002843 lactate dehydrogenase assay Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 201000007270 liver cancer Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- ZJTLZYDQJHKRMQ-UHFFFAOYSA-N menadiol Chemical compound C1=CC=CC2=C(O)C(C)=CC(O)=C21 ZJTLZYDQJHKRMQ-UHFFFAOYSA-N 0.000 description 2
- 229940100434 menadiol Drugs 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000007863 steatosis Effects 0.000 description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- QGVNJRROSLYGKF-UHFFFAOYSA-N thiobarbital Chemical compound CCC1(CC)C(=O)NC(=S)NC1=O QGVNJRROSLYGKF-UHFFFAOYSA-N 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241001295925 Gegenes Species 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 102000000587 Glycerolphosphate Dehydrogenase Human genes 0.000 description 1
- 108010041921 Glycerolphosphate Dehydrogenase Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- 240000006079 Schisandra chinensis Species 0.000 description 1
- 235000008422 Schisandra chinensis Nutrition 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- FHNINJWBTRXEBC-UHFFFAOYSA-N Sudan III Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC(C=C1)=CC=C1N=NC1=CC=CC=C1 FHNINJWBTRXEBC-UHFFFAOYSA-N 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920003064 carboxyethyl cellulose Polymers 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000005786 degenerative changes Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 231100000317 environmental toxin Toxicity 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 231100000334 hepatotoxic Toxicity 0.000 description 1
- 230000003082 hepatotoxic effect Effects 0.000 description 1
- 231100001026 histopathological changes in livers Toxicity 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 230000003228 microsomal effect Effects 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- LAZVTKQYCZFNSZ-UHFFFAOYSA-N nitro formate Chemical compound [O-][N+](=O)OC=O LAZVTKQYCZFNSZ-UHFFFAOYSA-N 0.000 description 1
- 150000004005 nitrosamines Chemical class 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 235000019533 nutritive sweetener Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- -1 osmotic pumps Polymers 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 229940099373 sudan iii Drugs 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000004260 weight control Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/274,618 US7419689B2 (en) | 2005-11-15 | 2005-11-15 | Plant-based formulations for improving liver health |
| PCT/US2006/044420 WO2007059250A2 (en) | 2005-11-15 | 2006-11-15 | Plant-based formulations for improving liver health |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515987A true JP2009515987A (ja) | 2009-04-16 |
| JP2009515987A5 JP2009515987A5 (enExample) | 2010-01-14 |
