JP2009515852A - Egfr/her2インヒビターを含む癌の組み合わせ治療 - Google Patents

Egfr/her2インヒビターを含む癌の組み合わせ治療 Download PDF

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JP2009515852A
JP2009515852A JP2008539441A JP2008539441A JP2009515852A JP 2009515852 A JP2009515852 A JP 2009515852A JP 2008539441 A JP2008539441 A JP 2008539441A JP 2008539441 A JP2008539441 A JP 2008539441A JP 2009515852 A JP2009515852 A JP 2009515852A
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amino
group
cancer
carcinoma
oxo
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JP2009515852A5 (OSRAM
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フラヴィオ ゾルカ
アンドレー アメルスベルク
ゲルト シュテーレ
メール ヤコブス セー アー ファン
アンケ バウム
Original Assignee
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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Publication of JP2009515852A publication Critical patent/JP2009515852A/ja
Publication of JP2009515852A5 publication Critical patent/JP2009515852A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008539441A 2005-11-11 2006-11-09 Egfr/her2インヒビターを含む癌の組み合わせ治療 Pending JP2009515852A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05110669 2005-11-11
PCT/EP2006/068314 WO2007054551A1 (en) 2005-11-11 2006-11-09 Combination treatment of cancer comprising egfr/her2 inhibitors

Publications (2)

Publication Number Publication Date
JP2009515852A true JP2009515852A (ja) 2009-04-16
JP2009515852A5 JP2009515852A5 (OSRAM) 2010-01-07

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Family Applications (1)

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JP2008539441A Pending JP2009515852A (ja) 2005-11-11 2006-11-09 Egfr/her2インヒビターを含む癌の組み合わせ治療

Country Status (11)

Country Link
US (3) US20090306101A1 (OSRAM)
EP (2) EP1948180B1 (OSRAM)
JP (1) JP2009515852A (OSRAM)
CA (1) CA2629249C (OSRAM)
CY (1) CY1114040T1 (OSRAM)
DK (1) DK1948180T3 (OSRAM)
ES (1) ES2412879T3 (OSRAM)
PL (1) PL1948180T3 (OSRAM)
PT (1) PT1948180E (OSRAM)
SI (1) SI1948180T1 (OSRAM)
WO (1) WO2007054551A1 (OSRAM)

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JP2010503717A (ja) * 2006-09-18 2010-02-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Egfr変異を有する腫瘍を治療するための方法
JP2011098964A (ja) * 2009-11-09 2011-05-19 Wyeth Llc 被覆錠剤製剤
JP2012526767A (ja) * 2009-05-14 2012-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌及び線維性疾患の処置における新規な併用療法
JP2013512882A (ja) * 2009-12-07 2013-04-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング トリプルネガティブ乳癌の治療に使用するbibw2992
JP2016525532A (ja) * 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
JP2017081966A (ja) * 2010-08-26 2017-05-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Egfr阻害剤の投与方法
JP2017518282A (ja) * 2014-05-13 2017-07-06 アリアド ファーマシューティカルズ, インコーポレイテッド キナーゼ阻害のためのヘテロアリール化合物

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DE10349113A1 (de) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
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UA107560C2 (uk) * 2008-06-06 2015-01-26 Фармацевтична лікарська форма для негайного вивільнення похідної індолінону
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JP2012515184A (ja) * 2009-01-14 2012-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 大腸がんの治療方法
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US20180086744A1 (en) 2018-03-29
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PL1948180T3 (pl) 2013-09-30
CA2629249C (en) 2015-05-05
CY1114040T1 (el) 2016-07-27
PT1948180E (pt) 2013-05-10
EP1948180A1 (en) 2008-07-30
EP2340837B1 (en) 2017-03-15
US20090306101A1 (en) 2009-12-10
CA2629249A1 (en) 2007-05-18
US20140199298A1 (en) 2014-07-17
SI1948180T1 (sl) 2013-06-28
DK1948180T3 (da) 2013-05-27
EP1948180B1 (en) 2013-03-13

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