JP2009515887A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009515887A5 JP2009515887A5 JP2008540207A JP2008540207A JP2009515887A5 JP 2009515887 A5 JP2009515887 A5 JP 2009515887A5 JP 2008540207 A JP2008540207 A JP 2008540207A JP 2008540207 A JP2008540207 A JP 2008540207A JP 2009515887 A5 JP2009515887 A5 JP 2009515887A5
- Authority
- JP
- Japan
- Prior art keywords
- aminophenyl
- methoxyphenyl
- methylphenyl
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 4-methoxyphenyl 2,4-dimethoxyphenyl Chemical group 0.000 claims 89
- 150000001875 compounds Chemical class 0.000 claims 32
- 239000000203 mixture Substances 0.000 claims 17
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical group NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 claims 14
- 208000024412 Friedreich ataxia Diseases 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 12
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 12
- LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical group NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 claims 12
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 12
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 claims 12
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 12
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 12
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 9
- 108020004999 messenger RNA Proteins 0.000 claims 6
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 4
- 150000007514 bases Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 3
- 108090000217 Frataxin Proteins 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 239000002585 base Substances 0.000 claims 3
- 239000012024 dehydrating agents Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- FPIRBHDGWMWJEP-UHFFFAOYSA-N 1-hydroxy-7-azabenzotriazole Chemical compound C1=CN=C2N(O)N=NC2=C1 FPIRBHDGWMWJEP-UHFFFAOYSA-N 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 102000003869 Frataxin Human genes 0.000 claims 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 239000007822 coupling agent Substances 0.000 claims 2
- 230000006195 histone acetylation Effects 0.000 claims 2
- BXGTVNLGPMZLAZ-UHFFFAOYSA-N n'-ethylmethanediimine;hydrochloride Chemical compound Cl.CCN=C=N BXGTVNLGPMZLAZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 102000003964 Histone deacetylase Human genes 0.000 claims 1
- 108090000353 Histone deacetylase Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 150000001342 alkaline earth metals Chemical class 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 0 C*(C)C(N(O*)I)=O Chemical compound C*(C)C(N(O*)I)=O 0.000 description 3
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73548305P | 2005-11-11 | 2005-11-11 | |
| US83890806P | 2006-08-18 | 2006-08-18 | |
| US82305106P | 2006-08-21 | 2006-08-21 | |
| PCT/US2006/043745 WO2007058927A1 (en) | 2005-11-11 | 2006-11-10 | Histone deacetylase inhibitors as therapeutics for neurological diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515887A JP2009515887A (ja) | 2009-04-16 |
| JP2009515887A5 true JP2009515887A5 (https=) | 2009-12-10 |
Family
ID=37806954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540207A Withdrawn JP2009515887A (ja) | 2005-11-11 | 2006-11-10 | 神経系疾患のための治療薬としてのヒストンデアセチラーゼ阻害剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US20070219244A1 (https=) |
| EP (2) | EP1951656B1 (https=) |
| JP (1) | JP2009515887A (https=) |
| WO (1) | WO2007058927A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009515887A (ja) | 2005-11-11 | 2009-04-16 | ザ スクリプス リサーチ インスティテュート | 神経系疾患のための治療薬としてのヒストンデアセチラーゼ阻害剤 |