Family
ID=37692535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541325A Pending JP2009515987A (ja) | 2005-11-15 | 2006-11-15 | 肝臓の健康状態を改善するための植物を主体とした製剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7419689B2 (enExample) |
| JP (1) | JP2009515987A (enExample) |
| KR (1) | KR101350053B1 (enExample) |
| CN (1) | CN101415433B (enExample) |
| WO (1) | WO2007059250A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528144A (ja) * | 2009-05-26 | 2012-11-12 | 株式会社アモーレパシフィック | サポニンの生体利用率増進組成物 |
| WO2025159204A1 (ja) * | 2024-01-25 | 2025-07-31 | イーエヌ大塚製薬株式会社 | 組成物 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7419689B2 (en) * | 2005-11-15 | 2008-09-02 | Access Business Group International Llc. | Plant-based formulations for improving liver health |
| WO2009105123A1 (en) * | 2008-02-22 | 2009-08-27 | The Trustees Of Columbia University In The City Of New York | Compounds, compositions and methods for treating or preventing diseases |
| US8859615B2 (en) | 2008-08-27 | 2014-10-14 | Samuel J. Danishefsky | Compounds, compositions and methods for reducing toxicity and treating or preventing diseases |
| US20110135763A1 (en) * | 2009-12-03 | 2011-06-09 | Alexander Fish | Antiseptic formulation especially for prevention of complications associated with skin burns |
| US8298597B2 (en) * | 2010-04-13 | 2012-10-30 | Charles Thomas Muller | Composition to help protect a user against liver damage from alcohol consumption |
| CN102579968A (zh) * | 2011-01-14 | 2012-07-18 | 统欣生物科技股份有限公司 | 改善肝功能及降低肝损伤的组合物 |
| CN102511590B (zh) * | 2011-11-30 | 2013-05-08 | 西北农林科技大学 | 一种具有解酒醒酒功效的葛根蓝莓凉茶及其制备方法 |
| CN103494897A (zh) * | 2013-09-30 | 2014-01-08 | 秦福玉 | 一种治疗慢性肝炎的中药 |
| CN103610048B (zh) * | 2013-11-21 | 2016-02-10 | 西安医学院 | 对化学性肝损伤有辅助保护功能的保健食品及其制备方法 |
| DE202014005450U1 (de) * | 2014-07-04 | 2015-10-06 | Ursapharm Arzneimittel Gmbh | Lactosefreies Arzneimittel |
| CN106689933A (zh) * | 2016-12-29 | 2017-05-24 | 皖南医学院 | 一种富含天然成分提取物的解酒护肝饮料及其制备方法 |
| KR101990000B1 (ko) | 2018-03-02 | 2019-09-30 | 강원대학교산학협력단 | 초석잠 뿌리 추출물 또는 이의 분획물을 유효성분으로 포함하는 기능성 조성물 |
| US20240197801A1 (en) * | 2022-12-17 | 2024-06-20 | Porche Price | Liver Vitality |
| CN116987205A (zh) * | 2023-04-04 | 2023-11-03 | 北京中医药大学 | 一种具有防治阿尔茨海默症的三七多糖制备工艺及其相关产品 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09241164A (ja) * | 1996-03-04 | 1997-09-16 | Tsuneo Nanba | 肝臓保護作用成分ギンセノサイドＲｅ／ギンセノサイドＲｇ１からなる肝臓保護薬とその製造法 |
| JP2001064253A (ja) * | 1999-08-27 | 2001-03-13 | Kinjirushi Wasabi Kk | グルタチオン−ｓ−トランスフエラーゼの活性誘導物質およびこれを含む食品 |
| JP2001504443A (ja) * | 1996-07-06 | 2001-04-03 | アール ファルマ ゲゼルシャフト ミット ベシュレンクター ハフツング ウント コンパニー コマンデット ゲゼルシャフト | アーティチョーク（Ｃｙｎａｒａ）抽出物の使用 |
