|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
US5262319A
(en)
|
1985-04-19 |
1993-11-16 |
Oncogene Science, Inc. |
Method for obtaining bone marrow free of tumor cells using transforming growth factor β3
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
AU633011B2
(en)
|
1988-06-28 |
1993-01-21 |
La Jolla Cancer Research Foundation |
Suppression of cell proliferation by decorin
|
|
US5705609A
(en)
|
1988-06-28 |
1998-01-06 |
La Jolla Cancer Research Foundation |
Decorin fragments inhibiting cell regulatory factors
|
|
US5583103A
(en)
|
1988-06-28 |
1996-12-10 |
La Jolla Cancer Research Foundation |
Inhibition of transforming growth factor beta activity
|
|
US5654270A
(en)
|
1988-06-28 |
1997-08-05 |
La Jolla Cancer Research Foundation |
Use of fibromodulin to prevent or reduce dermal scarring
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5571714A
(en)
|
1988-12-22 |
1996-11-05 |
Celtrix Pharmaceuticals, Inc. |
Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
|
|
WO1991004748A1
(en)
|
1989-09-29 |
1991-04-18 |
La Jolla Cancer Research Foundation |
INHIBITING TRANSFORMING GROWTH FACTOR β TO PREVENT ACCUMULATION OF EXTRACELLULAR MATRIX
|
|
ES2083469T3
(es)
|
1989-11-22 |
1996-04-16 |
Genentech Inc |
Peptido asociado a una latencia y utilizaciones del mismo.
|
|
WO1991010727A1
(en)
|
1990-01-22 |
1991-07-25 |
La Jolla Cancer Research Foundation |
Inhibitors of cell regulatory factors
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
EP0585287B1
(en)
|
1990-07-10 |
1999-10-13 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
CA2405246A1
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with alterred binding properties
|
|
EP0575485A1
(en)
|
1991-03-01 |
1993-12-29 |
Dyax Corp. |
Process for the development of binding mini-proteins
|
|
DK0580737T3
(da)
|
1991-04-10 |
2004-11-01 |
Scripps Research Inst |
Heterodimere receptorbiblioteker ved anvendelse af phagemider
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
JP4124815B2
(ja)
|
1991-10-31 |
2008-07-23 |
ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ |
TGF−β型受容体cDNAおよびその用途
|
|
US6008011A
(en)
|
1991-10-31 |
1999-12-28 |
Whitehead Institute For Biomedical Research |
TGF-β type II receptor cDNAs
|
|
ES2188585T3
(es)
|
1991-11-14 |
2003-07-01 |
Jolla Cancer Res Found |
Inhibidores de factores reguladores celulares y procedimientos para evitar o reducir la formacion de cicatrices.
|
|
WO1993010808A1
(en)
|
1991-12-04 |
1993-06-10 |
La Jolla Cancer Research Foundation |
INHIBITING TRANSFORMING GROWTH FACTOR β TO PREVENT ACCUMULATION OF EXTRACELLULAR MATRIX
|
|
GB9205800D0
(en)
|
1992-03-17 |
1992-04-29 |
British Tech Group |
Treatment of fibrotic disorders
|
|
WO1993019177A1
(en)
|
1992-03-18 |
1993-09-30 |
The General Hospital Corporation |
FOUR NOVEL RECEPTORS OF THE TGF-β RECEPTOR FAMILY
|
|
WO1993019783A1
(en)
|
1992-04-01 |
1993-10-14 |
The Whittier Institute For Diabetes And Endocrinology |
Methods of inhibiting or enhancing scar formation in the cns
|
|
US5821234A
(en)
|
1992-09-10 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of proliferation of vascular smooth muscle cell
