JP2009513580A - チロシンキナーゼ阻害剤 - Google Patents

チロシンキナーゼ阻害剤 Download PDF

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Publication number
JP2009513580A
JP2009513580A JP2008536756A JP2008536756A JP2009513580A JP 2009513580 A JP2009513580 A JP 2009513580A JP 2008536756 A JP2008536756 A JP 2008536756A JP 2008536756 A JP2008536756 A JP 2008536756A JP 2009513580 A JP2009513580 A JP 2009513580A
Authority
JP
Japan
Prior art keywords
alkyl
aryl
cyclohepta
pyrido
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008536756A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009513580A5 (https=
Inventor
ディンズモア，クリストファー，ジェイ
オルテガ，ガバルダ，アナ，エステール
リム，ジョンウォン
マハーチェク，ミシェル，アール
ノーザップ，アラン，ビー
ヤング，ジヨナサン・アール
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2009513580A publication Critical patent/JP2009513580A/ja
Publication of JP2009513580A5 publication Critical patent/JP2009513580A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2008536756A 2005-10-21 2006-10-18 チロシンキナーゼ阻害剤 Withdrawn JP2009513580A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72882405P 2005-10-21 2005-10-21
PCT/US2006/040667 WO2007050383A2 (en) 2005-10-21 2006-10-18 Tyrosine kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2009513580A true JP2009513580A (ja) 2009-04-02
JP2009513580A5 JP2009513580A5 (https=) 2009-11-12

Family

ID=37968378

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008536756A Withdrawn JP2009513580A (ja) 2005-10-21 2006-10-18 チロシンキナーゼ阻害剤

Country Status (6)

Country Link
US (1) US20090131423A1 (https=)
EP (1) EP1951252A4 (https=)
JP (1) JP2009513580A (https=)
AU (1) AU2006306499A1 (https=)
CA (1) CA2624656A1 (https=)
WO (1) WO2007050383A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2408584C2 (ru) 2005-06-23 2011-01-10 Мерк Шарп Энд Домэ Корп. Ингибиторы тирозинкиназы
US7790739B2 (en) 2005-10-21 2010-09-07 Merck & Co., Inc. and Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
US7893081B2 (en) 2007-12-20 2011-02-22 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2011123427A2 (en) * 2010-04-01 2011-10-06 Virginia Commonwealth University Treatment of cancer by inhibiting activity or expression of late sv-40 factor
CN103626762B (zh) * 2012-08-24 2015-07-29 上海医药工业研究院 苯并吡啶氮杂卓类化合物及其应用
CN106946900B (zh) * 2017-03-27 2019-07-12 中国科学院新疆理化技术研究所 天山堇菜中具有二聚哌啶类ⅲ和ⅳ型骨架的生物碱化合物及制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (https=) * 1963-04-24
US4377588A (en) * 1979-09-11 1983-03-22 Merck Sharp & Dohme (I.A.) Corp. 4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
SG48750A1 (en) * 1993-10-15 1998-05-18 Schering Corp Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases
AU700386B2 (en) * 1995-10-16 1999-01-07 Kyowa Hakko Kogyo Co. Ltd. Triciclic compounds
US6576639B1 (en) * 1997-06-17 2003-06-10 Schering Corporation Compounds for the inhibition of farnesyl protein transferase
HRP970649B1 (en) * 1997-12-01 2004-12-31 Belupo Lijekovi I Kozmetika D Dibenzosuberone derivatives and processes for their preparation
CZ20033519A3 (en) * 2001-06-27 2004-06-16 Ube Industries, Ltd. Dibenzocycloheptene compound
ATE363473T1 (de) * 2001-09-19 2007-06-15 Pharmacia Corp Substituierte pyrazoloverbindungen zur behandlung von entzündungen
AU2003230758A1 (en) * 2002-04-02 2003-10-20 Merck And Co., Inc. 5h-benzo(4,5)cyclohepta(1,2-b)pyridine nmda/nr2b antagonists
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
ES2211315B1 (es) * 2002-11-12 2005-10-16 Almirall Prodesfarma, S.A. Nuevos compuestos triciclicos.
ES2545666T3 (es) * 2003-02-27 2015-09-14 Abbvie Inc. 5,10-Dihidro-11H-dibenzo[b,e][1,4]diazepin-11-ona como inhibidores de quinasa

Also Published As

Publication number Publication date
WO2007050383A2 (en) 2007-05-03
CA2624656A1 (en) 2007-05-03
EP1951252A2 (en) 2008-08-06
US20090131423A1 (en) 2009-05-21
AU2006306499A1 (en) 2007-05-03
WO2007050383A3 (en) 2009-05-28
EP1951252A4 (en) 2010-03-17

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