PT1638534E - Uso de etanol como plastificante para preparar implantes subcutâneos contendo princípios activos termolabiais dispersados numa matriz plga - Google Patents

Uso de etanol como plastificante para preparar implantes subcutâneos contendo princípios activos termolabiais dispersados numa matriz plga Download PDF

Info

Publication number
PT1638534E
PT1638534E PT04741884T PT04741884T PT1638534E PT 1638534 E PT1638534 E PT 1638534E PT 04741884 T PT04741884 T PT 04741884T PT 04741884 T PT04741884 T PT 04741884T PT 1638534 E PT1638534 E PT 1638534E
Authority
PT
Portugal
Prior art keywords
ethanol
plasticizer
implants containing
subcutaneous implants
active principles
Prior art date
Application number
PT04741884T
Other languages
English (en)
Inventor
Patrice Mauriac
Pierre Marion
Original Assignee
Mediolanum Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Pharmaceuticals Ltd filed Critical Mediolanum Pharmaceuticals Ltd
Publication of PT1638534E publication Critical patent/PT1638534E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/141—Plasticizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT04741884T 2003-06-26 2004-06-24 Uso de etanol como plastificante para preparar implantes subcutâneos contendo princípios activos termolabiais dispersados numa matriz plga PT1638534E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001302A ITMI20031302A1 (it) 2003-06-26 2003-06-26 Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga.

Publications (1)

Publication Number Publication Date
PT1638534E true PT1638534E (pt) 2008-09-29

Family

ID=30131301

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04741884T PT1638534E (pt) 2003-06-26 2004-06-24 Uso de etanol como plastificante para preparar implantes subcutâneos contendo princípios activos termolabiais dispersados numa matriz plga

Country Status (18)

Country Link
US (1) US8206621B2 (pt)
EP (1) EP1638534B1 (pt)
JP (1) JP2009513165A (pt)
KR (1) KR101143771B1 (pt)
CN (1) CN100509060C (pt)
AT (1) ATE398447T1 (pt)
AU (1) AU2004251456B2 (pt)
BR (1) BRPI0411759A (pt)
CA (1) CA2530117C (pt)
CY (1) CY1108346T1 (pt)
DE (1) DE602004014496D1 (pt)
ES (1) ES2308195T3 (pt)
HK (1) HK1089954A1 (pt)
IT (1) ITMI20031302A1 (pt)
MX (1) MXPA05013697A (pt)
PL (1) PL1638534T3 (pt)
PT (1) PT1638534E (pt)
WO (1) WO2005000277A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666445B2 (en) 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
US8329203B2 (en) 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
AU2005325213B2 (en) 2004-08-04 2010-10-07 Evonik Corporation Methods for manufacturing delivery devices and devices thereof
CA2614601C (en) * 2005-07-18 2015-04-07 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
ITMI20061539A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
EP2236546B1 (en) 2006-10-31 2011-12-28 Surmodics Pharmaceuticals, Inc. Speronized polymer particles
JP5502751B2 (ja) 2007-12-20 2014-05-28 エボニック コーポレイション 低残留溶媒濃度を有する微粒子を調製するためのプロセス
JP2012511519A (ja) * 2008-12-10 2012-05-24 アンフイ ジョンレン テクノロジー コーポレイション，リミテッド 制御放出組成物
WO2012003210A1 (en) * 2010-06-30 2012-01-05 Surmodics Pharmaceuticals, Inc. Implant processing methods for thermally labile and other bioactive agents and implants prepared from same
GB201314312D0 (en) * 2013-08-09 2013-09-25 Regentec Ltd Composition and delivery system
CN103623415B (zh) * 2013-12-04 2015-03-25 北京诺康达医药科技有限公司 一种用于生物多肽制剂的plga与乙醇的复合物
US20170231916A1 (en) * 2014-08-04 2017-08-17 Janssen Sciences Ireland Uc Compacted solid dosage form
GB201702475D0 (en) * 2017-02-15 2017-03-29 Locate Therapeutics Ltd Tissue scaffold and scaffold composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0549629A (ja) * 1991-08-23 1993-03-02 Konica Corp 医用放射線画像読影装置
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
DE60232987D1 (de) * 2001-11-14 2009-08-27 Durect Corp Injizierbare depotzusammensetzungen