| WO2009055675A1 (en) * | 2007-10-26 | 2009-04-30 | Repligen Corporation | Methods of identifying histone deacetylase inhibitors useful for neurological disorders |
| EP2231596A4 (en) * | 2007-12-14 | 2012-06-06 | Univ Georgetown | INHIBITORS OF HISTONATE ACETYLASE |
| EP2330894B8 (en) | 2008-09-03 | 2017-04-19 | BioMarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors |
| WO2010028193A1 (en) * | 2008-09-03 | 2010-03-11 | Repligen Corporation | Compounds including pimelic acid derivatives as hdac inhibitors |
| KR101535319B1 (ko) * | 2008-11-05 | 2015-07-10 | 유니버시티 오브 써던 캘리포니아 | 후생적 조절의 소형 분자 조절물질, 그리고 이들의 치료적 적용 |
| WO2010083327A2 (en) * | 2009-01-14 | 2010-07-22 | Mayo Foundation For Medical Education And Research | Measuring levels of frataxin |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| CN102633668B (zh) * | 2012-01-20 | 2015-05-06 | 天舒生物技术有限公司 | 化合物在转录因子失调相关疾病的治疗药物中的应用 |
| CN103288682B (zh) * | 2012-02-25 | 2016-06-22 | 浙江华海药业股份有限公司 | 一种简便的纯化(4-氨基苯基)氨基甲酸叔丁酯的方法 |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| CA2873769A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating hemoglobin gene family expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| CA2873766A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating atp2a2 expression |
| US9133105B2 (en) * | 2013-03-06 | 2015-09-15 | C&C Biopharma, Llc | Transcription factor modulators |
| WO2014143666A1 (en) | 2013-03-15 | 2014-09-18 | Biomarin Pharmaceutical Inc. | Hdac inhibitors |
| WO2015017861A1 (en) | 2013-08-02 | 2015-02-05 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment of friedreich's ataxia |
| JP2016531570A (ja) | 2013-08-16 | 2016-10-13 | ラナ セラピューティクス インコーポレイテッド | ユークロマチン領域を標的とするオリゴヌクレオチド |
| EP3033425A4 (en) * | 2013-08-16 | 2017-07-26 | Rana Therapeutics, Inc. | Compositions and methods for modulating expression of frataxin |
| EP3033423A4 (en) * | 2013-08-16 | 2017-04-26 | Rana Therapeutics Inc. | Epigenetic regulators of frataxin |
| US20160271090A1 (en) | 2013-10-29 | 2016-09-22 | Tokyo University Of Agriculture | Frataxin enhancer |
| EP3066077A4 (en) * | 2013-11-05 | 2017-08-09 | C & C Biopharma, LLC | Treatment of cardiac remodeling and other heart conditions |
| WO2015108940A2 (en) * | 2014-01-14 | 2015-07-23 | The Trustees Of The University Of Pennsylvania | Tailored combinatorial epigenetic therapies for p53 gain-of-function tumors |
| WO2016032569A1 (en) * | 2014-08-29 | 2016-03-03 | Celladon Corporation | Quinolines and their use for treating endoplasmic reticulum stress-caused diseases |
| US20200347038A1 (en) | 2014-08-29 | 2020-11-05 | Russell Dahl | Quinolines that modulate serca and their use for treating disease |
| WO2016130943A1 (en) | 2015-02-13 | 2016-08-18 | Rana Therapeutics, Inc. | Hybrid oligonucleotides and uses thereof |
| WO2017037567A1 (en) * | 2015-09-03 | 2017-03-09 | Pfizer Inc. | Regulators of frataxin |
| JP2018528968A (ja) * | 2015-09-17 | 2018-10-04 | ユニバーシティ オブ マサチューセッツ | Ｆｍｒ１発現を調節するための組成物および方法 |
| WO2017172914A1 (en) * | 2016-03-30 | 2017-10-05 | Wisconsin Alumni Research Foundation | Methods and compositions for modulating frataxin expression |
| WO2018098297A1 (en) * | 2016-11-28 | 2018-05-31 | The Scripps Research Institute | Precise small molecule recognition of a toxic cug rna repeat expansion |
| WO2018183679A1 (en) | 2017-03-29 | 2018-10-04 | Wisconsin Alumni Research Foundation | Methods and compositions for modulating gene expression |
| EP3664789B1 (en) * | 2017-08-09 | 2023-11-22 | Children's Hospital Medical Center | Methods for treating diseases and nerve injury |
| WO2019140417A1 (en) * | 2018-01-15 | 2019-07-18 | Daly Thomas P | Aminopyridine based buffers with wide buffering ranges antibiotics and myelin disease therapy |
