JP2009515823A5 - - Google Patents
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- Publication number
- JP2009515823A5 JP2009515823A5 JP2008535681A JP2008535681A JP2009515823A5 JP 2009515823 A5 JP2009515823 A5 JP 2009515823A5 JP 2008535681 A JP2008535681 A JP 2008535681A JP 2008535681 A JP2008535681 A JP 2008535681A JP 2009515823 A5 JP2009515823 A5 JP 2009515823A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- tlr
- oligonucleotide
- composition
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72603405P | 2005-10-12 | 2005-10-12 | |
| US60/726,034 | 2005-10-12 | ||
| US78424306P | 2006-03-21 | 2006-03-21 | |
| US60/784,243 | 2006-03-21 | ||
| US82544006P | 2006-09-13 | 2006-09-13 | |
| US60/825,440 | 2006-09-13 | ||
| PCT/US2006/039954 WO2007047396A2 (en) | 2005-10-12 | 2006-10-12 | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515823A JP2009515823A (ja) | 2009-04-16 |
| JP2009515823A5 true JP2009515823A5 (enExample) | 2018-08-30 |
| JP6406793B2 JP6406793B2 (ja) | 2018-10-17 |
Family
ID=37963095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008535681A Expired - Fee Related JP6406793B2 (ja) | 2005-10-12 | 2006-10-12 | トール様受容体に基づく免疫反応を調整する免疫調節ヌクレオチド(iro)化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8357665B2 (enExample) |
| EP (4) | EP2341059A1 (enExample) |
| JP (1) | JP6406793B2 (enExample) |
| KR (1) | KR101455081B1 (enExample) |
| CN (2) | CN101287742B (enExample) |
| AU (1) | AU2006304205C1 (enExample) |
| CA (1) | CA2624755C (enExample) |
| ES (2) | ES2542989T3 (enExample) |
| WO (1) | WO2007047396A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102604957B (zh) * | 2003-06-11 | 2015-10-07 | 艾德拉药物股份有限公司 | 稳定的免疫调节寡核苷酸 |
| EP2341059A1 (en) | 2005-10-12 | 2011-07-06 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| EP2446903B1 (en) | 2006-11-20 | 2019-10-09 | President and Fellows of Harvard College | Compositions for treating itch |
| JP5563455B2 (ja) * | 2007-08-01 | 2014-07-30 | イデラ ファーマシューティカルズ インコーポレイテッド | Tlr9の新規な合成アゴニスト |
| KR20100066512A (ko) * | 2007-08-15 | 2010-06-17 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨 유사 수용체 조절자 |
| CN102083984A (zh) * | 2007-12-26 | 2011-06-01 | 森托科尔奥索生物科技公司 | 食蟹猴Toll样受体3 |
| WO2009154610A1 (en) * | 2008-06-17 | 2009-12-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| CN101643496B (zh) * | 2008-08-07 | 2015-09-09 | 长春华普生物技术有限公司 | 一种具有免疫抑制功能的寡核苷酸 |
| EP2356216B1 (en) * | 2008-10-03 | 2016-06-01 | Janssen Biotech, Inc. | Papio cynocephalus toll-like receptor 3 |
| CN102281880A (zh) * | 2008-10-06 | 2011-12-14 | 艾德拉药物股份有限公司 | 类Toll受体抑制剂在高胆固醇血症和高脂血症及相关疾病的预防和治疗中的用途 |
| CA2742531A1 (en) | 2008-11-04 | 2010-05-14 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 5 expression by antisense oligonucleotides |
| US9394333B2 (en) | 2008-12-02 | 2016-07-19 | Wave Life Sciences Japan | Method for the synthesis of phosphorus atom modified nucleic acids |
| RU2011135993A (ru) * | 2009-01-30 | 2013-03-10 | Идера Фармасьютикалз, Инк. | Новые синтетические агонисты tlr9 |
| ES2534947T3 (es) | 2009-03-25 | 2015-04-30 | The Board Of Regents Of The University Of Texas System | Composiciones para la estimulación de resistencia inmunitaria innata de mamíferos a patógenos |
| CA2762206C (en) * | 2009-06-01 | 2017-06-27 | Idera Pharmaceuticals, Inc. | Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (iro) antagonists of tlr7 and tlr9 |
| MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| WO2011005942A2 (en) * | 2009-07-08 | 2011-01-13 | Idera Pharmaceuticals, Inc. | Oligonucleotide-based compounds as inhibitors of toll-like receptors |
| US20120172429A1 (en) | 2009-07-10 | 2012-07-05 | Woolf Clifford J | Permanently charged sodium and calcium channel blockers as anti- inflammatory agents |
| DE102009034779A1 (de) | 2009-07-25 | 2011-02-03 | Emc Microcollections Gmbh | Synthetische Analoga bakterieller Lipopeptide und ihre Anwendung zur Therapie und Prophylaxe allergischer Erkrankungen |
| HRP20150566T1 (hr) * | 2009-08-27 | 2015-07-17 | Idera Pharmaceuticals, Inc. | Kompozicija za inhibiciju ekspresije gena i njegova upotreba |