Also Published As

Publication number Publication date
HK1089954A1 (en) 2006-12-15
US20060171987A1 (en) 2006-08-03
AU2004251456B2 (en) 2009-12-03
CA2530117A1 (en) 2005-01-06
WO2005000277A1 (en) 2005-01-06
ITMI20031302A0 (it) 2003-06-26
CN100509060C (zh) 2009-07-08
PL1638534T3 (pl) 2009-02-27
JP2009513165A (ja) 2009-04-02
CY1108346T1 (el) 2014-02-12
EP1638534A1 (en) 2006-03-29
US8206621B2 (en) 2012-06-26
ITMI20031302A1 (it) 2004-12-27
CN1812770A (zh) 2006-08-02
MXPA05013697A (es) 2006-05-17
KR101143771B1 (ko) 2012-05-11
ES2308195T3 (es) 2008-12-01
KR20060079146A (ko) 2006-07-05
AU2004251456A1 (en) 2005-01-06
DE602004014496D1 (de) 2008-07-31
BRPI0411759A (pt) 2006-08-08
ATE398447T1 (de) 2008-07-15
EP1638534B1 (en) 2008-06-18
CA2530117C (en) 2012-01-10

Similar Documents

Publication Publication Date Title
HK1089954A1 (en) Use of ethanol as plasticizer for preparing subcutaneous implants
DE69918310D1 (de) Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
NZ601200A (en) Pharmaceutical dosage forms comprising poly(epsilon-caprolactone)
DE60017956D1 (de) Biodegradierbare polymerzusammensetzung
DK1061900T4 (da) Dermale præparater
BRPI0507683A8 (pt) dose unitária de formulação farmacêutica com liberação controlada, seu processo de preparação e uso de um copolímero de poli(acrilato de etila, metacrilato de metila) neutro
DE502004003914D1 (de) Quellbare hydrogelbildende polymere mit geringem feinstaubanteil
BRPI0416868A (pt) espuma absorvente, termoplástica, flexìvel, macia, de baixa densidade, de células abertas, artigo absorvente e método de fabricação da mesma
ATE510514T1 (de) Dentalfüllmaterial
MXPA06002859A (es) Composiciones de hidrogel con un miembro de respaldo erosionable.
BRPI0514293A (pt) sais de dicetopiperazina, sais de dicetomorfolina ou sais de dicetodioxano para administração de droga
AR044926A1 (es) Sistema de suministro de farmacos gelificante in situ
DE60220049D1 (de) Pharmazeutische zusammensetzungen enthaltend eine feste dispersion eines im wasser schwerlöslichen arzneimittels und ein löslichkeitsteigerndes polymer
DK1663326T3 (da) Gel-skum baseret på biopolymer
HK1148931A1 (en) Injectable sustained release implant having a bioerodible matrix core and a bioerodible skin
AU2002327774A1 (en) Method for formulating and immobilizing a protein matrix and a protein matrix for use in a sensor
PL1638535T3 (pl) Podskórne implanty o ograniczonym początkowym uwalnianiu składnika czynnego, a następnie o rozciągniętym w czasie uwalnianiu zmieniającym się liniowo
ATE326264T1 (de) Pharmazeutische formulierungen mit kontrollierter wirkstoff-freigabe enthaltend milchsäure-polymer, sowie deren herstellung
TW200635616A (en) Organic compounds
MY145832A (en) Pharmaceutical composition in the form of a gastric retention tablet containing an active ingredient
EA200901148A1 (ru) Подкожные имплантаты, высвобождающие активные компоненты в течение длительного периода времени
DE60111637D1 (de) Biomaterial in form von mikropartikeln von hyaluronsaure zur medizinischen verwendung
ATE284220T1 (de) Makrophagenhaltige zusammensetzung mit antiinfektiösen und hematopoietischen eigenschaften sowie deren herstellungsmethode
ATE479417T1 (de) Zahnfüllmaterial
ZA200605900B (en) Glycosylated steroid derivatives with anti-migratory activity