|
|
US5869462A
(en)
|
1992-09-10 |
1999-02-09 |
The Board Of Trustees Of The Leland Stanford Junior University |
Inhibition of proliferation of vascular smooth muscle cell
|
|
AU5587094A
(en)
|
1992-10-26 |
1994-05-24 |
Kirin Brewery Company, Limited |
Method for producing large latent transforming growth factor-beta complexes and large latency associated peptide
|
|
CA2146973C
(en)
|
1992-10-29 |
2008-09-02 |
Patricia R. Segarini |
Uses of tgf-.beta. receptor fragment as a therapeutic agent
|
|
AU5541094A
(en)
|
1992-10-30 |
1994-05-24 |
Consejo Superior De Investigaciones Cientificas |
Compositions and methods for modifying the regulatory activity of tgf-beta
|
|
US5830847A
(en)
|
1992-10-30 |
1998-11-03 |
Hsc Research & Development Limited Partnership |
Soluble TGF-β-binding endoglin polypeptides and homodimers
|
|
ATE235549T1
(de)
|
1993-04-30 |
2003-04-15 |
Biognostik Ges |
Antisense oligonukleotide zur behandlung von immunsuppressiven wirkungen von tgf-beta2
|
|
EP0737071A1
(en)
|
1993-06-15 |
1996-10-16 |
Il- Yang Pharm. Co., Ltd. |
Anti-sense oligodeoxynucleotide to fibrogenic cytokines and use thereof
|
|
AU8016894A
(en)
|
1993-10-15 |
1995-05-04 |
La Jolla Cancer Research Foundation |
Betaglycan polypeptides having tgf-beta binding activity
|
|
US5962427A
(en)
|
1994-02-18 |
1999-10-05 |
The Regent Of The University Of Michigan |
In vivo gene transfer methods for wound healing
|
|
WO1995030900A1
(en)
|
1994-05-04 |
1995-11-16 |
Mount Sinai Hospital Corporation |
MODULATORS OF CYTOKINES OF THE TGF-β SUPERFAMILY AND METHODS FOR ASSAYING FOR SAME
|
|
US5772995A
(en)
|
1994-07-18 |
1998-06-30 |
Sidney Kimmel Cancer Center |
Compositions and methods for enhanced tumor cell immunity in vivo
|
|
CA2156767A1
(en)
|
1994-08-25 |
1996-02-26 |
Kenichi Matsunaga |
Binding agent for growth factor
|
|
JPH08119984A
(ja)
|
1994-08-31 |
1996-05-14 |
Nkk Corp |
ストレプトミセス属放線菌及びこの菌由来のTGF−β 阻害剤
|
|
US5968770A
(en)
|
1995-02-10 |
1999-10-19 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
|
|
US5824655A
(en)
|
1995-02-15 |
1998-10-20 |
The University Of Utah |
Anti-transforming growth factor-β gene therapy
|
|
US5824299A
(en)
|
1995-06-22 |
1998-10-20 |
President & Fellows Of Harvard College |
Modulation of endothelial cell proliferation with IP-10
|
|
US5550127A
(en)
*
|
1995-09-07 |
1996-08-27 |
Pantano; James A. |
Method of treatment for eiph in racing stock
|
|
GB9601081D0
(en)
|
1995-10-06 |
1996-03-20 |
Cambridge Antibody Tech |
Specific binding members for human transforming growth factor beta;materials and methods
|
|
US5912224A
(en)
|
1996-02-22 |
1999-06-15 |
The General Hospital Corporation |
Methods and compositions for enhancing cellular response to TGF-β ligands
|
|
EP0921809A4
(en)
|
1996-04-30 |
2001-10-24 |
Genzyme Corp |
USE OF PROLACTIN AS A TGF-BETA ANTAGONIST
|
|
JPH1067674A
(ja)
|
1996-06-19 |
1998-03-10 |
Advanced Sukin Res Kenkyusho:Kk |
細胞外マトリツクスの異常蓄積抑制剤
|
|
WO1998003663A1
(en)
|
1996-07-24 |
1998-01-29 |
Chugai Seiyaku Kabushiki Kaisya |
Human taki dna encoding the same
|
|
US5807708A