| WO2004002238A1 (en) * | 2002-06-26 | 2004-01-08 | Nestec S.A. | Nutritional composition for detoxification and cancer prevention |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1126088A (zh) | 1995-07-28 | 1996-07-10 | 黄河溪 | 中药羚倍散及其配制方法 |
| US5783189A (en) * | 1996-04-23 | 1998-07-21 | Natural Pharmacia International, Inc. | Method for treating alcohol dependence |
| GB9704904D0 (en) * | 1997-03-10 | 1997-04-30 | Riley Fletcher Foundation The | Essential oil composition |
| CN1287857A (zh) | 1999-09-14 | 2001-03-21 | 徐锡祖 | 一种治疗肝炎病的中成药剂及制备方法 |
| WO2001091746A1 (en) * | 2000-06-01 | 2001-12-06 | The Mclean Hospital Corporation | Method for treating alcohol intoxication and alcohol abuse |
| KR100374004B1 (ko) | 2000-07-12 | 2003-03-03 | 박윤자 | 장어와 한약재를 주재료로 한 보약음료 및 그 제조방법 |
| US6592321B2 (en) * | 2000-08-03 | 2003-07-15 | Demag Cranes & Components Gmbh | Control and guiding device for manually operating a handling unit, and modular construction kit for making such devices of different configuration |
| US20030165557A1 (en) * | 2000-09-19 | 2003-09-04 | Sunstar, Inc. | Food, medicine and method relating to Bifidobacterium proliferation promoting action, allergy preventive action and human cholesterol lowering action |
| US6455078B1 (en) * | 2000-10-18 | 2002-09-24 | Tzu-Sheng Wu | Medicinal herbal composition for treating liver diseases and HIV |
| US6824798B2 (en) * | 2001-09-27 | 2004-11-30 | J. Gregory Koenig | Method of preventing veisalgia |
| US7740878B2 (en) * | 2001-10-22 | 2010-06-22 | Danisco A/S | Use of betaine to enhance exercise performance |
| US20050037094A1 (en) * | 2003-07-31 | 2005-02-17 | Xijun Yan | Composition for heart disease, its active ingredients, method to prepare same and uses thereof |
| KR100500521B1 (ko) | 2003-08-27 | 2005-07-18 | 한국식품연구원 | 알콜성 지방간 예방 및 숙취해소 효과가 있는 식품조성물및 그 제조방법 |
| US7078064B2 (en) * | 2003-12-03 | 2006-07-18 | George Zabrecky | Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis |
| CN1259070C (zh) | 2004-09-30 | 2006-06-14 | 张�林 | 对化学性肝损伤有辅助保护作用的保健胶囊及其制备方法 |
| US7419689B2 (en) * | 2005-11-15 | 2008-09-02 | Access Business Group International Llc. | Plant-based formulations for improving liver health |
-
2005
- 2005-11-15 US US11/274,618 patent/US7419689B2/en active Active
-
2006
- 2006-11-15 WO PCT/US2006/044420 patent/WO2007059250A2/en not_active Ceased
- 2006-11-15 CN CN2006800506996A patent/CN101415433B/zh active Active
- 2006-11-15 JP JP2008541325A patent/JP2009515987A/ja active Pending
- 2006-11-15 KR KR1020087011534A patent/KR101350053B1/ko active Active
-
2008
- 2008-07-16 US US12/218,585 patent/US7718201B2/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09241164A (ja) * | 1996-03-04 | 1997-09-16 | Tsuneo Nanba | 肝臓保護作用成分ギンセノサイドＲｅ／ギンセノサイドＲｇ１からなる肝臓保護薬とその製造法 |
| JP2001504443A (ja) * | 1996-07-06 | 2001-04-03 | アール ファルマ ゲゼルシャフト ミット ベシュレンクター ハフツング ウント コンパニー コマンデット ゲゼルシャフト | アーティチョーク（Ｃｙｎａｒａ）抽出物の使用 |