| CN102869775A (zh) | 2009-09-30 | 2013-01-09 | 哈佛大学校长及研究员协会 | 通过调节自噬抑制基因产物调节自噬的方法 |
| US8940310B2 (en) | 2010-06-16 | 2015-01-27 | Dynavax Technologies Corporation | Methods of treatment using TLR7 and/or TLR9 inhibitors |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| EP3213770B1 (en) * | 2010-11-19 | 2021-02-24 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| GB201021867D0 (en) | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| KR20240148947A (ko) | 2012-07-13 | 2024-10-11 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| SG11201500243WA (en) * | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| US10130632B2 (en) | 2012-11-27 | 2018-11-20 | Beth Israel Deaconess Medical Center, Inc. | Methods for treating renal disease |
| WO2014110081A1 (en) * | 2013-01-08 | 2014-07-17 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| US9688993B2 (en) | 2015-02-13 | 2017-06-27 | Idera Pharmaceuticals, Inc. | Toll-like receptor 9 antagonist and methods of use thereof |
| CN104807994B (zh) * | 2015-04-29 | 2016-08-24 | 大连理工大学 | 一种基于脱碱基位点的免标记凝血酶检测方法 |
| KR101745520B1 (ko) * | 2015-05-29 | 2017-06-12 | 아주대학교산학협력단 | 신규한 tlr4 길항제 |
| US11021443B2 (en) | 2015-08-03 | 2021-06-01 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| CN114807152A (zh) | 2016-06-08 | 2022-07-29 | 哈佛学院院长及董事 | 工程化病毒载体减少了炎症和免疫反应的诱导 |
| WO2018095697A1 (en) | 2016-11-23 | 2018-05-31 | Berlin Cures Holding Ag | Aptamers for use in inhibition and/or suppression of tlr9 activation |
| EP3690030A4 (en) | 2017-09-28 | 2021-06-23 | Industry-Academic Cooperation Foundation, Yonsei University | METHOD FOR MANUFACTURING MYELOID-DERIVED SUPPRESSOR CELLS, SUPPRESSOR CELLS MANUFACTURED FROM MYEOLID AND USES THEREOF |
| EP3707262A1 (en) | 2017-11-08 | 2020-09-16 | President and Fellows of Harvard College | Compositions and methods for inhibiting viral vector-induced inflammatory responses |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| MX2020010410A (es) | 2018-04-09 | 2021-01-15 | Checkmate Pharmaceuticals | Empaquetado de oligonucleotidos en particulas similares a virus. |
| JP7692834B2 (ja) | 2019-03-11 | 2025-06-16 | ノシオン セラピューティクス,インコーポレイテッド | 荷電したイオンチャンネル遮断薬および使用方法 |
| US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| MA55320A (fr) | 2019-03-11 | 2022-01-19 | Nocion Therapeutics Inc | Bloqueurs de canaux ioniques substitués par un ester et méthodes d'utilisation |
| CA3129111A1 (en) | 2019-03-11 | 2020-09-17 | Bridget M. Cole | Charged ion channel blockers and methods for use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| EP3939987A4 (en) * | 2019-03-13 | 2023-02-08 | Cartiprime Co., Ltd. | OLIGONUCLEOTIDE WITH ANTI-INFLAMMATORY ACTIVITY |
| US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CN114828845A (zh) | 2019-11-06 | 2022-07-29 | 诺西恩医疗公司 | 带电的离子通道阻滞剂及其使用方法 |
| US12162851B2 (en) | 2020-03-11 | 2024-12-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| EP4118070A4 (en) | 2020-03-11 | 2024-04-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| CN114099535B (zh) * | 2020-12-10 | 2023-01-03 | 南京吉迈生物技术有限公司 | Toll样受体9(TLR9)激动剂水凝胶免疫调节组合物 |
| CA3202133A1 (en) * | 2020-12-16 | 2022-06-23 | Martin Gohlke | Method for quantifying cpg-containing oligonucleotides in formulations comprising alum |
| WO2024137496A1 (en) | 2022-12-19 | 2024-06-27 | Six Therapeutics Inc. | Compositions and methods of using cpg oligonucleotides |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US97719A (en) * | 1869-12-07 | E-benez ee sperry | ||
| US239733A (en) * | 1881-04-05 | William w | ||
| AUPO203996A0 (en) | 1996-08-30 | 1996-09-26 | Novogen Research Pty Ltd | Therapeutic uses |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| JP5268214B2 (ja) * | 1999-08-13 | 2013-08-21 | イデラ ファーマシューティカルズ インコーポレイテッド | ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG−媒体免疫刺激の変調 |
| US6899891B2 (en) | 1999-12-16 | 2005-05-31 | Harry J. Siskind | Nutritional composition, methods of producing said composition and methods of using said composition |