(en)
|
1996-07-30 |
1998-09-15 |
Millennium Pharmaceuticals, Inc. |
Conservin nucleic acid molecules and compositions
|
|
WO1998007735A1
(en)
|
1996-08-16 |
1998-02-26 |
Human Genome Sciences, Inc. |
Pancreas-derived plasminogen activator inhibitor
|
|
US6017755A
(en)
|
1996-08-22 |
2000-01-25 |
Hsc Research & Development Limited |
MADR2 tumour suppressor gene
|
|
AU3215597A
(en)
|
1996-08-30 |
1998-03-19 |
Biomeasure Incorporated |
Method of inhibiting fibrosis with a somatostatin agonist
|
|
JPH10114676A
(ja)
*
|
1996-10-09 |
1998-05-06 |
Toray Ind Inc |
β型トランスフォーミング増殖因子産生抑制剤
|
|
DE69734894T2
(de)
|
1996-10-25 |
2006-07-20 |
Ethicon, Inc. |
Testverfahren für antifibrotischen wirkstoff
|
|
US5948639A
(en)
|
1997-04-10 |
1999-09-07 |
Millennium Pharmaceuticals, Inc. |
TGF-β pathway genes
|
|
JP2001515360A
(ja)
|
1997-04-18 |
2001-09-18 |
バイオジェン,インコーポレイテッド |
▲II▼型TGF−βレセプター/免疫グロブリン定常領域融合タンパク質
|
|
JPH10295381A
(ja)
|
1997-04-23 |
1998-11-10 |
Seibutsu Bunshi Kogaku Kenkyusho:Kk |
新規シグナル伝達因子、およびそれをコードする遺伝子
|
|
US6251628B1
(en)
|
1997-05-20 |
2001-06-26 |
Ludwig Institute For Cancer Research |
Isolated nucleic acid molecules encoding Smad7
|
|
AU7705398A
(en)
|
1997-05-28 |
1998-12-30 |
President And Fellows Of Harvard College |
Methods and reagents for modulating tgf-beta superfamily signaling
|
|
EP0994945B1
(en)
|
1997-06-02 |
2003-11-05 |
Vlaams Interuniversitair Instituut voor Biotechnologie |
Smad-interacting polypeptides and their use
|
|
JP3626206B2
(ja)
|
1997-06-13 |
2005-03-02 |
ルードヴィッヒ インスティテュート フォー キャンサー リサーチ |
Smad6及びその使用
|
|
WO1999050296A1
(en)
|
1998-03-27 |
1999-10-07 |
Eli Lilly And Company |
Treatment and prevention of vascular disease
|
|
WO2000040227A2
(en)
*
|
1999-01-05 |
2000-07-13 |
University Of Utah |
Methods for treating conditions associated with the accumulation of excess extracellular matrix
|
|
JP2003509030A
(ja)
*
|
1999-09-17 |
2003-03-11 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
トランスフォーミング成長因子−β発現のアンチセンスオリゴヌクレオチド調節
|
|
US20030113330A1
(en)
*
|
1999-11-08 |
2003-06-19 |
Uhal Bruce D. |
Methods for treating pulmonary fibrosis
|
|
US20040197333A1
(en)
*
|
2000-02-10 |
2004-10-07 |
Cornell Research Foundation, Inc. |
Use of TGF-beta antagonists to inhibit tumor cell formation or progression
|
|
US7101543B2
(en)
*
|
2000-03-31 |
2006-09-05 |
Novarx |
Genetically modified cells expressing a TGFβ inhibitor, the cells being lung cancer cells
|
|
WO2003049773A1
(en)
*
|
2001-12-11 |
2003-06-19 |
Fibrogen, Inc. |
Methods for inhibiting ocular processes
|
|
AU2003256783A1
(en)
*
|
2002-07-25 |
2004-02-16 |
Scios, Inc. |
METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-Beta INHIBITORS
|
|
WO2005004913A1
(ja)
*
|
2003-07-09 |
2005-01-20 |
Anges Mg, Inc. |
デコイを含む薬学的組成物およびその使用方法
|
|
US20060229266A1
(en)
*
|
2003-08-13 |
2006-10-12 |
Kumar Nalin M |
Silencing of tgf-beta receptor type II expression by sirna
|
|
US7462185B1
(en)
*
|
2004-12-23 |
2008-12-09 |
Cardican Inc. |
Intravascular stapling tool
|
|
IT1395574B1
(it)
|
2009-09-14 |
2012-10-16 |
Guala Dispensing Spa |
Dispositivo di erogazione
|