| JP2001064253A (ja) * | 1999-08-27 | 2001-03-13 | Kinjirushi Wasabi Kk | グルタチオン−ｓ−トランスフエラーゼの活性誘導物質およびこれを含む食品 |
| WO2004002238A1 (en) * | 2002-06-26 | 2004-01-08 | Nestec S.A. | Nutritional composition for detoxification and cancer prevention |
Non-Patent Citations (9)
| Title |
|---|
| JPN6012028558; Ｊ．Ａ．Ｄｕｋｅ著／星合和夫 訳: デューク グリーンファーマシィ 第１版第１刷, 20020828, ｐ．３３７, ＣＭＰジャパン株式会社 * |
| JPN6012028560; 竹田茂文 他: '五味子リグナン成分Ｇｏｍｉｓｉｎ Ａ （ＴＪＮ-１０１）のラット肝機能におよぼす影響' 日本薬理学雑誌 Ｖｏｌ．９１，Ｎｏ．４, 1988, Ｐａｇｅ．２３７-２４４ * |
| JPN6012028562; 鈴木洋著: 漢方のくすりの辞典-生薬・ハーブ・民間薬- 第１版第７刷, 20040620, ｐ．１５９, 医歯薬出版株式会社 * |
| JPN6012028564; 平川智規 他: 'オレアナン型トリテルペンの肝保護作用ならびに抗ヘルペス作用' 日本薬学会年会要旨集 Ｖｏｌ．１２０ｔｈ，Ｎｏ．２, 2000, Ｐａｇｅ．５６ * |
| JPN6012028565; ＫＥＵＮＧ Ｗ Ｍ ｅｔ ａｌ: 'Ｄａｉｄｚｉｎ ｉｎｈｉｂｉｔｓ ｍｉｔｏｃｈｏｎｄｒｉａｌ ａｌｄｅｈｙｄｅ ｄｅｈｙｄｒｏｇｅｎａｓｅ ａｎｄ ｓｕｐｐｒｅｓｓｅｓ ｅｔｈａｎｏｌ ｉｎｔａｋｅ ｏｆ Ｓｙｒｉａｎ ｇｏｌｄｅｎ' Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ Ｖｏｌ．９４，Ｎｏ．５, 1997, Ｐａｇｅ．１６７５-１６７９ * |
| JPN6012028566; ＡＲＡＯ Ｔ， ｅｔ ａｌ: 'Ｐｒｅｖｅｎｔｉｖｅ Ｅｆｆｅｃｔｓ ｏｆ Ｓａｐｏｎｉｎｓ ｆｒｏｍ ｔｈｅ Ｐｕｅｒａｒｉａ ｌｏｂａｔａ Ｒｏｏｔ ｏｎ ｉｎ ｖｉｔｒｏ Ｉｍｍｕｎｏｌｏｇｉｃａｌ Ｌｉｖｅｒ Ｉｎｊｕｒｙ' Ｐｌａｎｔａ Ｍｅｄ Ｖｏｌ．６４，Ｎｏ．５, 1998, Ｐａｇｅ．４１３-４１６ * |
| JPN6012028567; ＬＯＭＮＩＴＳＫＩ Ｌ ｅｔ ａｌ: 'Ｅｆｆｅｃｔｓ ｏｆ Ａｐｏｃｙｎｉｎ ａｎｄ Ｎａｔｕｒａｌ Ａｎｔｉｏｘｉｄａｎｔ ｆｒｏｍ Ｓｐｉｎａｃｈ ｏｎ Ｉｎｄｕｃｉｂｌｅ Ｎｉｔｒｉｃ Ｏｘｉｄｅ Ｓｙｎｔｈａｓｅ ａｎｄ Ｃｙｃｌ' Ｐｈａｒｍａｃｏｌ Ｔｏｘｉｃｏｌ Ｖｏｌ．８７，Ｎｏ．１, 2000, Ｐａｇｅ．１８-２５ * |
| JPN6012028568; Ｌｉｎ，Ｙｕｎ-Ｌｉａｎ ｅｔ ａｌ: 'Ｂｅｎｚｏｌｉｇｎａｎｏｉｄ ａｎｄ ｐｏｌｙｐｈｅｎｏｌｓ ｆｒｏｍ Ｏｒｉｇａｎｕｍ ｖｕｌｇａｒｅ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｉｎｅｓｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ５０（５）, 2003, ｐｐ．１０７９-１０８３ * |
| JPN6012028569; ＧＥＢＨＡＲＤＴ Ｒ ｅｔ ａｌ: 'Ａｎｔｉｏｘｉｄａｎｔ ａｎｄ Ｈｅｐａｔｏｐｒｏｔｅｃｔｉｖｅ Ｅｆｆｅｃｔｓ ｏｆ Ａｒｔｉｃｈｏｋｅ Ｅｘｔｒａｃｔｓ ａｎｄ Ｃｏｎｓｔｉｔｕｅｎｔｓ ｉｎ Ｃｕｌｔｕｒｅｄ Ｒａｔ Ｈｅｐａ' Ｔｏｘｉｃｏｌ Ｉｎ Ｖｉｔｒｏ Ｖｏｌ．１１，Ｎｏ．５, 1997, Ｐａｇｅ．６６９-６７２ * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012528144A (ja) * | 2009-05-26 | 2012-11-12 | 株式会社アモーレパシフィック | サポニンの生体利用率増進組成物 |
| WO2025159204A1 (ja) * | 2024-01-25 | 2025-07-31 | イーエヌ大塚製薬株式会社 | 組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US7419689B2 (en) | 2008-09-02 |
| US20070110831A1 (en) | 2007-05-17 |
| KR101350053B1 (ko) | 2014-01-29 |
| CN101415433B (zh) | 2013-01-30 |
| WO2007059250A2 (en) | 2007-05-24 |
| CN101415433A (zh) | 2009-04-22 |
| US20090011054A1 (en) | 2009-01-08 |
| US7718201B2 (en) | 2010-05-18 |
| HK1129839A1 (en) | 2009-12-11 |
| KR20080066802A (ko) | 2008-07-16 |
| WO2007059250A3 (en) | 2007-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7718201B2 (en) | Method of inducing liver phase II enzymes | |
| Türk et al. | Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats | |
| Karamalakova et al. | Hepatoprotective properties of Curcuma longa L. extract in bleomycin-induced chronic hepatotoxicity | |
| Nwanjo et al. | Anti-lipid peroxidative activity of Gongronema latifoluim in streptozotocin-induced diadetic rat | |