| EP3843845B1 (en) * | 2018-08-29 | 2026-03-11 | University Of Massachusetts | Inhibition of protein kinases to treat friedreich ataxia |
| KR20210105375A (ko) * | 2018-12-19 | 2021-08-26 | 키테라 (쑤저우) 파마슈티컬스 컴퍼니 리미티드 | Cdk 저해제로서의 대환식 화합물, 이의 제조 방법, 및 의약에서의 이의 용도 |
| US11730729B2 (en) | 2020-07-20 | 2023-08-22 | Neurodon Corporation | Quinolines that modulate SERCA and their use for treating disease |
| KR20240002833A (ko) | 2022-06-30 | 2024-01-08 | 세메스 주식회사 | 제조 공장에서 물품을 이송하는 반송 대차 및 이를 포함하는 물품 반송 시스템 |
| WO2025042293A1 (en) * | 2023-08-22 | 2025-02-27 | Auckland Uniservices Limited | Compounds for treating diabetes and related conditions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| ATE199906T1 (de) | 1993-06-29 | 2001-04-15 | Mitsubishi Chem Corp | Phosphonat-nukleotid ester-derivate |
| EA200601252A1 (ru) * | 1999-09-08 | 2006-10-27 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Новый класс веществ, вызывающих дифференцировку клеток и являющихся ингибиторами гистондеацетилазы, и способы их применения |
| US20040077591A1 (en) * | 2002-03-28 | 2004-04-22 | The Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's Disease |
| PT2527315E (pt) * | 2002-05-31 | 2014-06-24 | Proteotech Inc | Compostos, composições e métodos para o tratamento de doenças da amiloide e sinucleínopatias tais como doença de alzheimer, diabetes do tipo 2, e doença de parkinson |
| DE60211875T2 (de) * | 2002-07-01 | 2006-10-26 | Santhera Pharmaceuticals (Schweiz) Ag | Screeningverfahren und Verbindungen zur Behandlung von Friedreich ataxia |
| US20070043076A1 (en) * | 2003-10-06 | 2007-02-22 | Cai Sui X | Substituted 2-arylmethylene-n-aryl-n'aryl-malonamides and analogs as activators of caspases and inducers of apoptosis |
| JP2009515887A (ja) | 2005-11-11 | 2009-04-16 | ザ スクリプス リサーチ インスティテュート | 神経系疾患のための治療薬としてのヒストンデアセチラーゼ阻害剤 |
-
2006
- 2006-11-10 JP JP2008540207A patent/JP2009515887A/ja not_active Withdrawn
- 2006-11-10 EP EP06837299.4A patent/EP1951656B1/en not_active Not-in-force
- 2006-11-10 WO PCT/US2006/043745 patent/WO2007058927A1/en not_active Ceased
- 2006-11-10 EP EP15179699.2A patent/EP3006424A1/en not_active Withdrawn
- 2006-11-10 US US11/595,779 patent/US20070219244A1/en not_active Abandoned
-
2010
- 2010-05-04 US US12/773,032 patent/US20110021562A1/en not_active Abandoned
-
2013
- 2013-04-15 US US13/862,727 patent/US8835502B2/en active Active
-
2014
- 2014-09-09 US US14/480,899 patent/US9957225B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009515887A5 (https=) | ||
| JP4775259B2 (ja) | アニリン誘導体 | |
| TWI236474B (en) | Antagonists of MCP-1 function and methods of use thereof | |
| CN102143752B (zh) | Pde10抑制剂以及相关组合物和方法 | |
| JPH10500697A (ja) | タチキニン ｎｋ▲下３▼ 受容体アンタゴニストとしてのキノリン誘導体 | |
| JP2011500638A5 (https=) | ||
| TW201002703A (en) | Quinazolinedione derivatives as TRPA1 modulators | |
| JP2008512490A5 (https=) | ||
| JP2010132674A (ja) | リン酸塩輸送インヒビター | |
| JP2012508249A5 (https=) | ||
| CA2440438A1 (en) | Heterocyclic compounds | |
| KR20080094962A (ko) | 아미드 유도체 또는 그의 염 | |
| CN116354901B (zh) | 一种噻唑烷二酮类化合物及其制备方法和应用 | |
| JP4889487B2 (ja) | 置換されたピペリジン化合物とその使用方法 | |
| CN1243507A (zh) | 用作mmp抑制剂的双磺酰胺异羟肟酸类化合物 | |
| CN107001333A (zh) | 多杂芳基组蛋白脱乙酰基酶抑制剂及其治疗用途 | |
| JP2004518628A (ja) | 窒素含有化合物およびそれらのグリシン輸送阻害薬としての使用法 | |
| CN110885332A (zh) | 一种PDEδ蛋白降解靶向嵌合体及其制备方法和应用 | |
| JP2009538296A (ja) | 疼痛、胃腸疾患及びがんの処置に有用なイソインドール誘導体 | |
| JP2008512438A (ja) | 療法用ジフェニルエーテル系リガンド | |
| CN101525316A (zh) | 喹啉类衍生物及其制备方法和用途 | |
| JP2002520315A5 (https=) | ||
| WO2001085724A1 (en) | Gastrin and cholecystokinin receptor ligands (iii) | |
| CN107814758A (zh) | 一种吡咯磺酸类化合物盐型制备 | |
| JP2017516824A5 (https=) |