JP2009513165A5 - - Google Patents
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- Publication number
- JP2009513165A5 JP2009513165A5 JP2006516183A JP2006516183A JP2009513165A5 JP 2009513165 A5 JP2009513165 A5 JP 2009513165A5 JP 2006516183 A JP2006516183 A JP 2006516183A JP 2006516183 A JP2006516183 A JP 2006516183A JP 2009513165 A5 JP2009513165 A5 JP 2009513165A5
- Authority
- JP
- Japan
- Prior art keywords
- plga
- weight
- plasticized
- temperature
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000007943 implant Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000007920 subcutaneous administration Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 4
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001302A ITMI20031302A1 (it) | 2003-06-26 | 2003-06-26 | Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga. |
| PCT/EP2004/051226 WO2005000277A1 (en) | 2003-06-26 | 2004-06-24 | Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a plga matrix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009513165A JP2009513165A (ja) | 2009-04-02 |
| JP2009513165A5 true JP2009513165A5 (enExample) | 2011-05-06 |
Family
ID=30131301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006516183A Pending JP2009513165A (ja) | 2003-06-26 | 2004-06-24 | Ｐｌｇａマトリックス中に分散された熱不安定性活性成分を含有する皮下インプラントを製造するための可塑剤としてのエタノールの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8206621B2 (enExample) |
| EP (1) | EP1638534B1 (enExample) |
| JP (1) | JP2009513165A (enExample) |
| KR (1) | KR101143771B1 (enExample) |
| CN (1) | CN100509060C (enExample) |
| AT (1) | ATE398447T1 (enExample) |
| AU (1) | AU2004251456B2 (enExample) |
| BR (1) | BRPI0411759A (enExample) |
| CA (1) | CA2530117C (enExample) |
| CY (1) | CY1108346T1 (enExample) |
| DE (1) | DE602004014496D1 (enExample) |
| ES (1) | ES2308195T3 (enExample) |
| IT (1) | ITMI20031302A1 (enExample) |
| MX (1) | MXPA05013697A (enExample) |
| PL (1) | PL1638534T3 (enExample) |
| PT (1) | PT1638534E (enExample) |
| WO (1) | WO2005000277A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666445B2 (en) | 2000-10-20 | 2010-02-23 | The Trustees Of The University Of Pennsylvania | Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use |
| US8329203B2 (en) | 2004-01-12 | 2012-12-11 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
| US8541028B2 (en) | 2004-08-04 | 2013-09-24 | Evonik Corporation | Methods for manufacturing delivery devices and devices thereof |
| EP1909689A4 (en) * | 2005-07-18 | 2011-11-16 | Univ Pennsylvania | PHARMACEUTICAL IMPLANTS AND METHOD OF USE THEREOF |
| ITMI20061539A1 (it) * | 2006-08-02 | 2008-02-03 | Mediolanum Pharmaceuticals Ltd | Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo |
| DE602007008125D1 (de) | 2006-10-31 | 2010-09-09 | Surmodics Pharmaceuticals Inc | Kugelförmige polymer-teilchen |
| ES2718612T3 (es) | 2007-12-20 | 2019-07-03 | Evonik Corp | Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual |
| US9498431B2 (en) * | 2008-12-10 | 2016-11-22 | Jianjian Xu | Controlled releasing composition |
| CA2804035A1 (en) * | 2010-06-30 | 2012-01-05 | Evonik Degussa Corporation | Implant processing methods for thermally labile and other bioactive agents and implants prepared from same |
| GB201314312D0 (en) * | 2013-08-09 | 2013-09-25 | Regentec Ltd | Composition and delivery system |
| CN103623415B (zh) * | 2013-12-04 | 2015-03-25 | 北京诺康达医药科技有限公司 | 一种用于生物多肽制剂的plga与乙醇的复合物 |
| EP3177319A1 (en) * | 2014-08-04 | 2017-06-14 | Janssen Sciences Ireland UC | Compacted solid dosage form |
| GB201702475D0 (en) * | 2017-02-15 | 2017-03-29 | Locate Therapeutics Ltd | Tissue scaffold and scaffold composition |
| EP3459527B1 (en) * | 2017-09-20 | 2022-11-23 | Tillotts Pharma Ag | Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0549629A (ja) * | 1991-08-23 | 1993-03-02 | Konica Corp | 医用放射線画像読影装置 |
| US5520923A (en) * | 1994-09-19 | 1996-05-28 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| IT1304152B1 (it) * | 1998-12-10 | 2001-03-08 | Mediolanum Farmaceutici Srl | Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato |
| CN100446809C (zh) | 2001-11-14 | 2008-12-31 | 阿尔扎有限公司 | 可注射的长效组合物 |
-
2003
- 2003-06-26 IT IT001302A patent/ITMI20031302A1/it unknown
-
2004
- 2004-06-24 DE DE602004014496T patent/DE602004014496D1/de not_active Expired - Lifetime
- 2004-06-24 US US10/562,707 patent/US8206621B2/en not_active Expired - Fee Related
- 2004-06-24 MX MXPA05013697A patent/MXPA05013697A/es active IP Right Grant
- 2004-06-24 BR BRPI0411759-0A patent/BRPI0411759A/pt not_active IP Right Cessation
- 2004-06-24 AT AT04741884T patent/ATE398447T1/de active
- 2004-06-24 JP JP2006516183A patent/JP2009513165A/ja active Pending
- 2004-06-24 CA CA2530117A patent/CA2530117C/en not_active Expired - Fee Related
- 2004-06-24 WO PCT/EP2004/051226 patent/WO2005000277A1/en not_active Ceased
- 2004-06-24 PL PL04741884T patent/PL1638534T3/pl unknown
- 2004-06-24 CN CNB2004800177773A patent/CN100509060C/zh not_active Expired - Fee Related
- 2004-06-24 KR KR1020057024514A patent/KR101143771B1/ko not_active Expired - Fee Related
- 2004-06-24 PT PT04741884T patent/PT1638534E/pt unknown
- 2004-06-24 AU AU2004251456A patent/AU2004251456B2/en not_active Ceased
- 2004-06-24 EP EP04741884A patent/EP1638534B1/en not_active Expired - Lifetime
- 2004-06-24 ES ES04741884T patent/ES2308195T3/es not_active Expired - Lifetime
-
2008
- 2008-09-17 CY CY20081101000T patent/CY1108346T1/el unknown
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