| TW200940081A (en) | A plant composition | |
| Nuhu et al. | Effects of Cassia occidentalis aqueous leaf extract on biochemical markers of tissue damage in rats | |
| AU2009216012A1 (en) | Leaves extract of panax SP., a process of making the same and uses thereof | |
| Spanou et al. | Effects of Greek legume plant extracts on xanthine oxidase, catalase and superoxide dismutase activities | |
| CN105902998B (zh) | 保肝胶囊 | |
| Indira et al. | Comparative hepato-ameliorative effects of Bambusa nutans fresh and fermented shoot extracts on STZ induced diabetic LACA mice | |
| Nguyen et al. | Optimization of Spray Drying Process of Mangiferin Extract from Mango Leaf (Mangifera indica L.) and Encapsulation for Diabetes Treatment | |
| Hanna et al. | Impact of Energy Drinks on kidney Tissue and Oxidative Stress in Female Wistar Rats and Their Neonates | |
| Tsakiris et al. | α-Tocopherol supplementation reduces the elevated 8-hydroxy-2-deoxyguanosine blood levels induced by training in basketball players. | |
| HK1129839B (en) | Plant-based formulations for improving liver health | |
| Sunil et al. | Antihyperglycemic, antihyperlipidemic and antioxidant activities of Euphorbia hirta stem extract | |
| Tian et al. | Evaluation of inhalation toxicology after a 90-day xylitol aerosol exposure in Sprague-Dawley rats | |
| Ibrahim et al. | Hepatic-and renal protective effects of Chrysophyllum albidum (African star apple) fruit-skin supplementation on streptozotocin-induced diabetic rats | |
| Ojimelukwe et al. | Effect of Odogwu Bitters on Biochemical Indices of Albino Rats | |
| Osibemhe et al. | Sub-chronic toxicity of extracts of Strophanthus hispidus stem bark in normal rats | |
| Darbar et al. | Ethanol Intoxicated Hepatic Oxidative Stress Mitigated by Poly-Herbal Formulation–Trasina® in Murine Model | |
| JP3587359B2 (ja) | ムラサキサツマイモ由来の血液循環改善作用を有する食品素材 | |
| Mirzaei et al. | Increased risk of cerebral dysfunction by high-fructose diet consumption: A 90-day study in female rats | |
| Oluwabunmi et al. | Chronic Administration of Monosodium Glutamate Induced Changes on Some Blood Electrolytes And Heart Enzymes in Male Sprague Dawley Rats | |
| Enoyoze et al. | Biosafety assessment and In vitro antioxidant activity of Musanga cecropioides root sap | |
| Abdulshaheed et al. | Effects of lead toxicity on renal biochemical indices before and after treatment with Pimpinella anisum aqueous extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20091116 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20091116 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120604 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120904 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120911 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130415 |