JP5602365B2 - マルファン症候群及び関連疾患を治療するための方法及び組成物。 - Google Patents
マルファン症候群及び関連疾患を治療するための方法及び組成物。 Download PDFInfo
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- JP5602365B2 JP5602365B2 JP2008537953A JP2008537953A JP5602365B2 JP 5602365 B2 JP5602365 B2 JP 5602365B2 JP 2008537953 A JP2008537953 A JP 2008537953A JP 2008537953 A JP2008537953 A JP 2008537953A JP 5602365 B2 JP5602365 B2 JP 5602365B2
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- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- Wood Science & Technology (AREA)
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- Ophthalmology & Optometry (AREA)
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- Plant Pathology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72997605P | 2005-10-25 | 2005-10-25 | |
| US60/729,976 | 2005-10-25 | ||
| PCT/US2006/041846 WO2007050793A2 (en) | 2005-10-25 | 2006-10-25 | Methods and compositions for the treatment of marfan syndrome and associated disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009513663A JP2009513663A (ja) | 2009-04-02 |
| JP2009513663A5 JP2009513663A5 (https=) | 2012-10-04 |
| JP5602365B2 true JP5602365B2 (ja) | 2014-10-08 |
Family
ID=37968564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537953A Expired - Fee Related JP5602365B2 (ja) | 2005-10-25 | 2006-10-25 | マルファン症候群及び関連疾患を治療するための方法及び組成物。 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8597646B2 (https=) |
| EP (2) | EP1948675B1 (https=) |
| JP (1) | JP5602365B2 (https=) |
| ES (1) | ES2526705T3 (https=) |
| WO (1) | WO2007050793A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009056419A1 (en) * | 2007-11-02 | 2009-05-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for producing a non human animal model for aortic aneurysm |
| JP5737721B2 (ja) * | 2009-04-20 | 2015-06-17 | 国立大学法人 東京大学 | Htra1変異と家族性虚血性脳小血管病との関連 |
| CA2774389A1 (en) * | 2009-10-01 | 2011-04-07 | Symphony Evolution, Inc. | Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors |
| RU2456925C1 (ru) * | 2011-03-15 | 2012-07-27 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Министерства здравоохранения и социального развития Российской Федерации" | Способ прогнозирования риска развития идиопатического сколиоза у детей |
| WO2012142476A2 (en) * | 2011-04-14 | 2012-10-18 | The Johns Hopkins University | Methods and compositions for the treatment of marfan syndrome and associated disorders |
| WO2013078261A1 (en) | 2011-11-22 | 2013-05-30 | The University Of Maryland, Baltimore | Treatment of muscular conditions and muscular dystrophies |
| JP6240379B2 (ja) * | 2012-10-06 | 2017-11-29 | 株式会社 バイオエルティ | 循環型TGF−βの抑制剤 |
| US20150284455A1 (en) * | 2012-11-06 | 2015-10-08 | Scholar Rock, Inc. | Compositions and methods for modulating cell signaling |
| PT2971048T (pt) | 2013-03-11 | 2019-02-06 | Genzyme Corp | Anticorpos anti-tgf-beta manipulados e fragmentos de ligação a antigénios |
| HRP20251426T1 (hr) | 2013-05-06 | 2026-01-02 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| CA2912635A1 (en) * | 2013-05-24 | 2014-11-27 | Tarix Pharmaceuticals Ltd. | Angiotensin peptides in treating marfan syndrome and related disorders |
| JP2019511911A (ja) | 2016-02-17 | 2019-05-09 | ノバルティス アーゲー | Tgfベータ2抗体 |
| US11692028B2 (en) | 2017-03-02 | 2023-07-04 | The Johns Hopkins University | Map kinase pathway targets for the treatment of Marfan syndrome |
| EP3675880B1 (en) | 2017-09-01 | 2023-06-07 | The Johns Hopkins University | Targeted epigenetic therapy for inherited aortic aneurysm condition |
| WO2022115611A1 (en) | 2020-11-25 | 2022-06-02 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
| WO2022139493A1 (ko) * | 2020-12-23 | 2022-06-30 | 한국과학기술연구원 | TGF-β 신호전달을 억제할 수 있는 신규한 펩타이드 및 이의 용도 |
| JP2025529287A (ja) * | 2022-09-06 | 2025-09-04 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | マルファン症候群の処置のためのtrem-2アゴニスト |
| WO2025085731A1 (en) * | 2023-10-18 | 2025-04-24 | Children's National Medical Center | TRANSFORMING GROWTH FACTOR ß (TGF-ß) OLIGONUCLEOTIDE COMBINATION THERAPY FOR TREATING MUSCULOSKELETAL DISEASES |
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- 2006-10-25 JP JP2008537953A patent/JP5602365B2/ja not_active Expired - Fee Related
- 2006-10-25 WO PCT/US2006/041846 patent/WO2007050793A2/en not_active Ceased
- 2006-10-25 EP EP14002636.0A patent/EP2862867A3/en not_active Withdrawn
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| EP1948675A4 (en) | 2009-09-23 |
| EP1948675B1 (en) | 2014-07-30 |
| US20100034806A1 (en) | 2010-02-11 |
| WO2007050793A3 (en) | 2008-01-24 |
| EP2862867A2 (en) | 2015-04-22 |
| WO2007050793A2 (en) | 2007-05-03 |
| JP2009513663A (ja) | 2009-04-02 |
| EP2862867A3 (en) | 2015-08-05 |
| US8597646B2 (en) | 2013-12-03 |
| ES2526705T3 (es) | 2015-01-14 |
| EP1948675A2 (en) | 2008-07-30 |
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