| AU783687B2 (en) | 2000-01-26 | 2005-11-24 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| JP2003531915A (ja) * | 2000-05-01 | 2003-10-28 | ハイブリドン・インコーポレイテッド | ヌクレオシドの位置的修飾によるオリゴヌクレオチドCpG誘導性免疫刺激の調節 |
| US7105495B2 (en) | 2001-04-30 | 2006-09-12 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| SE0201701D0 (sv) * | 2002-06-05 | 2002-06-05 | Gotovax Ab | Treatment of epithelial tumors and infections |
| AU2003243409A1 (en) * | 2002-06-05 | 2003-12-22 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids |
| EP1393745A1 (en) * | 2002-07-29 | 2004-03-03 | Hybridon, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5'ends |
| WO2004094671A2 (en) * | 2003-04-22 | 2004-11-04 | Coley Pharmaceutical Gmbh | Methods and products for identification and assessment of tlr ligands |
| CA2526212C (en) * | 2003-05-16 | 2013-08-27 | Hybridon, Inc. | Synergistic treatment of cancer using immunomers in conjunction with chemotherapeutic agents |
| EA200600069A1 (ru) * | 2003-06-20 | 2006-08-25 | Коли Фармасьютикал Гмбх | Низкомолекулярные антагонисты toll-подобных рецепторов (tlr) |
| MXPA06000619A (es) * | 2003-07-15 | 2006-04-11 | Hybridon Inc | Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion. |
| US20050239733A1 (en) | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
| GB0329146D0 (en) | 2003-12-16 | 2004-01-21 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2005282889B2 (en) | 2004-09-01 | 2012-03-15 | Dynavax Technologies Corporation | Methods and conpositions for inhibition of innate immune responses and autoimmunity |
| EP1819364A4 (en) | 2004-12-08 | 2010-12-29 | 3M Innovative Properties Co | COMPOSITIONS, IMMUNOMODULATORY COMBINATIONS AND ASSOCIATED METHODS |
| CA2591582A1 (en) | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| JP2009510096A (ja) | 2005-09-27 | 2009-03-12 | コーリー ファーマシューティカル ゲーエムベーハー | アダプターオリゴヌクレオチドを用いたtlr媒介免疫応答の調節 |
| US8383598B2 (en) | 2005-10-12 | 2013-02-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| US8426375B2 (en) | 2005-10-12 | 2013-04-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| US8399423B2 (en) | 2005-10-12 | 2013-03-19 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| EP2341059A1 (en) | 2005-10-12 | 2011-07-06 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| US8377898B2 (en) | 2006-10-12 | 2013-02-19 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| KR20100066512A (ko) | 2007-08-15 | 2010-06-17 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨 유사 수용체 조절자 |
| CA2703931C (en) | 2007-10-26 | 2016-08-16 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| WO2009058361A1 (en) | 2007-10-31 | 2009-05-07 | Dynavax Technologies Corp. | Inhibition of type i ifn production |
-
2006
- 2006-10-12 EP EP11000806A patent/EP2341059A1/en not_active Withdrawn
- 2006-10-12 EP EP15168723.3A patent/EP2982679A1/en not_active Withdrawn
- 2006-10-12 AU AU2006304205A patent/AU2006304205C1/en not_active Ceased
- 2006-10-12 EP EP06825856.5A patent/EP1934239B8/en not_active Not-in-force
- 2006-10-12 JP JP2008535681A patent/JP6406793B2/ja not_active Expired - Fee Related
- 2006-10-12 CN CN200680038283.2A patent/CN101287742B/zh not_active Expired - Fee Related
- 2006-10-12 WO PCT/US2006/039954 patent/WO2007047396A2/en not_active Ceased
- 2006-10-12 US US11/549,048 patent/US8357665B2/en not_active Expired - Fee Related
- 2006-10-12 EP EP10013989.8A patent/EP2343307B1/en not_active Not-in-force
- 2006-10-12 KR KR1020087011265A patent/KR101455081B1/ko not_active Expired - Fee Related
- 2006-10-12 ES ES06825856.5T patent/ES2542989T3/es active Active
- 2006-10-12 CN CN201410469705.8A patent/CN104278037B/zh not_active Expired - Fee Related
- 2006-10-12 CA CA2624755A patent/CA2624755C/en active Active
- 2006-10-12 ES ES10013989.8T patent/ES2544877T3/es active Active
-
2012
- 2012-12-31 US US13/731,492 patent/US9206430B2/en not_active Expired - Fee Related
-
2015
- 2015-12-01 US US14/955,418 patent/US9453228B2/en not_active Expired - Fee Related
-
2016
- 2016-08-16 US US15/238,074 patent/US20170145417A1/en not_active Abandoned
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